Neurodegen Dz Myopathy MCQ's

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  • 1/10 Questions

    A 69-year-old well educated African American woman is brought to the physician by her daughter, who has become concerned about her mother’s behavior. The mother volunteers at the local library shelving books, but for the past few months she has had trouble remembering where the books go.  In addition, she often forgets to turn the stove after cooking her family’s long-time favorite dishes. Which of the following brain structures are most likely affected by the disease process in this patient?

    • Temporal, frontal and parietal cortex, and hippocampus
    • Brainstem, amygdala, substantia nigra, thalamus, and cerebral cortex
    • Caudate nucleus, putamen, globus pallidus, and frontal cortex
    • Periventricular grey matter, medial thalamus, cerebellar vermis and cortex
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Neurodegen Dz Myopathy MCQ
About This Quiz

Peripheral neuropathy is a relatively common neurological disorder that can occur as the result of a wide range of underlying conditions or diseases. Treatment of peripheral neuropathy depends on whether an underlying condition can be identified. Take this quiz on demyelination diseases and get to learn more. All the best!

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  • 2. 

    Combination of Parkinsonism and profound dementia is characteristically found in

    • Parkinson disease

    • Alzheimer disease

    • Diffuse Lewy body disease

    • Spinocerebellar ataxia

    Correct Answer
    A. Diffuse Lewy body disease
    Explanation
    The combination of Parkinsonism and profound dementia is characteristically found in diffuse Lewy body disease. This neurodegenerative disorder is characterized by the presence of abnormal protein deposits called Lewy bodies in the brain. These Lewy bodies disrupt the normal functioning of brain cells, leading to symptoms such as tremors, muscle stiffness, cognitive decline, and visual hallucinations. Diffuse Lewy body disease shares some similarities with Parkinson's disease and Alzheimer's disease but is distinguished by the combination of Parkinsonism and profound dementia.

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  • 3. 

    Patients in the moderate stage of Alzheimer’s disease exhibit atrophy of which of the following structures?

    • Thalamus

    • Hypothalamus

    • Hippocampus

    • Substantia nigra

    • Raphe

    Correct Answer
    A. Hippocampus
    Explanation
    In the moderate stage of Alzheimer's disease, patients exhibit atrophy of the hippocampus. The hippocampus is a crucial structure in the brain involved in memory formation and consolidation. It plays a vital role in the formation of new memories and spatial navigation. As Alzheimer's disease progresses, the hippocampus is one of the first regions to be affected, leading to memory loss and cognitive decline. Therefore, the atrophy of the hippocampus is a characteristic feature of Alzheimer's disease in its moderate stage.

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  • 4. 

    Tau proteins are associated with

    • Normal aging

    • Parkinson’s dz

    • Lewy Bodies

    • Transient Ischemic Attacks

    • Alzheimer’s dementia

    Correct Answer
    A. Alzheimer’s dementia
    Explanation
    Tau proteins are associated with Alzheimer's dementia. Tau proteins are found in high concentrations in the brain and are involved in stabilizing microtubules, which are essential for maintaining the structure and function of neurons. In Alzheimer's disease, abnormal accumulation and aggregation of tau proteins occur, forming neurofibrillary tangles. These tangles disrupt the normal functioning of neurons and contribute to the development of cognitive decline and memory loss characteristic of Alzheimer's dementia. Tau pathology is a hallmark feature of Alzheimer's disease and is closely linked to the neurodegenerative process in this condition.

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  • 5. 

    Which of the following morphologic changes are characteristic for Alzheimer disease?

    • Lewy bodies, neurofibrillary tangles, and neuritic plaques

    • Neurofibrillary tangles, neuritic plaques, and watershed liquefactive necrosis

    • Cortical atrophy, neurofibrillary tangles, and neuritic plaques

    • Amyloid angiopathy, loss of neurons in the caudate nucleus and hippocampus, and senile plaques

    Correct Answer
    A. Cortical atrophy, neurofibrillary tangles, and neuritic plaques
    Explanation
    Cortical atrophy, neurofibrillary tangles, and neuritic plaques are characteristic morphologic changes seen in Alzheimer's disease. Cortical atrophy refers to the shrinking of the cerebral cortex, which is a hallmark feature of the disease. Neurofibrillary tangles are abnormal protein aggregates that form inside nerve cells, disrupting their normal function. Neuritic plaques, also known as senile plaques, are clumps of beta-amyloid protein that accumulate between nerve cells. These three changes are commonly observed in the brains of individuals with Alzheimer's disease and play a significant role in the pathogenesis of the condition.

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  • 6. 

    You visit an island in the pacific with a small population to do field work.  You notice that a significant number of young children and adolescents in the population exhibit a lordotic posture when walking, score poorly on IQ tests, and have scoliosis of the spine.  Many of these children have problems walking and the older children are often in wheelchairs. You suspect?

    • Duchenne muscular dystrophy

    • Multiple sclerosis

    • Limb girdle muscular dystrophy

    • Becker muscular dystrophy

    • Friedrich’s ataxia

    Correct Answer
    A. Duchenne muscular dystrophy
    Explanation
    Based on the symptoms described, such as lordotic posture, poor performance on IQ tests, scoliosis of the spine, difficulty walking, and the need for wheelchairs in older children, the most likely explanation is Duchenne muscular dystrophy. This is a genetic disorder that primarily affects boys and leads to progressive muscle weakness and degeneration. The symptoms mentioned align with the characteristic signs of Duchenne muscular dystrophy, making it the most probable explanation.

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  • 7. 

    Production of connective tissue and collagen accumulation are characteristically associated with:

    • Creutzfeldt-Jacob disease

    • Chronic brain abscess

    • Multiple sclerosis

    • Alzheimer disease

    Correct Answer
    A. Chronic brain abscess
    Explanation
    Chronic brain abscess is characterized by the production of connective tissue and collagen accumulation. This is due to the chronic inflammation and healing process that occurs in response to the abscess. Creutzfeldt-Jacob disease is a neurodegenerative disorder caused by abnormal proteins, not connective tissue production. Multiple sclerosis is characterized by the destruction of myelin, not connective tissue production. Alzheimer's disease is characterized by the accumulation of beta-amyloid plaques and tau tangles, not connective tissue production.

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  • 8. 
    A 69-year-old African American female is brought to her family physician because of rapidly progressive loss of cognitive function, involuntary jerky movements, and excessive somnolence. Physical examination reveals dementia; no other neurologic signs are noted. Laboratory and instrumental evaluation reveals normal CNS findings, and burst of high-voltage slow-wave activity on EEG. Histopathologic changes of the brain characteristic for the presented disease are shown in the image below. Which of the following is the most likely diagnosis? - ProProfs

    A 69-year-old African American female is brought to her family physician because of rapidly progressive loss of cognitive function, involuntary jerky movements, and excessive somnolence. Physical examination reveals dementia; no other neurologic signs are noted. Laboratory and instrumental evaluation reveals normal CNS findings, and burst of high-voltage slow-wave activity on EEG. Histopathologic changes of the brain characteristic for the presented disease are shown in the image below. Which of the following is the most likely diagnosis?

    • Creutzfeld-Jacobs disease

    • Alzheimer disease

    • Parkinson disease

    • Huntington disease

    Correct Answer
    A. Creutzfeld-Jacobs disease
    Explanation
    The histopathologic changes of the brain shown in the image are characteristic of Creutzfeld-Jacobs disease. This disease is a rare, degenerative, and fatal brain disorder that affects cognitive function and movement control. The symptoms described in the question, such as rapidly progressive loss of cognitive function, involuntary jerky movements, and excessive somnolence, are consistent with Creutzfeld-Jacobs disease. Additionally, the presence of burst of high-voltage slow-wave activity on EEG is a typical finding in this disease. Therefore, Creutzfeld-Jacobs disease is the most likely diagnosis in this case.

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  • 9. 

    You are examining a large brain. The patient’s clinical diagnosis is psychomotor regression, probably lipid storage disease. Which is the most appropriate stain to confirm the diagnosis?

    • PAS stain

    • Congo red

    • GFAP stain

    • Oil red O

    • H & E stain

    Correct Answer
    A. Oil red O
    Explanation
    Oil red O stain is the most appropriate stain to confirm the diagnosis of lipid storage disease in a large brain with a clinical diagnosis of psychomotor regression. Oil red O stain specifically stains lipids, allowing for the visualization of lipid droplets in cells. This stain is commonly used to identify lipid accumulation in various tissues, including the brain, and can help confirm the presence of lipid storage disease in this case.

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  • 10. 

    A patient who has been treated for Parkinson’s disease for about a year presents with purplish, mottled changes to her skin. Which of the following drugs is the most likely cause?

    • Amantadine

    • Bromocriptine

    • Levodopa (alone)

    • Levodopa + Carbidopa

    • Pramipexole

    Correct Answer
    A. Amantadine
    Explanation
    This cutaneous response, called livedo reticularis , is characteristically associated with amantadine. Recall that this seldom-used antiparkinson drug probably works by releasing endogenous dopamine and blocking its neuronal reuptake. Livedo reticularis is not associated with levodopa (used with or without carbidopa), nor with the dopamine agonists bromocriptine or pramipexole. You might also recall that amantadine is also used for prophylaxis of some strains of influenza virus infections.

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  • Mar 20, 2023
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  • Sep 06, 2012
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    Chachelly
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