Peripheral Nervous System And Synaptic Pharmacology 8: Neurotransmitters

23 Questions | Total Attempts: 206

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Neurotransmitter Quizzes & Trivia

Lecture 8


Questions and Answers
  • 1. 
    Most neurotransmitters are located within the PNS
    • A. 

      True

    • B. 

      False

  • 2. 
    Which of the following is not one of the four criteria required for a substance to be considered a neurotransmitter?
    • A. 

      Synthesis within the neuron

    • B. 

      Presence within the synaptic terminal and release in amounts sufficient to initiate an effect on the postsynaptic cell

    • C. 

      When applied exogenously, it has a seperate effect from when it is applied endogenously

    • D. 

      A seperate mechanism exists for removing it from the synaptic cleft

  • 3. 
    Which of the following neurotransmitters is not a biogenic amine?  
    • A. 

      Noradrenaline

    • B. 

      Adrenaline

    • C. 

      Acetylcholine

    • D. 

      Dopamine

    • E. 

      Serotonin

    • F. 

      Histamine

  • 4. 
    Which of the following neurotransmitters is not an amino acid?
    • A. 

      5-HT

    • B. 

      Glutamate

    • C. 

      GABA (gamma-aminobutyric acid)

    • D. 

      Glycine

  • 5. 
    Nitric Oxides action as as a neuromodulator is interfered with by the action of which drug?  
    • A. 

      Aspirin

    • B. 

      Posaconazole

    • C. 

      Sildenafil

    • D. 

      Simvastin

  • 6. 
    Acetylecholine acts as a neurotransmitter of the somatic efferent system
    • A. 

      True

    • B. 

      False

  • 7. 
    Acetylcholine acts as the neurotransmitter of all post-ganglionic fibres of the autonomic nervous system
    • A. 

      True

    • B. 

      False

  • 8. 
    Acetylecholine acts as a neurotransmitter in the post-ganglionic fibres of the parasympathetic nervous system  
    • A. 

      True

    • B. 

      False

  • 9. 
    Noradrenaline acts as a neurotransmitter at which of the following
    • A. 

      The pre-ganglionic fibres of the sympathetic nervous system

    • B. 

      The pre-ganglionic fibres of the parasympathetic nervous system

    • C. 

      The post-ganglionic fibres of the sympathetic nervous system

    • D. 

      The post-ganglionic fibres of the parasympathetic nervous system

  • 10. 
    Acetylcholine is produced via the modification of choline with an acetyl c-enzyme. Which other enzyme is involved in this process?
    • A. 

      Acetylcholine synthase

    • B. 

      Choline kinase

    • C. 

      Acetylcholine estertransferase

    • D. 

      Choline acetyltransferase

  • 11. 
    Once synthesised, how is acetylcholine transferred into the synaptic vesicles?
    • A. 

      Passive transport through the vesicle membrane (facillitated diffusion)

    • B. 

      Cotransported against its concentration gradient using a proton pump to generate energy and an antiport coupled channel (ACh-H+) to tranfer it into the cell

    • C. 

      Utilization of energy from the hydrolysis of ATP to transport it against its concentration gradient (active transport)

    • D. 

      Cotransported against its concentration gradient using a proton pump to generate energy and a symport coupled channel (ACh-H+) to tranfer it into the cell

  • 12. 
    When acetylcholine is broken down back into choline by acetylcholinesterase, how is the choline reuptaken into the pre-synaptic terminal?
    • A. 

      Through a specific Ch-Na+ symport cotransporter

    • B. 

      Through a specific Ch-Na+ antiport cotransporter

    • C. 

      Through a specific Ch-K+ symport cotransporter

    • D. 

      Through a specific Ch-K+ antiport cotransporter

  • 13. 
    Nicotonic receptors...
    • A. 

      Are G-protein coupled receptors (ionotropic receptors)

    • B. 

      Are ligand-gated ion channels (ionotropic receptors)

    • C. 

      Are G-protein coupled receptors (metabotropic receptors)

    • D. 

      Are ligand-gated ion channels (metabotropic receptors)

  • 14. 
    Muscarinic receptors...
    • A. 

      Are G-protein coupled receptors (ionotropic receptors)

    • B. 

      Are ligand-gated ion channels (ionotropic receptors)

    • C. 

      Are G-protein coupled receptors (metabotropic receptors)

    • D. 

      Are ligand-gated ion channels (metabotropic receptors)

  • 15. 
    Which is the correct pathway in the synthesis of adrenaline from tyrosine?
    • A. 

      Tyrosine -> Dopamine -> DOPA -> Noradrenaline -> Adrenaline

    • B. 

      Tyrosine -> DOPA -> Noradrenaline -> Dopamine -> Adrenaline

    • C. 

      Tyrosine -> Dopamine -> Noradrenaline -> DOPA -> Adrenaline

    • D. 

      Tyrosine -> DOPA -> Dopamine -> Noradrenaline -> Adrenaline

  • 16. 
    The conversion of tyrosine to DOPA is catalysed by which enzyme?
    • A. 

      Tyrosine hydroxylase

    • B. 

      Phenylethanolamine N-methyl transferase

    • C. 

      Dopamine beta-hydroxylase

    • D. 

      DOPA decarboxylase

  • 17. 
    The conversion of dopamine to noradrenaline is catalysed by which enzyme?
    • A. 

      Tyrosine hydroxylase

    • B. 

      Phenylethanolamine N-methyl transferase

    • C. 

      Dopamine beta-hydroxylase

    • D. 

      DOPA decarboxylase

  • 18. 
    The conversion of DOPA to dopamine is catalysed by which enzyme?
    • A. 

      Tyrosine hydroxylase

    • B. 

      Phenylethanolamine N-methyl transferase

    • C. 

      Dopamine beta-hydroxylase

    • D. 

      DOPA decarboxylase

  • 19. 
    The conversion of noradrenaline to adrenaline is catalysed by which enzyme?
    • A. 

      Tyrosine hydroxylase

    • B. 

      Phenylethanolamine N-methyl transferase

    • C. 

      Dopamine beta-hydroxylase

    • D. 

      DOPA decarboxylase

  • 20. 
    In the uptake 1 mechanism of noradrenaline breakdown...
    • A. 

      Noradrenaline is recycled back into the synaptic terminal (NET)

    • B. 

      Noradenaline is taken up by adjacent cells (VMAT)

  • 21. 
    Glutamate...
    • A. 

      Is the major inhbitory neurotransmitter of the CNS

    • B. 

      Is an inhibitory neurotransmitter of the CNS

    • C. 

      Is the major excitatory neurotransmitter of the CNS

    • D. 

      Is an excitatory neurotransmitter of the CNS

  • 22. 
    GABA...
    • A. 

      Is the major inhbitory neurotransmitter of the CNS

    • B. 

      Is an inhibitory neurotransmitter of the CNS

    • C. 

      Is the major excitatory neurotransmitter of the CNS

    • D. 

      Is an excitatory neurotransmitter of the CNS

  • 23. 
    Glycine...
    • A. 

      Is the major inhbitory neurotransmitter of the CNS

    • B. 

      Is an inhibitory neurotransmitter of the CNS

    • C. 

      Is the major excitatory neurotransmitter of the CNS

    • D. 

      Is an excitatory neurotransmitter of the CNS