What Do You Know About Gluconeogenesis? Trivia Quiz
What do you know about gluconeogenesis? The brain needs energy to operate and the main source for this energy is found in glucose which we consume from other foods. Glucose is produced when the food is broken down. Do take up this quiz and see what you know about how glucose is produced and using which enzymes. All the best and see what new facts you might learn in the process.
- 1.Gluconeogenesis is the production of glucose from non-carbohydrate molecules. Which of the following is not substrate for gluconeogenesis?
- A.
Lactate
- B.
Alanine
- C.
Glycerol
- D.
Acetly CoA
- 2.Gluconeogenesis occurs in the liver and kidney. Which is of the following enzymes are important for gluconeogenesis are expressed exclusively in these tissues?
- A.
Glucose-6-phosphatase
- B.
Fructose-1,6-Bisphosphatase
- C.
Phosphoenol pyruvate carboxykinase
- D.
Pyruvate carboxylase
- 3.During gluconeogenesis, the three irreversible steps of glycolysis have to be bypassed. The first step is the conversion of pyruvate to phosphoenolpyruvate. Which of the following statement is false regarding the reaction step?
- A.
This reaction involves two step process catalyzed by pyruvate carboxylase and phosphoenolpyruvate caboxykinase
- B.
Conversion of oxaloacetate from pyruvate occurs in mitochondria and shuttled into cytosol.
- C.
Phosphoenol pyruvate utilizes both ATP and GTP as energy source.
- D.
Acetly CoA is an activator of enzyme pyruvate carboxylase.
- 4.During gluconeogenesis, the three irreversible steps of glycolysis have to be bypassed. The final step is the conversion of glucose-6-P to glucose that is catalyzed by glucose-6-phosphatase. Which of the following statement is true about the reaction step?
- A.
Conversion of glucose-6-phosphate to glucose releases one ATP molecule
- B.
It is highly active enzyme in skeletal muscle
- C.
Defect in glucose-6-phosphatase leads to abnormal accumulation of glycogen in liver
- D.
The reaction occurs in mitochondria
- 5.During prolonged starvation, which of the following hormone is responsible for increasing gluconeogenesis in the liver.
- A.
Insulin
- B.
Glucogon
- C.
TSH
- D.
Thyroxine
- 6.Which of the following statements about gluconeogenesis is correct?
- A.
Muscles have a large glycogen store which gives rise to blood glucose during prolonged starvation.
- B.
Fatty acids are plentiful in the blood during starvation and are used for glucose synthesis.
- C.
The enzyme glucose-6-phosphatase hydrolyses glucose-6-phosphate and is present in most cells.
- D.
Gluconeogenesis enables the liver to maintain blood glucose levels during starvation
- 7.Which of the following statements about the use and synthesis of glucose in the body is correct
- A.
Brain can use fatty acids for all its energy needs.
- B.
Red blood cells can use fatty acids for all their energy needs.
- C.
The brain can use ketone bodies for all its energy needs.
- D.
The brain can use glucose for all its energy needs.
- 8.Which of the following statements about the process of gluconeogenesis is correct?
- A.
In gluconeogenesis, pyruvate is first converted to phosphoenolpyruvate by phosphoenolpyruvate carboxykinase.
- B.
In gluconeogenesis fructose-1:6-bisphosphatase converts fructose-1:6-bisphosphate into fructose-1-phosphate.
- C.
Glucose-6-phosphatase hydrolyses glucose-6-phosphate to release glucose into the blood.
- D.
Glucose-6-phosphatase hydrolyses glucose-6-phosphate and is found in liver and muscle.
- 9.Which of the following statements about the sources of pyruvate used by the liver for gluconeogenesis is correct?
- A.
The main source of glucose carbons for gluconeogenesis is pyruvate synthesised from acetyl-CoA.
- B.
The main source of glucose carbons for gluconeogenesis is alanine derived from breakdown of muscle proteins.
- C.
The main source of glucose carbons cannot occur from muscles as they do not undergo gluconeogenesis.
- D.
The main source of glucose carbons in gluconeogenesis is pyruvate released from muscles
- 10.Which of the following statements about the effect of ethanol metabolism on gluconeogenesis is correct?
- A.
The metabolism of ethanol by the liver decreases the NADH/NAD+ ratio reducing its ability to perform gluconeogenesis.
- B.
The reduction of ethanol by the liver increases the NADH/NAD+ ratio reducing its ability to perform gluconeogenesis.
- C.
The oxidation of ethanol by the liver increases the NADH/NAD+ ratio increasing its ability to perform gluconeogenesis.
- D.
The metabolism of ethanol by the liver increases the NADH/NAD+ ratio reducing its ability to perform gluconeogenesis.
- 11.Which of the following statements about gluconeogenesis is not correct?
- A.
Lactate from muscle vigorous muscle activity can be used as a carbon source in gluconeogenesis.
- B.
Glycerol from the hydrolysis of triacylglycerols is converted to glucose in gluconeogenesis.
- C.
Lactate from red blood cells can be used as a carbon source in gluconeogenesis.
- D.
Fatty acids from the hydrolysis of triacylglycerols can be used as a carbon source in gluconeogenesis.
- 12.Which of the following statements regarding the general principles of glucose metabolism are correct?
- A.
Gluconeogenesis is the formation of glucose from glycogen.
- B.
Glucose may be stored as glycogen or converted to fat.
- C.
Glycogenolysis and gluconeogenesis are functions of the liver.
- D.
Gluconeogenesis is stimulated when plasma glucose is low.
- E.
Glycogenesis is stimulated when cellular ATP reserves are low.
- 13.Gluconeogenesis is often associated with
- A.
Ketosis
- B.
Hexoses
- C.
Pentoses
- D.
None of above
- 14.Number of enzyme catalyzed reactions in gluconeogenesis are
- A.
12
- B.
11
- C.
13
- D.
10
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