Acetyl Coa & Tca Cycle

14 Questions | By Iyanna.peppers | Last updated: Mar 21, 2022 | Total Attempts: 218

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1.

Pyruvate dehydrogenase complex catalyzes the:
- A.
  
  Oxidative decarboxylation of pyruvate to CO₂ and acetyl CoA
- B.
  
  Citrate to isocitrate reaction
- C.
  
  Addition of a carboxylic acid to pyruvate, forming oxaloacetate
- D.
  
  Formation of fumarate and FADH2 from succinate
2.

1 mole of pyruvate to acetyl-CoA yields ___ mole(s) of NADH.
- A.
  
  1
- B.
  
  2
- C.
  
  4
- D.
  
  3
3.

Which cofactors of the pyruvate dehydrogenase reaction are permanently bound?
- A.
  
  Thiamine pyrophosphate
- B.
  
  Lipoamide
- C.
  
  Flavin adenine dinucleotide
- D.
  
  Nicotinamide adenine dinucleotide
- E.
  
  Coenzyme A
4.

Which pyruvate dehydrogenase cofactors are acyl group carriers?
- A.
  
  Coenzyme A
- B.
  
  Lipoamide
- C.
  
  FAD
- D.
  
  NAD+
- E.
  
  TPP
5.

Molecules with ____, such as dihydrolipoamide, are targets for covalent modification by arsenite.
- A.
  
  Proximal thiols
- B.
  
  Distal thiols
- C.
  
  Proximal hydroxyls
- D.
  
  Distal hydroxyls
6.

______ is complex II of the mitochondrial electron transport chain.
- A.
  
  Succinate dehydrogenase
- B.
  
  Malate dehydrogenase
- C.
  
  α-ketoglutarate dehydrogenase
- D.
  
  Aconitase
7.

____ and _____ inhibit key steps of the TCA cycle.
- A.
  
  ATP; NADH
- B.
  
  NAD⁺; ADP
- C.
  
  Succinyl CoA; ADP
- D.
  
  ATP: NAD⁺
8.

Which PRODUCTS are not formed when there is an excess of ATP and NADH?
- A.
  
  Acetyl CoA
- B.
  
  α-ketoglutarate
- C.
  
  Succinyl-CoA
- D.
  
  Isocitrate
- E.
  
  Pyruvate
9.

Catabolic action yields:
- A.
  
  High energy metabolites
- B.
  
  New material (ie, amino acids, porphyrins)
10.

The TCA cycle is considered to be anapleurotic. This describes:
- A.
  
  That there are multiple points around the cycle where reactants feed in.
- B.
  
  The circular, regenerative nature of the TCA cycle.
- C.
  
  That malate is the only TCA cycle product that can be shunted through the mitochondrial membrane.
- D.
  
  That the TCA cycle is reversible when needed.

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