This quiz discusses some of the agents used in patients with dyslipidemia.
Inhibits lipolysis in adipose tissue to disrupt mobilization of free fatty acids
Decreases cholesterol synthesis in the liver
Decreases absorption of cholesterol in the intestine
Bind to bile salts in the intestine
It decreases VLDL and LDL
It decreases triglycerides
Its vitamin effect requires higher doses
It increases HDL
Flushing
Exacerbation of peptic ulcer
Hyperglycemia
Myopathy
All of the above
Inhibit lipolysis in adipose tissue to disrupt mobilization of free fatty acids
Agonize peroxisome proliferator-activated receptor alpha (PPARa)
Decrease cholesterol synthesis in the liver
Decrease absorption of cholesterol in the intestine
Triglycerides
HDL
LDL
VLDL
GI effects and myopathy may occur
Can cause gallstones by increasing biliary cholesterol secretion
May require reduction in warfarin dosage
Concomitant use with statins may increase myopathy risk
All of the above
Decrease production of cholesterol in the liver
Decrease absorption of cholesterol in the intestine
Bind to bile salts in the intestine
Inhibit lipolysis in adipose tissue
Decrease LDL
Decrease VLDL
Decrease triglycerides
Decrease HDL
Systemic toxicities
Decreased absorption of other drugs
Myopathy
Abdominal discomfort
Inhibit production of cholesterol in the liver
Decrease cholesterol absorption in the intestine
Bind bile salts in the intestine
Stimulate lipoprotein lipase
Decreasing HDL
Increasing HDL
Decreasing LDL
Decreasing triglycerides
AST/ALT elevations
Myopathy
Drug-drug interactions
A and B
All of the above
Simvastatin
Fluvastatin
Atorvastatin
Lovastatin
It is contraindicated with azole antifgunals
Its maximum dosage is 10 mg qhs with diltiazem or verapamil
Its maximum dosage is 20 mg qhs with amlodipine
80 mg qhs should be the start dose in every patient
Inhibits cholesterol absorption in the intestine
Decreases cholesterol synthesis in the liver
Stimulates lipoprotein lipase
Inhibits lipolysis in adipose tissue
It is synergistic with statins for LDL-lowering effects
There are some GI effects associated with it
It interacts with bile acid sequestrants
It interacts with cyclosporine
All of the above
They help decrease triglyceride synthesis from the liver
Belching and altered taste are examples of adverse effects
They are clinically proven to protect individuals from atherosclerosis
They may potentially increase bleeding times
Individuals cannot make HDL
Individuals cannot make LDL receptors
Individuals cannot absorb cholesterol
Individuals live long, healthy lives
Diet
Weight reduction
Exercise
Smoking cessation
All of the above
Emphasis is now placed on assessing cardiovascular risks rather than cholesterol goals
There are "Four Statin Benefit Groups"
Patients over 75 should receive high-intensity statin therapy
Weight management and lifestyle changes are still recommended
All of the above
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