Peripheral Nervous System And Synaptic Pharmacology 8: Neurotransmitters
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Lecture 8
- 1.Most neurotransmitters are located within the PNS
- A.
True
- B.
False
- 2.Which of the following is not one of the four criteria required for a substance to be considered a neurotransmitter?
- A.
Synthesis within the neuron
- B.
Presence within the synaptic terminal and release in amounts sufficient to initiate an effect on the postsynaptic cell
- C.
When applied exogenously, it has a seperate effect from when it is applied endogenously
- D.
A seperate mechanism exists for removing it from the synaptic cleft
- 3.Which of the following neurotransmitters is not a biogenic amine?
- A.
Noradrenaline
- B.
Adrenaline
- C.
Acetylcholine
- D.
Dopamine
- E.
Serotonin
- F.
Histamine
- 4.Which of the following neurotransmitters is not an amino acid?
- A.
5-HT
- B.
Glutamate
- C.
GABA (gamma-aminobutyric acid)
- D.
Glycine
- 5.Nitric Oxides action as as a neuromodulator is interfered with by the action of which drug?
- A.
Aspirin
- B.
Posaconazole
- C.
Sildenafil
- D.
Simvastin
- 6.Acetylecholine acts as a neurotransmitter of the somatic efferent system
- A.
True
- B.
False
- 7.Acetylcholine acts as the neurotransmitter of all post-ganglionic fibres of the autonomic nervous system
- A.
True
- B.
False
- 8.Acetylecholine acts as a neurotransmitter in the post-ganglionic fibres of the parasympathetic nervous system
- A.
True
- B.
False
- 9.Noradrenaline acts as a neurotransmitter at which of the following
- A.
The pre-ganglionic fibres of the sympathetic nervous system
- B.
The pre-ganglionic fibres of the parasympathetic nervous system
- C.
The post-ganglionic fibres of the sympathetic nervous system
- D.
The post-ganglionic fibres of the parasympathetic nervous system
- 10.Acetylcholine is produced via the modification of choline with an acetyl c-enzyme. Which other enzyme is involved in this process?
- A.
Acetylcholine synthase
- B.
Choline kinase
- C.
Acetylcholine estertransferase
- D.
Choline acetyltransferase
- 11.Once synthesised, how is acetylcholine transferred into the synaptic vesicles?
- A.
Passive transport through the vesicle membrane (facillitated diffusion)
- B.
Cotransported against its concentration gradient using a proton pump to generate energy and an antiport coupled channel (ACh-H+) to tranfer it into the cell
- C.
Utilization of energy from the hydrolysis of ATP to transport it against its concentration gradient (active transport)
- D.
Cotransported against its concentration gradient using a proton pump to generate energy and a symport coupled channel (ACh-H+) to tranfer it into the cell
- 12.When acetylcholine is broken down back into choline by acetylcholinesterase, how is the choline reuptaken into the pre-synaptic terminal?
- A.
Through a specific Ch-Na+ symport cotransporter
- B.
Through a specific Ch-Na+ antiport cotransporter
- C.
Through a specific Ch-K+ symport cotransporter
- D.
Through a specific Ch-K+ antiport cotransporter
- 13.Nicotonic receptors...
- A.
Are G-protein coupled receptors (ionotropic receptors)
- B.
Are ligand-gated ion channels (ionotropic receptors)
- C.
Are G-protein coupled receptors (metabotropic receptors)
- D.
Are ligand-gated ion channels (metabotropic receptors)
- 14.Muscarinic receptors...
- A.
Are G-protein coupled receptors (ionotropic receptors)
- B.
Are ligand-gated ion channels (ionotropic receptors)
- C.
Are G-protein coupled receptors (metabotropic receptors)
- D.
Are ligand-gated ion channels (metabotropic receptors)
- 15.Which is the correct pathway in the synthesis of adrenaline from tyrosine?
- A.
Tyrosine -> Dopamine -> DOPA -> Noradrenaline -> Adrenaline
- B.
Tyrosine -> DOPA -> Noradrenaline -> Dopamine -> Adrenaline
- C.
Tyrosine -> Dopamine -> Noradrenaline -> DOPA -> Adrenaline
- D.
Tyrosine -> DOPA -> Dopamine -> Noradrenaline -> Adrenaline
- 16.The conversion of tyrosine to DOPA is catalysed by which enzyme?
- A.
Tyrosine hydroxylase
- B.
Phenylethanolamine N-methyl transferase
- C.
Dopamine beta-hydroxylase
- D.
DOPA decarboxylase
- 17.The conversion of dopamine to noradrenaline is catalysed by which enzyme?
- A.
Tyrosine hydroxylase
- B.
Phenylethanolamine N-methyl transferase
- C.
Dopamine beta-hydroxylase
- D.
DOPA decarboxylase
- 18.The conversion of DOPA to dopamine is catalysed by which enzyme?
- A.
Tyrosine hydroxylase
- B.
Phenylethanolamine N-methyl transferase
- C.
Dopamine beta-hydroxylase
- D.
DOPA decarboxylase
- 19.The conversion of noradrenaline to adrenaline is catalysed by which enzyme?
- A.
Tyrosine hydroxylase
- B.
Phenylethanolamine N-methyl transferase
- C.
Dopamine beta-hydroxylase
- D.
DOPA decarboxylase
- 20.In the uptake 1 mechanism of noradrenaline breakdown...
- A.
Noradrenaline is recycled back into the synaptic terminal (NET)
- B.
Noradenaline is taken up by adjacent cells (VMAT)
- 21.Glutamate...
- A.
Is the major inhbitory neurotransmitter of the CNS
- B.
Is an inhibitory neurotransmitter of the CNS
- C.
Is the major excitatory neurotransmitter of the CNS
- D.
Is an excitatory neurotransmitter of the CNS
- 22.GABA...
- A.
Is the major inhbitory neurotransmitter of the CNS
- B.
Is an inhibitory neurotransmitter of the CNS
- C.
Is the major excitatory neurotransmitter of the CNS
- D.
Is an excitatory neurotransmitter of the CNS
- 23.Glycine...
- A.
Is the major inhbitory neurotransmitter of the CNS
- B.
Is an inhibitory neurotransmitter of the CNS
- C.
Is the major excitatory neurotransmitter of the CNS
- D.
Is an excitatory neurotransmitter of the CNS
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