Hardest Trivia Test On Microbiology! Quiz

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Microbiology Quizzes & Trivia

Do you want a career in the medical field as a microbiologist and since you started your classes think that you have gathered a lot of information in this discipline? Let’s us take your memory for a test drive by seeing just how well you can tackle the hardest trivia test on microbiology below and see just how high you score.


Questions and Answers
  • 1. 
    The innate response resists a particular foreign agent; moreover, innate immune responses improve on repeated exposure to the agent.  
    • A. 

      True

    • B. 

      False

  • 2. 
    Blood cell development occurs in the bone marrow of mammals during the process of  
    • A. 

      Hemolysis

    • B. 

      Hematopoesis

    • C. 

      Hemostasis

    • D. 

      None of the above

  • 3. 
     Substances that are recognized as foreign and provoke immune responses are called  
    • A. 

      Antibodies

    • B. 

      Antigens

    • C. 

      Infective agents

    • D. 

      Inducers

  • 4. 
    Which of the following is a physical barrier in the nonspecific defense of a mammalian host?  
    • A. 

      Inflammation

    • B. 

      Phagocytosis

    • C. 

      Fever

    • D. 

      Mucous membranes

  • 5. 
    The lungs are protected from microorganisms by  
    • A. 

      the mucociliary blanket.

    • B. 

        lysozyme in mucus. 


    • C. 

      Phagocytic action of alveolar macrophages.

    • D. 

      all of the choices

  • 6. 
    Tears protect the eyes by  
    • A. 

      Flushing and lysozyme.


    • B. 

      Inflammation

    • C. 

      Vasodilation

    • D. 

      Stimulating opsonization.


    • E. 

       flushing and lysozyme and vasodilation

  • 7. 
    Under normal circumstances, which of the following is(are) normally sterile environments in mammals?  
    • A. 

      Kidneys

    • B. 

      Ureters

    • C. 

      Urinary bladder

    • D. 

      All of these

  • 8. 
    Which of the following is used to help protect the lungs from infection?  
    • A. 

      Turbulent airflow deposits airborne pathogens on sticky mucosal surfaces.

    • B. 

      The mucociliary escalator moves trapped organisms away from the lungs by ciliary action.

    • C. 

      Coughing and sneezing forcefully expel organisms away from the lungs.

    • D. 

      all of the choices

  • 9. 
     Lysozyme is an enzyme that lyses  
    • A. 

      Viruses

    • B. 

      Fungi

    • C. 

      Bacteria

    • D. 

      Parasites

  • 10. 
     The skin surface (epidermis) is a very favorable environment for colonization by microorganisms.  
    • A. 

      True

    • B. 

      False

  • 11. 
    The lower genitourinary tract is usually free of microorganisms.  
    • A. 

      True

    • B. 

      False

  • 12. 
    Lactobacillus contributes to the antimicrobial defenses for the adult female reproductive tract by making lactic acid to lower the pH.  
    • A. 

      True

    • B. 

      False

  • 13. 
    Cervical mucus has antibacterial activity.  
    • A. 

      True

    • B. 

      False

  • 14. 
    The shorter urethra in females is one reason why urinary tract infections are more common in females than in males.  
    • A. 

      True

    • B. 

      False

  • 15. 
    The mucociliary blanket is found in the digestive system of mammals.    
    • A. 

      True

    • B. 

      False

  • 16. 
    ____________ are a group of cytokines produced by some eukaryotic cells in response to a viral infection.  
  • 17. 
     _____________ is a process by which microorganisms or other particles are coated by serum components, preparing them for recognition and ingestion by phagocytic cells.  
  • 18. 
    Lectin binds to certain carbohydrates to begin the activation of the classical complement pathway.  
    • A. 

      True

    • B. 

      False

  • 19. 
    The bacteriocins produced by Escherichia coli are called colicins.  
    • A. 

      True

    • B. 

      False

  • 20. 
    Body temperature is a physiological barrier against certain microorganisms.  
    • A. 

      True

    • B. 

      False

  • 21. 
    The alternative complement pathway plays an important role in innate immunity, but it is not an effective defense against intravascular invasion by bacteria and some fungi.  
    • A. 

      True

    • B. 

      False

  • 22. 
    Human fevers are commonly caused by viral or bacterial infections, and in almost every instance fever results from an exogenous pyrogen produced by the microorganism or virus.  
    • A. 

      True

    • B. 

      False

  • 23. 
    • A. 

      Lipopolysaccharide

    • B. 

      Peptidoglycan

    • C. 

      Phospholipids of the cytoplasmic membrane. 


    • D. 

      Two of the choices

    • E. 

        all of the choices

  • 24. 
    A fever augments the host's defenses by  
    • A. 

       stimulating leukocytes into action.

    • B. 

      Enhancing microbiostasis.


    • C. 

      Enhancing the activity of the immune system.


    • D. 

       all of these

  • 25. 
    Which of the following is considered to be a biological defense mechanism?  
    • A. 

      Skin

    • B. 

      Fever

    • C. 

        gastric acid 


    • D. 

      Normal microbiota

  • 26. 
    Which of the following pathways for complement activation is generally dependent upon the formation of antigen-antibody complexes?  
    • A. 

       the classical pathway

    • B. 

       the alternative pathway


    • C. 

       the lectin complement pathway


    • D. 

       all of the choices

  • 27. 
    Complement mediated lysis is achieved by  
    • A. 

      Entry of lysozyme into gram-positive bacteria.


    • B. 

       entry of lysozyme into gram-negative bacteria.


    • C. 

      Entry of lysozyme into gram-positive bacteria and entry of lysozyme into gram-negative bacteria.

    • D. 

      None of the choices

  • 28. 
    Which of the following is not a way in which fever augments the host's defenses?  
    • A. 

      Inhibition of the parasite's growth by raising the temperature above the optimum growth temperature

    • B. 

      Inhibition of growth by decreasing the availability of iron to the organism

    • C. 

       stimulation of leukocytes into action so that they can kill the organism

    • D. 

      Enhances the activity of the immune system

  • 29. 
    Complement  
    • A. 

      Augments opsonization of bacteria by antibodies.


    • B. 

      Results in lysis of Gram-negative bacteria.

    • C. 

       results in lysis of Gram-positive bacteria.


    • D. 

       both augments opsonization of bacteria by antibodies and results in lysis of Gram-negative bacteria

    • E. 

       all of the choices

  • 30. 
    Cytokines  
    • A. 

      Cause lysis of invading microorganisms.


    • B. 

       play key roles in both specific and non-specific immunity.


    • C. 

       are required for regulation of the immune response.


    • D. 

      Play key roles in both specific and non-specific immunity and are required for regulation of the immune response.

  • 31. 
    The alternate complement pathway plays an important role in  
    • A. 

      Innate immunity.

    • B. 

       aquired immunity.


    • C. 

      Specific immunity.

    • D. 

      Both innate immunity and specific immunity.

  • 32. 
    Which of the following is (are) way(s) that the complement system aids in the defensive responses of an organism?  
    • A. 

       lysis of antibody coated gram-negative bacteria


    • B. 

      Attract phagocytic cells


    • C. 

      Activation of phagocytic cells

    • D. 

      All of these are ways that the complement system aids in the defensive responses of an organism.

  • 33. 
    Macrophage  
    • A. 

      Are derived from monocytes.

    • B. 

      Have receptors for compounds released by the immune system that coat microorganisms and enhance phagocytosis.

    • C. 

      Spread throughout the body of animals and take up residence in specific tissues.

    • D. 

      All of the choices

  • 34. 
     Dendritic cells  
    • A. 

       play an important role in the development of allergies and hypersensitivity.

    • B. 

      Contain granules with histamine and other pharmacologically active substances that contribute to the inflammatory response.

    • C. 

      Are capable of recognizing specific pathogen-associated molecular patterns and play an important role in non-specific resistance.


    • D. 

      Are mainly important in the defense against protozoan and helminth parasites.

  • 35. 
     Which of the following releases histamine?  
    • A. 

      Mast cells 


    • B. 

      Basophils

    • C. 

      Plasma cells

    • D. 

      Mast cells and basophils 


    • E. 

      none of the choices

  • 36. 
    Lymphocytes are comprised of which of the following cell types?  
    • A. 

        T cells

    • B. 

      B cells

    • C. 

      Natural killer cells 


    • D. 

      all of the choices

    • E. 

      T cells and B cells only

  • 37. 
    Macrophages are derived from  
    • A. 

      Granulocytes

    • B. 

      Basophils

    • C. 

      Neutrophils

    • D. 

      Monocytes

  • 38. 
     Macrophages have surface receptors for all of the following except  
    • A. 

      Mannose and fucose.

    • B. 

      Zymosan

    • C. 

      Antibodies

    • D. 

      Peptidoglycan

    • E. 

      Macrophages have receptors for all of the choices.

  • 39. 
     Eosinophils defend against protist and helminth parasites by  
    • A. 

      phagocytosis.

    • B. 

      Complement activation. 


    • C. 

      Antibody production. 


    • D. 

      releasing cationic proteins and reactive oxygen metabolites.

  • 40. 
     Which of the following remain in the blood circulation rather than taking up residence in other tissues?  
    • A. 

      Monocytes

    • B. 

      Macrophages

    • C. 

      Neutrophils

    • D. 

      All of the choices

  • 41. 
    Which of the following cell types migrates to the lymphoid tissue after encountering pathogens in the skin or the mucous membranes?  
    • A. 

      Mast cells.

    • B. 

      Dendritic cells

    • C. 

      Macrophages

    • D. 

      None of the choices

  • 42. 
    A mature activated B cell is called a(n)  
    • A. 

      Plasma cell.

    • B. 

      Dendritic cell.

    • C. 

      Natural killer cell.

    • D. 

      Spleen cell.

  • 43. 
    Natural killer cells specifically kill which of the following?  
    • A. 

      Tumor cells and cells infected by microorganisms

    • B. 

      Gram positive bacteria

    • C. 

      fungi and protozoa

    • D. 

      Foreign transplanted tissue

  • 44. 
    The average adult has approximately 100,000 leukocytes per mm3of blood.  
    • A. 

      True

    • B. 

      False

  • 45. 
    T cells undergo maturation in the bone marrow.  
    • A. 

      True

    • B. 

      False

  • 46. 
    Lymphoid tissues are always highly organized cellular complexes.  
    • A. 

      True

    • B. 

      False

  • 47. 
    The lymph nodes lie at the junctions of lymphatic vessels where they filter out microbes and antigens from the lymph.  
    • A. 

      True

    • B. 

      False

  • 48. 
    An intraepidermal lymphocyte migrates to a lymph node and matures into a dendritic cell after phagocytosing an antigen.  
    • A. 

      True

    • B. 

      False

  • 49. 
    GALT is an acronym that stands for: Glial Associated Lymphoid Target.  
    • A. 

      True

    • B. 

      False

  • 50. 
    In birds, the __________ of Fabricius is where B cells undergo maturation.  
  • 51. 
     The ________ is a large organ in the abdominal cavity that specializes in filtering the blood and trapping blood-borne microorganisms and antigens.  
  • 52. 
    A class of pathogen recognition receptors that function exclusively as signaling receptors are known as the ______________ receptors.  (2 words)  
  • 53. 
    Defensins act against bacteria and fungi by permeabilizing cell membranes.  
    • A. 

      True

    • B. 

      False

  • 54. 
    Reactive oxygen intermediates and reactive nitrogen intermediates produced by phagocytic cells are effective in killing invading microorganisms.  
    • A. 

      True

    • B. 

      False

  • 55. 
     Phagocytosis leads to destruction of engulfed pathogens by which of the following mechanisms?  
    • A. 

       lysosomal mediated hydrolysis


    • B. 

      Production of bacteriocins

    • C. 

       complement fixation


    • D. 

      All of the choices

  • 56. 
    Opsonizing antibodies must be against __________ components if they are to effectively stimulate phagocytosis.  
    • A. 

      Surface

    • B. 

      Internal

    • C. 

      Protein

    • D. 

      Polysaccharide

  • 57. 
    During the acute inflammatory response, ____________ binds to receptors on the capillary wall to open junctions between the cells that allow fluid and leukocytes to enter the tissue.  
  • 58. 
     Inflammation is a nonspecific defensive reaction to a tissue injury.  
    • A. 

      True

    • B. 

      False

  • 59. 
    During chronic inflammation when the macrophages are unable to protect the host from tissue damage, the body attempts to wall off and isolate the site by forming a(n)  
    • A. 

      Clot

    • B. 

      Cyst

    • C. 

      Granuloma

    • D. 

      Vesicle