Alzheimer's Pharmacology (Hoyt)

1. Rivastigmine (Exelon), an cholinesterase inhibitor used in AD, has a greater potency for one of the two isoforms of AChE in the brain because with AD progression, there is preferential loss of one of the isoforms and thus the drug targets the one that IS remaining. Which isoform does rivastigmine (Exelon) target?

2. Memantine (Namenda) is a ______ antagonist at the NMDA receptor which is a channel of ____ and ____ ions.

3. Which of the following enzymes are important in choline signaling that is considerably reduced in the development of AD? (Check TWO that apply)

4. Which of the cholinesterase inhibitors used in AD is also a positive allosteric modulator of nicotinic acetylcholine receptors to synergistically increase the [acetylcholine] in the synapse?

5. The pathogenesis of AD is associated with loss of brain tissue and neurons in which areas of the brain? (Check all that apply)