Daily Bugle's Biochem Test
- 1.Characteristic sign of glycogenosis is muscle pain during physical work. Blood examination usually reveals hypoglycemia. This pathology is caused by congenital deficiency of the following enzyme:
- A.
Glycogen phosphorylase
- B.
γ-amylase
- C.
Glucose 6-phosphate dehydrogenase
- D.
α-amylase
- 2.Pancreas is known as a mixed gland. Endocrine functions include production of insulin by beta cells. This hormone affects metabolism of carbohydrates. What is its effect on the activity of glycogen phosphorylase (GP) and glycogen synthase (GS)?
- A.
It inhibits GP and activates GS
- B.
It inhibits both GP and GS
- C.
It activates both GP and GS
- D.
It activates GP and inhibits GS
- 3.A patient suffering from diabetes mellitus fainted after the introduction of insulin, and then cramps appeared. What level of sugar was determined in the patient's blood by means of biochemical analysis?
- A.
3.3 mM/1
- B.
5.5 mM/1
- C.
8.0 mM/1
- D.
1.5 mM/1
- 4.A 39 old male patient was diagnosed with a Wernicke-Korsakoff syndrome, caused by a severe deficiency of thiamine pyrophosphate (TPP) mostly resulting by chronic, heavy alcohol consumption which interferes with the intestinal absorption of thiamin. Which enzyme of pentose phosphate pathway needs TPP as a coenzyme?
- A.
Phosphopentose isomerase
- B.
Transketolase Lactonase
- C.
Transketolase
- D.
Transaldolase
- 5.A patient complains about dyspnea provoked by the physical activity. Clinical examination revealed anaemia and presence of the paraprotein in the zone of gamma-globulins. To confirm the myeloma diagnosis it is necessary to determine the following index in the patient’s urine:
- A.
Bilirubin
- B.
Bence Jones protein
- C.
Ceruloplasmin
- D.
Antitrypsin
- 6.A tooth extraction in a patient with chronic persistent hepatitis was complicated with prolonged hemorrhage. What is the reason for the haemorrhagic syndrome?
- A.
Increase in thromboplastin production
- B.
Decrease in thrombin production
- C.
Fibrinolysis intensification
- D.
Decrease in fibrin production
- 7.A patient is diagnosed with hereditary coagulopathy that is characterised by factor VIII deficiency. Specify the phase of blood clotting during which coagulation will be disrupted in the given case:
- A.
Thrombin formation
- B.
Fibrin formation
- C.
Clot retraction
- D.
Thromboplastin formation
- 8.In order to speed up healing of a wound of oral mucosa a patient was prescribed a drug that is a thermostable protein occuring in tears, saliva, mother’s milk as well as in a new-laid hen’s egg. It is known that this protein is a factor of natural resistance of an organism. What is it called?
- A.
Lysozyme
- B.
Interleukin
- C.
Interferon
- D.
Complement
- 9.An infant born prematurely 2 days ago presents with yellow coloring of skin and mucosa. Such a condition in the infant is caused by temporary deficiency of the following enzyme:
- A.
Biliverdine reductase
- B.
Heme oxygenase
- C.
Aminolevulinate synthase
- D.
UDP-glucuronyl transferase
- 10.A 48 y.o. patient was admitted to the hospital with complaints about weakness, irritability, sleep disturbance. Objectively: skin and scleras are yellow. In blood: conjugated bilirubin, cholalemia. Feces are acholic. Urine is of dark colour (bilirubin). What jaundice is it?
- A.
Gilbert’s syndrome
- B.
Parenchymatous
- C.
Mechanic
- D.
Crigler-Najjar syndrome
- 11.Feces of a patient contain high amount of undissociated fats and have grayish-white color. Specify the cause of this phenomenon:
- A.
Hypoactivation of pepsin by hydrochloric acid
- B.
Obturation of bile duct
- C.
Cholaemia
- D.
Bilirubinuria
- 12.A 16-year-old adolescent is diagnosed with hereditary UDP (uridine di- phosphate) glucuronyltransferase deficiency. Laboratory tests revealed hyperbilirubinemia caused mostly by increased blood content of the following substance:
- A.
Conjugated bilirubin
- B.
Unconjugated bilirubin
- C.
Stercobilinogen
- D.
Biliverdin
- 13.A 1,7-year-old child with a developmental delay and manifestations of self-agression has the concentration of uric acid in blood at the rate of 1,96 millimole/l. What metabolic disoder is this typical for?
- A.
Gierke’s disease
- B.
Acquired immunodeficiency syndrome
- C.
Cushing’s basophilism
- D.
Lesch-Nyhan syndrome
- 14.Before the cells can utilize the glucose, it is first transported from the extracellular space through the plasmatic membrane inside them. This process is stimulated by the following hormone:
- A.
Insulin
- B.
Glucagon
- C.
Aldosterone
- D.
Adrenalin
- 15.Experimental studies revealed steroid hormones to have an effect on proteosynthesis. They influence synthesis of the following substances:
- A.
Specific transfer RNA
- B.
Adenosine triphosphate
- C.
Specific ribosomal RNA
- D.
Specific messenger RNA
- 16.Examination of a child who hasn’t got fresh fruit and vegetables during winter revealed numerous subcutaneous hemorrhages, gingivitis, carious cavities in teeth. What vitamin combination should be prescribed in this case?
- A.
Thiamine and pyridoxine
- B.
Calciferol and ascorbic acid
- C.
Ascorbic acid and rutin
- D.
Folic acid and cobalamin
- 17.What vitamin deficit causes the simultaneous disorder of reproductive function and dystrophy of skeletal musculature?
- A.
Vitamin D
- B.
Vitamin Е
- C.
Vitamin K
- D.
Vitamin K1
- 18.A 48-year-old female patient with a history of cholelithiasis has recurring steatorrhea. What vitamin deficiency may develop as a complication of the current disease?
- A.
B6
- B.
C
- C.
B12
- D.
K
- 19.Preventive examination of 1-1.5- year-old children living in an orphanage revealed focal thickening of ribs and wri-sts, bowed legs. The dentist pointed out delayed teething, wrong eruption order, irregular mineralization of the enamel and dentin, high-arched palate. What disease has developed in children?
- A.
Metabolic calcification
- B.
Osteomalacia
- C.
Dystrophic calcification
- D.
Rickets
- E.
Metastatic calcification
- 20.The patient, who for a long time has been keeping to an unbalanced low-protein diet, developed fatty liver infiltration. Name the substabce, absence of which in the diet can lead to this condition:
- A.
Arachidonic acid
- B.
Methionine
- C.
Alanine
- D.
Cholesterol
- 21.A 25-year-old patient with a heredi-tary enzymopathy (Gilbert’s disease) has a disorder of bilirubin conjugation in liver. What enzyme is not synthesized in this patient?
- A.
UDP-glucose pyrophosphorylase
- B.
UDP-glucuronyl transferase
- C.
UDP-glycogen transferase
- D.
Mido phosphoribosyl transferase
- 22.For several days a 55-year-old woman has been suffering from pain attacks in the right upper quadrant after eating fatty foods. Visually, there is yellowness of sclera and skin. The pati ent has acholic stool, beer-colored urine. What substance present in the patient’s urine causes its dark color?
- A.
Unconjugated bilrubin
- B.
Stercobilin
- C.
Conjugated bilirubin
- D.
Ketone bodies
- 23.A 25-year-old patient has been diagnosed with chronic hepatitis. The patient complains of 10 kg weight loss within 2 months. Objectively: the patient has dry peeling skin, pale with yellow shade, petechial haemorrhages, stomatorrhagia. Petechial haemorrhagesand stomatorrhagia are caused by the disturbance of the following hepatic function:
- A.
Chromogenic
- B.
Protein synthesizing
- C.
Detoxication
- D.
Glycogen synthesizing
- 24.Proteins are of great importance for vital functions. What value of pH results in zero electrophoretic mobility of gelatin (gelatin isoelectric point equals 4,7)?
- A.
7,0
- B.
14,0
- C.
9,4
- D.
4,7
- 25.Tricarboxylic acid cycle is a general way of carbohydrates, amino acids, and fatty acids oxidation. Specify the acid with which acetyl-CoA reacts first in tricarboxylic acid cycle:
- A.
Citric
- B.
Oxaloacetic
- C.
Isocitric
- D.
Fumaric
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