Treatment Of Dyslipidemia
This quiz discusses some of the agents used in patients with dyslipidemia.
- 1.Which of the following correctly describes the mechanism of action of niacin?
- A.
Inhibits lipolysis in adipose tissue to disrupt mobilization of free fatty acids
- B.
Decreases cholesterol synthesis in the liver
- C.
Decreases absorption of cholesterol in the intestine
- D.
Bind to bile salts in the intestine
- 2.Which of the following is false regarding the uses of niacin?
- A.
It decreases VLDL and LDL
- B.
It decreases triglycerides
- C.
Its vitamin effect requires higher doses
- D.
It increases HDL
- 3.Which of the following are adverse effects of niacin?
- A.
Flushing
- B.
Exacerbation of peptic ulcer
- C.
Hyperglycemia
- D.
Myopathy
- E.
All of the above
- 4.Which of the following correctly describes the mechanism of action of fibric acid derivatives?
- A.
Inhibit lipolysis in adipose tissue to disrupt mobilization of free fatty acids
- B.
Agonize peroxisome proliferator-activated receptor alpha (PPARa)
- C.
Decrease cholesterol synthesis in the liver
- D.
Decrease absorption of cholesterol in the intestine
- 5.Which of the following components is most greatly reduced by fibric acid derivatives?
- A.
Triglycerides
- B.
HDL
- C.
LDL
- D.
VLDL
- 6.Which of the following are clinical teachings regarding fibric acid derivatives?
- A.
GI effects and myopathy may occur
- B.
Can cause gallstones by increasing biliary cholesterol secretion
- C.
May require reduction in warfarin dosage
- D.
Concomitant use with statins may increase myopathy risk
- E.
All of the above
- 7.Which of the following correctly describes the mechanism of action of bile acid binding resins (bile acid sequestrants)?
- A.
Decrease production of cholesterol in the liver
- B.
Decrease absorption of cholesterol in the intestine
- C.
Bind to bile salts in the intestine
- D.
Inhibit lipolysis in adipose tissue
- 8.Which of the following is the main effect of bile acid sequestrants?
- A.
Decrease LDL
- B.
Decrease VLDL
- C.
Decrease triglycerides
- D.
Decrease HDL
- 9.Which of the following is the most relevant adverse effect of bile acid sequestrants?
- A.
Systemic toxicities
- B.
Decreased absorption of other drugs
- C.
Myopathy
- D.
Abdominal discomfort
- 10.Which of the following is the correct mechanism of action of statins?
- A.
Inhibit production of cholesterol in the liver
- B.
Decrease cholesterol absorption in the intestine
- C.
Bind bile salts in the intestine
- D.
Stimulate lipoprotein lipase
- 11.Which of the following is the main effect of HMG-CoA reductase inhibitors?
- A.
Decreasing HDL
- B.
Increasing HDL
- C.
Decreasing LDL
- D.
Decreasing triglycerides
- 12.Which of the following are concerns of statins?
- A.
AST/ALT elevations
- B.
Myopathy
- C.
Drug-drug interactions
- D.
A and B
- E.
All of the above
- 13.Which of the following statins is NOT metabolized by CYP3A4?
- A.
Simvastatin
- B.
Fluvastatin
- C.
Atorvastatin
- D.
Lovastatin
- 14.Which of the following is false regarding simvastatin?
- A.
It is contraindicated with azole antifgunals
- B.
Its maximum dosage is 10 mg qhs with diltiazem or verapamil
- C.
Its maximum dosage is 20 mg qhs with amlodipine
- D.
80 mg qhs should be the start dose in every patient
- 15.Which of the following is the correct mechanism of action of ezetimibe?
- A.
Inhibits cholesterol absorption in the intestine
- B.
Decreases cholesterol synthesis in the liver
- C.
Stimulates lipoprotein lipase
- D.
Inhibits lipolysis in adipose tissue
- 16.Which of the following is true regarding ezetimibe?
- A.
It is synergistic with statins for LDL-lowering effects
- B.
There are some GI effects associated with it
- C.
It interacts with bile acid sequestrants
- D.
It interacts with cyclosporine
- E.
All of the above
- 17.Which of the following is false regarding omega-3 fatty acids?
- A.
They help decrease triglyceride synthesis from the liver
- B.
Belching and altered taste are examples of adverse effects
- C.
They are clinically proven to protect individuals from atherosclerosis
- D.
They may potentially increase bleeding times
- 18.Which of the following correctly characterizes homozygous familial hypercholesterolemia?
- A.
Individuals cannot make HDL
- B.
Individuals cannot make LDL receptors
- C.
Individuals cannot absorb cholesterol
- D.
Individuals live long, healthy lives
- 19.Which of the following strategies is recommended as lifestyle changes for dyslipidemia?
- A.
Diet
- B.
Weight reduction
- C.
Exercise
- D.
Smoking cessation
- E.
All of the above
- 20.According to the 2013 American College of Cardiology/American Heart Association (ACC/AHA) Prevention Guidelines, which of the following is true?
- A.
Emphasis is now placed on assessing cardiovascular risks rather than cholesterol goals
- B.
There are "Four Statin Benefit Groups"
- C.
Patients over 75 should receive high-intensity statin therapy
- D.
Weight management and lifestyle changes are still recommended
- E.
All of the above
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