Block 10 Skeletal Mus Myopath And DNA Tech MCQ's

12 Questions | By Chachelly | Last updated: Mar 21, 2022 | Total Attempts: 228

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1.

A 45 year old male has been recently diagnosed with amyotrophic lateral sclerosis. On a follow up visit he complains of constant spasms. So his physician prescribes a spasmolytic drug which facilitates GABA actions in the spinal cord. Which of the following drugs would fit the criteria?
- A.
  
  Dantrolene
- B.
  
  Botulinum toxin
- C.
  
  Riluzole
- D.
  
  Succinylcholine
- E.
  
  Diazepam
2.

A 54 year old man with a recent condition of cervical dystonia, a movement disorder causing his neck to involuntarily turn to the left and upwards, has been treated with a drug which has effectively reduced the painful muscle spasms with the progress of drug treatment. Which of the following drugs could the patient have received?
- A.
  
  Mivacurium
- B.
  
  Tubocurarine
- C.
  
  Botulinum toxin
- D.
  
  Succinylcholine
- E.
  
  Dantrolene
3.

A 22 year old woman presents with the symptom of cerebral palsy and complains of severe pain that is associated with spasms in the lower leg muscles. Which of the following drugs will reduce the skeletal muscle spasticity by producing an action inside the muscle cell?
- A.
  
  Botulinum toxin
- B.
  
  Tubocurarine
- C.
  
  Diazepam
- D.
  
  Baclofen
- E.
  
  Dantrolene
4.

A 34-year-old woman while recuperating from a cesarean delivery 2 days earlier, becomes rigid, appears confused at times, and has a body temperature of 102°F. She developed serious tachycardia and hypercapnea. Her clinical notes indicated that halothane was the choice of anesthesia used for the del ivery, supplemented with a skeletal muscle relaxant, succinylchol ine. Which of the following drugs should immediately be given IV to this patient?
- A.
  
  Dantrolene
- B.
  
  Atropine
- C.
  
  Neostigmine
- D.
  
  Baclofen
- E.
  
  Prazosine
5.

A 19 year old man who has a history of asthmatic attacks arrives to the ER complaining of intense pain in the right lower side of his abdomen. Patient complains of pain starting centrally before localizing to the right iliac fossa, and after gentle palpation the doctor finds the patient is sensitive to gentle pressure on the left iliac fossa therefore the diagnosis is typical appendicitis requiring major surgery. A drug is administered preoperatively and the anesthesia is supplemented with a skeletal muscle relaxant. Which of the following drugs would be contraindicated for this patient?
- A.
  
  Tubocurarine
- B.
  
  Glycopyrrolate
- C.
  
  Clonidine
- D.
  
  Vecuronium
- E.
  
  Cisatracurium
6.

A 34 year old woman while recuperating from a cesarean delivery 2 days earlier becomes rigid, appears confused at times and has a body temperature of 1020F, and also develops tachycardia, and hypercapnia. Halothane had been the choice of anesthesia used for her delivery, supplemented with skeletal muscle relaxant succinylcholine. Which of the following drugs should be immediately given IV to this patient?
- A.
  
  Atropine
- B.
  
  Tizanidine
- C.
  
  Dantrolene
- D.
  
  Baclofen
- E.
  
  Prazosin
7.

A 24 year-old man presents with hypoxia, respiratory distress, pulmonary edema and stiff legs. He is diagnosed with Acute Respiratory Distress. He is given a neuromuscular blocking agent to facilitate lung protection while on the mechanical ventilator. Which non -depolarizing drug is likely infused for 48 hours while the patient is on a ventilator?
- A.
  
  Succinylcholine
- B.
  
  Dantrolene
- C.
  
  Baclofen
- D.
  
  Cisatracurium
- E.
  
  Mivacurium
8.

A 55-year-old man is going to have internal surgery and a muscle relaxant is given. What kind of drug keeps the channel open, desensitizes the channel and blocks the ability to initiate an action potential?
- A.
  
  Nondepolarizing drug
- B.
  
  Central spasmolytic drug
- C.
  
  Depolarizing drug
- D.
  
  Peripheral spasmolytic drug
9.

A 66 year old woman visits the neurologist. She is brought by her daughter because she has recently noticed her mother has developed the following symptoms which include: difficulty swallowing, difficulty opening the mouth, spasms of the jaw, pain in the jaw also and has difficulty speaking. She also has uncontrollable squinting of the eyes when she talks. The neurologist who specializes in movement disorders immediately recognizes the condition and makes the diagnosis of Meige's syndrome and schedules a treatment regimen that includes injection of a peripheral spasmolytic drug. Which of the following is the most appropriate pharmacotherapy at this time?
- A.
  
  Neostigmine
- B.
  
  Succinylcholine
- C.
  
  Riluzole
- D.
  
  Gabapentin
- E.
  
  Botulinum toxin
10.

A 52-year-old man comes to his physician today, complaining of excruciating pain in his left toe. On examination of the patient's foot, the doctor notes a swollen, red, first metatarsophalangeal joint which is warm to the touch, and also 0.5cm mobile nodules near the olecranon bilaterally. PMH reports that over a two year period he had twice presented with similar complaints about a painful joint; his doctor had treated the acute pain with ibuprofen. Today, the acute pain is treated with a three-day regimen of Drug A, which binds to tubulin, inhibiting neutrophil activation. Two weeks after the acute attack had resolved , the doctor prescribes another drug, Drug B, a long term prophylactic, to manage this patient's chronic cond ition. Which of the following pairs of drugs fits the characteristics of drugs "A" and "B"?
- A.
  
  Ibuprofen and cortisone
- B.
  
  Probenecid and indomethacin
- C.
  
  Indomethacin and cortisone
- D.
  
  Allopurinol and colchicines
- E.
  
  Colchicine and allopurinol
11.

In which of the following conditions will electromyography likely show no denervation?
- A.
  
  Poliomyelitis
- B.
  
  Amyotrophic Lateral Sclerosis
- C.
  
  Carpal Tunnel Syndrome
- D.
  
  Primary Lateral Sclerosis
- E.
  
  Sl radiculopathy
12.

In an experiment Dr. Kirlin intends to silence VEGF genes associated with abnormal proliferation of blood vessels in mice with induced age-related macular degeneration (AMD). The synthetic siRNAs that he injected intravitreally into the mouse eye for this purpose are most likely:
- A.
  
  75 nbp long double stranded RNA fragments
- B.
  
  22 nbp long double stranded RNA fragments
- C.
  
  120 nbp long cDNA strands
- D.
  
  9 nbp long mRNA sequences
- E.
  
  1000 nbp long DNA sequences