In today’s quiz on drugs associated with particular medical conditions, we’ll be looking at antihyperlipidemic agents, which are used in the treatment of high levels of fats and cholesterol in the blood. What can you tell us about these drugs and what their specific uses are?
Latanoprost
Famotidine
Timolol
Sucralfate
Lovastatin
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Adipocytes
Capillary endothelial cells
Platelets
Hepatocytes
Intestinal epithelial cells
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The combination decreases the risk of lovastatin-induced myopathy
The combination results in synergistic cholesterol-lowering effects
Ezetimibe slows down the metabolism of lovastatin
Ezetimibe increases the intestinal absorption of lovastatin
The combination strongly increases HDL plasma levels
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Alteplase
Aspirin
Lovastatin
Heparin
Ezetimibe
Metoprolol
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Cholestyramine
Ezetimibe
Gemfibrozil
Niacin
Lovastatin
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Down-regulation of hepatic LDL receptors
Increased synthesis of lipoprotein lipase
Decreased synthesis of mevalonic acid
Decreased storage of LDL in hepatic endosomes
Increased plasma levels of hepatic aminotransferases
Increased plasma levels of creatine phosphokinase
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VLDL
HDL
LDL
Chylomicrons
Triglycerides
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Warfarin
Atropine
Aspirin
Prazosin
Gemfibrozil
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Cholestyramine
Niacin
Ezetimibe
Lovastatin
Gemfibrozil
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Liver
Small intestine
Colon
Plasma
Adipose tissue
Gall bladder
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Cholestyramine
Ezetimibe
Gemfibrozil
Niacin
Lovastatin
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Inhibition of VLDL production by the hepatocyte
Inhibition of HDL synthesis by the liver
Increase of circulating fibrinogen
Stimulation of lipolysis in adipose tissue
Decreased absorption of exogenous cholesterol
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Lovastatin
Insulin
Niacin
Gemfibrozil
Cholestyramine
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Smooth endoplasmic reticulum
Nucleus
Cell membrane
Cytoplasm
Rough endoplasmic reticulum
Mitochondria
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Gemfibrozil
Lovastatin
Cholestyramine
Niacin
Ezetimibe
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Cholestyramine
Ezetimibe
Gemfibrozil
Niacin
Lovastatin
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Renal elimination of propranolol increased
Renal elimination of hydrochlorothiazide decreased
Oral bioavailability of propranolol increased
Oral bioavailability of hydrochlorothiazide decreased
Volume of distribution of propranolol increased
Volume of distribution of hydrochlorothiazide decreased
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Decrease of lipid synthesis on adipose tissue
Down-regulation of LDL receptors in the liver
Inhibition HMG-CoA reductase activity in the liver
Stimulation of lipoprotein lipase synthesis
Decreased absorption of exogenous cholesterol
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Lovastatin
Cholestyramine
Ezetimibe
Niacin
Gemfibrozil
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