Pharm Skel Muscle Relaxants Part 1
Welcome to another instalment of our long list of pharmacology quizzes, everybody! In today’s game, we’ll be tackling the pharmaceuticals used to relax the muscles and reduce tension in them; skeletal muscle relaxants. What do you know about how these drugs work? Let’s find out together!
- 1.Directions 1- 4 (handouts) For each numbered item select the one lettered option which is most closely associated with it (each lettered option can be selected once, more than once, or not at all). This drug can block Nn receptors in the autonomic ganglia
- A.
Tubocurarine
- B.
Baclofen
- C.
Cisatracurium
- D.
Dantrolene
- E.
Diazepam
- F.
Mivacurium
- G.
Succinylcholine
- H.
Tizanidine
- 2.Directions 1- 4 (handouts) For each numbered item select the one lettered option which is most closely associated with it (each lettered option can be selected once, more than once, or not at all). This drug acts as an agonist at Nm receptors.
- A.
Tubocurarine
- B.
Baclofen
- C.
Cisatracurium
- D.
Dantrolene
- E.
Diazepam
- F.
Mivacurium
- G.
Succinylcholine
- H.
Tizanidine
- 3.Directions 1- 4 (handouts) For each numbered item select the one lettered option which is most closely associated with it (each lettered option can be selected once, more than once, or not at all). This drug acts as an agonist mainly at alpha-2 receptors located In the spinal cord
- A.
Tubocurarine
- B.
Baclofen
- C.
Cisatracurium
- D.
Dantrolene
- E.
Diazepam
- F.
Mivacurium
- G.
Succinylcholine
- H.
Tizanidine
- 4.Directions 1- 4 (handouts) For each numbered item select the one lettered option which is most closely associated with it (each lettered option can be selected once, more than once, or not at all). This drug can activate M2 receptors in the heart.
- A.
Tubocurarine
- B.
Baclofen
- C.
Cisatracurium
- D.
Dantrolene
- E.
Diazepam
- F.
Mivacurium
- G.
Succinylcholine
- H.
Tizanidine
- 5.A 61-year-old woman underwent surgery to remove an ovarian cancer. Anesthesia was induced by thiopental and maintained by sevoflurane and tubocurarine. After surgery the anesthesiologist administered a drug to overcome the residual muscle relaxant effect fo tubocurarine. Which of the following drugs was most likely given?
- A.
Neostigmine
- B.
Succinylcholine
- C.
Cisatracurium
- D.
Tizanidine
- E.
Dantrolene
- F.
Baclofen
- 6.A 67-year-old woman required intubation and mechanical ventilation for management of respiratory failure. Tubocurarine was given IV to reduce chest wall resistance and ineffective spontaneous ventilation. Which of the following membrane potentials was most likely blocked by tubocurarine in this patient?
- A.
Action potential of motor nerve
- B.
Miniature end plate potential
- C.
Resting potential of smooth muscle
- D.
Action potential of cardiac muscle
- E.
Action potential of corticospinal tract
- 7.A 65-year-old woman underwent hysterectomy to remove a uterine carcinoma. The anesthesiologist chose thiopental sodium for induction and isoflurane and tubocurarine for maintenance of general anesthesia. The anesthesiologist also administered another drug in order to counteract tubocurarine induced hypotension. A drug belonging to which of the following classes was most likely given?
- A.
Beta-1 agonist
- B.
D1 antagonist
- C.
Muscarinic agonist
- D.
Cholinesterase inhibitor
- E.
H1 antagonist
- 8.A 66-year-old woman was brought to the Emergency Room following a car accident. A surgical operation was needed to repair a badly damaged leg. The woman was currently receiving gentamicin and tolterodine for an urinary tract infection, timolol and latanoprost for glaucoma, and lovastatin for hypercholesterolemia. The anesthesiologist chose thiopental sodium for induction and isoflurane plus tubocurarine for maintenance of general anesthesia. Which of the following patient’s medications most likely enhanced the action of tubocurarine?
- A.
Gentamicin
- B.
Tolterodine
- C.
Timolol
- D.
Latanoprost
- E.
Lovastatin
- 9.A 73-year-old man underwent thoracic surgery to remove a lung cancer. General anesthesia was supplemented with tubocurarine. Which of the following molecular actions most likely mediated the muscle relaxant effect of this drug?
- A.
Stimulation of plasma cholinesterase
- B.
Long lasting activation of postsynaptic Nm receptors
- C.
Competitive blockade of postsynaptic Nm receptors
- D.
Blockade of action potential of the motor nerves
- E.
Blockade of Ca++ release from sarcoplasmic reticulum
- F.
Competitive blockade of Nn receptors in brain
- 10.A 38-year-old patient was admitted to the emergency room with extensive soft-tissue burns. He was semiconscious and was artificially ventilated. His uncoordinated respiratory movements were interfering with the mechanical ventilation. Which of the following drugs was most likely administered to decrease the patient’s spontaneous breathing?
- A.
Atropine
- B.
Vecuronium
- C.
Botulinum toxin
- D.
Dantrolene
- E.
Neostigmine
- F.
Fluoxetine
- 11.A 49-year-old woman required intubation and mechanical ventilation for management of respiratory failure resulting from severe emphysema. The patient was agitated, attempting to sit up in bed and reach for his endotracheal tube. Lorazepam was give IV for sedation and the patient got drowsy but motor restlessness was only marginally improved. A muscle relaxant was given IV. The patient relaxed as paralysis developed but 5 minutes later her heart rate was 160 bpm. Which of the following drugs most likely caused this adverse effect?
- A.
Botulinum toxin
- B.
Dantrolene
- C.
Succinylcholine
- D.
Tubocurarine
- E.
Cisatracurium
- 12.A 57-year-old woman was admitted semiconscious to the emergency room after a car accident. Artificial ventilation was need and a drug was given to facilitate intubation. The administered drug has the lowest duration of action among the skeletal muscle relaxant. Which of the following drugs was most likely given?
- A.
Succinylcholine
- B.
Cisatracurium
- C.
Dantrolene
- D.
Vecuronium
- E.
Tubocurarine
- F.
Tizanidine
- 13.A 33-year-old woman was hospitalized with the diagnosis of schizophrenia and was started on a high dose of haloperidol. After 2 days of therapy she became rigid, appeared confused at times and had a fever of 104° F. The physical examination revealed tachycardia, labile blood pressure, profuse diaphoresis, sialorrhea, dyspnea and urinary incontinence. Which of the following drugs was most likely given immediately to the patient?
- A.
Atropine
- B.
Succinylcholine
- C.
Dantrolene
- D.
Dopamine
- E.
Prazosin
- F.
Baclofen
- 14.A 55-year-old woman was undergoing major surgery to remove a breast carcinoma. The woman, who was an heavy smoker, had been suffering from chronic obstructive pulmonary disease for 15 years. A drug was administered preoperatively and the anesthesia was supplemented with a skeletal muscle relaxant. Which of the following drugs would be contraindicated for this patient?
- A.
Tubocurarine
- B.
Glycopyrrolate
- C.
Clonidine
- D.
Vecuronium
- E.
Cisatracurium
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