Clinical Science Consultants # 2

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| By Levather Johnson
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Levather Johnson
Community Contributor
Quizzes Created: 1 | Total Attempts: 35
| Attempts: 35
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  • 1/20 Questions

    In the Diel study “Evidence-based Comparison of Commercial Interferon-gamma Release Assays for Detecting Active Tuberculosis -- a Meta-Analysis,” select the appropriate value for the TSpot cut-off used to be considered for a positive result? 

    • 10 spots
    • 3 spots
    • > or equal to 6 spots
    • Less than or equal to 5 spots
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About This Quiz

This quiz, titled 'Clinical Science Consultants #2', assesses knowledge on the Diel study comparing commercial Interferon-gamma Release Assays for detecting active tuberculosis. It focuses on T-Spot and QFT test sensitivities, specificities, and their application in clinical settings.

Clinical Science Consultants # 2 - Quiz

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  • 2. 

    False-negative TST results can occur when children suffer from severe active TB or immune suppression. 

    • True

    • False

    Correct Answer
    A. True
    Explanation
    In Long, “Interferon-Release Assay for the Diagnosis of Latent Mycobacterium tuberculosis Infection in Children Younger Than 5 Years: A Meta-Analysis,” False-negative TST results can occur when children suffer from severe active TB or immune suppression.

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  • 3. 

    In the Diel study mentioned above, there were only ___ of the 679 obtained papers met the inclusion criteria for this meta-analysis.

    • 124 publications

    • 412 publications

    • 214 publications

    • 142 publications

    Correct Answer
    A. 124 publications
    Explanation
    In the Deil study, there were only 124 of the 679 obtained papers met the inclusion criteria for this meta-analysis.

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  • 4. 

    Of the available LTBI blood tests, which test demonstrated a better performance trend in BCG-vaccinated children?

    • TST

    • QFT

    • T-Spot

    • None of the above.

    Correct Answer
    A. QFT
    Explanation
    Although not statistically significant, QFT demonstrated a better performance trend in BCG-vaccinated children. Note, TST is not a blood test.

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  • 5. 

    It was suggested in the Diel study “Negative and Positive Predictive Value of a Whole-Blood Interferon-g Release Assay for Developing Active Tuberculosis’” that QFT is more reliable than the TST for identifying those who will soon progress to active TB, especially in children. 

    • True

    • False

    Correct Answer
    A. True
    Explanation
    Results suggest that QFT is more reliable than the TST for identifying those who will soon progress to active TB, especially in children.

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  • 6. 

    Which diagnostic assay has the least amount of subjectivity in diagnosing latent TB infection?

    • QFT-TB Gold

    • TST

    • T-Spot

    • None of the above.

    Correct Answer
    A. QFT-TB Gold
    Explanation
    QuantiFERON-TB Gold has proven to have less subjectivity in diagnosing LTBI.

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  • 7. 

    According to Diel, which statement is correct? 

    • QFT has a higher sensitivity and higher specificity than T-Spot.

    • QFT has a higher sensitivity and lower specificity than T-Spot.

    • T-Spot has a higher sensitivity and higher specificity than QFT.

    • T-Spot has a higher sensitivity and lower specificity than QFT.

    Correct Answer
    A. T-Spot has a higher sensitivity and lower specificity than QFT.
    Explanation
    T-Spot has a higher sensitivity and lower specificity than QFT.

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  • 8. 

    In the Diel study “Negative and Positive Predictive Value of a Whole-Blood Interferon Gamma Release Assay for Developing Active Tuberculosis’”, none of the contacts who tested QFT negative developed active TB.

    • True

    • False

    Correct Answer
    A. True
    Explanation
    In the Diel study, none of the contacts who tested QFT negative developed active TB.

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  • 9. 

    In the Howley study, “Evaluation of QuantiFERON-TB Gold In-Tube and Tuberculin Skin Tests among Immigrant Children being Screened for Latent Tuberculosis Infection,” which of the following was not one of the 3 countries in which the children were applying for immigration status from in this study.

    • Philippines

    • Africa

    • Vietnam

    • Mexico

    Correct Answer
    A. Africa
    Explanation
    In the Howley study, “Evaluation of QuantiFERON-TB Gold In-Tube and Tuberculin Skin Tests among Immigrant Children being Screened for Latent Tuberculosis Infection,” children from Mexico, Philippines and Vietnam were the 3 countries in which the children were applying for immigration status.
    • Mexico
    • Philippines
    • Vietnam

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  • 10. 

    In Long, “Interferon-Release Assay for the Diagnosis of Latent Mycobacterium tuberculosis Infection in Children Younger Than 5 Years: A Meta-Analysis,” showed that the sensitivity and specificity of ______ were slightly higher than ___ and can be used as supporting tools to detect LTBI in children younger than 5 years.

    • T-Spot and TST

    • TST and QFT-IT

    • IGRAs and TST

    • None of the above.

    Correct Answer
    A. IGRAs and TST
    Explanation
    In Long, “Interferon-Release Assay for the Diagnosis of Latent Mycobacterium tuberculosis Infection in Children Younger Than 5 Years: A Meta-Analysis,” showed that the sensitivity and specificity of IGRAs were slightly higher than TST and can be used as supporting tools to detect LTBI in children younger than 5 years.

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  • 11. 

    More positives and fewer in-determinants results were noted by which assay in the Cheallaigh “Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection in HIV Infected Individuals in a Low TB Burden Country" study? 

    • QFT-TB

    • T-Spot.TB

    • QFT-IT

    • TST

    Correct Answer
    A. QFT-IT
    Explanation
    In low TB prevalence settings, the QFT-IT yields more positive and fewer indeterminate results
    than T-SPOT.TB. Negative results on the QFT-IT and indeterminate/unavailable results on the T-SPOT.TB were more common in individuals with low CD4+ T-cell counts.

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  • 12. 

    The Negative Predictive Value (NPV) for the QFT in the Diel study was 98%.

    • True

    • False

    Correct Answer
    A. False
    Explanation
    The Negative Predictive Value (NPV) for the QFT in this Diel study was 100%.

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  • 13. 

    In the Garazzino study titled “Performance of interferon-γ Release Assay for the Diagnosis of Active or Latent Tuberculosis in Children in the First 2 Years of Age,” in-determinants results were found to be related to age. 

    • True

    • False

    Correct Answer
    A. False
    Explanation
    False.

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  • 14. 

    In Starke’s article “Interferon-γ Release Assays for Diagnosis of Tuberculosis Infection and Disease in Children,” about 50% infants who received a BCG-vaccine will respond with a significant induration to a TST.

    • True

    • False

    Correct Answer
    A. True
    Explanation
    The statement is true because in Starke's article, it is mentioned that approximately 50% of infants who received a BCG vaccine will have a significant induration (hardened bump) in response to a Tuberculin Skin Test (TST). This means that the BCG vaccine can cause a reaction that mimics a positive result for tuberculosis infection in the TST.

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  • 15. 

    Cheallaigh, “Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection inHIV-Infected Individuals in a Low TB Burden Country,” states tuberculosis is the most common opportunistic infection in HIV-infected individuals and is responsible for how many of HIV associated deaths?

    • 1/2

    • 1/4

    • 1/3

    • 1/5

    Correct Answer
    A. 1/3
    Explanation
    In the Cheallaigh study, “Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection in
    HIV-Infected Individuals in a Low TB Burden Country,” states tuberculosis is the most common opportunistic infection in HIV-infected individuals and is responsible for one-third of HIV associated deaths.

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  • 16. 

    Of the 2 U.S. commercially-available IGRAs, which one had a higher pooled sensitivity.

    • T-Spot

    • QuantiFERON-TB Gold

    Correct Answer
    A. T-Spot
    Explanation
    Of the 2 commercially-available IGRAs,T-Spot has a higher pooled sensitivity.

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  • 17. 

    In the Diel study “Negative and Positive Predictive Value of a Whole-Blood Interferon-g Release Assay for Developing Active Tuberculosis,” how many of the TB contacts would the TST at >10mm cutoff were missed in the study that progressed to active TB?

    • 10 out of 20

    • 9 out of 19

    • 8 out of 20

    • 7 out of 19

    Correct Answer
    A. 9 out of 19
    Explanation
    In the Diel study, 9 out of 19 TB contacts who progressed to active TB with at TST cut-off of 10mm were missed.

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  • 18. 

    CDC recommends either TST or an IGRA for screening immigrant children age ___  from high risk countries.

    • 2-14 years

    • < 5 years

    • >15 years

    • None of the above.

    Correct Answer
    A. 2-14 years
    Explanation
    The CDC recommends either a Tuberculin Skin Test (TST) or an Interferon-Gamma Release Assay (IGRA) for screening immigrant children aged 2-14 years from high-risk countries. This age range is considered to be at higher risk for tuberculosis infection and therefore requires screening to ensure early detection and appropriate treatment if necessary.

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  • 19. 

    IGRAs are the "Gold Standard" for active TB testing.

    • True

    • False

    Correct Answer
    A. False
    Explanation
    There is no "Gold Standard" assay for active TB testing. IGRAs test for latent TB not active.

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  • 20. 

    In the Diel study “Evidence-based Comparison of Commercial Interferon-gamma Release Assays for Detecting Active Tuberculosis -- a Meta-Analysis,” immuno-compromised patient had fewer in-determinates with T-SPOT.

    • True

    • False

    Correct Answer
    A. True
    Explanation
    In Diel, immuno-compromised patients, TSpot had fewer indeterminates.

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Quiz Review Timeline (Updated): Apr 18, 2023 +

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  • Current Version
  • Apr 18, 2023
    Quiz Edited by
    ProProfs Editorial Team
  • Jan 28, 2016
    Quiz Created by
    Levather Johnson
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