Dyslipidemia Pathophysiology

1. Type IV familial hyper TG is associated with obese, diabetic, IHD, and hyperurecimic

True

False

2. Risk factors for familial hypercholesterolemia includes being male, LDL>330, smoking, low HDL, high Lp(a), parental history of CAD

True

False

3. Hypothyroidism, renal disease, ethanol use, liver disease, AIDS are causes of secondary hyperlipidemia

True

False

4. LPL is activated by insulin and thus in diabetes Type I (absolute lack of insulin) you see a decrease in LPL and thus increase in VLDL and chylomicrons

True

False

5. Other causes of hypercholesterolemia includes polygenic hypercholesterolemia, and defective B100

True

False

Polygenic hypercholesterolemia is the most common hereditary cause that cause elevated cholesterol

Explanation

Polygenic hypercholesterolemia is the most common hereditary cause that cause elevated cholesterol

6. TG>150 and small LDL particles and low LDL are CHD risk factors and associated with hyperTG

True

False

7. IHD and tendinous xanthomas are associated with this disease

Type I: Familial Hyperchylomicronemia

Type II: Familial Hypercholesterolemia

Type IV: Familial hyperTG

Type V:Familial mixed hyperTG

painless nodules on elbows and buttocks and xanthelesma on eyes

Explanation

painless nodules on elbows and buttocks and xanthelesma on eyes

8. Increased LDL, decreased HDL, smaller particle HDL and increased CETP is associated with this disease

Type I: Familial Hyperchylomicronemia

Type II: Familial Hypercholesterolemia

Type IV: Familial hyperTG

Type V:Familial mixed hyperTG

painless nodules on elbows and buttocks and xanthelesma on eyes

Explanation

painless nodules on elbows and buttocks and xanthelesma on eyes

9. Mutant Apo E is associated with this disease

Type I: Familial Hyperchylomicronemia

Type IIb: Familial Hypercholesterolemia

Type IV: Familial hyperTG

Type V:Familial mixed hyperTG

Type III: Familial dysbetalipoproteinemia

same as apo CII deficiency

Explanation

same as apo CII deficiency

10. Tuberous Xanthomas, strae palmaris and accelerated PV disease is associated with this disease, and there is a increased level IDL

Type I: Familial Hyperchylomicronemia

Type IIb: Familial Hypercholesterolemia

Type IV: Familial hyperTG

Type V:Familial mixed hyperTG

Type III: Familial dysbetalipoproteinemia

same as apo CII deficiency

Explanation

same as apo CII deficiency

11. Increased VLDL synthesis by liver is associated with this disease

Type I: Familial Hyperchylomicronemia

Type II: Familial Hypercholesterolemia

Type IV: Familial hyperTG

Type V:Familial mixed hyperTG

12. LPL deficiency leads to this disease

Type I: Familial Hyperchylomicronemia

Type II: Familial Hypercholesterolemia

Type IV: Familial hyperTG

Type V:Familial mixed hyperTG

same as apo CII deficiency

Explanation

same as apo CII deficiency

13. Eruptive xanthomas are associates with this disease

Type I: Familial Hyperchylomicronemia

Type II: Familial Hypercholesterolemia

Type IV: Familial hyperTG

Type V:Familial mixed hyperTG

painless nodules on elbows and buttocks and xanthelesma on eyes

Explanation

painless nodules on elbows and buttocks and xanthelesma on eyes

14. Acute pancreatitis and xanthomas are associated with this disease

Type I: Familial Hyperchylomicronemia

Type II: Familial Hypercholesterolemia

Type IV: Familial hyperTG

Type V:Familial mixed hyperTG

painless nodules on elbows and buttocks and xanthelesma on eyes

Explanation

painless nodules on elbows and buttocks and xanthelesma on eyes

15. Often associated with insulin resistance and it is the most common lipid disorder in survivors of MI

Type I: Familial Hyperchylomicronemia

Type IIb: Familial Hypercholesterolemia

Type IV: Familial hyperTG

Type V:Familial mixed hyperTG

same as apo CII deficiency

Explanation

same as apo CII deficiency

Dyslipidemia Pathophysiology

1. Type IV familial hyper TG is associated with obese, diabetic, IHD, and hyperurecimic

2.

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2. Risk factors for familial hypercholesterolemia includes being male, LDL>330, smoking, low HDL, high Lp(a), parental history of CAD

3. Hypothyroidism, renal disease, ethanol use, liver disease, AIDS are causes of secondary hyperlipidemia

4. LPL is activated by insulin and thus in diabetes Type I (absolute lack of insulin) you see a decrease in LPL and thus increase in VLDL and chylomicrons

5. Other causes of hypercholesterolemia includes polygenic hypercholesterolemia, and defective B100

6. TG>150 and small LDL particles and low LDL are CHD risk factors and associated with hyperTG

7. IHD and tendinous xanthomas are associated with this disease

8. Increased LDL, decreased HDL, smaller particle HDL and increased CETP is associated with this disease

9. Mutant Apo E is associated with this disease

10. Tuberous Xanthomas, strae palmaris and accelerated PV disease is associated with this disease, and there is a increased level IDL

11. Increased VLDL synthesis by liver is associated with this disease

12. LPL deficiency leads to this disease

13. Eruptive xanthomas are associates with this disease

14. Acute pancreatitis and xanthomas are associated with this disease

15. Often associated with insulin resistance and it is the most common lipid disorder in survivors of MI