Through several mechanisms of action, these agents are used to achieve the fine balance between clotting and systemic bleeding. These drugs are very common, so you should become an expert on every detail regarding them. Test your wit with various forms of questions and see if you have what it takes to be a pharmacist!
Albumin
Alpha-1 acid glycoprotein
Hemoglobin
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True
False
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True
False
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1 day
2-5 days
5-10 days
90 days
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Primary prophylaxis
Secondary prophylaxis
Treatment of acute coronary syndromes
Treatment of acute ischemic stroke
Treatment of peripheral arterial disease
All of the above are indications of aspirin
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CYP 3A4 inhibitors
CYP 2D6 inhibitors
CYP 2E1 inhibitors
CYP 2C19 inhibitors
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Abciximab (Reopro)
Eptifibatide (Integrilin)
Tirofiban (Aggrastat)
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CYP 3A4 inhibitors
CYP 3A4 inducers
CYP 2C19 inhibitors
CYP 2D6 inhibitors
A and B
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Secondary MI prophylaxis
Fibrinolysis
Recurrent stroke prophylaxis
Primary MI prophylaxis
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5-10%
10-15%
15-20%
20-25%
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Invasive management during a PCI
Treatment of heart failure
Chronic prevention of blood clots
Coating of invasive lines
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True
False
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Secondary prophylaxis
Intermittent claudication (peripheral arterial disease)
Invasive management of PCI
Stroke prevention
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Demographics
Vitamin K intake
Hepatic function
Drug interactions
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True
False
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Age
Body weight
Serum creatinine
CYP 3A4 or P-gp inhibitors
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Do not require cofactor (antithrombin)
Bind clot-bound thrombin
Predictable effects of anticoagulation
Decreased bleeding compared to heparin
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Weight
Indication
Renal function
Prior use of fondaparinux
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Prophylaxis of VTE
Treatment of VTE (DVT/PE)
Prophylaxis of stroke/systemic embolism
Mechanical aortic valve
Mechanical mitral valve
Bioprosthetic aortic valve
Bioprosthetic mitral valve
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