Organ Pathology - Handout 1 - Genetics And Teratogens
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- 1.Which of the following diseases has an autosomal dominant inheritance pattern?
- A.
Cystic Fibrosis
- B.
PKU
- C.
Huntington's Disease
- D.
Sickle Cell Anemia
- 2.G6P Dehydrogenase deficiency is a disease with a(n) ____________ inheritance pattern
- A.
X-Linked Dominant
- B.
Y-Linked
- C.
Chromosome 12 Recessive
- D.
X-Linked Recessive
- 3.Translation occurs when DNA becomes mRNA, transcription occurs when mRNA becomes a protein
- A.
True
- B.
False
- 4.Which of the following are true regarding Down Syndrome (select 2)
- A.
It is a trisomy of the 21st chromosome
- B.
It is a trisomy of the 18th chromosome
- C.
A hallmark symptom is a big, wrinkled tongue
- D.
An exclusive trait is mental retardation
- E.
A Down syndrome patient only has 1 X chromosome
- 5.Which of the following is true regarding albinism?
- A.
Its disease originates on chromosome 15
- B.
It is caused by a deficiency of N-acetyalhexoaminidase
- C.
The patient is unable to convert tyrosine to DOPA
- D.
An albino must have a low protein diet to prevent mental retardation
- 6.Your friend smells like your lab mice and he tells you he can't eat beans, meat, and most dairy. You conclude he has
- A.
Albinism
- B.
A disease with the inability to digest phenylalanine
- C.
Too much phenylalanine hydroxylase
- D.
A disease originating on chromosome 7
- 7.Your female patient has Leber's disease. Which of the following family members would also have the disease? (Select 3)
- A.
The patients mother
- B.
The patient's father
- C.
The patient's grandfather
- D.
The patient's daughter
- E.
The patient's brother
- 8.In which scenario is a teratogenic effect going to be most dramatic?
- A.
During migration
- B.
During cell death
- C.
During rapid cell differentiation
- D.
After birth
- 9.Which of the following is true regarding fetal alcohol syndrome (Select 2)
- A.
Alcohol is absorbed by the baby's bloodstream and impairs development by switching DNA base pairs
- B.
The high metabolic demand of alcohol decreases the oxygen available to the fetus
- C.
It requires large doses of alcohol to occur
- D.
A distinguishing feature is a newborn with an indistinct philtrum
- 10.Which of the following are true regarding smoking during pregnancy? (Select 2)
- A.
Smoking causes constriction of blood vessels and reduced blood flow (and nutrients) to the uterus
- B.
Smoking causes vasodilation and nutrient transfer to the fetus is normal, however oxygen is low
- C.
Smoking raises the concentration of carbon monoxide in mother and fetus bloodstream
- D.
Nicotine does not cross the placental barrier
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