Through several mechanisms of action, these agents are used to achieve the fine balance between clotting and systemic bleeding. These drugs are very common, so you should become an expert on every detail regarding them. Test your wit with various forms of questions and see if you have what it takes to be a pharmacist!
1 day
2-5 days
5-10 days
90 days
Yes
No
Primary prophylaxis
Secondary prophylaxis
Treatment of acute coronary syndromes
Treatment of acute ischemic stroke
Treatment of peripheral arterial disease
All of the above are indications of aspirin
CYP 3A4 inhibitors
CYP 2D6 inhibitors
CYP 2E1 inhibitors
CYP 2C19 inhibitors
CYP 3A4 inhibitors
CYP 3A4 inducers
CYP 2C19 inhibitors
CYP 2D6 inhibitors
A and B
Secondary prophylaxis
Intermittent claudication (peripheral arterial disease)
Invasive management of PCI
Stroke prevention
Secondary MI prophylaxis
Fibrinolysis
Recurrent stroke prophylaxis
Primary MI prophylaxis
Invasive management during a PCI
Treatment of heart failure
Chronic prevention of blood clots
Coating of invasive lines
Abciximab (Reopro)
Eptifibatide (Integrilin)
Tirofiban (Aggrastat)
Albumin
Alpha-1 acid glycoprotein
Hemoglobin
Demographics
Vitamin K intake
Hepatic function
Drug interactions
Prophylaxis of VTE
Treatment of VTE (DVT/PE)
Prophylaxis of stroke/systemic embolism
Mechanical aortic valve
Mechanical mitral valve
Bioprosthetic aortic valve
Bioprosthetic mitral valve
True
False
Do not require cofactor (antithrombin)
Bind clot-bound thrombin
Predictable effects of anticoagulation
Decreased bleeding compared to heparin
True
False
Weight
Indication
Renal function
Prior use of fondaparinux
Age
Body weight
Serum creatinine
CYP 3A4 or P-gp inhibitors
True
False
True
False
5-10%
10-15%
15-20%
20-25%
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