Antibacterial Agents Quiz

Penicillin G

Penicillin V

Benzathine penicillin

Ampicillin

Procaine Penicillin

Highest G+ coverage

High antipseudomonal activity

Eliminated through filtration

Some G- coverage

B-lactamase sensitive

G+ cocci

G- cocci

G+ bacilli

Treponema Pallidum

All of the above

Hypersensitivity

Diarrhea

A and B

This test is killing me

I can't wait till i'm done with it tomorrow

Pen. G

Pen. V

Pen. C

Pen. H

Pen. B

Nafcillin

Ampicillin

Cloxacillin

Oxacillin

A, C, and D

Lower G+ activity, and some G- coverage

Some anaerobe coverage

Some are acid stable (oxacillin)

Hepatic metabolism and renal excretion

All of the above

Nafcillin and Ampicillin

Amoxicillin and Methicillin

Ampicillin and Amoxicillin

Cloxacillin and Oxacillin

None of the above

False

True

Is only administered parenterally

Is obtained when Amoxicillin is combined with sulbactam

Can treat B-lactamase-producing organisms due to clavulanic acid

Should not be offered to patients with a previous history of seizures

All of the above

Comprised of Ticarcillin and Piperacillin

Extended spectrum plus enteric G- bacilli

Acid resistant (can be administered orally)

Renal excretion

Susceptible to B-lactam

Inactivation ( destruction by b-lactamase)

Decreased permeability of bact. cell wall or lack of cell wall

Alteration in PBP's to hinder penicillin binding

Inactivation of autolytic enzymes

All of the above

Allergy-anaphylactic shock (give Epinephrine)

Electrolyte imbalance

GI dsturbances

Superinfections

All of the above

True

False

Good G+ coverage and moderate G- activity

No antipseudomonal activity

Renal excretion

Acid resistance-orally given

All of the above are true

Have lower G+ activity

Have higher G- activity

Lack antipseudomonal activity and are acid sensitive

Have B-lactamase resistance and are excreted by the kidney

Include Cephaclor and Cefprozil

Metabolized by the liver and excreted by the kidney

Have good CNS penetration (cefoperazone, cefotaxime)

Are very effective against G-, less effective against G+, and have antipseudomonal activity (few)

Acid resistant and increased B-lactamase resistance

All of the above

Is the only 4th generation cephalosporin

Is more resistant to B-lactamase and can only be given parenterally

Has antipseudomonal activity and has better G+ coverage

Is excreted renally

All of the above

They're fairly safer than penicillins

Still cause superinfections

Can cause dose-dependend renal tubular necrosis

Synergistic nephrotoxicity with aminoglycosides

All of the above

Are resistant to B-lactamases

Have no activity agains G+ and anaerobes

Acid sensitive (IM/IV only)

No cross-sensitivity with other b-lactam antibiotics

All of the above

Are Imipenem and Meropenem

Given IV only

Broad spectrum activity but pseudomonal resistance may develop (combination with aminoglycosides is recommended)

Imipenem can cause seizures

All of the above

Prevents peptidoglycan elongation and is bactericidal

Is very useful against penicillin/methicillin-resistant S. aureus

VRE are usually resistant to all other antibiotics (drug of last resort)

Adverse effects are ototoxicity, nephrotoxicity, and red man syndrome (flushing from histamine release)

All of the above

Inhibits transmembrane transport of the peptidoglycan subunits

Is a cyclic polypeptide

Is used topically due to nephrotoxicity

A, B, and C are correct

All of the above are incorrect

Is a broad-spectrum antibiotic

Inhibits attachment of peptide side chain to the peptidoglycan

Used only to treat TB (second line)

All of the above

None of the above

Cell wall formatio inhibitors

Inhibitors of cell membrane permeability

Inhibitors of protein synthesis

Broad-spectrum

Penicillins are among them

Bind the 50S subunit irreversibly

Effective againt lots of G+, but majority of G- is resistant to it

All are taken orally

All except Azithromycin are eliminated by bile and through feces

All of the above

Powerless agains many G- bacteria

The DOC for treatment of Legionnaire's disease and M. pneumoniae

All of the above are correct

Reversibly binds 50S ribosomal subunit and is metabolized by the liver

Against a wide range of G+ aerobics and anaerobic G+ and G-

Bactericidal or bacteriostatic and can cross the placenta readily

Can be given in any way but exhibits poor CNS penetration

All of the above

Streptomycin, gentamycin, tobramycin, amikacin, and neomycin

Bind 30 S subunit

Poor cns penetration (except in case of inflammation) and should be given parenterally

Rapidly excreted by the kidney

All of the above

Reversibly binds 50S subunit and is bacteriostatic

Broad spectrum and rapid absorption after oral consumption

Best CNS penetration and effective against anaerobes

Liver metabolism, renal excretion

All of the above

Bind reversibly to 30S

Bacteriostatic in therapeutic concentrations

Deposited in bones/teeth (Fe2+)

Used to treat severe acne (topical/oral administration)

All of the above

Compete with PABA in folate synthesis

Generally bacteriostatic

Oral absorption

Liver metabolism and renal excretion

All of the above

Fluoroquinolones (ciprofloxacin, ofloxacin, moxifloxacin)

Bactericidal/inhibition of DNA gyrase

Effective against G- aerobic cocci and antipseudomonal

Prophylaxis against antrax, oral, excellent tissue penetration

All of the above

Mechanism not understood

Bactericidal (ROS)

Effective against anaerobes

Disulfiram-like effect

All of the above

Standard prophylaxis-amoxicillin

Allergic to penicillins-ampicillins

Unable to take orally-ampicillin

Allergic to penicillin and can't swallow pills-cindamycin/cefazolin

Allergic to penicillin-clindamycin/cephalexin/azithromycin