Clinical Science Consultants # 2

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| By Levather Johnson

Levather Johnson

Community Contributor

Quizzes Created: 1 | Total Attempts: 35

| Attempts: 35

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1/20 Questions

In the Diel study “Evidence-based Comparison of Commercial Interferon-gamma Release Assays for Detecting Active Tuberculosis -- a Meta-Analysis,” select the appropriate value for the TSpot cut-off used to be considered for a positive result?
- 10 spots
- 3 spots
- > or equal to 6 spots
- Less than or equal to 5 spots

About This Quiz

This quiz, titled 'Clinical Science Consultants #2', assesses knowledge on the Diel study comparing commercial Interferon-gamma Release Assays for detecting active tuberculosis. It focuses on T-Spot and QFT test sensitivities, specificities, and their application in clinical settings.

2.

False-negative TST results can occur when children suffer from severe active TB or immune suppression.
- True
- False
Correct Answer

A. True

Explanation

In Long, “Interferon-Release Assay for the Diagnosis of Latent Mycobacterium tuberculosis Infection in Children Younger Than 5 Years: A Meta-Analysis,” False-negative TST results can occur when children suffer from severe active TB or immune suppression.

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3.

In the Diel study mentioned above, there were only ___ of the 679 obtained papers met the inclusion criteria for this meta-analysis.
- 124 publications
- 412 publications
- 214 publications
- 142 publications
Correct Answer

A. 124 publications

Explanation

In the Deil study, there were only 124 of the 679 obtained papers met the inclusion criteria for this meta-analysis.

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4.

Of the available LTBI blood tests, which test demonstrated a better performance trend in BCG-vaccinated children?
- TST
- QFT
- T-Spot
- None of the above.
Correct Answer

A. QFT

Explanation

Although not statistically significant, QFT demonstrated a better performance trend in BCG-vaccinated children. Note, TST is not a blood test.

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5.

It was suggested in the Diel study “Negative and Positive Predictive Value of a Whole-Blood Interferon-g Release Assay for Developing Active Tuberculosis’” that QFT is more reliable than the TST for identifying those who will soon progress to active TB, especially in children.
- True
- False
Correct Answer

A. True

Explanation

Results suggest that QFT is more reliable than the TST for identifying those who will soon progress to active TB, especially in children.

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6.

Which diagnostic assay has the least amount of subjectivity in diagnosing latent TB infection?
- QFT-TB Gold
- TST
- T-Spot
- None of the above.
Correct Answer

A. QFT-TB Gold

Explanation

QuantiFERON-TB Gold has proven to have less subjectivity in diagnosing LTBI.

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7.

According to Diel, which statement is correct?
- QFT has a higher sensitivity and higher specificity than T-Spot.
- QFT has a higher sensitivity and lower specificity than T-Spot.
- T-Spot has a higher sensitivity and higher specificity than QFT.
- T-Spot has a higher sensitivity and lower specificity than QFT.
Correct Answer

A. T-Spot has a higher sensitivity and lower specificity than QFT.

Explanation

T-Spot has a higher sensitivity and lower specificity than QFT.

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8.

In the Diel study “Negative and Positive Predictive Value of a Whole-Blood Interferon Gamma Release Assay for Developing Active Tuberculosis’”, none of the contacts who tested QFT negative developed active TB.
- True
- False
Correct Answer

A. True

Explanation

In the Diel study, none of the contacts who tested QFT negative developed active TB.

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9.

In the Howley study, “Evaluation of QuantiFERON-TB Gold In-Tube and Tuberculin Skin Tests among Immigrant Children being Screened for Latent Tuberculosis Infection,” which of the following was not one of the 3 countries in which the children were applying for immigration status from in this study.
- Philippines
- Africa
- Vietnam
- Mexico
Correct Answer

A. Africa

Explanation

In the Howley study, “Evaluation of QuantiFERON-TB Gold In-Tube and Tuberculin Skin Tests among Immigrant Children being Screened for Latent Tuberculosis Infection,” children from Mexico, Philippines and Vietnam were the 3 countries in which the children were applying for immigration status.
• Mexico
• Philippines
• Vietnam

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10.

In Long, “Interferon-Release Assay for the Diagnosis of Latent Mycobacterium tuberculosis Infection in Children Younger Than 5 Years: A Meta-Analysis,” showed that the sensitivity and specificity of ______ were slightly higher than ___ and can be used as supporting tools to detect LTBI in children younger than 5 years.
- T-Spot and TST
- TST and QFT-IT
- IGRAs and TST
- None of the above.
Correct Answer

A. IGRAs and TST

Explanation

In Long, “Interferon-Release Assay for the Diagnosis of Latent Mycobacterium tuberculosis Infection in Children Younger Than 5 Years: A Meta-Analysis,” showed that the sensitivity and specificity of IGRAs were slightly higher than TST and can be used as supporting tools to detect LTBI in children younger than 5 years.

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11.

More positives and fewer in-determinants results were noted by which assay in the Cheallaigh “Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection in HIV Infected Individuals in a Low TB Burden Country" study?
- QFT-TB
- T-Spot.TB
- QFT-IT
- TST
Correct Answer

A. QFT-IT

Explanation

In low TB prevalence settings, the QFT-IT yields more positive and fewer indeterminate results
than T-SPOT.TB. Negative results on the QFT-IT and indeterminate/unavailable results on the T-SPOT.TB were more common in individuals with low CD4+ T-cell counts.

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12.

The Negative Predictive Value (NPV) for the QFT in the Diel study was 98%.
- True
- False
Correct Answer

A. False

Explanation

The Negative Predictive Value (NPV) for the QFT in this Diel study was 100%.

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13.

In the Garazzino study titled “Performance of interferon-γ Release Assay for the Diagnosis of Active or Latent Tuberculosis in Children in the First 2 Years of Age,” in-determinants results were found to be related to age.
- True
- False
Correct Answer

A. False

Explanation

False.

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14.

In Starke’s article “Interferon-γ Release Assays for Diagnosis of Tuberculosis Infection and Disease in Children,” about 50% infants who received a BCG-vaccine will respond with a significant induration to a TST.
- True
- False
Correct Answer

A. True

Explanation

The statement is true because in Starke's article, it is mentioned that approximately 50% of infants who received a BCG vaccine will have a significant induration (hardened bump) in response to a Tuberculin Skin Test (TST). This means that the BCG vaccine can cause a reaction that mimics a positive result for tuberculosis infection in the TST.

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15.

Cheallaigh, “Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection inHIV-Infected Individuals in a Low TB Burden Country,” states tuberculosis is the most common opportunistic infection in HIV-infected individuals and is responsible for how many of HIV associated deaths?
- 1/2
- 1/4
- 1/3
- 1/5
Correct Answer

A. 1/3

Explanation

In the Cheallaigh study, “Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection in
HIV-Infected Individuals in a Low TB Burden Country,” states tuberculosis is the most common opportunistic infection in HIV-infected individuals and is responsible for one-third of HIV associated deaths.

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16.

Of the 2 U.S. commercially-available IGRAs, which one had a higher pooled sensitivity.
- T-Spot
- QuantiFERON-TB Gold
Correct Answer

A. T-Spot

Explanation

Of the 2 commercially-available IGRAs,T-Spot has a higher pooled sensitivity.

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17.

In the Diel study “Negative and Positive Predictive Value of a Whole-Blood Interferon-g Release Assay for Developing Active Tuberculosis,” how many of the TB contacts would the TST at >10mm cutoff were missed in the study that progressed to active TB?
- 10 out of 20
- 9 out of 19
- 8 out of 20
- 7 out of 19
Correct Answer

A. 9 out of 19

Explanation

In the Diel study, 9 out of 19 TB contacts who progressed to active TB with at TST cut-off of 10mm were missed.

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18.

CDC recommends either TST or an IGRA for screening immigrant children age ___ from high risk countries.
- 2-14 years
- < 5 years
- >15 years
- None of the above.
Correct Answer

A. 2-14 years

Explanation

The CDC recommends either a Tuberculin Skin Test (TST) or an Interferon-Gamma Release Assay (IGRA) for screening immigrant children aged 2-14 years from high-risk countries. This age range is considered to be at higher risk for tuberculosis infection and therefore requires screening to ensure early detection and appropriate treatment if necessary.

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19.

IGRAs are the "Gold Standard" for active TB testing.
- True
- False
Correct Answer

A. False

Explanation

There is no "Gold Standard" assay for active TB testing. IGRAs test for latent TB not active.

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20.

In the Diel study “Evidence-based Comparison of Commercial Interferon-gamma Release Assays for Detecting Active Tuberculosis -- a Meta-Analysis,” immuno-compromised patient had fewer in-determinates with T-SPOT.
- True
- False
Correct Answer

A. True

Explanation

In Diel, immuno-compromised patients, TSpot had fewer indeterminates.

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Current Version
Apr 18, 2023

Quiz Edited by
ProProfs Editorial Team
Jan 28, 2016

Quiz Created by
Levather Johnson

Clinical Science Consultants # 2

In the Diel study “Evidence-based Comparison of Commercial Interferon-gamma Release Assays for Detecting Active Tuberculosis -- a Meta-Analysis,” select the appropriate value for the TSpot cut-off used to be considered for a positive result?

Quiz Preview

False-negative TST results can occur when children suffer from severe active TB or immune suppression.

In the Diel study mentioned above, there were only ___ of the 679 obtained papers met the inclusion criteria for this meta-analysis.

Of the available LTBI blood tests, which test demonstrated a better performance trend in BCG-vaccinated children?

It was suggested in the Diel study “Negative and Positive Predictive Value of a Whole-Blood Interferon-g Release Assay for Developing Active Tuberculosis’” that QFT is more reliable than the TST for identifying those who will soon progress to active TB, especially in children.

Which diagnostic assay has the least amount of subjectivity in diagnosing latent TB infection?

According to Diel, which statement is correct?

In the Diel study “Negative and Positive Predictive Value of a Whole-Blood Interferon Gamma Release Assay for Developing Active Tuberculosis’”, none of the contacts who tested QFT negative developed active TB.

More positives and fewer in-determinants results were noted by which assay in the Cheallaigh “Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection in HIV Infected Individuals in a Low TB Burden Country" study?

The Negative Predictive Value (NPV) for the QFT in the Diel study was 98%.

In the Garazzino study titled “Performance of interferon-γ Release Assay for the Diagnosis of Active or Latent Tuberculosis in Children in the First 2 Years of Age,” in-determinants results were found to be related to age.

In Starke’s article “Interferon-γ Release Assays for Diagnosis of Tuberculosis Infection and Disease in Children,” about 50% infants who received a BCG-vaccine will respond with a significant induration to a TST.

Cheallaigh, “Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection inHIV-Infected Individuals in a Low TB Burden Country,” states tuberculosis is the most common opportunistic infection in HIV-infected individuals and is responsible for how many of HIV associated deaths?

Of the 2 U.S. commercially-available IGRAs, which one had a higher pooled sensitivity.

In the Diel study “Negative and Positive Predictive Value of a Whole-Blood Interferon-g Release Assay for Developing Active Tuberculosis,” how many of the TB contacts would the TST at >10mm cutoff were missed in the study that progressed to active TB?

CDC recommends either TST or an IGRA for screening immigrant children age ___ from high risk countries.

IGRAs are the "Gold Standard" for active TB testing.

In the Diel study “Evidence-based Comparison of Commercial Interferon-gamma Release Assays for Detecting Active Tuberculosis -- a Meta-Analysis,” immuno-compromised patient had fewer in-determinates with T-SPOT.