Calcium Channel Blockers

54 Questions | Total Attempts: 787

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Calcium Quizzes & Trivia

Questions and Answers
  • 1. 
    Calcium channel blockers can be divided into three class based on their chemical structure. Which of the following is not a class of calcium channel blockers?
    • A. 

      Nitrates

    • B. 

      Penylalkylamines

    • C. 

      Dihydropyridines

    • D. 

      Benzothiazepines

  • 2. 
    Calcium channel blockers can be used as anti-anginal drugs.
    • A. 

      True

    • B. 

      False

  • 3. 
    Which of the following are classified as "dihydropyridines" of the calcium channel blockers?
    • A. 

      Nicardipine

    • B. 

      Amlodipine

    • C. 

      Diltiazem

    • D. 

      Nifedipine

    • E. 

      Verapamil

    • F. 

      Felodipine

  • 4. 
    In addition to angina, calcium channel blockers can be used therapeutically in the treatment of which of the following diseases?
    • A. 

      Essential hypertension

    • B. 

      Cardiac arrhythmias

    • C. 

      Type II Diabetes

  • 5. 
    Calcium enters excitable cells via potential or voltage-dependent calcium channels, which are similar to other ion channels.
    • A. 

      True

    • B. 

      False

  • 6. 
    Which of the following is NOT a type of calcium channel?
    • A. 

      L

    • B. 

      S

    • C. 

      N

    • D. 

      T

  • 7. 
    Calcium is responsible for the __________ of muscle.
  • 8. 
    Which type of calcium channel do the calcium channel blockers selectively inhibit?
    • A. 

      N

    • B. 

      T

    • C. 

      L

  • 9. 
    Calcium channel blockers allow calcium movement from outside the cell to inside the cell through their channels.
    • A. 

      True

    • B. 

      False

  • 10. 
    Which of the following are characteristics of the L type calcium channels?
    • A. 

      Long lasting current

    • B. 

      High conductance

    • C. 

      Large channels

    • D. 

      Enriched in the neurons

    • E. 

      Enriched in cardiac and smooth muscle, in the SA node and Purkinje cells

    • F. 

      Blocked by spider and snail toxins

    • G. 

      Blocked by calcium channel blockers

  • 11. 
    Because L type calcium channels are enriched in the cardiac and smooth muscle, SA node, and Purkinje cells, they play an important role in __________.
    • A. 

      Contration, heart rate, and conduction

    • B. 

      Neurotransmitter release

  • 12. 
    Which of the following are characteristic of the T type calcium channel?
    • A. 

      Found in the SA node and Purkinje cells

    • B. 

      Tiny, transient current

    • C. 

      Intermediate current

    • D. 

      Blocked by calcium channel blockers

    • E. 

      Blocked by spider and snail toxins

    • F. 

      Very small calcium entry

  • 13. 
    T type calcium channels were once a target for anti-anginal drugs as they are located in the SA node and Purkinje cells, playing a role in pacemaker activity and conduction, but the ones developed were found to be toxic. It is still a possible area for development of anti-anginals.
    • A. 

      True

    • B. 

      False

  • 14. 
    Which of the following are characteristic of N type calcium channels?
    • A. 

      Large conductance

    • B. 

      Small conductance

    • C. 

      Intermediate conductance

    • D. 

      Blocked by calcium channel blockers

    • E. 

      Blocked by spider and snail toxins

    • F. 

      Enriched in neurons

    • G. 

      Enriched in cardiac muscle

    • H. 

      Play a role in neurotransmitter release

  • 15. 
    Which of the following is not true regarding L-type calcium channels?
    • A. 

      Widespread in cardiovascular system

    • B. 

      Activated when the cell is depolarized

    • C. 

      Large conductance of long lasting duration

    • D. 

      Inhibited by calcium channel blockers

    • E. 

      Responsible for the upstroke of the cardiac action potential

    • F. 

      Responsible for the plateau phase of the cardiac action potential

  • 16. 
    Calcium channel blockers exhibit a mechanism of action in both cardiac cells and vascular muscle cells.
    • A. 

      True

    • B. 

      False

  • 17. 
    In vascular smooth muscle, contraction is dependent upon an increase in intracellular calcium. Which of the following occurs when calcium enters a vascular smooth muscle cell?
    • A. 

      Calmodulin activates myosin LC kinase to phosphorylate myosin LC

    • B. 

      Calcium binds to calmodulin

    • C. 

      Calmodulin inhibits myosin LC kinase, so myosin LC cannot be phosphorylated

    • D. 

      Phopshorylated myosin LC interacts with actin

    • E. 

      Contraction occurs because phosphorylated myosin LC interacts with actin

  • 18. 
    Which of the following occurs because calcium entry into vascular smooth muscle is blocked by calcium channel blockers?
    • A. 

      Contraction

    • B. 

      Relaxation

  • 19. 
    By preventing calcium entry, calcium channel blockers are thereby stopping which of the following mechanisms from occuring?
    • A. 

      Calcium's binding to calmodulin

    • B. 

      Calmodulin's activation of myosin LC kinase

    • C. 

      Phosphorylated myosin LC's interaction with actin

    • D. 

      Contraction

  • 20. 
    Calcium channel blockers have a much more prominent effect in decreasing vascular smooth muscle contraction in arteries.
    • A. 

      True

    • B. 

      False

  • 21. 
    The relaxation produced in coronary and peripheral vascular smooth muscle decreases peripheral resistance, which results in which of the following?
    • A. 

      Decrease pressure and decreased cardiac preload

    • B. 

      Increased pressure and increase cardiac preload

    • C. 

      Decreased pressure and decreased cardiac afterload

  • 22. 
    Through their mechanisms, calcium channel blockers work in angina because they reduce the oxygen demand (through decreasing resistance), as well as increase the oxygen supply (through relaxation of the arteries).
    • A. 

      True

    • B. 

      False

  • 23. 
    Calcium channel blockers have a large effect on the veins, as well as the cardiac preload.
    • A. 

      True

    • B. 

      False

  • 24. 
    Calcium entry is responsible for which phase in the action potential?
    • A. 

      Phase 0

    • B. 

      Phase 1

    • C. 

      Phase 2

  • 25. 
    Calcium channels are sometimes called slow channels because of their delayed response in the cardiac action potential.
    • A. 

      True

    • B. 

      False

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