Neurodegen Dz Myopathy MCQ's

10 Questions | By Chachelly | Last updated: Mar 20, 2022 | Total Attempts: 553

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Peripheral neuropathy is a relatively common neurological disorder that can occur as the result of a wide range of underlying conditions or diseases. Treatment of peripheral neuropathy depends on whether an underlying condition can be identified. Take this quiz on demyelination diseases and get to learn more. All the best!

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1.

You are examining a large brain. The patient’s clinical diagnosis is psychomotor regression, probably lipid storage disease. Which is the most appropriate stain to confirm the diagnosis?
- A.
  
  PAS stain
- B.
  
  Congo red
- C.
  
  GFAP stain
- D.
  
  Oil red O
- E.
  
  H & E stain
2.

Which of the following morphologic changes are characteristic for Alzheimer disease?
- A.
  
  Lewy bodies, neurofibrillary tangles, and neuritic plaques
- B.
  
  Neurofibrillary tangles, neuritic plaques, and watershed liquefactive necrosis
- C.
  
  Cortical atrophy, neurofibrillary tangles, and neuritic plaques
- D.
  
  Amyloid angiopathy, loss of neurons in the caudate nucleus and hippocampus, and senile plaques
3.

Production of connective tissue and collagen accumulation are characteristically associated with:
- A.
  
  Creutzfeldt-Jacob disease
- B.
  
  Chronic brain abscess
- C.
  
  Multiple sclerosis
- D.
  
  Alzheimer disease
4.

Patients in the moderate stage of Alzheimer’s disease exhibit atrophy of which of the following structures?
- A.
  
  Thalamus
- B.
  
  Hypothalamus
- C.
  
  Hippocampus
- D.
  
  Substantia nigra
- E.
  
  Raphe
5.

Tau proteins are associated with
- A.
  
  Normal aging
- B.
  
  Parkinson’s dz
- C.
  
  Lewy Bodies
- D.
  
  Transient Ischemic Attacks
- E.
  
  Alzheimer’s dementia
6.

A 69-year-old well educated African American woman is brought to the physician by her daughter, who has become concerned about her mother’s behavior. The mother volunteers at the local library shelving books, but for the past few months she has had trouble remembering where the books go. In addition, she often forgets to turn the stove after cooking her family’s long-time favorite dishes. Which of the following brain structures are most likely affected by the disease process in this patient?
- A.
  
  Temporal, frontal and parietal cortex, and hippocampus
- B.
  
  Brainstem, amygdala, substantia nigra, thalamus, and cerebral cortex
- C.
  
  Caudate nucleus, putamen, globus pallidus, and frontal cortex
- D.
  
  Periventricular grey matter, medial thalamus, cerebellar vermis and cortex
7.

A 69-year-old African American female is brought to her family physician because of rapidly progressive loss of cognitive function, involuntary jerky movements, and excessive somnolence. Physical examination reveals dementia; no other neurologic signs are noted. Laboratory and instrumental evaluation reveals normal CNS findings, and burst of high-voltage slow-wave activity on EEG. Histopathologic changes of the brain characteristic for the presented disease are shown in the image below. Which of the following is the most likely diagnosis?
- A.
  
  Creutzfeld-Jacobs disease
- B.
  
  Alzheimer disease
- C.
  
  Parkinson disease
- D.
  
  Huntington disease
8.

Combination of Parkinsonism and profound dementia is characteristically found in
- A.
  
  Parkinson disease
- B.
  
  Alzheimer disease
- C.
  
  Diffuse Lewy body disease
- D.
  
  Spinocerebellar ataxia
9.

You visit an island in the pacific with a small population to do field work. You notice that a significant number of young children and adolescents in the population exhibit a lordotic posture when walking, score poorly on IQ tests, and have scoliosis of the spine. Many of these children have problems walking and the older children are often in wheelchairs. You suspect?
- A.
  
  Duchenne muscular dystrophy
- B.
  
  Multiple sclerosis
- C.
  
  Limb girdle muscular dystrophy
- D.
  
  Becker muscular dystrophy
- E.
  
  Friedrich’s ataxia
10.

A patient who has been treated for Parkinson’s disease for about a year presents with purplish, mottled changes to her skin. Which of the following drugs is the most likely cause?
- A.
  
  Amantadine
- B.
  
  Bromocriptine
- C.
  
  Levodopa (alone)
- D.
  
  Levodopa + Carbidopa
- E.
  
  Pramipexole