This quiz, titled 'BLOCK 7 MICHIGAN GENETIC - Pt 2', assesses knowledge on genetic diseases like sickle cell anemia, cystic fibrosis, and type-1 diabetes. It covers genetic associations, recurrence risks, and evidence supporting genetic links, essential for medical students and professionals.
Association of ankylosing spondylitis with the B27 allele of the HLA-B locus.
Linkage of ankylosing spondylitis to the HLA-B locus.
Neither.
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Pancreatic B-cell autoantibodies are frequently present
Approximately 10% of affected individuals have an affected sibling.
Onset of disease is usually in childhood
The concordance rate in monozygotic twins is approximately 30%.
The concordance rate in monozygotic twins is five times that in dizygotic twins.
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An autosomal dominant disease.
Always caused by the same point mutation in the beta-globin gene.
Rarely due to the same mutation in unrelated individuals.
Caused by mutations in either the alpha-globin gene or the beta-globin gene
An X-linked recessive disease
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Mitotic crossover
Loss of the normal chromosome 13
Independent second mutation
Loss of the normal chromosome 13 and reduplication of the mutant chromosome 13
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The maternal copy of the gene(s) responsible for Angelman syndrome (AS) is imprinted and is not expressed.
PWS results from an anomaly of X-chromosome inactivation
The paternal copy of the gene(s) responsible for PWS is imprinted and is not expressed.
The maternal copy of the gene(s) responsible for PWS is imprinted and is not expressed
The maternal copy of the gene(s) responsible for PWS exerts a dominant negative effect of the paternal allele
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