Biochemistry - Glycolysis & Gluconeogensis Questions
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- 1.Which statement about glycolysis is correct
- A.
The reaction pathway liberates 1400 kJ/mol of energy
- B.
The pathway involves 10 reactions
- C.
5 of the reactions in glycolysis are essentially irreversible
- D.
The coenzyme NADPH is required in the pathway
- E.
Involves the splitting of a 6 carbon compound into three 2 carbon compounds
- 2.In glycolysis, most reactions have G values around zero except:
- A.
Reactions 1, 3, 10
- B.
Reactions 2, 4, 5
- C.
Reactions 7 and 8
- D.
Reactions 9 and 10
- E.
Reaction 8 and 10
- 3.The catabolism of 4 mol of glucose into 8 mol of pyruvate via glycolysis yields:
- A.
1 mol of ATP and 4 mol of NADH
- B.
2 mol of ATP and 1 mol of NADH
- C.
8 mol of ATP and 8 mol of NADH
- D.
32 mol of ATP and 2 mol of NADH
- E.
None of the above
- 4.Following glycolysis, which of these molecules is NOT a possible fate of pyruvate catabolism?
- A.
Glycogen
- B.
CO2
- C.
Ethanol
- D.
Lactate
- E.
Acetyl CoA
- 5.In glycolysis, the reaction(s) that produce(s) NADH is?
- A.
Reaction 5
- B.
Reaction 6
- C.
Reactions 5 & 6
- D.
Reaction 9
- E.
Reaction 7
- 6.In glycolysis, the two priming reactions (requiring ATP) are?
- A.
1 & 3
- B.
7 & 10
- C.
6 & 4
- D.
7 & 9
- E.
3 & 7
- 7.In comparison with the resting state, actively contracting human muscle tissue has a
- A.
Higher concentrations of ATP
- B.
Higher rate of lactate formation
- C.
Lower consumption of glucose
- D.
Lower rate of consumption of oxygen
- E.
Lower ratio of NADH to NAD+
- 8.Which statement about the energy production and usage in glycolysis and gluconeogenesis is correct?
- A.
Glycolysis produces 2 ATP; gluconeogenesis requires 2 ATP
- B.
Glycolysis produces 32 ATP; gluconeogenesis produces 2 ATP
- C.
Glycolysis requires a net input of 2 ATP to run the final reaction (step 10); gluconeogenesis requires the net input of 6 ATP
- D.
Glycolysis uses 2 ATP but produces 4 ATP. Gluconeogenesis requires 4 ATP and 2 GTP
- E.
All enzymes in glycolysis and gluconeogenesis require energy in the form of ATP
- 9.The irreversible reactions of glycolysis are bypassed in gluconeogenesis using the following enzymes:
- A.
Oxaloacetase, PFK-1, glycogen phosphorylase, debranching enzyme
- B.
Phosphoglucomutase, branching enzyme, glycogen synthase
- C.
PFK-1, Hexokinase, Aldolase
- D.
Glucose 6-phosphatase; fructose 1,6 bisphosphatase; Pyruvate carboxylase; PEP carboxykinase
- E.
NADH, FADH2, glucose, glycogen
- 10.Which enzyme does NOT catalyse an irreversible reaction in either glycolysis or gluconeogenesis?
- A.
Hexokinase
- B.
Glucose 6-phosphatase
- C.
Pyruvate kinase
- D.
Phosphofructokinase-1
- E.
Enolase
- 11.State the stoichiometry of the glycolytic pathway, in relation to both ATP and NADH production. Describe the appropriate reactions in your answer.
- 12.Describe the fates of pyruvate in both aerobic and anaerobic tissues.
- 13.Explain the steps in the gluconeogenesis pathway which are not the reverse of reactions of the glycolysis pathway.
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