Although it is not nearly as precedent today as it was in the late 1800s as a result of medicinal innovation, tuberculosis is a devastating disease that has led to an incredible amount of deaths in its peak. What do you know about the drugs used to aid the treatment of this condition, however? Let’s take a look.
Mycolic acids
Peptidoglycan
Arabinogalactan
Topoisomerase II
DNA-dependent RNA polymerase
Streptomycin
Ethambutol
Rifampin
Isoniazid
Pyrazinamide
Catalase-peroxidase
DNA-dependent RNA polymerase
Topoisomerase II
Acetyltransferase
Transpeptidase
Folic acid
Pyridoxine
Cyanocobalamin
Vitamic C
Folinic acid
DNA dependent RNA-polymerase
Arabinosyl transferase
Transpeptidase
Topoisomerase II
RNA-dependent DNA-polymerase
Loss of mycolic acid
Altered bacterial topoisomerase II
Altered bacterial RNA polymerase
Altered bacterial peptidyl-transferase
Increased bacterial acetylation of the drug
Rifampin
Pyrazinamide
Isoniazid
Streptomycin
Azithromycin
Amikacin
Piperacillin
Isoniazid
Nafcillin
Rifampin
To increase the dose of warfarin
To reduce the dose of isoniazid
To increase the dose of rifampin
To stop pyrazinamide
Isoniazid
Pyrazinamide
Rifampin
Ethambutol
Streptomycin
To enhance the antibacterial activity of pyrazinamide
To provide antibacterial activity against atypical mycobacteria
To prevent the neurotoxic effects of isoniazid
To prevent Pneumocystis carinii pneumonia
To delay the emergence of drug resistance
Ceftriaxone
Doxycycline
Metronidazole
Azithromycin
Vancomycin
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