CNS -- Pharmacology -- (Adds + Apds + Aeds)

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  • 1/28 Questions

    Abnormal excessive secretion of milk from breasts in females is called:

    • Amenorrhea
    • Galactorrhea
    • Gynecomastia
    • Libido
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About This Quiz

This quiz focuses on CNS pharmacology, specifically addressing drugs for ADD, APDs, and AEDs. It covers side effects, drug mechanisms, and specific conditions like galactorrhea and mood swings. Essential for medical students and professionals in psychiatry and neurology.

CNS -- Pharmacology -- (Adds + Apds + Aeds) - Quiz

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  • 2. 

    Orthostatic hypotension is a side effect of the following drugs except:

    • Bupropion

    • Amitriptyline

    • Phenothiazines

    • Thioxanthenes

    Correct Answer
    A. Bupropion
    Explanation
    Orthostatic hypotension is a condition characterized by a sudden drop in blood pressure when standing up from a sitting or lying position. This can cause symptoms such as dizziness, lightheadedness, and fainting. Bupropion is a medication commonly used for the treatment of depression and smoking cessation. It does not typically cause orthostatic hypotension as a side effect. On the other hand, amitriptyline, phenothiazines, and thioxanthenes are all classes of medications that can potentially cause orthostatic hypotension.

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  • 3. 

    All of the following are neuroleptic drugs except:

    • Lamotrigine

    • Thioxanthenes

    • Clozapine

    • Haloperidol.

    Correct Answer
    A. Lamotrigine
    Explanation
    Lamotrigine is not classified as a neuroleptic drug because it does not primarily act on dopamine receptors in the brain. Neuroleptic drugs, such as thioxanthenes, clozapine, and haloperidol, are commonly used to treat psychiatric disorders by blocking dopamine receptors. Lamotrigine, on the other hand, is an anticonvulsant medication primarily used to treat epilepsy and bipolar disorder by stabilizing neuronal membranes and inhibiting the release of glutamate. Therefore, lamotrigine does not belong to the neuroleptic drug class.

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  • 4. 

    The following drug inhibits the re-uptake of Dopamine:

    • Amitriptyline.

    • Bupropion

    • Venlafaxine

    • Sertraline

    Correct Answer
    A. Bupropion
    Explanation
    Bupropion is the correct answer because it is a norepinephrine-dopamine reuptake inhibitor (NDRI), meaning it inhibits the reuptake of both norepinephrine and dopamine. This action increases the levels of dopamine in the brain, which can help improve mood and alleviate symptoms of depression. Amitriptyline, Venlafaxine, and Sertraline are not specifically known for inhibiting the reuptake of dopamine.

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  • 5. 

    Influenza-like symptoms may result after ingestion of:

    • Carbamazepine

    • Phenytoin

    • Lamotrigine

    • Valproate

    Correct Answer
    A. Lamotrigine
    Explanation
    Lamotrigine is an anticonvulsant medication commonly used to treat epilepsy and bipolar disorder. While it is generally well-tolerated, some individuals may experience side effects, including influenza-like symptoms such as fever, body aches, and fatigue. This can occur as a result of an allergic reaction or hypersensitivity to the medication. It is important to monitor for these symptoms and consult a healthcare professional if they occur.

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  • 6. 

    Ethusoximide exerts its anti-epileptic effect at which area of the brain:

    • Thalamus

    • Area of relay of thalamic neurons in the cortex

    • Basal ganglia

    • Brain stem

    Correct Answer
    A. Area of relay of thalamic neurons in the cortex
    Explanation
    Ethusoximide exerts its anti-epileptic effect at the area of relay of thalamic neurons in the cortex. This means that the drug targets the specific region in the cortex where thalamic neurons relay information. By acting on this area, ethusoximide is able to regulate the transmission of signals and prevent abnormal electrical activity that leads to seizures. The drug's mechanism of action in this specific brain region helps to control and reduce epileptic episodes.

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  • 7. 
    According to the image, this abnormal sign in males is a side effect of a group of CNS drugs.What is the most probable answer: - ProProfs

    According to the image, this abnormal sign in males is a side effect of a group of CNS drugs.What is the most probable answer:

    • Fluoxetine..​

    • Chlorpromazine.

    • Imipramine.

    • Clozapine.

    Correct Answer
    A. Chlorpromazine.
    Explanation
    The most probable answer is Chlorpromazine because it is a CNS drug known to have side effects that can cause abnormal signs in males. Fluoxetine, Imipramine, and Clozapine are also CNS drugs, but there is no evidence or indication in the question or image that suggests they cause the specific abnormal sign mentioned.

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  • 8. 

    Lithium is very beneficial in treating mood swings in manic-depressive disorders but it has serious side effects which include the following except:

    • Sick-Sinus syndrome.

    • Edema.

    • Polyuria

    • Increased thyroid function

    Correct Answer
    A. Increased thyroid function
    Explanation
    Lithium is commonly used to treat mood swings in manic-depressive disorders. However, it is known to have serious side effects. One of these side effects is increased thyroid function. This means that lithium can cause the thyroid gland to become overactive, leading to symptoms such as weight loss, increased heart rate, and anxiety. The other options listed, sick-sinus syndrome, edema, and polyuria, are all potential side effects of lithium treatment.

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  • 9. 

    What is the most probable CNS drug to cause insulin resistance:

    • Imipramine

    • Chlorpromazine

    • Phenytoin

    • Clozapine

    Correct Answer
    A. Clozapine
    Explanation
    Clozapine is the most probable CNS drug to cause insulin resistance. Clozapine is an atypical antipsychotic medication commonly used to treat schizophrenia. It has been associated with an increased risk of metabolic side effects, including weight gain, dyslipidemia, and insulin resistance. Insulin resistance is a condition in which the body's cells become less responsive to the effects of insulin, leading to elevated blood sugar levels. This can increase the risk of developing type 2 diabetes. Therefore, among the given options, clozapine is the most likely CNS drug to cause insulin resistance.

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  • 10. 

    The following is a drug which blocks the re-uptake of Noradrenaline but has no alpha-adrenergic blocking effect: 

    • Imipramine.

    • Amitriptyline.

    • Citalopram.

    • Venlafaxine.

    Correct Answer
    A. Venlafaxine.
    Explanation
    Venlafaxine is the correct answer because it is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) that primarily blocks the reuptake of both serotonin and norepinephrine. It does not have significant alpha-adrenergic blocking effects, unlike Imipramine and Amitriptyline which are tricyclic antidepressants that have both norepinephrine and serotonin reuptake inhibition as well as alpha-adrenergic blocking effects. Citalopram is a selective serotonin reuptake inhibitor (SSRI) and does not have any noradrenergic effects.

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  • 11. 

    The anti-depressant drug which is still approved to be used in all ages is:

    • Imipramine.

    • Fluoxetine.

    • Venlafaxine.

    • Chlorpromazine.

    Correct Answer
    A. Fluoxetine.
    Explanation
    Fluoxetine is the correct answer because it is an anti-depressant drug that is approved for use in all age groups. Imipramine is also an anti-depressant drug, but it is not approved for use in children. Venlafaxine is approved for use in adults, but not in children or adolescents. Chlorpromazine is an antipsychotic medication, not an anti-depressant. Therefore, Fluoxetine is the only option that is approved for use in all ages.

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  • 12. 

    The following drug is approved for first-line treatment of absence seizures when Ethusoximide is not available:

    • Tegretol

    • Depakene

    • Phenytoin

    • Lamotrigine

    Correct Answer
    A. Depakene
    Explanation
    Depakene is the correct answer because it is approved for first-line treatment of absence seizures when Ethusoximide is not available. Depakene, also known as valproic acid, is an anticonvulsant medication that is effective in controlling absence seizures. It works by increasing the levels of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain, which helps to reduce the occurrence of seizures. Tegretol, Phenytoin, and Lamotrigine are also anticonvulsant medications, but they are not specifically approved for the treatment of absence seizures when Ethusoximide is not available.

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  • 13. 

    Neuroleptanalgesia is produced by which combination:

    • Chlorpromazine + Haloperidol

    • Risperidone + Phenothiazine

    • Droperidol + Fentanyl

    • None of the above

    Correct Answer
    A. Droperidol + Fentanyl
    Explanation
    Droperidol is a neuroleptic medication that acts as a tranquilizer, reducing anxiety and inducing sedation. Fentanyl is a potent opioid analgesic that provides pain relief. When combined, droperidol and fentanyl produce neuroleptanalgesia, a state of reduced pain and anxiety. This combination is commonly used in medical procedures and surgeries to provide both sedation and analgesia to patients.

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  • 14. 

    Reflex tachycardia is a serious problem for a 62-year-old patient after ingestion of the following drug/s:(you can choose more than one)

    • Paroxetine

    • Imipramine

    • Chlorpromazine

    • Tranylcypromine

    Correct Answer(s)
    A. Imipramine
    A. Chlorpromazine
    Explanation
    Imipramine and chlorpromazine are both known to cause reflex tachycardia as a side effect. Reflex tachycardia is an increase in heart rate that occurs as a compensatory response to a drop in blood pressure. Imipramine is a tricyclic antidepressant that can cause orthostatic hypotension, leading to reflex tachycardia. Chlorpromazine is an antipsychotic medication that can also cause orthostatic hypotension and subsequent reflex tachycardia. Paroxetine and tranylcypromine are not typically associated with reflex tachycardia.

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  • 15. 

    Choose 2 drugs that their combination may cause serotonin syndrome.

    • Fluvoxamine

    • Imipramine

    • Tranylcipromine

    • MAO-B inhibitor

    Correct Answer(s)
    A. Fluvoxamine
    A. Tranylcipromine
    Explanation
    Fluvoxamine and tranylcipromine are both drugs that can inhibit the reuptake of serotonin in the brain. When these drugs are used in combination, there is an increased risk of serotonin syndrome, a potentially life-threatening condition characterized by excessive levels of serotonin in the body. Serotonin syndrome can cause symptoms such as agitation, confusion, rapid heartbeat, high blood pressure, dilated pupils, and even seizures. Therefore, it is important to avoid combining these two drugs to prevent the occurrence of serotonin syndrome.

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  • 16. 

    Immunosupression may be a side effect of the following drug/s:(you may choose more than one)

    • Phenytoin

    • Clozapine

    • Carbamazepine

    • Lamotrigine

    Correct Answer(s)
    A. Clozapine
    A. Carbamazepine
    Explanation
    Clozapine and Carbamazepine can both cause immunosuppression as a side effect. Clozapine is an antipsychotic medication used to treat schizophrenia, and it can suppress the immune system, making individuals more susceptible to infections. Carbamazepine is an anticonvulsant medication used to treat epilepsy and bipolar disorder. It can also have immunosuppressive effects, reducing the body's ability to fight off infections. Phenytoin and Lamotrigine, on the other hand, do not typically cause immunosuppression as a side effect.

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  • 17. 

    Combination between Bupropion and Tranylcipromine may cause hypertensive crisis.

    • True

    • False

    Correct Answer
    A. True
    Explanation
    The combination of Bupropion and Tranylcipromine can result in a hypertensive crisis. This means that when these two medications are taken together, it can lead to a dangerous increase in blood pressure. It is important to avoid this combination as it can have severe health consequences.

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  • 18. 

    T-type calcium channels are blocked by the following drug/s:(you may choose more than one)

    • Carbamazepine

    • Lamotrigine

    • Ethosuximide

    • Depakene

    Correct Answer(s)
    A. Ethosuximide
    A. Depakene
    Explanation
    Ethosuximide and Depakene are both known to block T-type calcium channels. T-type calcium channels are low voltage-activated calcium channels that play a role in regulating neuronal excitability. Blocking these channels can help reduce abnormal electrical activity in the brain, making them effective in the treatment of certain types of seizures. Carbamazepine and Lamotrigine, on the other hand, do not specifically target T-type calcium channels and have different mechanisms of action in the treatment of seizures.

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  • 19. 

    The following drug is most probable choice of all to treat tonic-clonic seizures

    • Tegretol

    • Dilantin

    • Depakene

    • Ethusoximide

    Correct Answer
    A. Depakene
    Explanation
    Depakene is the most probable choice to treat tonic-clonic seizures because it is commonly prescribed for this type of seizure. It is an anticonvulsant medication that works by stabilizing electrical activity in the brain, preventing seizures. Tegretol and Dilantin are also anticonvulsant medications, but they are typically used for different types of seizures. Ethosuximide is primarily used to treat absence seizures, not tonic-clonic seizures. Therefore, Depakene is the most appropriate choice for treating tonic-clonic seizures.

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  • 20. 

    A 33-year-old epileptic patient which is recently diagnosed for negative signs of schizophrenia.The following combination is highly recommended:

    • Tegretol + Risperidone.

    • Carbamazepine + Clozapine.

    • Valproate + Chlorpromazine.

    • Valproate + Haloperidol.

    Correct Answer
    A. Tegretol + Risperidone.
    Explanation
    The combination of Tegretol and Risperidone is highly recommended for the given patient. Tegretol (Carbamazepine) is an anticonvulsant medication commonly used to treat epilepsy. It can also be effective in managing symptoms of schizophrenia, particularly negative signs such as social withdrawal and lack of motivation. Risperidone is an atypical antipsychotic medication often prescribed for schizophrenia. It helps to reduce positive symptoms like hallucinations and delusions. Therefore, the combination of Tegretol and Risperidone can address both the epilepsy and negative signs of schizophrenia in the patient.

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  • 21. 

    Thrombocytopenia may result from the chronic use of the following drug/s:(you may choose more than one)

    • Valproate

    • Phenytoin

    • Carbamazepine

    • Lamotrigine

    Correct Answer(s)
    A. Valproate
    A. Carbamazepine
    Explanation
    Thrombocytopenia is a condition characterized by a low platelet count in the blood. Valproate and carbamazepine are both anticonvulsant medications that have been associated with thrombocytopenia as a potential side effect. These drugs can suppress the production of platelets in the bone marrow or cause immune-mediated destruction of platelets. Phenytoin and lamotrigine, on the other hand, are not commonly associated with thrombocytopenia. Therefore, the chronic use of valproate and carbamazepine can lead to thrombocytopenia.

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  • 22. 

    Down-regulation of 5-HT2A receptors is a target for the following drug/s: (you can choose more than one)

    • Fluoxetine

    • Chlorpromazine

    • Risperidone

    • Bupropion

    Correct Answer(s)
    A. Fluoxetine
    A. Risperidone
    Explanation
    Remember that I told you to choose more than one ;)

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  • 23. 

    This is a side effect of a CNS drug.

  • 24. 

    What is this manifestation called ?!

  • 25. 

    Which neurotransmitter is involved in it?

  • 26. 

    Name 2 drugs that may cause this manifestation.

  • 27. 

    Mention 2 characteristic side effects for Phenytoin.

  • 28. 

    Mention the effect of (Carbamazepine, Phenytoin & Valproate) on hepatic CytP450.

  • 29. 

    Enumerate the steps of emergency control over Status Epilepticus respectively.

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  • Current Version
  • May 10, 2024
    Quiz Edited by
    ProProfs Editorial Team
  • Dec 16, 2016
    Quiz Created by
    Dr_Brand
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