Pha - Autonomic Nervous System Drugs

36 Questions | Total Attempts: 165

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Autonomic Nervous System Quizzes & Trivia

Questions and Answers
  • 1. 
    Increases effect/agonist. binds to postsynaptic axon receptor directly and mimicks the effects of NE/neurotransmitter. manipulates adrenergic receptors.
    • A. 

      Direct Sympathomimetics

    • B. 

      Indirect Sympathomimetics

    • C. 

      Mixed Sympathomimetics

  • 2. 
    Increases effect/agonist. works on presynaptic axon, increases release of NE/neurotransmitter. manipulates adrenergic receptors.
    • A. 

      Direct Sympathomimetics

    • B. 

      Indirect Sympathomimetics

    • C. 

      Mixed Sympathomimetics

  • 3. 
    • Mechanism of Action:      
      • Alpha and Beta receptor agonist
    • Vascular Effects:
      • Vasoconstriction via a1 and vasodilation via b2
    • Cardiac Effects:
      • Increased heart rate, increased contractility (via b1)
    • Pulmonary Effects:
      • Bronchodilation (b2) and decreased secretions (a1)
    • Special Characteristics:
      • Is injected with local anesthetics to delay distribution away from the injection site through vasoconstriction.**
    • A. 

      Epinephrine

    • B. 

      Norepinephrine

    • C. 

      Isoproterenol

    • D. 

      Dobutamine

    • E. 

      Dopamine

    • F. 

      Phenylephrine

    • G. 

      Albuterol

    • H. 

      Salmeterol

    • I. 

      Levalbuterol

  • 4. 
    • Mechanism of Action:
      • Alpha>Beta-1>>Beta-2 agonist
    • Vascular Effects:
      • Intense vasoconstriction via a1 leading to an increase in MAP (mean artery pressure)
      • Vasoconstriction is unopposed because it doesn’t bind to the b2 receptors
    • Cardiac Effects:
      • Reflex slowing of the heart due to vasoconstriction (because blood pressure gets too high)
    • Pulmonary Effects:
      • No b2 effect
    • Special Characteristics:
      • Used in septic shock (intense blood pressure drop) when intense vasoconstriction is needed***
    • A. 

      Norepinephrine

    • B. 

      Levalbuterol

    • C. 

      Salmeterol

    • D. 

      Albuterol

    • E. 

      Phenylephrine

    • F. 

      Dopamine

    • G. 

      Dobutamine

    • H. 

      Isoproterenol

    • I. 

      Epinephrine

  • 5. 
    • Mechanism of Action:
      • Only Beta (B2 more than B1)
    • Vascular Effects:
      • Intense vasodilation via b2 with no alpha
    • Cardiac Effects:
      • Stimulates the heart with greater effect than Epinephrine due to the vasodilation
    • Pulmonary Effects:
      • Is the most potent bronchodilator*** (stops wheezing, asthma inhalers)
    • Special Characteristics:
      • Used to prevent bronchospasm
    • A. 

      Isoproterenol

    • B. 

      Dobutamine

    • C. 

      Dopamine

    • D. 

      Phenylephrine

    • E. 

      Albuterol

    • F. 

      Salmeterol

    • G. 

      Levalbuterol

    • H. 

      Norepinephrine

    • I. 

      Epinephrine

  • 6. 
    • Mechanism of Action:
      • Beta-1* more than Beta-2 and Alpha
    • Vascular Effects:
      • No change in resistance because of low affinity for b2 and a1
    • Cardiac Effects:
      • Drug of choice to stimulate heart** (because of its strong effect on b1); Minor change in heart rate but it makes the heart more efficient
    • Pulmonary Effects:
      • None
    • Special Characteristics:
      • Is a synthetic derivative of dopamine but has no effect on dopamine receptors
    • A. 

      Dobutamine

    • B. 

      Dopamine

    • C. 

      Phenylephrine

    • D. 

      Albuterol

    • E. 

      Salmeterol

    • F. 

      Levalbuterol

    • G. 

      Isoproterenol

    • H. 

      Norepinephrine

    • I. 

      Epinephrine

  • 7. 
    • Mechanism of Action:
      • Dopamine receptors and Beta-1
    • Vascular Effects:
      • **Low dose: constricts vessels in sites other than the kidneys or brain
      • High Dose: constricts all vessels
    • Cardiac Effects:
      • Increases contractility and increase in systolic blood pressure*
    • Pulmonary Effects:
      • None
    • Special Characteristics:
      • Used to treat *shock related to underperfusion (not enough fluids in blood vessels) and reflex vasoconstriction
    • A. 

      Dopamine

    • B. 

      Phenylephrine

    • C. 

      Albuterol

    • D. 

      Salmeterol

    • E. 

      Levalbuterol

    • F. 

      Dobutamine

    • G. 

      Isoproterenol

    • H. 

      Norepinephrine

    • I. 

      Epinephrine

  • 8. 
    • Mechanism of Action:
      • Alpha
    • Vascular Effects:
      • Intense vasoconstriction with an increased MAP (mean artery pressure)
    • Cardiac Effects:
      • Decreases heart rate due to a reflex reaction to the increase arterial pressure
    • Pulmonary Effects:
      • None
    • Special Characteristics:
      • **Used to treat SVT (supraventrical tachycardia)
      • **Is included in cold remedies as a decongestant due to nasal vasoconstriction
    • A. 

      Phenylephrine

    • B. 

      Albuterol

    • C. 

      Salmeterol

    • D. 

      Levalbuterol

    • E. 

      Dopamine

    • F. 

      Dobutamine

    • G. 

      Isoproterenol

    • H. 

      Norepinephrine

    • I. 

      Epinephrine

  • 9. 
    • Mechanism of Action:
      • Beta-2
    • Vascular Effects:
      • Vasodilation
    • Cardiac Effects:
      • None but may have reflex tachycardia
    • Pulmonary Effects:
      • bronchodilation
    • Special Characteristics:
      • Used to treat acute asthma exacerbations**
    • A. 

      Albuterol

    • B. 

      Salmeterol

    • C. 

      Levalbuterol

    • D. 

      Phenylephrine

    • E. 

      Dopamine

    • F. 

      Dobutamine

    • G. 

      Isoproterenol

    • H. 

      Norepinephrine

    • I. 

      Epinephrine

  • 10. 
    • Mechanism of Action:
      • Beta-2
    • Vascular Effects:
      • Vasodilation
    • Cardiac Effects:
      • None but may have reflex tachycardia
    • Pulmonary Effects:
      • Bronchodilation
    • Special Characteristics:
      • Is long acting**
    • A. 

      Salmeterol

    • B. 

      Levalbuterol

    • C. 

      Albuterol

    • D. 

      Phenylephrine

    • E. 

      Dopamine

    • F. 

      Dobutamine

    • G. 

      Isoproterenol

    • H. 

      Norepinephrine

    • I. 

      Epinephrine

  • 11. 
    • Mechanism of Action:
      • Beta-2
    • Vascular Effects:
      • vasodilation
    • Cardiac Effects:
      • None but may have reflex tachycardia
    • Pulmonary Effects:
      • Bronchodilation
    • Special Characteristics:
      • Less cardiac side effects than albuterol**
    • A. 

      Levalbuterol

    • B. 

      Salmeterol

    • C. 

      Albuterol

    • D. 

      Phenylephrine

    • E. 

      Dopamine

    • F. 

      Dobutamine

    • G. 

      Isoproterenol

    • H. 

      Norepinephrine

    • I. 

      Epinephrine

  • 12. 
    • Bind to alpha-1, alpha-2, beta-1 and beta 2 receptors
    • Turn on second messengers which mediate the various effects associated with each receptor
    • Drugs include:
      • Epinephrine
      • Norepinephrine
      • Isoproterenol
      • Dobutamine
      • Dopamine
      • Phenylephrine
      • Albuterol
      • Salmeterol
      • Levalbuterol
    • A. 

      Direct Sympathomimetics

    • B. 

      Indirect Sympathomimetics

    • C. 

      Mixed Sympathomimetics

  • 13. 
    • Cause norepinephrine release but do not bind to adrenergic receptors.
    • They enter the presynaptic terminal and displace NE from storage vesicles.
    • Drugs include:
      • Amphetamine
      • Methamphetamine
    • A. 

      Indirect Sympathomimetics

    • B. 

      Mixed Sympathomimetics

    • C. 

      Direct Sympathomimetics

  • 14. 
    • Mechanism of Action:
      • Enter presynaptic terminal and displace NE from storage vesicles
    • Vascular Effects:
      • vasoconstriction
    • Cardiac Effects:
      • Increase in contraction with a reflex bradycardia from increased MAP (mean artery pressure)
    • CNS Effects:
      • Wakefulness, euphoria
    • Unwanted Side Effects:
      • Hypertension, cerebral hemorrhage, convulsions, tremor
    • Special Characteristics:
      • Used for narcolepsy, ADD, Parkinson’s**
    • A. 

      Amphetamine/Methamphetmaine

    • B. 

      Ephedrine

    • C. 

      Methyldopa

    • D. 

      Clonidine

  • 15. 
    • Both displace NE from storage vesicles and bind to adrenergic receptors
    • Drugs Include:
      • Ephedrine
    • A. 

      Mixed Sympathomimetics

    • B. 

      Central Adrenergic Nerve Blockers

    • C. 

      Adrenergic Antagonists

    • D. 

      Indirect Sympathomimetics

  • 16. 
    • Mechanism of Action:
      • Displaces NE from storage vesicles and binds to adrenergic receptors
    • Vascular Effects:
      • Vasoconstriction with an increased MAP (mean artery pressure) via a1
    • Cardiac Effects:
      • Similar to epinephrine but with no change in heart rate
    • CNS Effects:
      • Stimulation
    • Special Characteristics:
      • Used to treat narcolepsy**
      • Causes bronchodilation**
      • Used to treat asthma and nasal congestion**
      • Used to dilate pupils
    • A. 

      Ephedrine

    • B. 

      Methyldopa

    • C. 

      Clonidine

    • D. 

      Amphetamine/Methamphetmaine

  • 17. 
    • Bind to alpha-2 receptors on neurons and prevent the release of NE from nerves**
    • Drugs include:
      • Clonidine
      • Methyldopa
    • A. 

      Central Adrenergic Nerve Blockers

    • B. 

      Mixed Sympathomimetics

    • C. 

      Indirect Sympathomimetics

    • D. 

      Adrenergic Antagonists

  • 18. 
    • Blockade Mechanism:
      • Potent alpha-2 agonist
    • Actions:
      • Decreases preganglionic sympathetic outflow which results in a decreased blood pressure**
    • Side Effects:
      • Orthostatic hypotension
      • Sedation
      • Rebound hypertension
    • Clinical Use:
      • Hypertension***
    • A. 

      Clonidine

    • B. 

      Methyldopa

    • C. 

      Ephedrine

    • D. 

      Amphetamine/Methamphetmaine

  • 19. 
    • Blockade Mechanism:
      • Metabolized to alpha-methylnorepinephrine which is a potent alpha-2 agonist
    • Actions:
      • Decreases sympathetic outflow causing a rapid decrease in blood pressure**
    • Side Effects:
      • Sedation, mild orthostatic hypotension, coombs positive RBC (can cause allergies), rebound HTN
    • Clinical Use:
      • Hypertension**
    • A. 

      Methyldopa

    • B. 

      Clonidine

    • C. 

      Ephedrine

    • D. 

      Amphetamine/Methamphetmaine

  • 20. 
    • Block NE from binding to the postsynaptic adrenergic receptors
    • Drugs include:
      • Phenoxybenzamine
      • Phentolamine
      • Prazosin
      • Doxazosin
      • Labetalol
      • Propranolol
      • Timilol
      • Metoprolol
    • A. 

      Adrenergic Antagonists

    • B. 

      Central Adrenergic Nerve Blockers

    • C. 

      Mixed Sympathomimetics

    • D. 

      Indirect Sympathomimetics

  • 21. 
    • Receptor:
      • Alpha-1 and alpha-2
    • Actions:
      • Vasodilation, blocks sympathetic outflow from the brain
    • Clinical Use:
      • Pheochromocytoma (adrenal gland tumor)**
    • Controls Hypertension**
    • Side Effects:
      • Postural hypotension, reflex tachycardia, sexual dysfunction**
    • Special Features:
      • none
    • A. 

      Phenoxybenzamine

    • B. 

      Phentolamine

    • C. 

      Prazosin

    • D. 

      Doxazosin

    • E. 

      Labetalol

    • F. 

      Propranolol

    • G. 

      Timilol

    • H. 

      Metroprolol

  • 22. 
    • Receptor:
      • Alpha-1, alpha-2
    • Actions:
      • Vasodilation
    • Clinical Use:
      • Pheochromocytoma (adrenal gland tumor)**
        • To control HTN and is the pharmacological test
    • Side Effects:
      • Tachycardia, arrhythmias, hypotensive episodes**
    • Special Features:
      • None
    • A. 

      Phentolamine

    • B. 

      Phenoxybenzamine

    • C. 

      Prazosin

    • D. 

      Doxazosin

    • E. 

      Labetalol

    • F. 

      Propranolol

    • G. 

      Timilol

    • H. 

      Metroprolol

  • 23. 
    • Receptor:
      • Alpha-1
    • Actions:
      • vasodilation
    • Clinical Use:
      • Hypertension
    • Side Effects:
      • Postural hypotension with first dose**
    • Special Features:
      • None
    • A. 

      Prazosin

    • B. 

      Phentolamine

    • C. 

      Phenoxybenzamine

    • D. 

      Doxazosin

    • E. 

      Labetalol

    • F. 

      Propranolol

    • G. 

      Timilol

    • H. 

      Metroprolol

  • 24. 
    • Receptor:
      • Alpha-1
    • Actions:
      • vasodilation
    • Clinical Use:
      • HTN, Benign Prostate Hyperplasia
        • Relaxes smooth muscle in the bladder neck
    • Side Effects:
      • Postural hypotension with first dose
    • Special Features:
      • None
    • A. 

      Doxazosin

    • B. 

      Labetalol

    • C. 

      Propranolol

    • D. 

      Timilol

    • E. 

      Metroprolol

    • F. 

      Prazosin

    • G. 

      Phentolamine

    • H. 

      Phenoxybenzamine

  • 25. 
    • Receptor:
      • Alpha-1, Beta-1, Beta-2
    • Actions:
      • Decreases BP from alpha 1 blockade without a reflex tachycardia from b1 blockade**
    • Clinical Use:
      • Hypertension**
    • Side Effects:
      • Suppresses a failing heart, impotence, orthostatic HTN**
    • Special Features:
      • Contraindicated in patients with asthma or bradycardia**
    • A. 

      Labetalol

    • B. 

      Propranolol

    • C. 

      Timilol

    • D. 

      Metroprolol

    • E. 

      Doxazosin

    • F. 

      Prazosin

    • G. 

      Phentolamine

    • H. 

      Phenoxybenzamine

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