Cholinergic Pharmacology
(176).jpg "Cholinergic Pharmacology - Quiz")
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- 1.What of the following is true about the Nicotinic Cholinergic Receptors in the Periphery
- A.
Found on postganlionic neurons of the parasympathetic nervous system
- B.
Ligand gated ion channels
- C.
Also found at neuromuscular junctions of the somatic nervous system
- D.
Gate for Na+
- E.
All are true
- 2.Which of the following are true about Muscarinic Cholinergic Receptors in the Periphery
- A.
M1,3,5 are mainly stimulatory, couple to Gq
- B.
M2,4 are mainly inhibitory, couple to Gi
- C.
GPCRs found at sympathetic and parasympathetic sites
- D.
All are true
- 3.Autonomic nerve fibers plays a role in regulating
- A.
Blood pressure and flow
- B.
Metabolism
- C.
Blood glucose levels
- D.
Micturition and defecation
- E.
Pupillary light and accommodation reflexes
- F.
Glandular secretions
- G.
Bronchial dilation
- H.
Body temperature
- I.
Gastrointestinal movements and secretions
- 4.What are the actions of atropine. What is it used for?
- A.
Compete with ACh for a common binding site on muscarinic receptors
- B.
Inhibit with ACh for a common binding site on muscarinic receptors
- C.
Compete with NE for a common binding site on muscarinic receptors
- D.
Inhibit with NE for a common binding site on muscarinic receptors
- 5.What are the effects of ACh on cardiovascular function?
- A.
A. Direct is by parasympathetic fiber activation; decreases cardiac output
- B.
B. Indirect is by inhibition of NE secretion
- C.
C. Indirect is by inhibition of ACh secretion
- D.
A and b
- E.
A and c
- 6.What are the effects of ACh on heart function?
- A.
Decrease in cardiac force of contraction
- B.
Decreased heart rate
- C.
Vasodilation
- D.
Decreased conduction rate in SA and AV nodes
- E.
Vasoconstriction
- F.
Increased heart rate
- 7.Muscarinic receptors are responsible for __________ are located on _____________
- 8.What are the nonselective ACh agonists
- A.
Carbechol
- B.
Arecoline
- C.
Pilocarpine
- D.
Muscarine
- E.
Bethanechol
- F.
Methacholine
- 9.What are the muscarinic selective ACh agonists
- A.
Carbechol
- B.
Arecoline
- C.
Pilocarpine
- D.
Muscarine
- E.
Bethanechol
- F.
Methacholine
- 10.Muscarinic receptor antagonists block muscarinic receptors on
- A.
Smooth muscle
- B.
Vascular muscle
- C.
Cardiac muscle
- D.
Gland cell
- E.
Peripheral ganglia
- F.
CNS
- 11.Muscarinic receptor antagonists
- A.
Increase tone and motility of GI
- B.
Decrease tone and motility of GI
- C.
Actions are comparable to homotropine
- D.
Actions are not comparable to atropine
- 12.Which of the sympathetic muscarinic receptor antagonists do not cross the BBB
- A.
Tiotropium
- B.
Homatropine
- C.
Ipratropium
- D.
Tropicamide
- E.
Methylatropine
- 13.Physiological Effects of Muscarinic Antagonists on the CNS
- A.
Cause euphoria; can also cause hallucination, delirium
- B.
Cause CNS depression (drowsiness, fatigue, amnesia, dreamless sleep, etc..)
- C.
Used in Parkinson’s disease as adjuncts to levodopa; also used to treat tardive dyskinesia
- D.
Cause mild vagus nerve inhibition by inhibiting medulla and higher brain centers
- E.
Cause mild vagus nerve excitation by stimulating medulla and higher brain centers
- 14.Cholinergic autonomic neurotransmission is mainly regulated by activation of ______________
- 15.Physiological Effects of Muscarinic Antagonists on the respiratory system inhibit _________ and _____________
- 16.Ingestion of __________ is a major cause of poisoning
- 17.Many drugs are ‘dirty’, and bind muscarinic receptors to produce unwanted effects:
- A.
Phenothiazines
- B.
Histamine H1 antagonists
- C.
Tricyclic antidepressants
- D.
Beta blockers
- E.
Newer antipsychotic drugs
- F.
Calcium channel blockers
- 18.Acetylcholinesterase
- Degrades ACh by ___________ , producing a choline and an acetate group
- Active site composed of an _____ site and esteratic site that bind to ACh
-
Have very high catalytic activity
- Degrade ___molecules of ACh/second/single AChE
- 19.What is true about reversible AChE inhibitors
- A.
Some have high affinity for the anionic site of AChE (edrophonium is prototype)
- B.
Acid transforming inhibitors bind to AChE and form an intermediate acid-enzyme compound
- C.
Carbamated AChE cannot hydrolyze ACh
- D.
Bind AChE at the esteratic site
- E.
Form a stable but inactive compound
- 20.What is true about irreversible AChE inhibitors
- A.
Some have high affinity for the anionic site of AChE (edrophonium is prototype)
- B.
Acid transforming inhibitors bind to AChE and form an intermediate acid-enzyme compound
- C.
Carbamated AChE cannot hydrolyze ACh
- D.
Bind AChE at the esteratic site
- E.
Form a stable but inactive compound
- 21.Reversible AChE Inhibitors
- A.
Carbamates and acridines
- B.
Nerve gases (sarin, tabun, soman
- C.
Tacrine
- D.
Carbaryl
- E.
Phystostigmine
- 22.Irreversible AChE Inhibitors
- A.
Carbamates and acridines
- B.
Nerve gases (sarin, tabun, soman
- C.
Tacrine
- D.
Carbaryl
- E.
Phystostigmine
- 23.ACh inhibitor that
- Synthetic, binds to anionic site
- Does not cross BBB
- Also has actions at nicotinic receptors in neuromuscular junctions
- A.
Edrophonium
- B.
Physostigmine
- C.
Neostigmine
- D.
Diazinon
- 24.ACh inhibitor that
- Binds anionic site
- Alkaloid made from the calabar bean
- A.
Edrophonium
- B.
Physostigmine
- C.
Neostigmine
- D.
Diazinon
- 25.ACh inhibitor that
- Binds to anionic site and blocks ACh binding
- Reversible inhibitor
- A.
Edrophonium
- B.
Physostigmine
- C.
Neostigmine
- D.
Diazinon
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