Pharm Arthritis And Gout Part 1

20 Questions | Total Attempts: 1183

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Pharm Arthritis And Gout Part 1

In today’s pharmacology quiz we’ll be looking at arthritis – a disorder that affects the joints – with particular reference to gout, a form of arthritis which is cause by an excess amount of uric acid in the bloodstream. What can you tell us about these disorders and how to treat them? Find out now!


Questions and Answers
  • 1. 
    drug that decreases uric acid levels both in blood and in urine.
    • A. 

      Acetaminophen

    • B. 

      Allopurinol

    • C. 

      Aspirin

    • D. 

      Auranofin

    • E. 

      Azathioprine

    • F. 

      Celecoxib

    • G. 

      Colchicine

    • H. 

      Hydroxychloroquine

    • I. 

      Indomethacin

    • J. 

      Ketorolac

    • K. 

      Mesalamine

    • L. 

      Naproxen

    • M. 

      Piroxicam

    • N. 

      Probenecid

  • 2. 
    An irreversible inhibitor of cyclooxygenase
    • A. 

      Acetaminophen

    • B. 

      Allopurinol

    • C. 

      Aspirin

    • D. 

      Auranofin

    • E. 

      Azathioprine

    • F. 

      Celecoxib

    • G. 

      Colchicine

    • H. 

      Hydroxychloroquine

    • I. 

      Indomethacin

    • J. 

      Ketorolac

    • K. 

      Mesalamine

    • L. 

      Naproxen

    • M. 

      Piroxicam

    • N. 

      Probenecid

  • 3. 
    An immunosuppressant drug used in the treatment of rheumatoid arthritis
    • A. 

      Acetaminophen

    • B. 

      Allopurinol

    • C. 

      Aspirin

    • D. 

      Auranofin

    • E. 

      Azathioprine

    • F. 

      Celecoxib

    • G. 

      Colchicine

    • H. 

      Hydroxychloroquine

    • I. 

      Indomethacin

    • J. 

      Ketorolac

    • K. 

      Mesalamine

    • L. 

      Naproxen

    • M. 

      Piroxicam

    • N. 

      Probenecid

  • 4. 
    An inhibitor of cell mitosis used in the gouty attack.
    • A. 

      Acetaminophen

    • B. 

      Allopurinol

    • C. 

      Aspirin

    • D. 

      Auranofin

    • E. 

      Azathioprine

    • F. 

      Celecoxib

    • G. 

      Colchicine

    • H. 

      Hydroxychloroquine

    • I. 

      Indomethacin

    • J. 

      Ketorolac

    • K. 

      Mesalamine

    • L. 

      Naproxen

    • M. 

      Piroxicam

    • N. 

      Probenecid

  • 5. 
    An antimalarial drug also used in the treatment of rheumatoid arthritis.
    • A. 

      Acetaminophen

    • B. 

      Allopurinol

    • C. 

      Aspirin

    • D. 

      Auranofin

    • E. 

      Azathioprine

    • F. 

      Celecoxib

    • G. 

      Colchicine

    • H. 

      Hydroxychloroquine

    • I. 

      Indomethacin

    • J. 

      Ketorolac

    • K. 

      Mesalamine

    • L. 

      Naproxen

    • M. 

      Piroxicam

    • N. 

      Probenecid

  • 6. 
    A salicylate derivative mainly used in inflammatory bowel disease.
    • A. 

      Acetaminophen

    • B. 

      Allopurinol

    • C. 

      Aspirin

    • D. 

      Auranofin

    • E. 

      Azathioprine

    • F. 

      Celecoxib

    • G. 

      Colchicine

    • H. 

      Hydroxychloroquine

    • I. 

      Indomethacin

    • J. 

      Ketorolac

    • K. 

      Mesalamine

    • L. 

      Naproxen

    • M. 

      Piroxicam

    • N. 

      Probenecid

  • 7. 
    A selective inhibitor of cyclooxygenase 2.
    • A. 

      Acetaminophen

    • B. 

      Allopurinol

    • C. 

      Aspirin

    • D. 

      Auranofin

    • E. 

      Azathioprine

    • F. 

      Celecoxib

    • G. 

      Colchicine

    • H. 

      Hydroxychloroquine

    • I. 

      Indomethacin

    • J. 

      Ketorolac

    • K. 

      Mesalamine

    • L. 

      Naproxen

    • M. 

      Piroxicam

    • N. 

      Probenecid

  • 8. 
    A gold compound used in the treatment rheumatoid arthritis.
    • A. 

      Acetaminophen

    • B. 

      Allopurinol

    • C. 

      Aspirin

    • D. 

      Auranofin

    • E. 

      Azathioprine

    • F. 

      Celecoxib

    • G. 

      Colchicine

    • H. 

      Hydroxychloroquine

    • I. 

      Indomethacin

    • J. 

      Ketorolac

    • K. 

      Mesalamine

    • L. 

      Naproxen

    • M. 

      Piroxicam

    • N. 

      Probenecid

  • 9. 
    Which of the following statements regarding NSAIDs drugs are correct? (Check all that apply)
    • A. 

      Individual drugs differ widely one from another in their potency

    • B. 

      Their antipyretic effectiveness is the highest in case of fever due to heat stroke

    • C. 

      Their analgesic effectiveness is the highest in case of visceral or ischemic pain

    • D. 

      They are generally contraindicated in thromboembolic disorders

    • E. 

      Their anti-inflammatory effect is most pronounced in the early phase of the inflammatory reaction

    • F. 

      Most drugs of this class are able to block prostaglandin receptors in the hypothalamus

  • 10. 
    Administration of NSAIDs will reduce mainly the biosynthesis of which if the following pairs of endogenous compounds?
    • A. 

      Thromboxanes and leukotrienes

    • B. 

      Prostaglandins and leukotrienes

    • C. 

      Prostacyclin and thromboxanes

    • D. 

      Prostaglandins and bradykinin

    • E. 

      Thromboxanes and bradykinin

  • 11. 
    Which of the following are pharmacological effects of toxic doses of salicylates?
    • A. 

      Depression of the respiratory center

    • B. 

      Hypothermia

    • C. 

      Stimulation of the chemoreceptor trigger zone

    • D. 

      Increased coagulability of blood

    • E. 

      Peripheral vasoconstriction

    • F. 

      A & C

    • G. 

      B & C

    • H. 

      A & E

  • 12. 
    Which of the following NSAIDs follows a zero order kinetics when given at intermediate to high doses?
    • A. 

      Acetylsalicylic acid

    • B. 

      Ibuprofen

    • C. 

      Mesalamine

    • D. 

      Indomethacin

    • E. 

      Salicylic acid

    • F. 

      Diflunisal

  • 13. 
    Which of the following disease states is a contraindication to salicylate therapy?
    • A. 

      Leukemias under methotrexate treatment

    • B. 

      Osteoarthritis

    • C. 

      Dysmenorrhea

    • D. 

      Previous cerebrovascular disorders

    • E. 

      Post-operative deep vein thrombosis

  • 14. 
    Which of the following statements best explains why aspirin, unlike other NSAIDs, causes an irreversible inhibition of prostaglandin biosynthesis?
    • A. 

      It acetylates the enzyme cyclooxygenase

    • B. 

      It competitively inhibits the enzyme cyclooxygenase

    • C. 

      It acetylates the enzyme phospholipase A2

    • D. 

      It irreversibly blocks the production of arachidonic acid

    • E. 

      It stimulates the breakdown of cyclooxygenase into inactive metabolites

  • 15. 
    Which of the following is a remission-inducing, disease-modifying antiarthritic drug that may stay in the body for months or even years after prolonged therapy?
    • A. 

      Hydroxychloroquine

    • B. 

      Methotrexate

    • C. 

      Azathioprine

    • D. 

      Auranofin

    • E. 

      Sulfasalazine

    • F. 

      Etanercept

  • 16. 
    The mother of a 17-month-old girl called the pediatrician because she found that the rectal temperature of her daughter was 39.5 C° (103.1 F°). After physical examination the pediatrician said that the fever was most likely due to a viral infection and prescribed ibuprofen, oral drops. Which of the following statements best explains the mechanism of the antipyretic effect of the drug in this patient?
    • A. 

      Binding of the drug to prostaglandin receptors in the hypothalamus

    • B. 

      Inhibition of phospholipase A2 in the hypothalamus

    • C. 

      Inhibition of release of interleukin-1 from tissue macrophages

    • D. 

      Decreased concentration of prostaglandins in the hypothalamus

    • E. 

      Inhibition of cyclooxygenase in peripheral tissues

  • 17. 
    A 42-year-old woman recently diagnosed with rheumatoid arthritis started a treatment with aspirin, but after three days of therapy she complained of severe abdominal pain. The physician discontinued aspirin and prescribed ibuprofen. The inhibition of which of the following enzymes best explains the antiinflammatory effect of this drug?
    • A. 

      Phospholipase A2

    • B. 

      Cyclooxygenase 1

    • C. 

      5-lipoxygenase

    • D. 

      Phospholipase C

    • E. 

      Cyclooxygenase 2

    • F. 

      12-lipoxygenase

  • 18. 
    A 34-year-old woman, who underwent conization 6 months ago for a fibroid of the cervix, has been suffering severe pain during menses. The physician prescribed ibuprofen, one tablet as needed. Which of the following statements best explains the reason of the analgesic effect of the drug in this patient?
    • A. 

      Binding of the drug to prostaglandin receptors in the myometrium

    • B. 

      Decreased production of prostaglandins by the endometrium

    • C. 

      Inhibition of prostaglandins biosynthesis in the hypothalamus

    • D. 

      Anti-inflammatory action of the drug in the pelvic area

    • E. 

      Decrease production of leukotrienes by the endometrium

  • 19. 
    A 56-year-old woman with sinusitis and nasal polyps was brought to the emergency room because of serious breathing difficulty. Two hours earlier she had taken a drug for headache. Physical examination showed a severe bronchospasm. Which of the following drugs most likely caused this adverse effect?
    • A. 

      Ergotamine

    • B. 

      Acetaminophen

    • C. 

      Acetylsalicylic acid

    • D. 

      Sumatriptan

    • E. 

      Cyproheptadine

  • 20. 
    A 10-year-old boy with acute rheumatic fever started a high dose salicylate treatment. One week later laboratory values indicated increased blood pH, decreased PCO2 and decreased plasma bicarbonate content. Which of the following acid-base disturbances was most likely caused by salicylate treatment?
    • A. 

      Respiratory acidosis

    • B. 

      Respiratory alkalosis

    • C. 

      Metabolic acidosis

    • D. 

      Metabolic alkalosis

    • E. 

      Mixed acidosis

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