Immunology Study Questions

41 Questions | By Amandaregal | Last updated: May 1, 2013 | Total Attempts: 3019

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MLT Study Questions

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1.

Antibodies are secreted by
- A.
  
  Killer cells
- B.
  
  Marrow stem cells
- C.
  
  Mast cells
- D.
  
  B cells
2.

Antibody class and antibody subclass is determined by major physiochemical differences and antigenic variation found primarily in the
- A.
  
  Constant region of heavy chain
- B.
  
  Constant region of light chain
- C.
  
  Variable regions of heavy and light chains
- D.
  
  Constant regions of heavy and light chains
3.

With which of the following immunoglobulin classes is secretory component or transport piece associated?
- A.
  
  IgA
- B.
  
  IgD
- C.
  
  IgE
- D.
  
  IgG
4.

The immunoglobin isotype that is bound to mast cells or basophils is
- A.
  
  IgG
- B.
  
  IgE
- C.
  
  IgM
- D.
  
  IgD
5.

The immunoglobulin isotype that is bound to mast cells or basophils is
- A.
  
  IgA
- B.
  
  IgE
- C.
  
  IgG
- D.
  
  IgM
6.

Cells involved in phagocytosis include: 1. Polymorphonuclear neutrophil 2. Monocytes 3. Histiocytes 4. Macrophages
- A.
  
  1, 2, & 3
- B.
  
  1 & 3
- C.
  
  4
- D.
  
  All of the above
7.

IgA is found in: 1. Saliva 2. Tears 3. Colostrum 4. Serum
- A.
  
  1, 2, & 3
- B.
  
  1 & 3
- C.
  
  4
- D.
  
  All
8.

The immunoglobulin class associated with hypersensitivity or allergenic reactions:
- A.
  
  IgA
- B.
  
  IgM
- C.
  
  IgD
- D.
  
  IgE
9.

Which of the following immunoglobulins is the most efficient agglutinator?
- A.
  
  IgG
- B.
  
  IgA
- C.
  
  IgM
- D.
  
  IgE
10.

All of the following events are mediated by both the alternative and classical pathways except:
- A.
  
  Proteolysis of C4 to C4a and C4b
- B.
  
  Proteolysis of C3 to C3a and C3b
- C.
  
  Proteolysis of C5 to C5a and C5b
- D.
  
  Release of anaphylatoxins
11.

Which of the following is an important cellular mediator of immune complex tissue injury?
- A.
  
  Monocyte
- B.
  
  Neutrophil
- C.
  
  Basophil
- D.
  
  Eosinophil
12.

The visible serologic reaction between soluble antigen and its specific antibody is
- A.
  
  Sensitization
- B.
  
  Precipitation
- C.
  
  Agglutination
- D.
  
  Opsonization
13.

While performing a test for febrile agglutinins, an analyst observes that the first 3 tubes have no reaction, the next 4 tubes have agglutination, and the last 3 tubes show no agglutination. Tubes #1, 2 and 3 indicate:
- A.
  
  Prozone phenomenon
- B.
  
  Antigen excess
- C.
  
  Equivalence
- D.
  
  Postzone phenomenon
14.

A substrate is first exposed to patient's serum, then exposed to a fluorescent antihuman immunoglobulin. The procedure described is:
- A.
  
  Fluorescent quenching
- B.
  
  Direct fluorescence
- C.
  
  Indirect fluorescence
- D.
  
  Fluorescence inhibition
15.

Which statement(s) is/are correct concerning the nephelometric determination of immunoglobulin levels? 1. Uses a beam of light to pass through a suspension in a cuvette. 2. Utilizes the precipitation of soluble antigen with its antibody. 3. Measures light that has been scattered as it passes through a suspension. 4. Most easily detects large particles formed by the reactants.
- A.
  
  1 2 and 3
- B.
  
  1 and 3
- C.
  
  4
- D.
  
  All
16.

A rubella enzyme immunoassay which utilizes patient serum, rubella antigen, and enzyme bound to antibuman gamma globulin describes a/an ________ assay.
- A.
  
  Inhibition
- B.
  
  Competitive
- C.
  
  Double antibody
- D.
  
  Indirect
17.

If 3 ml of a butter were added to a tube containing 1 ml of a standard reagent, the resulting dilution of the standard reagent would be:
- A.
  
  1:2
- B.
  
  1:3
- C.
  
  1:4
- D.
  
  3:1
- E.
  
  4:1
18.

The more specific immunoassay procedure for serum HCG utilizes antisera against whivh subunit of HCG?
- A.
  
  Alpha
- B.
  
  Gamma
- C.
  
  Chorionic
- D.
  
  Beta
19.

Which of the following describes the relationship between test data and analyte concentration in the classical competitive binding immunoassay:
- A.
  
  Directly proportional
- B.
  
  Indirectly proportional
- C.
  
  Relative
- D.
  
  Non-specific
20.

A serologic test for syphilis that depends upon the detection of cardiolipin-lecithin-cholesterol antigen is:
- A.
  
  FTA-ABS
- B.
  
  RPR
- C.
  
  MHA-TP
- D.
  
  TPI
21.

An important use of non-terponemal antibody (NTA) testing is in:
- A.
  
  Establishing the diagnosis of acute active syphilis
- B.
  
  Establishing the diagnosis of chronic syphilis
- C.
  
  Evaluating the success of therapy
- D.
  
  Determining the prevalence of disease in the general population
22.

The serologic test for syphilis recommended for detecting antibody in cerebrospinal fluid is
- A.
  
  Non-treponemal antibody
- B.
  
  CSF-VDRL
- C.
  
  FTA-ABS
- D.
  
  MHA-TP
23.

In direct fluorescent antibody screening for the diagnosis of primary syphilis, which of the following labels is used?
- A.
  
  Antibody for the presence of spirochetes in the chancre
- B.
  
  Antibody for the presence of spirochetes in the skin rash
- C.
  
  Antigen for the presence of circulating antibodies
- D.
  
  Antigen for the presence of antibodies in situ
24.

The initial immune response following fetal infection with rubella is in the production of:
- A.
  
  IgG antibody
- B.
  
  IgA antibody
- C.
  
  IgM antibody
- D.
  
  Both IgG and IgA antibody
25.

A 26 year old nurse developed fatigue, a low-grade fever, polyarthralgias and urticaria. Two months earlier she has cared for a patient with hepatitis. Which of the following findings are liely to be observed in this nurse?
- A.
  
  A negative hepatitis B surface antigen test
- B.
  
  Elevated AST and ALT activites
- C.
  
  A positive rheumatoid factor
- D.
  
  A positive Monospot test