Immunology Study Questions

41 Questions | Total Attempts: 3019

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MLT Study Questions


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  • 1. 
    Antibodies are secreted by
    • A. 

      Killer cells

    • B. 

      Marrow stem cells

    • C. 

      Mast cells

    • D. 

      B cells

  • 2. 
    Antibody class and antibody subclass is determined by major physiochemical differences and antigenic variation found primarily in the
    • A. 

      Constant region of heavy chain

    • B. 

      Constant region of light chain

    • C. 

      Variable regions of heavy and light chains

    • D. 

      Constant regions of heavy and light chains

  • 3. 
    With which of the following immunoglobulin classes is secretory component or transport piece associated?
    • A. 

      IgA

    • B. 

      IgD

    • C. 

      IgE

    • D. 

      IgG

  • 4. 
    The immunoglobin isotype that is bound to mast cells or basophils is
    • A. 

      IgG

    • B. 

      IgE

    • C. 

      IgM

    • D. 

      IgD

  • 5. 
    The immunoglobulin isotype that is bound to mast cells or basophils is
    • A. 

      IgA

    • B. 

      IgE

    • C. 

      IgG

    • D. 

      IgM

  • 6. 
    Cells involved in phagocytosis include: 1. Polymorphonuclear neutrophil 2. Monocytes 3. Histiocytes 4. Macrophages
    • A. 

      1, 2, & 3

    • B. 

      1 & 3

    • C. 

      4

    • D. 

      All of the above

  • 7. 
    IgA is found in: 1. Saliva 2. Tears 3. Colostrum 4. Serum
    • A. 

      1, 2, & 3

    • B. 

      1 & 3

    • C. 

      4

    • D. 

      All

  • 8. 
    The immunoglobulin class associated with hypersensitivity or allergenic reactions:
    • A. 

      IgA

    • B. 

      IgM

    • C. 

      IgD

    • D. 

      IgE

  • 9. 
    Which of the following immunoglobulins is the most efficient agglutinator?
    • A. 

      IgG

    • B. 

      IgA

    • C. 

      IgM

    • D. 

      IgE

  • 10. 
    All of the following events are mediated by both the alternative and classical pathways except:
    • A. 

      Proteolysis of C4 to C4a and C4b

    • B. 

      Proteolysis of C3 to C3a and C3b

    • C. 

      Proteolysis of C5 to C5a and C5b

    • D. 

      Release of anaphylatoxins

  • 11. 
    Which of the following is an important cellular mediator of immune complex tissue injury?
    • A. 

      Monocyte

    • B. 

      Neutrophil

    • C. 

      Basophil

    • D. 

      Eosinophil

  • 12. 
    The visible serologic reaction between soluble antigen and its specific antibody is
    • A. 

      Sensitization

    • B. 

      Precipitation

    • C. 

      Agglutination

    • D. 

      Opsonization

  • 13. 
    While performing a test for febrile agglutinins, an analyst observes that the first 3 tubes have no reaction, the next 4 tubes have agglutination, and the last 3 tubes show no agglutination. Tubes #1, 2 and 3 indicate:
    • A. 

      Prozone phenomenon

    • B. 

      Antigen excess

    • C. 

      Equivalence

    • D. 

      Postzone phenomenon

  • 14. 
    A substrate is first exposed to patient's serum, then exposed to a fluorescent antihuman immunoglobulin. The procedure described is:
    • A. 

      Fluorescent quenching

    • B. 

      Direct fluorescence

    • C. 

      Indirect fluorescence

    • D. 

      Fluorescence inhibition

  • 15. 
    Which statement(s) is/are correct concerning the nephelometric determination of immunoglobulin levels? 1. Uses a beam of light to pass through a suspension in a cuvette. 2. Utilizes the precipitation of soluble antigen with its antibody. 3. Measures light that has been scattered as it passes through a suspension. 4. Most easily detects large particles formed by the reactants.
    • A. 

      1 2 and 3

    • B. 

      1 and 3

    • C. 

      4

    • D. 

      All

  • 16. 
    A rubella enzyme immunoassay which utilizes patient serum, rubella antigen, and enzyme bound to antibuman gamma globulin describes a/an ________ assay.
    • A. 

      Inhibition

    • B. 

      Competitive

    • C. 

      Double antibody

    • D. 

      Indirect

  • 17. 
    If 3 ml of a butter were added to a tube containing 1 ml of a standard reagent, the resulting dilution of the standard reagent would be:
    • A. 

      1:2

    • B. 

      1:3

    • C. 

      1:4

    • D. 

      3:1

    • E. 

      4:1

  • 18. 
    The more specific immunoassay procedure for serum HCG utilizes antisera against whivh subunit of HCG?
    • A. 

      Alpha

    • B. 

      Gamma

    • C. 

      Chorionic

    • D. 

      Beta

  • 19. 
    Which of the following describes the relationship between test data and analyte concentration in the classical competitive binding immunoassay:
    • A. 

      Directly proportional

    • B. 

      Indirectly proportional

    • C. 

      Relative

    • D. 

      Non-specific

  • 20. 
    A serologic test for syphilis that depends upon the detection of cardiolipin-lecithin-cholesterol antigen is:
    • A. 

      FTA-ABS

    • B. 

      RPR

    • C. 

      MHA-TP

    • D. 

      TPI

  • 21. 
    An important use of non-terponemal antibody (NTA) testing is in:
    • A. 

      Establishing the diagnosis of acute active syphilis

    • B. 

      Establishing the diagnosis of chronic syphilis

    • C. 

      Evaluating the success of therapy

    • D. 

      Determining the prevalence of disease in the general population

  • 22. 
    The serologic test for syphilis recommended for detecting antibody in cerebrospinal fluid is
    • A. 

      Non-treponemal antibody

    • B. 

      CSF-VDRL

    • C. 

      FTA-ABS

    • D. 

      MHA-TP

  • 23. 
    In direct fluorescent antibody screening for the diagnosis of primary syphilis, which of the following labels is used?
    • A. 

      Antibody for the presence of spirochetes in the chancre

    • B. 

      Antibody for the presence of spirochetes in the skin rash

    • C. 

      Antigen for the presence of circulating antibodies

    • D. 

      Antigen for the presence of antibodies in situ

  • 24. 
    The initial immune response following fetal infection with rubella is in the production of:
    • A. 

      IgG antibody

    • B. 

      IgA antibody

    • C. 

      IgM antibody

    • D. 

      Both IgG and IgA antibody

  • 25. 
    A 26 year old nurse developed fatigue, a low-grade fever, polyarthralgias and urticaria. Two months earlier she has cared for a patient with hepatitis. Which of the following findings are liely to be observed in this nurse?
    • A. 

      A negative hepatitis B surface antigen test

    • B. 

      Elevated AST and ALT activites

    • C. 

      A positive rheumatoid factor

    • D. 

      A positive Monospot test

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