Let's Learn About Diabetes Drugs
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- 1.What two classes of drugs are classified as insulin secretagogues??
- A.
Biguanides, Glinides
- B.
Thiazolidinediones, Biguanides
- C.
Glinides, Sulfonylureas
- D.
Sulfonylrueas, Biguanides
- 2.You see a patient that is already taking Metformin for the DM. You want to add another drug because monotherapy isn't working. While looking over the pt's medication list, you notice they are currently taking a dose of erythromyacin. Which of the following drugs do you NOT want to give this pt d/t harmful drug interactions.
- A.
Glyburide
- B.
Repaglinide
- C.
Metformin
- D.
Acarbose
- 3.Which of the following class of DM drugs is used in both DM2 and DM1??
- A.
Alpha-glucosidase inhibitors
- B.
Sulfonylrueas
- C.
Thiazolidinediones
- D.
Glinides
- 4.One of your regular patients comes in for her annual appointment and you notice that the Metformin just isn't keeping her DM under control anymore. You want to prescribe a second drug, and are thinking a sulfonylurea would be a good choice. While looking at the routine lab results, you notice that she is 10 weeks pregnant. You realize that there is only one drug that you can prescribe her in this drug class. What is it?
- A.
Glipizide
- B.
Tolbutamide
- C.
Glyburide
- D.
Glimepiride
- 5.Which has a faster onset?
- A.
Glimpepiride
- B.
Repaglinide
- 6.What is a standard dose of Metformin
- A.
300 mg after meals
- B.
300 mg before meals
- C.
500 mg after meals
- D.
500 mg before meals
- 7.Which drug can lead to unintended pregnancy, even with a pt taking oral contraceptives?
- A.
Miglitol
- B.
Pramlintide
- C.
Metformin
- D.
Repaglinide
- 8.What is the major side effect of Biguanide drugs??
- A.
Hypoglycemia
- B.
Weight gain
- C.
GI symptoms
- D.
Neurological symptoms
- 9.Which class of drugs is restricted in the US and prohibited in Europe??
- A.
Alpha-glucoside inhibitors
- B.
Thiazolidinediones
- C.
Amylin Analogs
- D.
DPP-4 resistant analogs
- 10.In what patient would you want to temporarily discontinue Metformin?
- A.
70 y/o man getting MRI on knee
- B.
35 year old female who just found out she is pregnant
- C.
30 y/o patient getting a CT with contrast
- 11.What other disease is Metformin used to treat??
- A.
AIDS
- B.
HTN
- C.
PCOS
- D.
Cancer
- 12.In what pt would Acarbose and Miglitol be contraindicated?
- A.
50 y/o female with liver failure
- B.
34 y/o male with kidney cancer
- C.
18 y/o male with AIDS
- D.
56 y/o male with Crohn's Disease
- 13.In a pt taking Pramlintide, how much do you want to decrease their rapid or short-acting insulin dose by before meals??
- A.
33%
- B.
25%
- C.
50%
- D.
75%
- 14.A patient was recently started on a new medication for their DM. At their next appointment, you ask how the medication is working for them. They say it seems to be working well, but they complain that they have noticed an increased in the number of headaches they get and say that they seem to be getting more colds too. What is the drug that you recently started them on?
- A.
Glyburide
- B.
Acarbase
- C.
Sitagliptin
- D.
Pramlintide
- 15.The drug sitagliptin inhibits DPP-4, thus prolonging the activity of GLP-1, an incretin hormone. This extended activity results in what in response to meals?
- A.
Increased glucagon release
- B.
Decreased glucagon release
- C.
Increased insulin release
- D.
Decreased insulin release
- 16.How must exenatide be administered??
- A.
IV
- B.
IM
- C.
PO
- D.
SQ
- 17.What is a drawback of exenatide?
- A.
Causes hypoglycemia when given alone
- B.
Gives pts frequent headaches
- C.
Short duration of action
- D.
Complciated pharmacokinetics
- 18.Which classes of drugs have the benefit of lowering insulin resistance??
- A.
Alpha-glucosidase inhibitors and Glinides
- B.
DDP-4 inhibitors and amylin analogs
- C.
Incretin mimetics and sulfonylrueas
- D.
Thiazolidinediones and biguanides
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