.
Oxidative decarboxylation of pyruvate to CO2 and acetyl CoA
Citrate to isocitrate reaction
Addition of a carboxylic acid to pyruvate, forming oxaloacetate
Formation of fumarate and FADH2 from succinate
1
2
4
3
Thiamine pyrophosphate
Lipoamide
Flavin adenine dinucleotide
Nicotinamide adenine dinucleotide
Coenzyme A
Coenzyme A
Lipoamide
FAD
NAD+
TPP
Proximal thiols
Distal thiols
Proximal hydroxyls
Distal hydroxyls
Succinate dehydrogenase
Malate dehydrogenase
α-ketoglutarate dehydrogenase
Aconitase
ATP; NADH
NAD+; ADP
Succinyl CoA; ADP
ATP: NAD+
Acetyl CoA
α-ketoglutarate
Succinyl-CoA
Isocitrate
Pyruvate
High energy metabolites
New material (ie, amino acids, porphyrins)
That there are multiple points around the cycle where reactants feed in.
The circular, regenerative nature of the TCA cycle.
That malate is the only TCA cycle product that can be shunted through the mitochondrial membrane.
That the TCA cycle is reversible when needed.