Nervous System Pathology 2
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- 1.Which of the following statements about Multiple sclerosis are true? (Select 2)
- A.
Is autoimmune with T-Cell involvement
- B.
CNS axons are destroyed
- C.
A symptom is a shock like sensation when the patient flexes their neck (Lhermitte's sign)
- D.
Grey matter in the CNS is selectively destroyed, but not in the PNS.
- 2.A patient presents with paralysis in her feet and is beginning to notice weakness in her hands. She has diminished reflexes in her lower limbs as well. You do a thorough case history and find she was ill 3 weeks ago with a viral infection. What should you rule out first?
- A.
Multiple sclerosis
- B.
Parkinson disease
- C.
Huntington disease
- D.
Guillain-Barre syndrome
- 3.Alzheimer's disease is irreversible.
- A.
True
- B.
False
- 4.Alzheimer's disease (Select 2)
- A.
Is associated with destruction of dopaminergic neurons
- B.
Shows Beta-amyloid plaques, Lewis bodies, and neurofibrillary tangles
- C.
Will initially show loss of long term memory
- D.
Can be treated by blocking the action of Cholinesterase
- E.
Can be treated by activating the NMDA receptor
- 5.Which of the following is NOT true regarding Parkinson's disease?
- A.
It is a hypokinetic disorder
- B.
Dopamine deficiency is believed to be the main cause
- C.
Lewis bodies are often present in the diagnosis
- D.
A decrease in acetylcholine is present
- E.
A COMT agonist would be a poor treatment option
- 6.In Duchenne Muscular Dystrophy (Select 2)
- A.
There is an absence of dystrophin
- B.
The defective gene is the PIG-A gene on the X chromosome
- C.
There is a decreased production of dystrophin
- D.
It is caused by an increase in acetylcholine receptor destruction at the NMJ
- 7.Chloroquine use is associated with which type of disease?
- A.
Myasthenia Gravis
- B.
Parkinson's disease
- C.
Muscular dystrophy
- D.
CIPD
- 8.A Tensilon test is used to help in the diagnosis of which disease and why? (Select 2)
- A.
Myasthenia Gravis
- B.
Duchenne Muscular Dystrophy
- C.
Guillan-Barre Syndrome
- D.
It will temporarily increase the amount of acetylcholine available and show temporary decreased clinical symptoms
- E.
It will temporarily activate the AchE enzyme and temporarily decrease the clinical symptoms of the disease
- 9.The most common primary brain tumor of adults is
- A.
Atrocytoma
- B.
Meningioma
- C.
Pituitary adenoma
- D.
Craniopharyngioma
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