Cholinergic Pharmacology

39 Questions | Total Attempts: 3565

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Cholinergic Pharmacology - Quiz

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Questions and Answers
  • 1. 
    What of the following is true about the Nicotinic Cholinergic Receptors in the Periphery
    • A. 

      Found on postganlionic neurons of the parasympathetic nervous system

    • B. 

      Ligand gated ion channels

    • C. 

      Also found at neuromuscular junctions of the somatic nervous system

    • D. 

      Gate for Na+

    • E. 

      All are true

  • 2. 
    Which of the following are true about Muscarinic Cholinergic Receptors in the Periphery
    • A. 

      M1,3,5 are mainly stimulatory, couple to Gq

    • B. 

      M2,4 are mainly inhibitory, couple to Gi

    • C. 

      GPCRs found at sympathetic and parasympathetic sites

    • D. 

      All are true

  • 3. 
    Autonomic nerve fibers plays a role in regulating
    • A. 

      Blood pressure and flow

    • B. 

      Metabolism

    • C. 

      Blood glucose levels

    • D. 

      Micturition and defecation

    • E. 

      Pupillary light and accommodation reflexes

    • F. 

      Glandular secretions

    • G. 

      Bronchial dilation

    • H. 

      Body temperature

    • I. 

      Gastrointestinal movements and secretions

  • 4. 
    What are the actions of atropine. What is it used for?
    • A. 

      Compete with ACh for a common binding site on muscarinic receptors

    • B. 

      Inhibit with ACh for a common binding site on muscarinic receptors

    • C. 

      Compete with NE for a common binding site on muscarinic receptors

    • D. 

      Inhibit with NE for a common binding site on muscarinic receptors

  • 5. 
    What are the effects of ACh on cardiovascular function?
    • A. 

      A. Direct is by parasympathetic fiber activation; decreases cardiac output

    • B. 

      B. Indirect is by inhibition of NE secretion

    • C. 

      C. Indirect is by inhibition of ACh secretion

    • D. 

      A and b

    • E. 

      A and c

  • 6. 
    What are the effects of ACh on heart function?
    • A. 

      Decrease in cardiac force of contraction

    • B. 

      Decreased heart rate

    • C. 

      Vasodilation

    • D. 

      Decreased conduction rate in SA and AV nodes

    • E. 

      Vasoconstriction

    • F. 

      Increased heart rate

  • 7. 
    Muscarinic receptors are responsible for __________ are located on _____________
  • 8. 
    What are the nonselective ACh agonists
    • A. 

      Carbechol

    • B. 

      Arecoline

    • C. 

      Pilocarpine

    • D. 

      Muscarine

    • E. 

      Bethanechol

    • F. 

      Methacholine

  • 9. 
    What are the muscarinic selective ACh agonists
    • A. 

      Carbechol

    • B. 

      Arecoline

    • C. 

      Pilocarpine

    • D. 

      Muscarine

    • E. 

      Bethanechol

    • F. 

      Methacholine

  • 10. 
    Muscarinic receptor antagonists block muscarinic receptors on
    • A. 

      Smooth muscle

    • B. 

      Vascular muscle

    • C. 

      Cardiac muscle

    • D. 

      Gland cell

    • E. 

      Peripheral ganglia

    • F. 

      CNS

  • 11. 
    Muscarinic receptor antagonists
    • A. 

      Increase tone and motility of GI

    • B. 

      Decrease tone and motility of GI

    • C. 

      Actions are comparable to homotropine

    • D. 

      Actions are not comparable to atropine

  • 12. 
    Which of the sympathetic muscarinic receptor antagonists do not cross the BBB
    • A. 

      Tiotropium

    • B. 

      Homatropine

    • C. 

      Ipratropium

    • D. 

      Tropicamide

    • E. 

      Methylatropine

  • 13. 
    Physiological Effects of Muscarinic Antagonists on the CNS
    • A. 

      Cause euphoria; can also cause hallucination, delirium

    • B. 

      Cause CNS depression (drowsiness, fatigue, amnesia, dreamless sleep, etc..)

    • C. 

      Used in Parkinson’s disease as adjuncts to levodopa; also used to treat tardive dyskinesia

    • D. 

      Cause mild vagus nerve inhibition by inhibiting medulla and higher brain centers

    • E. 

      Cause mild vagus nerve excitation by stimulating medulla and higher brain centers

  • 14. 
    Cholinergic autonomic neurotransmission is mainly regulated by activation of ______________
  • 15. 
    Physiological Effects of Muscarinic Antagonists on the respiratory system  inhibit _________ and _____________
  • 16. 
    Ingestion of __________ is a major cause of poisoning
  • 17. 
    Many drugs are ‘dirty’, and bind muscarinic receptors to produce unwanted effects:
    • A. 

      Phenothiazines

    • B. 

      Histamine H1 antagonists

    • C. 

      Tricyclic antidepressants

    • D. 

      Beta blockers

    • E. 

      Newer antipsychotic drugs

    • F. 

      Calcium channel blockers

  • 18. 
    Acetylcholinesterase
    • Degrades ACh by ___________ , producing a choline and an acetate group
    • Active site composed of an _____ site and esteratic site that bind to ACh
    • Have very high catalytic activity
      • Degrade ___molecules of ACh/second/single AChE
  • 19. 
    What is true about reversible AChE inhibitors
    • A. 

      Some have high affinity for the anionic site of AChE (edrophonium is prototype)

    • B. 

      Acid transforming inhibitors bind to AChE and form an intermediate acid-enzyme compound

    • C. 

      Carbamated AChE cannot hydrolyze ACh

    • D. 

      Bind AChE at the esteratic site

    • E. 

      Form a stable but inactive compound

  • 20. 
    What is true about irreversible AChE inhibitors
    • A. 

      Some have high affinity for the anionic site of AChE (edrophonium is prototype)

    • B. 

      Acid transforming inhibitors bind to AChE and form an intermediate acid-enzyme compound

    • C. 

      Carbamated AChE cannot hydrolyze ACh

    • D. 

      Bind AChE at the esteratic site

    • E. 

      Form a stable but inactive compound

  • 21. 
    Reversible AChE Inhibitors
    • A. 

      Carbamates and acridines

    • B. 

      Nerve gases (sarin, tabun, soman

    • C. 

      Tacrine

    • D. 

      Carbaryl

    • E. 

      Phystostigmine

  • 22. 
    Irreversible AChE Inhibitors
    • A. 

      Carbamates and acridines

    • B. 

      Nerve gases (sarin, tabun, soman

    • C. 

      Tacrine

    • D. 

      Carbaryl

    • E. 

      Phystostigmine

  • 23. 
    ACh inhibitor that
    • Synthetic, binds to anionic site
    • Does not cross BBB
    • Also has actions at nicotinic receptors in neuromuscular junctions
    • A. 

      Edrophonium

    • B. 

      Physostigmine

    • C. 

      Neostigmine

    • D. 

      Diazinon

  • 24. 
    ACh inhibitor that
    • Binds anionic site
    • Alkaloid made from the calabar bean
    • A. 

      Edrophonium

    • B. 

      Physostigmine

    • C. 

      Neostigmine

    • D. 

      Diazinon

  • 25. 
    ACh inhibitor that
    • Binds to anionic site and blocks ACh binding
    • Reversible inhibitor
    • A. 

      Edrophonium

    • B. 

      Physostigmine

    • C. 

      Neostigmine

    • D. 

      Diazinon