M&R Review By : KMSA-MED

1. Glycine mechanism of action is :-

Inhibitory post synaptic potential

Excitatory post synaptic potential

Na channel blocker

K channel blocker

2. [x] If A is suddenly withdrawn after chronic use and the patient has inverse symptoms like tachycardia, hypertension...You think A is....bcz ....

Metaprolol,up regulation

Salbutamol,up regulation

Dobutamine,down regulation

Yohimbine,up regulation

3. These drugs are used treatment of glaucoma except

Dobutamine

Timolol

Pilocarpine

Apraclonidine

4. Procaine mechanism of action is

Blocking Na channel

Blocking Na pump

Blocking Ca channel

Activating k channel

5. Na Ca exchanger consider a :-

Secondary active antiport

Secondary active symport

Primary active

Ligand gated channel

6. Capacitance of large unmyelinated fiber is :-

Higher than that of large myelinated fibers

Lower than that of myelinated fiber

Equal to capacitance of myelinated fibers

None of above

7. One of the followings is not a neurotransmitter

DAG

Glycine

Dopamine

Acetylcholine

8. The inverse agonist has Emax.............while antagonist Emax is..............

0,

>0,>0.

9. C sensory fibers have a characteristics of :-

Low resistance and high capacitance

High capacitance and high resistance

High resistance and low capacitance

Low resistance and low capacitance

10. Years old patient presented with fever and rectal temperature of 38.3 what would you predict about membrane cholesterol role in that patient :-

Decrease fluidity

Increase fluidity

Increase permeability

Both second and third choice

11. Apotransferrin dissociate from its receptors at

Neutral PH

Low PH

High Fe level

Low Fe level

12. Increase membrane Cl permeability results in :-

Difficulty to initiate a stimulatory action potential

Increase cell excitability

Block K channel

Decrease Na pumping activity

Feedback : increase Cl permeability mean the membrane exposed to an inhibitory neurotransmitter

Explanation

Feedback : increase Cl permeability mean the membrane exposed to an inhibitory neurotransmitter

13. V2 vasopressin receptors, activated by ------- . And located in------

ADH , kidney

ADH , blood vessels

Angiotensin 2 , kidney

Angiotensin 2 , blood vessels

14. B blocker help hypertensive by several mechanisms except

Vasodilation

Decrease SV

-ve chronotropic effect

Inhibition of renin system

15. Asthmatic pt due to allergy(allergic asthma) You prefer to give him

Beclomethasone

Diphenhydramine

Antihistamine

Cromoglycate

16. Drug's side effects tend to become less intense with time , even though drug administration is continued due to :-

Physiological adaptation

Receptor conformational changes

Numerical down regulation

Exhaustion of mediators

17. An case with MI due occlusion of one of coronary arteries due to thrombus has given warfarin, before coming to A&E he took allopurinol as treatment of gout arthritis and erythromycin as treatment of Tonsillitis drug interaction of drugs may lead to : .

Bleeding

Another thrombus

Angina

HyperAcute

the plot of Loge Drug level against time is a straight line called..
While the plot of Drug level against time is a straight line called..
Linear kinetic (First order),non linear (zero order)
Non linear (Zero order),linear(first order)

Explanation

the plot of Loge Drug level against time is a straight line called..
While the plot of Drug level against time is a straight line called..
Linear kinetic (First order),non linear (zero order)
Non linear (Zero order),linear(first order)

18. Prolonged usage of loop diuretic may cause :-

Hypokalemia

Hyperkalemia

Hypocalcemia

Hypercalcemia

19. These substances help in lowering of HT except

Methoxamine

Clonidine

Guanethedine

Insecticide organophosphorous

20. [x] This drug is cautious to give to a diabetic patient

Propanolol

Dopamine

Prazosin

Clonidine

21. [x] 43 years old hypertensive man suffer from enlarged prostate,the most suitable drug to give is(most suitable)

Prazosin

Dobutamine

Salbutamol

Tamsulusin

Answer is prazosin bcz its non selective alpha 1 antagonist so treats hypertension and prostate enlargement
If he is not hypertensive we will prefer to give tamsulusin which is an α 1 antagonist that is more selective to the α 1 receptor subtype (α 1A ) present in the prostate and less selective to the α 1 receptor subtype (α 1B ) present in the blood vessels.so we won’t have hypotension as side effect,in contrast the prazosin

Explanation

Answer is prazosin bcz its non selective alpha 1 antagonist so treats hypertension and prostate enlargement
If he is not hypertensive we will prefer to give tamsulusin which is an α 1 antagonist that is more selective to the α 1 receptor subtype (α 1A ) present in the prostate and less selective to the α 1 receptor subtype (α 1B ) present in the blood vessels.so we won’t have hypotension as side effect,in contrast the prazosin