Block 9 Pharm Adrenergic W Exp Prt 2

15 Questions | Total Attempts: 368

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Block 9 Pharm Adrenergic W Exp Prt 2

Questions and Answers
  • 1. 
    Which of the following statements correctly pairs the adrenergic agonist with its appropriate therapeutic use?
    • A. 

      Ephedrine - insomnia

    • B. 

      Dopamine - oliguria due to insufficient renal blood flow

    • C. 

      Dobutamine - anaphylactic shock

    • D. 

      Norepinephrine - neurogenic migraine

    • E. 

      Albuterol -intrauterine fetal death

    • F. 

      Salmeterol - exertional angina

  • 2. 
    A 12-year-old boy was stung by a wasp while walking in the woods. Few minutes later he developed pruritus and erythema, a generalized feeling of warm and impending doom, dyspnea, wheezing and dizziness. Increasing swelling of the face, eyes, lips and tongue was prominent. Paramedics were called and they administered a SC drug upon arrival. Which of the following drugs was most likely given?
    • A. 

      Norepinephrine

    • B. 

      Isoproterenol

    • C. 

      Epinephrine

    • D. 

      Ephedrine

    • E. 

      Phenylephrine

  • 3. 
    A 58-year-old man underwent surgery for the removal of a necrotic bowel tissue. Five days later he become confused and disoriented. Physical finding included fever of 103 F, blood pressure of 90/50 mm Hg, pulse 130 bpm, respiratory rate 30 breath/min. Pertinent lab values were Paco2 30 mm Hg (normal 33-45), HCO 3- 18 mEq/L (normal 22-28), serum pH 7.31, WBC count 22,000 cells/mm3. Arterial and pulmonary artery catheters were inserted, revealing a cardiac output of 6 L/min and a systemic vascular resistance of 610 dyneCsecCcm-5 (normal 800-1400). A fluid therapy was initiated but one hour later the mean blood pressure was still 60 mm Hg. An IV infusion of a drug was started . Which of the following drugs was most likely administered?
    • A. 

      Isoproterenol

    • B. 

      Epinephrine

    • C. 

      Norepinephrine

    • D. 

      Albuterol

    • E. 

      Clonidine

  • 4. 
    A 56-year-old woman suffering from idiopathic orthostatic hypotension is brought unconscious to the emergency department. She regains consciousness after a supportive treatment and an IV administration of phenylephrine. Which of the following actions most likely account for the therapeutic effectiveness of the drug in the present case?
    • A. 

      Dilation of cerebral vessels

    • B. 

      Increased heart rate

    • C. 

      Increased cardiac output

    • D. 

      Increased systemic blood pressure

    • E. 

      Increased levels of angiotensin II

  • 5. 
    A new autonomic drug that does not enter the brain was given IV to healthy volunteers. The cardiovascular effects are tabulated below: The effects of the new drug are most similar to those of which of the following agents?
    • A. 

      Dobutamine

    • B. 

      Epinephrine

    • C. 

      Isoproterenol

    • D. 

      Norepinephrine

    • E. 

      Phenylephrine

  • 6. 
    A 28-year-old woman was experiencing preterm labor in the 30th week of a twin gestation. Five hours after receiving tocolytic therapy to suppress preterm labor, progressive dyspnea associated with severe hypoxemia developed. A diagnosis of pulmonary edema was made and the woman was given intubation, oxygen and ventilatory support. A drug from which of the following classes did most likely contribute to the development of the patient’s syndrome?
    • A. 

      Beta-2 antagonists

    • B. 

      Beta-2 agonists

    • C. 

      Prostaglandins

    • D. 

      Alpha-1 agonists

    • E. 

      Alpha-1 antagonists

  • 7. 
    A 52-year-old woman, recently diagnosed with severe bronchial asthma, complained to her physician of tremors, muscle cramping, palpitations and anxiety. She had started an appropriate therapy two weeks previously. Which of the following drugs most likely caused the patient’s symptoms?
    • A. 

      Isoproterenol

    • B. 

      Salmeterol

    • C. 

      Propranolol

    • D. 

      Dobutamine

    • E. 

      Prazosin

  • 8. 
    A 6 year-old girl presented to the family physician in company of her mother, who was distraught over the teacher’s comment that the child was “unmanageable” at school. The teacher had referred that the girl was unable to remain seated for the duration of a structured activity and to listen when spoken to directly. She also often fidgeted with hands and feet, squirmed and talked excessively. Similar symptoms were noted during the doctor’s visit. Which of the following drugs would be appropriate to treat this condition?
    • A. 

      Phenylephrine

    • B. 

      Epinephrine

    • C. 

      Albuterol

    • D. 

      Dextroamphetamine

    • E. 

      Norepinephrine

  • 9. 
    A 44-year-old man presented to his local doctor complaining of an impaired voluntary raising of the eyelid. Physical examination showed miosis, ptosis, flushed facial skin and loss of sweating over the left side of the body. The physician instilled into the conjunctival sac of each eye one drop of cocaine, then (after washing) one drop of phenylephrine. The size of the pupils before and after the two treatments are shown in the table below. From the above data the physician concluded that there was a localized lesion in which of the following anatomical structures?
    • A. 

      Postganglionic sympathetic nerves innervating the face

    • B. 

      Preganglionic sympathetic nerves innervating the face

    • C. 

      Postganglionic parasympathetic nerves innervating the face

    • D. 

      Preganglionic parasympathetic nerves innervating the face

    • E. 

      Medulla oblongata

  • 10. 
    A 33-year-old man was brought to the emergency room after a car accident. Upon admission the patient was lucid but completely paralyzed with loss of all sensation and reflex activity below the thorax. Vital signs were: blood pressure 80/40 mm Hg, heart rate 42 bpm, respiration 36 breaths/min. A preliminary diagnosis of spinal shock, due to spinal cord injury, was made and an IV infusion of a drug was started . Which of the following drugs was most likely administered?
    • A. 

      Isoproterenol

    • B. 

      Clonidine

    • C. 

      Norepinephrine

    • D. 

      Albuterol

    • E. 

      Ephedrine

  • 11. 
    A 65-year-old man is undergoing a prostate biopsy because of a suspected prostate cancer. Before the operation the prostate is infiltrated with a solution of lidocaine plus epinephrine in order to provide local anesthesia. Which of the following statements best explains why epinephrine prolongs the effect of lidocaine in this patient?
    • A. 

      It inhibits microsomal enzymes which metabolize lidocaine

    • B. 

      It blocks Ca++ channels in prostate nerves

    • C. 

      It constricts prostate vessels

    • D. 

      It blocks Na+ channels in prostate nerves

    • E. 

      It relaxes prostate capsule

  • 12. 
    A 15-year-old girl was treated topically with eye drops during a routine ophthalmoscopic examination. After fifteen minutes the ophthalmologist registered a moderate increase in pupillary diameter, with negligible changes in lens curvature and intraocular pressure. Which of the following drugs was most likely administered to the patient?
    • A. 

      Phenylephrine

    • B. 

      Timolol

    • C. 

      Acetylcholine

    • D. 

      Apraclonidine

    • E. 

      Epinephrine

  • 13. 
    A 22-year-old man complained to his physician that his nasal stuffiness was getting worse. The man started two days ago an over-the-counter topical preparation containing phenylephrine because of an annoying common cold. Initially the preparation was effective but later the patient noticed that when the drug effect subsided, nasal stuffiness was worse than it originally had been. Which of the following statements best explains this averse drug effect?
    • A. 

      Poor patient compliance

    • B. 

      Insufficient dosing

    • C. 

      Drug induced increased blood pressure

    • D. 

      Drug induced reflex bradycardia

    • E. 

      Drug induced allergic reaction

    • F. 

      Rebound congestion

  • 14. 
    A new autonomic drug that does not enter the brain was given IV to healthy volunteers in a phase 1 clinical trial. The cardiovascular effects are tabulated below. Which of the following drugs does the new agent most resemble?
    • A. 

      Dobutamine

    • B. 

      Albuterol

    • C. 

      Isoproterenol

    • D. 

      Norepinephrine

    • E. 

      Phenylephrine

  • 15. 
    A 52-year-old man suffering from renovascular hypertension was admitted to the hospital because of 24 hours anuria. Pertinent plasma levels on admission were K+ 7.9 mEq/L, Ca++ 3 mEq/L, creatinine 7 mg/dL, BUN 52 mg/dL. An appropriate therapy was initiated which included albuterol IV. Which of the following statements best explains why this drug was given to the patient?
    • A. 

      To counteract the high creatinine values

    • B. 

      To counteract the hyperkalemia

    • C. 

      To counteract the hypocalcemia

    • D. 

      To increase kidney blood flow

    • E. 

      To activate diuresis

    • F. 

      To improve micturition

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