Immunosuppressive Drugs Pha 430

36 Questions | By Sdevlin | Last updated: Mar 21, 2022 | Total Attempts: 67

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1.

Which statement is incorrect regarding cyclosporine?
- A.
  
  It is lipophilic
- B.
  
  It binds to cyclophilins in the cytoplasm to form a complex
- C.
  
  It inhibits IL-2 synthesis as well as secretion
- D.
  
  The attenuation of IL-2 is achieved through decreased expression of transforming growth factor beta
2.

The cyclosporine-cyclophilin complex serves as an inhibitor on what component in the cytoplasm:
- A.
  
  Calcineurin
- B.
  
  Neuricalcin
- C.
  
  MTOR
- D.
  
  None of the above
3.

Phosphorylated NF-ATc binding with NF-ATn is what normally stimulates the release of IL-2
- A.
  
  True
- B.
  
  False
4.

Which statement is the most correct regarding cyclosporine and cellular effects?
- A.
  
  Causes lymphocyte death / does not cause apoptosis
- B.
  
  Does not cause lymphocyte death / does not cause apoptosis
- C.
  
  Causes lymphocyte death / causes apoptosis
- D.
  
  Does not cause lymphocyte death / causes apoptosis
5.

To prevent hemolytic disease of the newborn in Rh- mothers with Rh+ fetuses, RhoGAM needs to be administered when?
- A.
  
  Within 72 hours before birth of the first child
- B.
  
  Within 72 hours of birth of the first child
- C.
  
  Within 72 hours of birth of every child after the first
- D.
  
  Within 72 hours of birth of every child including the first
6.

Cyclosporine is poorly orally bioavailable, with an oral F of 20-50%.
- A.
  
  True
- B.
  
  False
7.

Cyclosporine metabolism primarily takes place how?
- A.
  
  Renally
- B.
  
  Hepatically
- C.
  
  Fecally
- D.
  
  Unknown
8.

Which of these are toxicities associated with cyclosporine? [Select all that apply]
- A.
  
  Nephrotoxicity
- B.
  
  Hypertension
- C.
  
  Neurological effects
- D.
  
  Substantially decreased liver enzymes
- E.
  
  Alopecia
- F.
  
  Gingival hyperplasia
9.

Cyclosporine is used for heart, kidney, and lung transplants, as well as GVHD, but not autoimmune disorders
- A.
  
  True
- B.
  
  False
10.

Tacrolimus is a macrolide antibiotic
- A.
  
  True
- B.
  
  False
11.

Tacrolimus is roughly 50-100x more potent than cyclosporine
- A.
  
  True
- B.
  
  False
12.

The MOA of tacrolimus is identical to cyclosporine, with no deviations
- A.
  
  True
- B.
  
  False
13.

What step of the MOA of tacrolimus is different from cyclosporine?
- A.
  
  Ca2+ influx does not occur
- B.
  
  Substrate complex; does not inhibit calcineurin
- C.
  
  Substrate Complex; Tac binds and forms Tac-FK06 complex
- D.
  
  NFATc/NFATn complex does not form
14.

Tacrolimus is less orally bioavailable than cyclosporine
- A.
  
  True
- B.
  
  False
15.

Nephrotoxicity associated with tac is equal to or worse than cyclosporine
- A.
  
  True
- B.
  
  False
16.

Rarely, tacrolimus is associated with:
- A.
  
  B-cell cancers
- B.
  
  T-cell cancers
- C.
  
  Both B- and T-cell cancers
- D.
  
  None of the above
17.

Rapamycin is similar to tacrolimus in that it is a macrolide, binds to FK in the cytoplasm, and inhibits calcineurin activation
- A.
  
  True
- B.
  
  False
18.

The inhibition of mTOR by rapamycin has which downstream effect? Pick the most correct statement
- A.
  
  Cell does not proceed to G2 phase of cell cycle
- B.
  
  Cell does not proceed to S phase of cell cycle
- C.
  
  Cell does not enter G1 phase of cell cycle
- D.
  
  Cell undergoes spontaneous apoptosis unrelated to cell cycle
19.

Rapamycin inhibits IL-2 receptor dependent cell cycling
- A.
  
  True
- B.
  
  False
20.

Because rapamycin is associated with _____________, it should be started _________ a transplant
- A.
  
  Impaired wound healing; after
- B.
  
  Accelerated wound repair; before
- C.
  
  Impaired wound healing; either before or after
- D.
  
  None of the above - contraindicated in transplant surgeries
21.

Select the correct statement(s) regarding rapamycin:
- A.
  
  May be used with cyclosporine
- B.
  
  Is not used in B-cell lymphoma
- C.
  
  DDIs are similar to cyclosporine
- D.
  
  Does not have a significant nephrotoxicity risk
22.

Everolimus is similar to rapamycin except that it is used after tissue transplantation for the prevention of graft rejection
- A.
  
  True
- B.
  
  False
23.

Everolimus is indicated for which of the following according to Dr. Khan's slides? Select all that apply
- A.
  
  Cardiac allograft vasculopathy
- B.
  
  Cardiac autograft vasculopathy
- C.
  
  Post-transplant lymphosuppressive disorders
- D.
  
  Post-transplant lymphoproliferative disorders
- E.
  
  Breast cancers
- F.
  
  Treatment of heart failure
- G.
  
  Treatment of MS
- H.
  
  Treatment of Parkinson's Disease
24.

Fingolimod is a prodrug requiring dephosphorylation to work properly
- A.
  
  True
- B.
  
  False
25.

Which is the most correct statement regarding the MOA of fingolimod
- A.
  
  Increases peripheral blood lymphocyte count
- B.
  
  Cells are hypersensitized to the presence of sphingosine-1 phosphate and respond overtly to its signal
- C.
  
  It is associated with little to no adverse events
- D.
  
  An internalization of G-protein linked receptors on thymocytes/lymphocytes