This quiz titled 'Immunosuppressive Drugs PHA 430' assesses knowledge on cyclosporine, including its mechanism, effects, and clinical applications. It also covers critical interventions like RhoGAM for Rh- mothers. Essential for students and professionals in pharmacology and medicine.
True
False
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True
False
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True
False
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True
False
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True
False
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Renally
Hepatically
Fecally
Unknown
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True
False
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Impaired wound healing; after
Accelerated wound repair; before
Impaired wound healing; either before or after
None of the above - contraindicated in transplant surgeries
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True
False
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Ca2+ influx does not occur
Substrate complex; does not inhibit calcineurin
Substrate Complex; Tac binds and forms Tac-FK06 complex
NFATc/NFATn complex does not form
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True
False
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True
False
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Bone marrow
Liver
Stomach/Kidney/Pancreas
Kidney
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It is lipophilic
It binds to cyclophilins in the cytoplasm to form a complex
It inhibits IL-2 synthesis as well as secretion
The attenuation of IL-2 is achieved through decreased expression of transforming growth factor beta
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True
False
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True
False
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True
False
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Cell does not proceed to G2 phase of cell cycle
Cell does not proceed to S phase of cell cycle
Cell does not enter G1 phase of cell cycle
Cell undergoes spontaneous apoptosis unrelated to cell cycle
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Increases peripheral blood lymphocyte count
Cells are hypersensitized to the presence of sphingosine-1 phosphate and respond overtly to its signal
It is associated with little to no adverse events
An internalization of G-protein linked receptors on thymocytes/lymphocytes
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True
False
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CD152
CD86
CD80
CD28
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True
False
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True
False
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Causes lymphocyte death / does not cause apoptosis
Does not cause lymphocyte death / does not cause apoptosis
Causes lymphocyte death / causes apoptosis
Does not cause lymphocyte death / causes apoptosis
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Within 72 hours before birth of the first child
Within 72 hours of birth of the first child
Within 72 hours of birth of every child after the first
Within 72 hours of birth of every child including the first
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True
False
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B-cell cancers
T-cell cancers
Both B- and T-cell cancers
None of the above
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True
False
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Fatal infection
Tachycardia
Bradycardia
DIC
Hemorrhage
Hypercapnia
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In rheumatoid arthritis across the lifespan
In rheumatoid arthritis in individuals 6+ years of age as first line therapy
In rheumatoid arthritis in individuals 6+ years of age when other DMARDs fail
With kineret to enhance its effect(s)
Not in combination with any TNF-alpha targeting agents
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May be used with cyclosporine
Is not used in B-cell lymphoma
DDIs are similar to cyclosporine
Does not have a significant nephrotoxicity risk
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Nephrotoxicity
Hypertension
Neurological effects
Substantially decreased liver enzymes
Alopecia
Gingival hyperplasia
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Cardiac allograft vasculopathy
Cardiac autograft vasculopathy
Post-transplant lymphosuppressive disorders
Post-transplant lymphoproliferative disorders
Breast cancers
Treatment of heart failure
Treatment of MS
Treatment of Parkinson's Disease
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