Antibacterial Agents Quiz

35 Questions | By Rita.niyigena | Last updated: Sep 24, 2018 | Total Attempts: 1662

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An antimicrobial is an agent that interferes with the growth and reproduction of bacteria. They may either kill or inhibit the growth of bacteria. There are different types of these drugs in use and a nurse should know when to prescribe each. Take up the quiz below and learn more on them.

Questions and Answers

1.

The folowing are narrow spectrum penicillins, except:
- A.
  
  Penicillin G
- B.
  
  Penicillin V
- C.
  
  Benzathine penicillin
- D.
  
  Ampicillin
- E.
  
  Procaine Penicillin
2.

All the following describe Penicillin G's general properties except:
- A.
  
  Highest G+ coverage
- B.
  
  High antipseudomonal activity
- C.
  
  Eliminated through filtration
- D.
  
  Some G- coverage
- E.
  
  B-lactamase sensitive
3.

Penicillin G works against:
- A.
  
  G+ cocci
- B.
  
  G- cocci
- C.
  
  G+ bacilli
- D.
  
  Treponema Pallidum
- E.
  
  All of the above
4.

What are the known side effects of Pen. G?
- A.
  
  Hypersensitivity
- B.
  
  Diarrhea
- C.
  
  A and B
- D.
  
  This test is killing me
- E.
  
  I can't wait till i'm done with it tomorrow
5.

Which Pen. is only available in oral form?
- A.
  
  Pen. G
- B.
  
  Pen. V
- C.
  
  Pen. C
- D.
  
  Pen. H
- E.
  
  Pen. B
6.

What three antimicrobial agents are designated antistaphylococcal penicillins?
- A.
  
  Nafcillin
- B.
  
  Ampicillin
- C.
  
  Cloxacillin
- D.
  
  Oxacillin
- E.
  
  A, C, and D
7.

What major properties do penicillinase resistant antibiotics have?
- A.
  
  Lower G+ activity, and some G- coverage
- B.
  
  Some anaerobe coverage
- C.
  
  Some are acid stable (oxacillin)
- D.
  
  Hepatic metabolism and renal excretion
- E.
  
  All of the above
8.

Name the two mos popular extended spectrum penicillins
- A.
  
  Nafcillin and Ampicillin
- B.
  
  Amoxicillin and Methicillin
- C.
  
  Ampicillin and Amoxicillin
- D.
  
  Cloxacillin and Oxacillin
- E.
  
  None of the above
9.

Ampicillin rash is not a hypersensitivity reaction in children or patients with EBV infection.
- A.
  
  False
- B.
  
  True
10.

Augmentin...
- A.
  
  Is only administered parenterally
- B.
  
  Is obtained when Amoxicillin is combined with sulbactam
- C.
  
  Can treat B-lactamase-producing organisms due to clavulanic acid
- D.
  
  Should not be offered to patients with a previous history of seizures
- E.
  
  All of the above
11.

Which of the following is not characteristic of antipseudomonal penicillins?
- A.
  
  Comprised of Ticarcillin and Piperacillin
- B.
  
  Extended spectrum plus enteric G- bacilli
- C.
  
  Acid resistant (can be administered orally)
- D.
  
  Renal excretion
- E.
  
  Susceptible to B-lactam
12.

By what means bacteria build resistance against antipseudomonaal penicillins?
- A.
  
  Inactivation ( destruction by b-lactamase)
- B.
  
  Decreased permeability of bact. cell wall or lack of cell wall
- C.
  
  Alteration in PBP's to hinder penicillin binding
- D.
  
  Inactivation of autolytic enzymes
- E.
  
  All of the above
13.

What is the single best answer for penicillin toxicity?
- A.
  
  Allergy-anaphylactic shock (give Epinephrine)
- B.
  
  Electrolyte imbalance
- C.
  
  GI dsturbances
- D.
  
  Superinfections
- E.
  
  All of the above
14.

Cephalosporins attack bacteria by blocking terminal cross-linking of peptidoglycans and by activating cell wall autolytic enzymes.
- A.
  
  True
- B.
  
  False
15.

Which best describes the general properties of 1st generation cephalosporins?
- A.
  
  Good G+ coverage and moderate G- activity
- B.
  
  No antipseudomonal activity
- C.
  
  Renal excretion
- D.
  
  Acid resistance-orally given
- E.
  
  All of the above are true
16.

Second generation Cephalosporins do not:
- A.
  
  Have lower G+ activity
- B.
  
  Have higher G- activity
- C.
  
  Lack antipseudomonal activity and are acid sensitive
- D.
  
  Have B-lactamase resistance and are excreted by the kidney
- E.
  
  Include Cephaclor and Cefprozil
17.

Third generation cephalosporins are:
- A.
  
  Metabolized by the liver and excreted by the kidney
- B.
  
  Have good CNS penetration (cefoperazone, cefotaxime)
- C.
  
  Are very effective against G-, less effective against G+, and have antipseudomonal activity (few)
- D.
  
  Acid resistant and increased B-lactamase resistance
- E.
  
  All of the above
18.

Cefepime...
- A.
  
  Is the only 4th generation cephalosporin
- B.
  
  Is more resistant to B-lactamase and can only be given parenterally
- C.
  
  Has antipseudomonal activity and has better G+ coverage
- D.
  
  Is excreted renally
- E.
  
  All of the above
19.

How toxic are cephalosporins in general?
- A.
  
  They're fairly safer than penicillins
- B.
  
  Still cause superinfections
- C.
  
  Can cause dose-dependend renal tubular necrosis
- D.
  
  Synergistic nephrotoxicity with aminoglycosides
- E.
  
  All of the above
20.

Monobactams...
- A.
  
  Are resistant to B-lactamases
- B.
  
  Have no activity agains G+ and anaerobes
- C.
  
  Acid sensitive (IM/IV only)
- D.
  
  No cross-sensitivity with other b-lactam antibiotics
- E.
  
  All of the above
21.

Carbapenems
- A.
  
  Are Imipenem and Meropenem
- B.
  
  Given IV only
- C.
  
  Broad spectrum activity but pseudomonal resistance may develop (combination with aminoglycosides is recommended)
- D.
  
  Imipenem can cause seizures
- E.
  
  All of the above
22.

Vancomycin
- A.
  
  Prevents peptidoglycan elongation and is bactericidal
- B.
  
  Is very useful against penicillin/methicillin-resistant S. aureus
- C.
  
  VRE are usually resistant to all other antibiotics (drug of last resort)
- D.
  
  Adverse effects are ototoxicity, nephrotoxicity, and red man syndrome (flushing from histamine release)
- E.
  
  All of the above
23.

Bacitracin...
- A.
  
  Inhibits transmembrane transport of the peptidoglycan subunits
- B.
  
  Is a cyclic polypeptide
- C.
  
  Is used topically due to nephrotoxicity
- D.
  
  A, B, and C are correct
- E.
  
  All of the above are incorrect
24.

Cycloserine...
- A.
  
  Is a broad-spectrum antibiotic
- B.
  
  Inhibits attachment of peptide side chain to the peptidoglycan
- C.
  
  Used only to treat TB (second line)
- D.
  
  All of the above
- E.
  
  None of the above
25.

Macrolides and aminoglycosides are generally known as...
- A.
  
  Cell wall formatio inhibitors
- B.
  
  Inhibitors of cell membrane permeability
- C.
  
  Inhibitors of protein synthesis
- D.
  
  Broad-spectrum
- E.
  
  Penicillins are among them