Clinical Science Consultants # 2

20 Questions | Total Attempts: 31

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Science Quizzes & Trivia

On-boarding knowledge survey for weeks 4-6.


Questions and Answers
  • 1. 
    In the Diel study “Evidence-based Comparison of Commercial Interferon-gamma Release Assays for Detecting Active Tuberculosis -- a Meta-Analysis,” select the appropriate value for the TSpot cut-off used to be considered for a positive result? 
    • A. 

      10 spots

    • B. 

      3 spots

    • C. 

      > or equal to 6 spots

    • D. 

      Less than or equal to 5 spots

  • 2. 
    In the Diel study mentioned above, there were only ___ of the 679 obtained papers met the inclusion criteria for this meta-analysis.
    • A. 

      124 publications

    • B. 

      412 publications

    • C. 

      214 publications

    • D. 

      142 publications

  • 3. 
    Of the 2 U.S. commercially-available IGRAs, which one had a higher pooled sensitivity.
    • A. 

      T-Spot

    • B. 

      QuantiFERON-TB Gold

  • 4. 
    In the Diel study “Evidence-based Comparison of Commercial Interferon-gamma Release Assays for Detecting Active Tuberculosis -- a Meta-Analysis,” immuno-compromised patient had fewer in-determinates with T-SPOT.
    • A. 

      True

    • B. 

      False

  • 5. 
    According to Diel, which statement is correct? 
    • A. 

      QFT has a higher sensitivity and higher specificity than T-Spot.

    • B. 

      QFT has a higher sensitivity and lower specificity than T-Spot.

    • C. 

      T-Spot has a higher sensitivity and higher specificity than QFT.

    • D. 

      T-Spot has a higher sensitivity and lower specificity than QFT.

  • 6. 
    The Negative Predictive Value (NPV) for the QFT in the Diel study was 98%.
    • A. 

      True

    • B. 

      False

  • 7. 
    In the Diel study “Negative and Positive Predictive Value of a Whole-Blood Interferon-g Release Assay for Developing Active Tuberculosis,” how many of the TB contacts would the TST at >10mm cutoff were missed in the study that progressed to active TB?
    • A. 

      10 out of 20

    • B. 

      9 out of 19

    • C. 

      8 out of 20

    • D. 

      7 out of 19

  • 8. 
    CDC recommends either TST or an IGRA for screening immigrant children age ___  from high risk countries.
    • A. 

      2-14 years

    • B. 

      < 5 years

    • C. 

      >15 years

    • D. 

      None of the above.

  • 9. 
    In the Diel study “Negative and Positive Predictive Value of a Whole-Blood Interferon Gamma Release Assay for Developing Active Tuberculosis’”, none of the contacts who tested QFT negative developed active TB.
    • A. 

      True

    • B. 

      False

  • 10. 
    Of the available LTBI blood tests, which test demonstrated a better performance trend in BCG-vaccinated children?
    • A. 

      TST

    • B. 

      QFT

    • C. 

      T-Spot

    • D. 

      None of the above.

  • 11. 
    In the Garazzino study titled “Performance of interferon-γ Release Assay for the Diagnosis of Active or Latent Tuberculosis in Children in the First 2 Years of Age,” in-determinants results were found to be related to age. 
    • A. 

      True

    • B. 

      False

  • 12. 
    In the Howley study, “Evaluation of QuantiFERON-TB Gold In-Tube and Tuberculin Skin Tests among Immigrant Children being Screened for Latent Tuberculosis Infection,” which of the following was not one of the 3 countries in which the children were applying for immigration status from in this study.
    • A. 

      Philippines

    • B. 

      Africa

    • C. 

      Vietnam

    • D. 

      Mexico

  • 13. 
    In Starke’s article “Interferon-γ Release Assays for Diagnosis of Tuberculosis Infection and Disease in Children,” about 50% infants who received a BCG-vaccine will respond with a significant induration to a TST.
    • A. 

      True

    • B. 

      False

  • 14. 
    IGRAs are the "Gold Standard" for active TB testing.
    • A. 

      True

    • B. 

      False

  • 15. 
    More positives and fewer in-determinants results were noted by which assay in the Cheallaigh “Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection in HIV Infected Individuals in a Low TB Burden Country" study? 
    • A. 

      QFT-TB

    • B. 

      T-Spot.TB

    • C. 

      QFT-IT

    • D. 

      TST

  • 16. 
    It was suggested in the Diel study “Negative and Positive Predictive Value of a Whole-Blood Interferon-g Release Assay for Developing Active Tuberculosis’” that QFT is more reliable than the TST for identifying those who will soon progress to active TB, especially in children. 
    • A. 

      True

    • B. 

      False

  • 17. 
    In Long, “Interferon-Release Assay for the Diagnosis of Latent Mycobacterium tuberculosis Infection in Children Younger Than 5 Years: A Meta-Analysis,” showed that the sensitivity and specificity of ______ were slightly higher than ___ and can be used as supporting tools to detect LTBI in children younger than 5 years.
    • A. 

      T-Spot and TST

    • B. 

      TST and QFT-IT

    • C. 

      IGRAs and TST

    • D. 

      None of the above.

  • 18. 
    Which diagnostic assay has the least amount of subjectivity in diagnosing latent TB infection?
    • A. 

      QFT-TB Gold

    • B. 

      TST

    • C. 

      T-Spot

    • D. 

      None of the above.

  • 19. 
    False-negative TST results can occur when children suffer from severe active TB or immune suppression. 
    • A. 

      True

    • B. 

      False

  • 20. 
    Cheallaigh, “Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection inHIV-Infected Individuals in a Low TB Burden Country,” states tuberculosis is the most common opportunistic infection in HIV-infected individuals and is responsible for how many of HIV associated deaths?
    • A. 

      1/2

    • B. 

      1/4

    • C. 

      1/3

    • D. 

      1/5

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