Immunology Study Questions
MLT Study Questions
- 1.
Antibodies are secreted by
- A.
Killer cells
- B.
Marrow stem cells
- C.
Mast cells
- D.
B cells
Correct Answer
D. B cells -
- 2.
Antibody class and antibody subclass is determined by major physiochemical differences and antigenic variation found primarily in the
- A.
Constant region of heavy chain
- B.
Constant region of light chain
- C.
Variable regions of heavy and light chains
- D.
Constant regions of heavy and light chains
Correct Answer
A. Constant region of heavy chain -
- 3.
With which of the following immunoglobulin classes is secretory component or transport piece associated?
- A.
IgA
- B.
IgD
- C.
IgE
- D.
IgG
Correct Answer
A. IgA -
- 4.
The immunoglobin isotype that is bound to mast cells or basophils is
- A.
IgG
- B.
IgE
- C.
IgM
- D.
IgD
Correct Answer
B. IgE -
- 5.
The immunoglobulin isotype that is bound to mast cells or basophils is
- A.
IgA
- B.
IgE
- C.
IgG
- D.
IgM
Correct Answer
C. IgG -
- 6.
Cells involved in phagocytosis include: 1. Polymorphonuclear neutrophil 2. Monocytes 3. Histiocytes 4. Macrophages
- A.
1, 2, & 3
- B.
1 & 3
- C.
4
- D.
All of the above
Correct Answer
D. All of the above -
- 7.
IgA is found in: 1. Saliva 2. Tears 3. Colostrum 4. Serum
- A.
1, 2, & 3
- B.
1 & 3
- C.
4
- D.
All
Correct Answer
D. All -
- 8.
The immunoglobulin class associated with hypersensitivity or allergenic reactions:
- A.
IgA
- B.
IgM
- C.
IgD
- D.
IgE
Correct Answer
D. IgE -
- 9.
Which of the following immunoglobulins is the most efficient agglutinator?
- A.
IgG
- B.
IgA
- C.
IgM
- D.
IgE
Correct Answer
C. IgM -
- 10.
All of the following events are mediated by both the alternative and classical pathways except:
- A.
Proteolysis of C4 to C4a and C4b
- B.
Proteolysis of C3 to C3a and C3b
- C.
Proteolysis of C5 to C5a and C5b
- D.
Release of anaphylatoxins
Correct Answer
A. Proteolysis of C4 to C4a and C4b -
- 11.
Which of the following is an important cellular mediator of immune complex tissue injury?
- A.
Monocyte
- B.
Neutrophil
- C.
Basophil
- D.
Eosinophil
Correct Answer
B. Neutrophil -
- 12.
The visible serologic reaction between soluble antigen and its specific antibody is
- A.
Sensitization
- B.
Precipitation
- C.
Agglutination
- D.
Opsonization
Correct Answer
B. Precipitation -
- 13.
While performing a test for febrile agglutinins, an analyst observes that the first 3 tubes have no reaction, the next 4 tubes have agglutination, and the last 3 tubes show no agglutination. Tubes #1, 2 and 3 indicate:
- A.
Prozone phenomenon
- B.
Antigen excess
- C.
Equivalence
- D.
Postzone phenomenon
Correct Answer
A. Prozone phenomenon -
- 14.
A substrate is first exposed to patient's serum, then exposed to a fluorescent antihuman immunoglobulin. The procedure described is:
- A.
Fluorescent quenching
- B.
Direct fluorescence
- C.
Indirect fluorescence
- D.
Fluorescence inhibition
Correct Answer
C. Indirect fluorescence -
- 15.
Which statement(s) is/are correct concerning the nephelometric determination of immunoglobulin levels? 1. Uses a beam of light to pass through a suspension in a cuvette. 2. Utilizes the precipitation of soluble antigen with its antibody. 3. Measures light that has been scattered as it passes through a suspension. 4. Most easily detects large particles formed by the reactants.
- A.
1 2 and 3
- B.
1 and 3
- C.
4
- D.
All
Correct Answer
A. 1 2 and 3 -
- 16.
A rubella enzyme immunoassay which utilizes patient serum, rubella antigen, and enzyme bound to antibuman gamma globulin describes a/an ________ assay.
- A.
Inhibition
- B.
Competitive
- C.
Double antibody
- D.
Indirect
Correct Answer
D. Indirect -
- 17.
If 3 ml of a butter were added to a tube containing 1 ml of a standard reagent, the resulting dilution of the standard reagent would be:
- A.
1:2
- B.
1:3
- C.
1:4
- D.
3:1
- E.
4:1
Correct Answer
C. 1:4 -
- 18.
The more specific immunoassay procedure for serum HCG utilizes antisera against whivh subunit of HCG?
- A.
Alpha
- B.
Gamma
- C.
Chorionic
- D.
Beta
Correct Answer
D. Beta -
- 19.
Which of the following describes the relationship between test data and analyte concentration in the classical competitive binding immunoassay:
- A.
Directly proportional
- B.
Indirectly proportional
- C.
Relative
- D.
Non-specific
Correct Answer
B. Indirectly proportional -
- 20.
A serologic test for syphilis that depends upon the detection of cardiolipin-lecithin-cholesterol antigen is:
- A.
FTA-ABS
- B.
RPR
- C.
MHA-TP
- D.
TPI
Correct Answer
B. RPR -
- 21.
An important use of non-terponemal antibody (NTA) testing is in:
- A.
Establishing the diagnosis of acute active syphilis
- B.
Establishing the diagnosis of chronic syphilis
- C.
Evaluating the success of therapy
- D.
Determining the prevalence of disease in the general population
Correct Answer
C. Evaluating the success of therapy -
- 22.
The serologic test for syphilis recommended for detecting antibody in cerebrospinal fluid is
- A.
Non-treponemal antibody
- B.
CSF-VDRL
- C.
FTA-ABS
- D.
MHA-TP
Correct Answer
B. CSF-VDRL -
- 23.
In direct fluorescent antibody screening for the diagnosis of primary syphilis, which of the following labels is used?
- A.
Antibody for the presence of spirochetes in the chancre
- B.
Antibody for the presence of spirochetes in the skin rash
- C.
Antigen for the presence of circulating antibodies
- D.
Antigen for the presence of antibodies in situ
Correct Answer
A. Antibody for the presence of spirochetes in the chancre -
- 24.
The initial immune response following fetal infection with rubella is in the production of:
- A.
IgG antibody
- B.
IgA antibody
- C.
IgM antibody
- D.
Both IgG and IgA antibody
Correct Answer
C. IgM antibody -
- 25.
A 26 year old nurse developed fatigue, a low-grade fever, polyarthralgias and urticaria. Two months earlier she has cared for a patient with hepatitis. Which of the following findings are liely to be observed in this nurse?
- A.
A negative hepatitis B surface antigen test
- B.
Elevated AST and ALT activites
- C.
A positive rheumatoid factor
- D.
A positive Monospot test
Correct Answer
B. Elevated AST and ALT activites -
- 26.
The rapid rise, elevated level, and prolonged production of antibody following a repeat exposure to antigen is called:
- A.
Hypersensitivity
- B.
Arthus reaction
- C.
Anamestic response
- D.
Primary response
Correct Answer
C. Anamestic response -
- 27.
The antigen marker most closely associated with transmissibility of HBV infection is:
- A.
HBs
- B.
Hbe
- C.
HBc
- D.
HBV
Correct Answer
B. Hbe -
- 28.
Which of the following causes 90% of post-transfusion hepatitis?
- A.
HAV
- B.
HBV
- C.
HCV
- D.
HDV
Correct Answer
C. HCV -
- 29.
Detection of which of the following substances is most useful to monitor the course of a patient with testicular cancer?
- A.
Alpha-fetoprotein
- B.
Carcinoembryonic antigen
- C.
Prolactin
- D.
Testosterone
- E.
17-ketosteroids
Correct Answer
A. Alpha-fetoprotein -
- 30.
When testing a patient for HIV antibody, which of the following is used to confirm a positive screening test?
- A.
Radioimmunoassay
- B.
Western blot
- C.
Immunofluorescence
- D.
ELISA
Correct Answer
B. Western blot -
- 31.
A false-negative cold agglutinin test may result if:
- A.
The specimen is centrifuged at room temperature
- B.
The cold agglutinin demonstrates anti-I specificity
- C.
The specimen is refrigerated prior to serum separation
- D.
Adult human O red cells are used in the assay
Correct Answer
C. The specimen is refrigerated prior to serum separation -
- 32.
The cold agglutinin test is used for the diagnosis of infection with
- A.
Streptococcus pneumoniae
- B.
Legionella pneumophilia
- C.
Mycoplasma pneumoniae
- D.
Klebsiella pneumoniae
Correct Answer
C. Mycoplasma pneumoniae -
- 33.
Antigenic determinants for the RA factor are found on the patient's own:
- A.
IgG
- B.
IgA
- C.
IgE
- D.
IgM
Correct Answer
A. IgG -
- 34.
The causative agent for rheumatoid arthritis is:
- A.
An antigen
- B.
An antibody
- C.
A virus
- D.
Bacterial cells
Correct Answer
B. An antibody -
- 35.
Which of the following diseases is associated with a high circulating concentration of T3 and T4, but a low concentration of TSH?
- A.
Rheumatoid Arthritis
- B.
Graves' Disease
- C.
Hashimoto's Disease
- D.
Systemic Lupus Erythematosus
Correct Answer
B. Graves' Disease -
- 36.
The Rheumatoid Factor:
- A.
Agglutinates inert substance
- B.
Precipitates inert substance
- C.
Hemolyzes red blood cells
- D.
Agglutinates gamma globulin coated inert substance
Correct Answer
D. Agglutinates gamma globulin coated inert substance -
- 37.
Infectious mononucleosis is a disease caused by a
- A.
Virus
- B.
Bacterium
- C.
Fungus
- D.
Spirochete
Correct Answer
A. Virus -
- 38.
Heterophile antibody of infectious mononucleosis is absorbed by:
- A.
Guinea pig kidney
- B.
Beef erythrocyte
- C.
Both
- D.
Neither
Correct Answer
B. Beef erythrocyte -
- 39.
Which one of the following disorders is associted with autoantibodies to phospholipid?
- A.
Rheumatoid Arthritis
- B.
Gravees Disease
- C.
Hashimoto's Disease
- D.
Systemic Lupus Erythematosus
Correct Answer
D. Systemic Lupus Erythematosus -
- 40.
Which of the following forms of exposure places a technologist at the highest risk for infection with human immunodeficiency virus (HIV)?
- A.
Aersol
- B.
Ingestion
- C.
Needlestick
- D.
Splash
Correct Answer
C. Needlestick -
- 41.
The most prevalent job related disease hazard in clinical laboratories is:
- A.
Tuberculosis
- B.
Hepatitis
- C.
AIDs
- D.
Meningitis
Correct Answer
B. Hepatitis -
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May 01, 2013Quiz Edited by
ProProfs Editorial Team -
May 01, 2013Quiz Created by
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