Clinical Science Consultants # 2

20 Questions | By LNeiceyJ | Last updated: Mar 19, 2022 | Total Attempts: 34

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On-boarding knowledge survey for weeks 4-6.

Questions and Answers

1.

In the Diel study “Evidence-based Comparison of Commercial Interferon-gamma Release Assays for Detecting Active Tuberculosis -- a Meta-Analysis,” select the appropriate value for the TSpot cut-off used to be considered for a positive result?
- A.
  
  10 spots
- B.
  
  3 spots
- C.
  
  > or equal to 6 spots
- D.
  
  Less than or equal to 5 spots
2.

In the Diel study mentioned above, there were only ___ of the 679 obtained papers met the inclusion criteria for this meta-analysis.
- A.
  
  124 publications
- B.
  
  412 publications
- C.
  
  214 publications
- D.
  
  142 publications
3.

Of the 2 U.S. commercially-available IGRAs, which one had a higher pooled sensitivity.
- A.
  
  T-Spot
- B.
  
  QuantiFERON-TB Gold
4.

In the Diel study “Evidence-based Comparison of Commercial Interferon-gamma Release Assays for Detecting Active Tuberculosis -- a Meta-Analysis,” immuno-compromised patient had fewer in-determinates with T-SPOT.
- A.
  
  True
- B.
  
  False
5.

According to Diel, which statement is correct?
- A.
  
  QFT has a higher sensitivity and higher specificity than T-Spot.
- B.
  
  QFT has a higher sensitivity and lower specificity than T-Spot.
- C.
  
  T-Spot has a higher sensitivity and higher specificity than QFT.
- D.
  
  T-Spot has a higher sensitivity and lower specificity than QFT.
6.

The Negative Predictive Value (NPV) for the QFT in the Diel study was 98%.
- A.
  
  True
- B.
  
  False
7.

In the Diel study “Negative and Positive Predictive Value of a Whole-Blood Interferon-g Release Assay for Developing Active Tuberculosis,” how many of the TB contacts would the TST at >10mm cutoff were missed in the study that progressed to active TB?
- A.
  
  10 out of 20
- B.
  
  9 out of 19
- C.
  
  8 out of 20
- D.
  
  7 out of 19
8.

CDC recommends either TST or an IGRA for screening immigrant children age ___ from high risk countries.
- A.
  
  2-14 years
- B.
  
  < 5 years
- C.
  
  >15 years
- D.
  
  None of the above.
9.

In the Diel study “Negative and Positive Predictive Value of a Whole-Blood Interferon Gamma Release Assay for Developing Active Tuberculosis’”, none of the contacts who tested QFT negative developed active TB.
- A.
  
  True
- B.
  
  False
10.

Of the available LTBI blood tests, which test demonstrated a better performance trend in BCG-vaccinated children?
- A.
  
  TST
- B.
  
  QFT
- C.
  
  T-Spot
- D.
  
  None of the above.
11.

In the Garazzino study titled “Performance of interferon-γ Release Assay for the Diagnosis of Active or Latent Tuberculosis in Children in the First 2 Years of Age,” in-determinants results were found to be related to age.
- A.
  
  True
- B.
  
  False
12.

In the Howley study, “Evaluation of QuantiFERON-TB Gold In-Tube and Tuberculin Skin Tests among Immigrant Children being Screened for Latent Tuberculosis Infection,” which of the following was not one of the 3 countries in which the children were applying for immigration status from in this study.
- A.
  
  Philippines
- B.
  
  Africa
- C.
  
  Vietnam
- D.
  
  Mexico
13.

In Starke’s article “Interferon-γ Release Assays for Diagnosis of Tuberculosis Infection and Disease in Children,” about 50% infants who received a BCG-vaccine will respond with a significant induration to a TST.
- A.
  
  True
- B.
  
  False
14.

IGRAs are the "Gold Standard" for active TB testing.
- A.
  
  True
- B.
  
  False
15.

More positives and fewer in-determinants results were noted by which assay in the Cheallaigh “Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection in HIV Infected Individuals in a Low TB Burden Country" study?
- A.
  
  QFT-TB
- B.
  
  T-Spot.TB
- C.
  
  QFT-IT
- D.
  
  TST
16.

It was suggested in the Diel study “Negative and Positive Predictive Value of a Whole-Blood Interferon-g Release Assay for Developing Active Tuberculosis’” that QFT is more reliable than the TST for identifying those who will soon progress to active TB, especially in children.
- A.
  
  True
- B.
  
  False
17.

In Long, “Interferon-Release Assay for the Diagnosis of Latent Mycobacterium tuberculosis Infection in Children Younger Than 5 Years: A Meta-Analysis,” showed that the sensitivity and specificity of ______ were slightly higher than ___ and can be used as supporting tools to detect LTBI in children younger than 5 years.
- A.
  
  T-Spot and TST
- B.
  
  TST and QFT-IT
- C.
  
  IGRAs and TST
- D.
  
  None of the above.
18.

Which diagnostic assay has the least amount of subjectivity in diagnosing latent TB infection?
- A.
  
  QFT-TB Gold
- B.
  
  TST
- C.
  
  T-Spot
- D.
  
  None of the above.
19.

False-negative TST results can occur when children suffer from severe active TB or immune suppression.
- A.
  
  True
- B.
  
  False
20.

Cheallaigh, “Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection inHIV-Infected Individuals in a Low TB Burden Country,” states tuberculosis is the most common opportunistic infection in HIV-infected individuals and is responsible for how many of HIV associated deaths?
- A.
  
  1/2
- B.
  
  1/4
- C.
  
  1/3
- D.
  
  1/5