Clinical Science Consultants # 2

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| By Levather Johnson

Levather Johnson

Community Contributor

Quizzes Created: 1 | Total Attempts: 35

Questions: 20 | Attempts: 35 | Updated: Apr 18, 2023

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Apr 18, 2023

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Jan 28, 2016

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Clinical Science Consultants # 2

In the Diel study “Evidence-based Comparison of Commercial Interferon-gamma Release Assays for Detecting Active Tuberculosis -- a Meta-Analysis,” select the appropriate value for the TSpot cut-off used to be considered for a positive result?

In the Diel study mentioned above, there were only ___ of the 679 obtained papers met the inclusion criteria for this meta-analysis.

Of the 2 U.S. commercially-available IGRAs, which one had a higher pooled sensitivity.

In the Diel study “Evidence-based Comparison of Commercial Interferon-gamma Release Assays for Detecting Active Tuberculosis -- a Meta-Analysis,” immuno-compromised patient had fewer in-determinates with T-SPOT.

According to Diel, which statement is correct?

The Negative Predictive Value (NPV) for the QFT in the Diel study was 98%.

In the Diel study “Negative and Positive Predictive Value of a Whole-Blood Interferon-g Release Assay for Developing Active Tuberculosis,” how many of the TB contacts would the TST at >10mm cutoff were missed in the study that progressed to active TB?

CDC recommends either TST or an IGRA for screening immigrant children age ___ from high risk countries.

In the Diel study “Negative and Positive Predictive Value of a Whole-Blood Interferon Gamma Release Assay for Developing Active Tuberculosis’”, none of the contacts who tested QFT negative developed active TB.

Of the available LTBI blood tests, which test demonstrated a better performance trend in BCG-vaccinated children?

In the Garazzino study titled “Performance of interferon-γ Release Assay for the Diagnosis of Active or Latent Tuberculosis in Children in the First 2 Years of Age,” in-determinants results were found to be related to age.

In Starke’s article “Interferon-γ Release Assays for Diagnosis of Tuberculosis Infection and Disease in Children,” about 50% infants who received a BCG-vaccine will respond with a significant induration to a TST.

IGRAs are the "Gold Standard" for active TB testing.

More positives and fewer in-determinants results were noted by which assay in the Cheallaigh “Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection in HIV Infected Individuals in a Low TB Burden Country" study?

It was suggested in the Diel study “Negative and Positive Predictive Value of a Whole-Blood Interferon-g Release Assay for Developing Active Tuberculosis’” that QFT is more reliable than the TST for identifying those who will soon progress to active TB, especially in children.

Which diagnostic assay has the least amount of subjectivity in diagnosing latent TB infection?

False-negative TST results can occur when children suffer from severe active TB or immune suppression.

Cheallaigh, “Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection inHIV-Infected Individuals in a Low TB Burden Country,” states tuberculosis is the most common opportunistic infection in HIV-infected individuals and is responsible for how many of HIV associated deaths?