Block 9 Pharm Cholinergic W Exp Prt 1

15 Questions | Total Attempts: 346

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Block 9 Pharm Cholinergic W Exp Prt 1

Questions and Answers
  • 1. 
    Inhibition of cholinesterases by this drug is very short (2-10 minutes)
    • A. 

      Acetylcholine

    • B. 

      Bethanechol

    • C. 

      Carbachol

    • D. 

      Donepezil

    • E. 

      Edrophonium

    • F. 

      Muscarine

    • G. 

      Neostigmine

    • H. 

      Parathion

    • I. 

      Pilocarpine

    • J. 

      Pralidoxime

    • K. 

      Physostigmine

  • 2. 
    This drug can inhibit cholinesterases in the periphery but not in the CNS
    • A. 

      Acetylcholine

    • B. 

      Bethanechol

    • C. 

      Carbachol

    • D. 

      Donepezil

    • E. 

      Edrophonium

    • F. 

      Muscarine

    • G. 

      Neostigmine

    • H. 

      Parathion

    • I. 

      Pilocarpine

    • J. 

      Pralidoxime

    • K. 

      Physostigmine

  • 3. 
    This drug can be absorbed effectively through the intact skin
    • A. 

      Acetylcholine

    • B. 

      Bethanechol

    • C. 

      Carbachol

    • D. 

      Donepezil

    • E. 

      Edrophonium

    • F. 

      Muscarine

    • G. 

      Neostigmine

    • H. 

      Parathion

    • I. 

      Pilocarpine

    • J. 

      Pralidoxime

    • K. 

      Physostigmine

  • 4. 
    This drug is able to regenerate cholinesterases blocked by organophosphates
    • A. 

      Acetylcholine

    • B. 

      Bethanechol

    • C. 

      Carbachol

    • D. 

      Donepezil

    • E. 

      Edrophonium

    • F. 

      Muscarine

    • G. 

      Neostigmine

    • H. 

      Parathion

    • I. 

      Pilocarpine

    • J. 

      Pralidoxime

    • K. 

      Physostigmine

  • 5. 
    This drug can inhibit cholinesterases and activate directly Mm receptors
    • A. 

      Acetylcholine

    • B. 

      Bethanechol

    • C. 

      Carbachol

    • D. 

      Donepezil

    • E. 

      Edrophonium

    • F. 

      Muscarine

    • G. 

      Neostigmine

    • H. 

      Parathion

    • I. 

      Pilocarpine

    • J. 

      Pralidoxime

    • K. 

      Physostigmine

  • 6. 
    Which of the following statements correctly pairs the effect of acetylcholine with the activation of the appropriate cholinergic receptor?
    • A. 

      Contraction of the ciliary muscle - M1

    • B. 

      Decreased A-V conduction - Nm

    • C. 

      Peripheral vasodilation - Nn

    • D. 

      Bronchoconstriction - M1

    • E. 

      Increased firing from ganglionic neurons - Nn

  • 7. 
    Which of the following statements correctly pairs the acetylcholine effect with the postreceptor mechanism that mediates the effect?
    • A. 

      Decreased rhythmicity of SA node - opening of ligand-gated Na+ channels

    • B. 

      Increased intestinal peristalsis - release of NO

    • C. 

      Decreased force of myocardial contraction -increased cAMP

    • D. 

      Bronchoconstriction - increased IP3 and DAG

    • E. 

      Miosis - decrease in IP3 and DAG

  • 8. 
    Which of the following cholinergic drugs given IV can cause signs of cholinergic activation in the CNS?
    • A. 

      Acetylcholine

    • B. 

      Carbachol

    • C. 

      Bethanechol

    • D. 

      Neostigmine

    • E. 

      Physostigmine

  • 9. 
    Which of the following is the most likely effect of muscarinic agonists upon the gastrointestinal system?
    • A. 

      Decreased pepsinogen secretion

    • B. 

      Increased tone of pylorus sphincter

    • C. 

      Relaxation of the external anal sphincter

    • D. 

      Contraction of the lower esophageal sphincter

    • E. 

      Decreased intestinal peristalsis

  • 10. 
    Which of the following effects of neostigmine is due only to the indirect activation of nicotinic receptors?
    • A. 

      Miosis

    • B. 

      Cyclospasm

    • C. 

      Increased epinephrine release from adrenal glands

    • D. 

      Increased secretion of sweat glands

    • E. 

      Bronchoconstriction

    • F. 

      Bradycardia

  • 11. 
    The following table shows the effects of some autonomic drugs on the eye when they are administered locally in the conjunctival sac. Examine the table and identify which one of the drugs A, B, C, D, E, is most likely to be physostigmine. (+ = increased ; - = decreased ; 0 = negligible effect)
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 12. 
    Which of the following is a potential adverse effect of muscarinic agonists?
    • A. 

      Urinary retention

    • B. 

      Xerostomia

    • C. 

      Cough

    • D. 

      Constipation

    • E. 

      Difficulty in near vision

  • 13. 
    Physostigmine can most effectively counteract which of the following drug-induced effects?
    • A. 

      Atropine-induced hallucinations

    • B. 

      Epinephrine-induced increase in blood pressure

    • C. 

      Prazosin-induced decrease in blood pressure

    • D. 

      Neostigmine-induced fasciculations

    • E. 

      Nicotine-induced tachycardia

  • 14. 
    In the figure below, curve C depicts the log dose-response curve for carbachol on contraction of nonvascular smooth muscle. Which of the curves best depicts the log dose-response curve for acetylcholine in the presence of a fixed and large dose of bethanechol?
    • A. 

      Curve A

    • B. 

      Curve B

    • C. 

      Curve C

    • D. 

      Curve D

    • E. 

      Curve E

  • 15. 
    A 65-year-old male suffering from open angle glaucoma has been receiving timolol over the last three months but the control of intraocular pressure has proven inadequate. The ophthalmologist decides to add a second drug and prescribed carbachol. Which of the following pairs of receptors most likely mediates the therapeutic efficacy of the drug in this patient?
    • A. 

      Nm and M2

    • B. 

      Nn and M3

    • C. 

      M3 and beta-2

    • D. 

      Nm and beta-2

    • E. 

      Nn and M2

    • F. 

      Nm and M3

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