CNS Drugs ETC - Pharmacology

9 Questions | Total Attempts: 1187

SettingsSettingsSettings
Please wait...
Pharmacology Drug Quizzes & Trivia

Questions and Answers
  • 1. 
    Glutamate
    • A. 

      Role = excitation

    • B. 

      Binds to NMDA channels which causes ion channels to open. Na+ and Ca2+ efflux and K+ influx

    • C. 

      Glutamate hypofunction is associated with negative symptoms of psychosis

    • D. 

      Smoking marijuana causes increased glutamate release

  • 2. 
    Dopamine
    • A. 

      Role = inhibition

    • B. 

      D2 receptors bound presynaptically by dopamine cause decreased Ca2+, which decreases dopamine release

    • C. 

      Low dopamine in the limbic system is linked with positive symptoms

    • D. 

      Antipsychotics that block D2 receptors can cause Parkinson's like symptoms

    • E. 

      Monoamine oxidase inhibitors cause decrease in dopamine

    • F. 

      Use of cocaine causes increased release of dopamine

  • 3. 
    GABA
    • A. 

      Role= Excitation

    • B. 

      Binds GABA(B) to increase Cl- influx into the cell

    • C. 

      Barbiturates in high doses can activate GABA receptors without the presence of GABA

  • 4. 
    Which of the following cause CNS depression?
    • A. 

      Tricyclic Antidepressants

    • B. 

      Phenobarbital

    • C. 

      Heroin

    • D. 

      Ethanol

  • 5. 
    The dopamine pathway associated with movement _______
  • 6. 
    Tricyclic antidepressants are used to treat _______depression
  • 7. 
    Which of the following is CORRECT?
    • A. 

      Clonidine helps with autonomic symptoms of withdrawal (from opiods, sedatives)

    • B. 

      Microsomal ethanol oxidizing system is always converting ethanol to acetaladehyde

    • C. 

      Symptoms of withdrawal are more common from use of benzodiazepines then from ethanol and barbiturates

    • D. 

      The adverse effects of stimulants are psychosis and delusions + decreased sympathomimetic activity

    • E. 

      Benzodiazepines are used to treat ethanol withdrawal

    • F. 

      Most hallucinogens are fatal with the exception of PCP which is generally safe

    • G. 

      All of the above

    • H. 

      A, b, e

    • I. 

      A and e

    • J. 

      A, d, e

  • 8. 
    Which of the following is CORRECT?
    • A. 

      Tangles = extracellular twists of phosphorylated tau protein

    • B. 

      Plaques = extracellular deposits of beta-amyloid protein

    • C. 

      Bupropion increases dopamine levels

    • D. 

      SSRIs activate P450 enzyme, which is the enzyme used to metabolize tricyclic antidepressants

    • E. 

      MAOIs take a long time to produce an effect because it takes time for changes to result from increased MAO levels (such as the production of BDNFs)

    • F. 

      All of the above

    • G. 

      B, c, e

    • H. 

      B and e

    • I. 

      B, c, d and e

  • 9. 
    Which of the following is CORRECT
    • A. 

      Lithium causes a decrease in IP3 and DAG

    • B. 

      Serotonin Syndrome = seizures, cardiovascular instability, hyperthermia and severe musclar rigidity

    • C. 

      Glutatmate hypothesis = NMDA antagonists cause decreased dopamine in the limbic system

    • D. 

      The metabolites of phenobarbital are active

    • E. 

      Olazapine blocks muscarinic receptors which results in atropine like symptoms

Back to Top Back to top