Immunosuppressive Drugs Pha 430

36 Questions | Total Attempts: 46

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Drug Quizzes & Trivia

Questions and Answers
  • 1. 
    Which statement is incorrect regarding cyclosporine?
    • A. 

      It is lipophilic

    • B. 

      It binds to cyclophilins in the cytoplasm to form a complex

    • C. 

      It inhibits IL-2 synthesis as well as secretion

    • D. 

      The attenuation of IL-2 is achieved through decreased expression of transforming growth factor beta

  • 2. 
    The cyclosporine-cyclophilin complex serves as an inhibitor on what component in the cytoplasm:
    • A. 

      Calcineurin

    • B. 

      Neuricalcin

    • C. 

      MTOR

    • D. 

      None of the above

  • 3. 
    Phosphorylated NF-ATc binding with NF-ATn is what normally stimulates the release of IL-2
    • A. 

      True

    • B. 

      False

  • 4. 
    Which statement is the most correct regarding cyclosporine and cellular effects?
    • A. 

      Causes lymphocyte death / does not cause apoptosis

    • B. 

      Does not cause lymphocyte death / does not cause apoptosis

    • C. 

      Causes lymphocyte death / causes apoptosis

    • D. 

      Does not cause lymphocyte death / causes apoptosis

  • 5. 
    To prevent hemolytic disease of the newborn in Rh- mothers with Rh+ fetuses, RhoGAM needs to be administered when?
    • A. 

      Within 72 hours before birth of the first child

    • B. 

      Within 72 hours of birth of the first child

    • C. 

      Within 72 hours of birth of every child after the first

    • D. 

      Within 72 hours of birth of every child including the first

  • 6. 
    Cyclosporine is poorly orally bioavailable, with an oral F of 20-50%.
    • A. 

      True

    • B. 

      False

  • 7. 
    Cyclosporine metabolism primarily takes place how?
    • A. 

      Renally

    • B. 

      Hepatically

    • C. 

      Fecally

    • D. 

      Unknown

  • 8. 
    Which of these are toxicities associated with cyclosporine? [Select all that apply]
    • A. 

      Nephrotoxicity

    • B. 

      Hypertension

    • C. 

      Neurological effects

    • D. 

      Substantially decreased liver enzymes

    • E. 

      Alopecia

    • F. 

      Gingival hyperplasia

  • 9. 
    Cyclosporine is used for heart, kidney, and lung transplants, as well as GVHD, but not autoimmune disorders
    • A. 

      True

    • B. 

      False

  • 10. 
    Tacrolimus is a macrolide antibiotic
    • A. 

      True

    • B. 

      False

  • 11. 
    Tacrolimus is roughly 50-100x more potent than cyclosporine
    • A. 

      True

    • B. 

      False

  • 12. 
    The MOA of tacrolimus is identical to cyclosporine, with no deviations
    • A. 

      True

    • B. 

      False

  • 13. 
    What step of the MOA of tacrolimus is different from cyclosporine?
    • A. 

      Ca2+ influx does not occur

    • B. 

      Substrate complex; does not inhibit calcineurin

    • C. 

      Substrate Complex; Tac binds and forms Tac-FK06 complex

    • D. 

      NFATc/NFATn complex does not form

  • 14. 
    Tacrolimus is less orally bioavailable than cyclosporine
    • A. 

      True

    • B. 

      False

  • 15. 
    Nephrotoxicity associated with tac is equal to or worse than cyclosporine
    • A. 

      True

    • B. 

      False

  • 16. 
    Rarely, tacrolimus is associated with:
    • A. 

      B-cell cancers

    • B. 

      T-cell cancers

    • C. 

      Both B- and T-cell cancers

    • D. 

      None of the above

  • 17. 
    Rapamycin is similar to tacrolimus in that it is a macrolide, binds to FK in the cytoplasm, and inhibits calcineurin activation
    • A. 

      True

    • B. 

      False

  • 18. 
    The inhibition of mTOR by rapamycin has which downstream effect? Pick the most correct statement
    • A. 

      Cell does not proceed to G2 phase of cell cycle

    • B. 

      Cell does not proceed to S phase of cell cycle

    • C. 

      Cell does not enter G1 phase of cell cycle

    • D. 

      Cell undergoes spontaneous apoptosis unrelated to cell cycle

  • 19. 
    Rapamycin inhibits IL-2 receptor dependent cell cycling
    • A. 

      True

    • B. 

      False

  • 20. 
    Because rapamycin is associated with _____________, it should be started _________ a transplant
    • A. 

      Impaired wound healing; after

    • B. 

      Accelerated wound repair; before

    • C. 

      Impaired wound healing; either before or after

    • D. 

      None of the above - contraindicated in transplant surgeries

  • 21. 
    Select the correct statement(s) regarding rapamycin:
    • A. 

      May be used with cyclosporine

    • B. 

      Is not used in B-cell lymphoma

    • C. 

      DDIs are similar to cyclosporine

    • D. 

      Does not have a significant nephrotoxicity risk

  • 22. 
    Everolimus is similar to rapamycin except that it is used after tissue transplantation for the prevention of graft rejection
    • A. 

      True

    • B. 

      False

  • 23. 
    Everolimus is indicated for which of the following according to Dr. Khan's slides? Select all that apply
    • A. 

      Cardiac allograft vasculopathy

    • B. 

      Cardiac autograft vasculopathy

    • C. 

      Post-transplant lymphosuppressive disorders

    • D. 

      Post-transplant lymphoproliferative disorders

    • E. 

      Breast cancers

    • F. 

      Treatment of heart failure

    • G. 

      Treatment of MS

    • H. 

      Treatment of Parkinson's Disease

  • 24. 
    Fingolimod is a prodrug requiring dephosphorylation to work properly
    • A. 

      True

    • B. 

      False

  • 25. 
    Which is the most correct statement regarding the MOA of fingolimod
    • A. 

      Increases peripheral blood lymphocyte count

    • B. 

      Cells are hypersensitized to the presence of sphingosine-1 phosphate and respond overtly to its signal

    • C. 

      It is associated with little to no adverse events

    • D. 

      An internalization of G-protein linked receptors on thymocytes/lymphocytes

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