Clinical Science Consultants # 2
20 Questions
| Total Attempts: 31
On-boarding knowledge survey for weeks 4-6.
Questions and Answers
- 1.In the Diel study “Evidence-based Comparison of Commercial Interferon-gamma Release Assays for Detecting Active Tuberculosis -- a Meta-Analysis,” select the appropriate value for the TSpot cut-off used to be considered for a positive result?
- A.
10 spots
- B.
3 spots
- C.
> or equal to 6 spots
- D.
Less than or equal to 5 spots
- 2.In the Diel study mentioned above, there were only ___ of the 679 obtained papers met the inclusion criteria for this meta-analysis.
- A.
124 publications
- B.
412 publications
- C.
214 publications
- D.
142 publications
- 3.Of the 2 U.S. commercially-available IGRAs, which one had a higher pooled sensitivity.
- A.
T-Spot
- B.
QuantiFERON-TB Gold
- 4.In the Diel study “Evidence-based Comparison of Commercial Interferon-gamma Release Assays for Detecting Active Tuberculosis -- a Meta-Analysis,” immuno-compromised patient had fewer in-determinates with T-SPOT.
- A.
True
- B.
False
- 5.According to Diel, which statement is correct?
- A.
QFT has a higher sensitivity and higher specificity than T-Spot.
- B.
QFT has a higher sensitivity and lower specificity than T-Spot.
- C.
T-Spot has a higher sensitivity and higher specificity than QFT.
- D.
T-Spot has a higher sensitivity and lower specificity than QFT.
- 6.The Negative Predictive Value (NPV) for the QFT in the Diel study was 98%.
- A.
True
- B.
False
- 7.In the Diel study “Negative and Positive Predictive Value of a Whole-Blood Interferon-g Release Assay for Developing Active Tuberculosis,” how many of the TB contacts would the TST at >10mm cutoff were missed in the study that progressed to active TB?
- A.
10 out of 20
- B.
9 out of 19
- C.
8 out of 20
- D.
7 out of 19
- 8.CDC recommends either TST or an IGRA for screening immigrant children age ___ from high risk countries.
- A.
2-14 years
- B.
< 5 years
- C.
>15 years
- D.
None of the above.
- 9.In the Diel study “Negative and Positive Predictive Value of a Whole-Blood Interferon Gamma Release Assay for Developing Active Tuberculosis’”, none of the contacts who tested QFT negative developed active TB.
- A.
True
- B.
False
- 10.Of the available LTBI blood tests, which test demonstrated a better performance trend in BCG-vaccinated children?
- A.
TST
- B.
QFT
- C.
T-Spot
- D.
None of the above.
- 11.In the Garazzino study titled “Performance of interferon-γ Release Assay for the Diagnosis of Active or Latent Tuberculosis in Children in the First 2 Years of Age,” in-determinants results were found to be related to age.
- A.
True
- B.
False
- 12.In the Howley study, “Evaluation of QuantiFERON-TB Gold In-Tube and Tuberculin Skin Tests among Immigrant Children being Screened for Latent Tuberculosis Infection,” which of the following was not one of the 3 countries in which the children were applying for immigration status from in this study.
- A.
Philippines
- B.
Africa
- C.
Vietnam
- D.
Mexico
- 13.In Starke’s article “Interferon-γ Release Assays for Diagnosis of Tuberculosis Infection and Disease in Children,” about 50% infants who received a BCG-vaccine will respond with a significant induration to a TST.
- A.
True
- B.
False
- 14.IGRAs are the "Gold Standard" for active TB testing.
- A.
True
- B.
False
- 15.More positives and fewer in-determinants results were noted by which assay in the Cheallaigh “Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection in HIV Infected Individuals in a Low TB Burden Country" study?
- A.
QFT-TB
- B.
T-Spot.TB
- C.
QFT-IT
- D.
TST
- 16.It was suggested in the Diel study “Negative and Positive Predictive Value of a Whole-Blood Interferon-g Release Assay for Developing Active Tuberculosis’” that QFT is more reliable than the TST for identifying those who will soon progress to active TB, especially in children.
- A.
True
- B.
False
- 17.In Long, “Interferon-Release Assay for the Diagnosis of Latent Mycobacterium tuberculosis Infection in Children Younger Than 5 Years: A Meta-Analysis,” showed that the sensitivity and specificity of ______ were slightly higher than ___ and can be used as supporting tools to detect LTBI in children younger than 5 years.
- A.
T-Spot and TST
- B.
TST and QFT-IT
- C.
IGRAs and TST
- D.
None of the above.
- 18.Which diagnostic assay has the least amount of subjectivity in diagnosing latent TB infection?
- A.
QFT-TB Gold
- B.
TST
- C.
T-Spot
- D.
None of the above.
- 19.False-negative TST results can occur when children suffer from severe active TB or immune suppression.
- A.
True
- B.
False
- 20.Cheallaigh, “Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection inHIV-Infected Individuals in a Low TB Burden Country,” states tuberculosis is the most common opportunistic infection in HIV-infected individuals and is responsible for how many of HIV associated deaths?
- A.
1/2
- B.
1/4
- C.
1/3
- D.
1/5
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