This quiz covers drugs affecting the immune response, focusing on interferon alfa-2a and rituximab. It includes administration routes, adverse effects, lab testing, and premedication protocols.
"You need to ask your doctor that question"
"No, manufacturers just name the drugs any way they wish"
"They are both from the same class of drugs, so the names sound alike, but the drugs are not used for the same purposes"
"Ive never heard of that other drug"
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"You know how doctors are-they want to check out everything"
"Cyclosporine can cause damage to your kidneys"
"Prednisone can stop your kidneys from working"
"I'll check-perhaps someone made a mistake"
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"Used a glass container, not plastic, to prevent possible chemical interactions."
"Mix the medication with grapefruit juice to disguise the taste"
"Measure the oral solution with the dosing syringe provided, not a tablespoon"
"You can mix this drug with chocolate milk"
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How to give a SC injection
How to avoid infections
When to return for blood tests
All of the above
None of the above
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Premedications to reduce the severity of infusion reactions
Postmedications in increase the efficacy of the drug
Diabetic medication
Frequency of vital signs
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IV
IM
SC
PO
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Kaposi scarcoma
Breast cancer
Lung cancer
Hodgekin's disease
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Infuse both drugs at the same time by piggybacking the cefamandole into the rituximab
Infuse both drugs at the same time but into two different IV insertion sites
Infuse the cefamandole either 2 h before or after the rituximab
Infuse the cefamandole and follow immediately with the rituximab
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Gastrointestinal
Genitourinary
Cardiovascular
Renal
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Complete blood count (CBC)
White cell differential
Liver and kidney function
Urinalysis
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None
Administer any antihypertensive meds just before the rituximab
Add a 2nd type of antihypertensive medication to the patient's regimen until the rituximab therapy is complete
Do not administer the antihypertensive agent for 12 h before and 12-24 h after rituzimab administration
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Ventricular tachycardia, supraventricular tachycardia, angina, hypotension, and hypertension
Profound bradychardia, pounding headache and hypotension
Cellulitis at the insertion site and fever
Increased respiratory rate, hypotension, and bradycardia
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Mix the drug with normal saline
Hold administration of antihypersensitive medications for 12 h before rituximab administration
Administer antihypersensitive medications immediately after the rituximab infusion is completed
Stop the infusion if the patient experiences an adverse effect
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"I will have a glass of wine before I go to bed tonight"
"I will drink plenty of water"
"I will refrain from eating dairy products for the next 24 h"
"I will take my temperature every hour for the next 12 h"
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Assume that this was a transcription error and administer 5 mg/kg/day PO
Contact the physician for a new order
Administer the 15 mg/kg/day as ordered
Request that the pharmacist dispense Neoral instead of Sandimmune
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Hypothyroidism
Diabetes insipidus
Constipation
GI bleeding
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Slightly elevated serum potassium
Slightly low neutrophil count
Significantly elevated blood urea nitrogen
None of the above should cause concern, they are all normal findings
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T lymphocytes
B lymphocytes
Cell-mediated immune reactions
Phagocytosis
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This is an unexpected reaction and you need to stop the drug immediately
This drug does not cause these symptoms, and the patient is just anxious
These are the expected symptoms that occur with approx 80% of patients
This is the beginning of a potentially life-threatening reaction
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Confusion, depression, hypothyroidism
Confusion, hypothyroidism, hypotension
Confusion, hypotension, flu-like symptoms
Confusion, lethargy, flu-like symptoms
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Respiratory system
Gastrointestinal system
Central nervous system
Integumentary system
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Blood pressure
Level of consciousness
Cardiac rhythm
Heart rate
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Provide warm blankets and ice chips
Seek an order for acetaminophen
Turn down the rate of rituximab infusion
Turn off the rituximab infusion
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Hypertension
Hypoglycemia
Depression
Electrolyte imbalance
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Trastuzumab
Cetuximab
Bevacizumab
Panitumumab
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Administer antipyretics after the first dose, if needed
Administer the drug by IV infusion using a pump
Administer a high dose initally and then taper the dose
Do all of the above
Do none of the above
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