1.
Calcium channel blockers can be divided into three class based on their chemical structure. Which of the following is not a class of calcium channel blockers?
A. 
B. 
C. 
D. 
2.
Calcium channel blockers can be used as anti-anginal drugs.
3.
Which of the following are classified as "dihydropyridines" of the calcium channel blockers?
A. 
B. 
C. 
D. 
E. 
F. 
4.
In addition to angina, calcium channel blockers can be used therapeutically in the treatment of which of the following diseases?
5.
Calcium enters excitable cells via potential or voltage-dependent calcium channels, which are similar to other ion channels.
6.
Which of the following is NOT a type of calcium channel?
A. 
B. 
C. 
D. 
7.
Calcium is responsible for the __________ of muscle.
8.
Which type of calcium channel do the calcium channel blockers selectively inhibit?
9.
Calcium channel blockers allow calcium movement from outside the cell to inside the cell through their channels.
10.
Which of the following are characteristics of the L type calcium channels?
A. 
B. 
C. 
D. 
E. 
Enriched in cardiac and smooth muscle, in the SA node and Purkinje cells
F. 
Blocked by spider and snail toxins
G. 
Blocked by calcium channel blockers
11.
Because L type calcium channels are enriched in the cardiac and smooth muscle, SA node, and Purkinje cells, they play an important role in __________.
A. 
Contration, heart rate, and conduction
B. 
12.
Which of the following are characteristic of the T type calcium channel?
A. 
Found in the SA node and Purkinje cells
B. 
C. 
D. 
Blocked by calcium channel blockers
E. 
Blocked by spider and snail toxins
F. 
13.
T type calcium channels were once a target for anti-anginal drugs as they are located in the SA node and Purkinje cells, playing a role in pacemaker activity and conduction, but the ones developed were found to be toxic. It is still a possible area for development of anti-anginals.
14.
Which of the following are characteristic of N type calcium channels?
A. 
B. 
C. 
D. 
Blocked by calcium channel blockers
E. 
Blocked by spider and snail toxins
F. 
G. 
Enriched in cardiac muscle
H. 
Play a role in neurotransmitter release
15.
Which of the following is not true regarding L-type calcium channels?
A. 
Widespread in cardiovascular system
B. 
Activated when the cell is depolarized
C. 
Large conductance of long lasting duration
D. 
Inhibited by calcium channel blockers
E. 
Responsible for the upstroke of the cardiac action potential
F. 
Responsible for the plateau phase of the cardiac action potential
16.
Calcium channel blockers exhibit a mechanism of action in both cardiac cells and vascular muscle cells.
17.
In vascular smooth muscle, contraction is dependent upon an increase in intracellular calcium. Which of the following occurs when calcium enters a vascular smooth muscle cell?
A. 
Calmodulin activates myosin LC kinase to phosphorylate myosin LC
B. 
Calcium binds to calmodulin
C. 
Calmodulin inhibits myosin LC kinase, so myosin LC cannot be phosphorylated
D. 
Phopshorylated myosin LC interacts with actin
E. 
Contraction occurs because phosphorylated myosin LC interacts with actin
18.
Which of the following occurs because calcium entry into vascular smooth muscle is blocked by calcium channel blockers?
19.
By preventing calcium entry, calcium channel blockers are thereby stopping which of the following mechanisms from occuring?
A. 
Calcium's binding to calmodulin
B. 
Calmodulin's activation of myosin LC kinase
C. 
Phosphorylated myosin LC's interaction with actin
D. 
20.
Calcium channel blockers have a much more prominent effect in decreasing vascular smooth muscle contraction in arteries.
21.
The relaxation produced in coronary and peripheral vascular smooth muscle decreases peripheral resistance, which results in which of the following?
A. 
Decrease pressure and decreased cardiac preload
B. 
Increased pressure and increase cardiac preload
C. 
Decreased pressure and decreased cardiac afterload
22.
Through their mechanisms, calcium channel blockers work in angina because they reduce the oxygen demand (through decreasing resistance), as well as increase the oxygen supply (through relaxation of the arteries).
23.
Calcium channel blockers have a large effect on the veins, as well as the cardiac preload.
24.
Calcium entry is responsible for which phase in the action potential?
25.
Calcium channels are sometimes called slow channels because of their delayed response in the cardiac action potential.