This quiz discusses some of the agents used in patients with dyslipidemia.
Inhibit production of cholesterol in the liver
Decrease cholesterol absorption in the intestine
Bind bile salts in the intestine
Stimulate lipoprotein lipase
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Decreasing HDL
Increasing HDL
Decreasing LDL
Decreasing triglycerides
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Inhibits cholesterol absorption in the intestine
Decreases cholesterol synthesis in the liver
Stimulates lipoprotein lipase
Inhibits lipolysis in adipose tissue
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GI effects and myopathy may occur
Can cause gallstones by increasing biliary cholesterol secretion
May require reduction in warfarin dosage
Concomitant use with statins may increase myopathy risk
All of the above
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Inhibits lipolysis in adipose tissue to disrupt mobilization of free fatty acids
Decreases cholesterol synthesis in the liver
Decreases absorption of cholesterol in the intestine
Bind to bile salts in the intestine
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Triglycerides
HDL
LDL
VLDL
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Inhibit lipolysis in adipose tissue to disrupt mobilization of free fatty acids
Agonize peroxisome proliferator-activated receptor alpha (PPARa)
Decrease cholesterol synthesis in the liver
Decrease absorption of cholesterol in the intestine
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Decrease production of cholesterol in the liver
Decrease absorption of cholesterol in the intestine
Bind to bile salts in the intestine
Inhibit lipolysis in adipose tissue
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Decrease LDL
Decrease VLDL
Decrease triglycerides
Decrease HDL
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Emphasis is now placed on assessing cardiovascular risks rather than cholesterol goals
There are "Four Statin Benefit Groups"
Patients over 75 should receive high-intensity statin therapy
Weight management and lifestyle changes are still recommended
All of the above
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Flushing
Exacerbation of peptic ulcer
Hyperglycemia
Myopathy
All of the above
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Individuals cannot make HDL
Individuals cannot make LDL receptors
Individuals cannot absorb cholesterol
Individuals live long, healthy lives
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AST/ALT elevations
Myopathy
Drug-drug interactions
A and B
All of the above
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It decreases VLDL and LDL
It decreases triglycerides
Its vitamin effect requires higher doses
It increases HDL
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It is contraindicated with azole antifgunals
Its maximum dosage is 10 mg qhs with diltiazem or verapamil
Its maximum dosage is 20 mg qhs with amlodipine
80 mg qhs should be the start dose in every patient
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Simvastatin
Fluvastatin
Atorvastatin
Lovastatin
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Systemic toxicities
Decreased absorption of other drugs
Myopathy
Abdominal discomfort
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They help decrease triglyceride synthesis from the liver
Belching and altered taste are examples of adverse effects
They are clinically proven to protect individuals from atherosclerosis
They may potentially increase bleeding times
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It is synergistic with statins for LDL-lowering effects
There are some GI effects associated with it
It interacts with bile acid sequestrants
It interacts with cyclosporine
All of the above
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