Bio1332 Biochemistry - Lecture Eight - Protein Folding And Stability

9 Questions | Total Attempts: 101

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Bio1332 Biochemistry - Lecture Eight - Protein Folding And Stability

Understand the physical basis of the various forces that hold proteins together. Understand that protein structure is determined by primary sequence. Understand that the folded native conformation is the most energetically favourable. Appreciate that protein folding is a directed process and conformations are not just cycled through until the best one is found.


Questions and Answers
  • 1. 
    Complete the following sentence:Interaction with solvent plays a major role in protein folding. Contact with solvent is _________ in a protein's unfolded state.
  • 2. 
    Which of the following is true?
    • A. 

      Most proteins are only stable between pH 5.0 and pH 9.0

    • B. 

      Most proteins are only stable at approx neutral pH 7.0

    • C. 

      Most proteins are only stable between pH 2.0 and pH 12.0

    • D. 

      Most proteins are only stable between pH 6.0 and pH 8.0

  • 3. 
    Complete the following sentence:Hydrophobic atoms have a _____ group.
  • 4. 
    Complete the following sentence:Electrostatic interaction only occurs on amino acids that have a ________ charge on their side chain.
  • 5. 
    Complete the following sentence:Van der Waals interactions are non-covalent interactions between electrically ______ molecules.
  • 6. 
    True or False?Van der Waals interactions are much weaker than ionic reactions.
    • A. 

      True

    • B. 

      False

  • 7. 
    Which of the following is true?Hydrogen bonds are...
    • A. 

      Electrostatic interactions between a weak acidic donor group and an acceptor atom

    • B. 

      Electrostatic interactions between a strong acidic donor group and an acceptor atom

    • C. 

      Electrostatic interactions between a weak alkaline donor group and an acceptor atom

    • D. 

      Electrostatic interactions between a strong alkaline donor group and an acceptor atom

  • 8. 
    Disulfide bonds are #_____# bonds between two #______# molecules in a protein chain when they approach each other in the 3D folded structure.
  • 9. 
    Complete the following sentence:Correct protein folding is helped in the cell by other proteins called _________.
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