Biochemistry - Glycolysis & Gluconeogensis Questions

13 Questions

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Biochemistry Quizzes & Trivia

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Questions and Answers
  • 1. 
    Which statement about glycolysis is correct
    • A. 

      The reaction pathway liberates 1400 kJ/mol of energy

    • B. 

      The pathway involves 10 reactions

    • C. 

      5 of the reactions in glycolysis are essentially irreversible

    • D. 

      The coenzyme NADPH is required in the pathway

    • E. 

      Involves the splitting of a 6 carbon compound into three 2 carbon compounds

  • 2. 
    In glycolysis, most reactions have G values around zero except: 
    • A. 

      Reactions 1, 3, 10

    • B. 

      Reactions 2, 4, 5

    • C. 

      Reactions 7 and 8

    • D. 

      Reactions 9 and 10

    • E. 

      Reaction 8 and 10

  • 3. 
    The catabolism of 4 mol of glucose into 8 mol of pyruvate via glycolysis yields: 
    • A. 

      1 mol of ATP and 4 mol of NADH

    • B. 

      2 mol of ATP and 1 mol of NADH

    • C. 

      8 mol of ATP and 8 mol of NADH

    • D. 

      32 mol of ATP and 2 mol of NADH

    • E. 

      None of the above

  • 4. 
    Following glycolysis, which of these molecules is NOT a possible fate of pyruvate catabolism?
    • A. 

      Glycogen

    • B. 

      CO2

    • C. 

      Ethanol

    • D. 

      Lactate

    • E. 

      Acetyl CoA

  • 5. 
    In glycolysis, the reaction(s) that produce(s) NADH is? 
    • A. 

      Reaction 5

    • B. 

      Reaction 6

    • C. 

      Reactions 5 & 6

    • D. 

      Reaction 9

    • E. 

      Reaction 7

  • 6. 
    In glycolysis, the two priming reactions (requiring ATP) are? 
    • A. 

      1 & 3

    • B. 

      7 & 10

    • C. 

      6 & 4

    • D. 

      7 & 9

    • E. 

      3 & 7

  • 7. 
    In comparison with the resting state, actively contracting human muscle tissue has a
    • A. 

      Higher concentrations of ATP

    • B. 

      Higher rate of lactate formation

    • C. 

      Lower consumption of glucose

    • D. 

      Lower rate of consumption of oxygen

    • E. 

      Lower ratio of NADH to NAD+

  • 8. 
    Which statement about the energy production and usage in glycolysis and gluconeogenesis is correct?  
    • A. 

      Glycolysis produces 2 ATP; gluconeogenesis requires 2 ATP

    • B. 

      Glycolysis produces 32 ATP; gluconeogenesis produces 2 ATP

    • C. 

      Glycolysis requires a net input of 2 ATP to run the final reaction (step 10); gluconeogenesis requires the net input of 6 ATP

    • D. 

      Glycolysis uses 2 ATP but produces 4 ATP. Gluconeogenesis requires 4 ATP and 2 GTP

    • E. 

      All enzymes in glycolysis and gluconeogenesis require energy in the form of ATP

  • 9. 
    The irreversible reactions of glycolysis are bypassed in gluconeogenesis using the following enzymes:
    • A. 

      Oxaloacetase, PFK-1, glycogen phosphorylase, debranching enzyme

    • B. 

      Phosphoglucomutase, branching enzyme, glycogen synthase

    • C. 

      PFK-1, Hexokinase, Aldolase

    • D. 

      Glucose 6-phosphatase; fructose 1,6 bisphosphatase; Pyruvate carboxylase; PEP carboxykinase

    • E. 

      NADH, FADH2, glucose, glycogen

  • 10. 
    Which enzyme does NOT catalyse an irreversible reaction in either glycolysis or gluconeogenesis?
    • A. 

      Hexokinase

    • B. 

      Glucose 6-phosphatase

    • C. 

      Pyruvate kinase

    • D. 

      Phosphofructokinase-1

    • E. 

      Enolase

  • 11. 
    State the stoichiometry of the glycolytic pathway, in relation to both ATP and NADH production. Describe the appropriate reactions in your answer. 
  • 12. 
    Describe the fates of pyruvate in both aerobic and anaerobic tissues. 
  • 13. 
    Explain the steps in the gluconeogenesis pathway which are not the reverse of reactions of the glycolysis pathway.