Clinical Second

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    Patients with Criglar najjar's syndrome may have:

    • Unconjugated hyperbilirubinemia 
    • Decreased number of reticulocytes 
    • Decreased bilirubin excretion 
    • G6PD deficiency 
    • Hemolysis and rhabdomyolysis 
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Clinical Second - Quiz

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  • 2. 

    All of the following are correct regarding parathyroid hormone (PTH) EXCEPT : 

    • It increases osteoclastic bone resorption 

    • It decrease renal calcium reabsorption 

    • It decreases renal phosphate reabsorption 

    • It decreases renal bicarbonate reabsorption causing mild acidosis 

    • It increases alpha 1 hydroxylation of vitamin D 

    Correct Answer
    A. It decrease renal calcium reabsorption 
  • 3. 

    Which of the following may be associated with decreased plasma free ionized calcium?

    • Acidosis

    • Hyperkalemia

    • Alkalosis

    • Primary hyperparathyroidism 

    • Hypermagnesemia

    Correct Answer
    A. Alkalosis
  • 4. 

    Which of the following is used to asses iron body stores ? 

    • Transferrin

    • Haptoglobin

    • CRP 

    • Ferritin 

    • Prealbumin 

    Correct Answer
    A. Ferritin 
  • 5. 

    Which of the following may cause hypocalcemia?

    • Primary hyperparathyroidism 

    • Thiazide diuretics 

    • Magnesium deficiency 

    • Vitamin D intoxication  

    • Thyrotoxicosis 

    Correct Answer
    A. Magnesium deficiency 
  • 6. 

    Alpha 1 antitrypsin :

    • Concentration may increase in patients with nephrotic syndrome 

    • Deficiency may result in edema 

    • Is normally excreted in urine 

    • Is an acute phase protein that is usually increased during infection 

    • Concentration may increase in patient with liver disease 

    Correct Answer
    A. Is an acute phase protein that is usually increased during infection 
  • 7. 

    All of the following are correct regarding jaundice EXCEPT : 

    • It may indicate the presence of liver disease

    • The drug rifampcin is among the causes of jaundice 

    • Neonatal jaundice is almost pathological 

    • It may result from reduced uptake of unconjugated bilirubin by the liver

    • Patients with jaundice may have increased serum level of either conjugated or unconjugated bilirubin.

    Correct Answer
    A. Neonatal jaundice is almost pathological 
  • 8. 

    All of the following are correct regarding osteoporosis EXCEPT:

    • Patients have normal alkaline phosphatase  (ALP)

    • Bones become more fragile 

    • Plasma calcium is usually high

    • Elderly persons have higher risk of osteoporosis compared toyoung persons 

    • Females have higher risk of osteoprosis compared to males 

    Correct Answer
    A. Plasma calcium is usually high
  • 9. 

    All of the following are correct about Albumin EXCEPT: 

    • It is used as a test for liver function

    • Patients with septicemia may develop hypoalbuminemia 

    • It act as a carrier for free fatty acids(FFA)

    • Hyperalbuminemia may cause oedema  

    • Albumin is a major protein in the blood  

    Correct Answer
    A. Hyperalbuminemia may cause oedema  
  • 10. 

    Patients with prolonged prothrombin time may have:

    • Increased risk of thrombosis

    • Defective hepatic excretory function 

    • Acute phase response 

    • Vitamin K deficiency 

    • Increased synthesis of clotting factors 

    Correct Answer
    A. Vitamin K deficiency 
  • 11. 

    Which of the following may increase in hepatocellular carcinoma: 

    • Alpha 1 antitrypsin

    • Alpha 1 fetoprotein 

    • Alpha 2 macroglobulin 

    • Transferrin 

    • Haptoglobin 

    Correct Answer
    A. Alpha 1 fetoprotein 
  • 12. 

    Caeruloplasmin level may decrease in all of the following EXCEPT:

    • Wilson's disease

    • Malnutrition and malabsorption 

    • Decompensated liver cirrhosis 

    • Acute phase response

    • Nephrotic syndrome

    Correct Answer
    A. Acute phase response
  • 13. 

    Patients with liver cirrhosis may develop ascites because of :

    • Reduced pre-albumin 

    • Decreased renin secretion 

    • Increased ammonia level

    • Decreased albumin synthesis 

    • Esophageal bleeding.

    Correct Answer
    A. Decreased albumin synthesis 
  • 14. 

    All of the following are typical findings in multiple myeloma EXCEPT: 

    • Increased creatinine 

    • IgA or IgG paraproteins 

    • Normal alkaline phosphatase (ALP) activity 

    • Anemia 

    • Decreased calcium

    Correct Answer
    A. Decreased calcium
  • 15. 

    Which of the following may cause secondary hyperparathyroidism 

    • Hypocalcemia 

    • Acidosis 

    • Obesity 

    • Hypermagnesmia 

    • Hyperaldosteronism

    Correct Answer
    A. Hypocalcemia 
  • 16. 

    Alkaline phosphatase (ALP) activity is expected to be elevated in all of the following conditions EXCEPT: 

    • Paget's diseas

    • Rickets 

    • Cholestasis 

    • Cirrhosis 

    • Pre-icteric phase of acute hepatitis 

    Correct Answer
    A. Pre-icteric phase of acute hepatitis 
  • 17. 

    All of the following findings are expected in the icteric phase of acute hepatitis EXCEPT : 

    • Increased ALT 

    • Normal or increased ALP

    • Increased urinary urobilinogen 

    • Normal albumin level

    • Marked elevation in plasma bilirubin 

    Correct Answer
    A. Increased urinary urobilinogen 
  • 18. 

    Which of the following is CORRECT regarding C reactive protein (CRP): 

    • It is decreased in acute phase response

    • It is decreased in bacterial infections 

    • Its elevation is a marker of cardiovascular risk 

    • It is increased in viral infection 

    • It is a valuable marker of inflammatory conditions such as rheumatoid arthritis 

    Correct Answer
    A. It is a valuable marker of inflammatory conditions such as rheumatoid arthritis 
  • 19. 

    Regarding transaminases (AST and ALT) , which of the following is TRUE: 

    • AST is more liver specific compared to ALT 

    • Both enzymes are usually highly elevated in crush injures and muscle diseases 

    • Both enzymes are usually highly elevated in nonalcoholic fatty liver disease

    • ALT is one of the markers that are usually elevated in acute hepatitis 

    • Both are highly elevated in myocardial infraction 

    Correct Answer
    A. ALT is one of the markers that are usually elevated in acute hepatitis 
  • 20. 

    Which of the following statements about uric acid is correct : 

    • Excretion occurs mainly though kidneys and to less extent through intestine 

    • In plasma, it is highly bound to protein , especially immunoglobulins 

    • It is the end product of protein catabolism 

    • In urine, it is excreted as urea , which is the most soluble form.

    • Allopurinol is a medication that enhances its renal excretion 

    Correct Answer
    A. Excretion occurs mainly though kidneys and to less extent through intestine 
  • 21. 

    Which of the following is an expected findings in hemolytic jaundice ?

    • Deep orange to brown urine

    • Decreased haptoglobin 

    • Increased conjugated bilirubin 

    • Marked elevation in AST

    • Marked increase in Lactate dehydrogenase (LDH) 

    Correct Answer
    A. Decreased haptoglobin 
  • 22. 

    In which condition this pattern is most likely: decreased calcium, decreasedphosphate, increased ALP and increased calcium excretion :

    • Hypoparathyroidism 

    • Renal failure

    • Osteomalacia 

    • Paget's disease 

    • Fanconi syndrome 

    Correct Answer
    A. Osteomalacia 
  • 23. 

    Which of the following may cause increased uric acid in blood (hyperuricemia) 

    • Anemia

    • High dose of salicylates 

    • Increased phosphoribosyl pyrophosphate synthase 

    • Liver cirrhosis 

    • Excess of dietary pyrimidine intake

    Correct Answer
    A. Increased phosphoribosyl pyrophosphate synthase 
  • 24. 

    Regarding bilirubin metabolism , which of the followingis NOT true:

    • Conjugation of bilirubin does occur in heptocytes and is mediated by glucuronyl transferase 

    • Unconjugated bilirubin is water insoluble and is totally bound to plasma protein albumin 

    • Conjugation of bilirubin is done with glucuronic acid to form mono- and di- glucuronides  

    • Conjugated bilirubin is normally excreted in urine 

    • Bilirubin is converted into urobilinogen in intestine by bacteria

    Correct Answer
    A. Conjugated bilirubin is normally excreted in urine 

Quiz Review Timeline (Updated): Mar 18, 2022 +

Our quizzes are rigorously reviewed, monitored and continuously updated by our expert board to maintain accuracy, relevance, and timeliness.

  • Current Version
  • Mar 18, 2022
    Quiz Edited by
    ProProfs Editorial Team
  • Dec 14, 2019
    Quiz Created by
    Pharmacgy
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