Pd Pharmacology (Hoyt)

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  • 1/13 Questions

    Dopamine is synthesized from the amino acid precursor _____ in the ____ of the brain.

    • Tyrosine; striatum
    • Tyrosine; substantia nigra
    • Tyrosine; basal ganglia
    • Tryptophan; striatum
    • Tryptophan; substantia nigra
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About This Quiz

Parkinson's Disease Pharmacology (HOYT)

Pharmacology Quizzes & Trivia

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  • 2. 

    Dopamine normally inhibits inhibitory GABA neurons in the striatum. It does this predominantly due to the activation of which dopamine receptor?

    • D1

    • D2

    • D3

    • D4

    • D5

    Correct Answer
    A. D2
    Explanation
    P128

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  • 3. 

    Which form of Parkinson's disease is more prevalent or common?

    • Primary Parkinson's disease

    • Secondary Parkinson's disease

    • Both forms have similar prevalence

    Correct Answer
    A. Primary Parkinson's disease
    Explanation
    P125

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  • 4. 
    What is the same of the enzyme that converts tyrosine to DOPA? - ProProfs

    What is the same of the enzyme that converts tyrosine to DOPA?

    • Dopamine-beta hydroxylase

    • DOPA decarboxylase

    • Aromatic amino acid decarboxylase

    • Tyrosine hydroxylase

    • None of the above

    Correct Answer
    A. Tyrosine hydroxylase
    Explanation
    P127

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  • 5. 

    Which of the following are observed in Parkinson's disease patients, postmortem?

    • Almost complete loss of dopamine neurons from substantia nigra and the striatum

    • Neuronal degeneration and depigmentation

    • Appearance of intracellular inclusions called Lewy bodies in dopamine neurons

    • Two of the above

    • All of the above

    Correct Answer
    A. All of the above
    Explanation
    P124

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  • 6. 

    PDDrug treatment of Parkinson's disease include all of the following strategies EXCEPT:

    • Remove GABA

    • Replace dopamine

    • Mimic action of dopamine

    • Increase release of dopamine/inhibit NMDA receptor

    • Antagonize acetylcholine

    Correct Answer
    A. Remove GABA
    Explanation
    P129

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  • 7. 

    The D1 type (D1 and D5) of dopamine receptors are generally _____ and ____ levels of cAMP.

    • Inhibitory; increase

    • Inhibitory; decrease

    • Excitatory; increase

    • Excitatory; decrease

    Correct Answer
    A. Excitatory; increase
    Explanation
    P126

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  • 8. 

    Which of the following is NOT a cause for secondary Parkinson's disease?

    • Drug side effects (e.g. antipsychotics and reserpine)

    • Viral infections (encephalitis lethargica)

    • Myocardial infarction

    • Stroke

    • Repetitive head trauma

    Correct Answer
    A. Myocardial infarction
    Explanation
    P126

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  • 9. 

    When symptoms resembling Parkinson's disease is induced in experimental animals, their bodies have similar compensatory responses to the depletion of dopamine as humans do. Which of the following is NOT a compensatory mechanism?

    • Hyperactivity of the remaining dopaminergic neurons

    • Increased rate of transmitter turnover

    • Increase in the number of dopamine receptors - "Denervation hypersensitivity"

    • Two of the above

    • None of the above, these are all compensatory mechanisms

    Correct Answer
    A. None of the above, these are all compensatory mechanisms
  • 10. 

    The pathogenesis of Parkinson's disease results from the loss of dopaminergic input to which of the following structures?

    • Frontal cortex

    • Basal ganglia

    • Nucleus accumbens

    • Substantia nigra

    • Striatum

    Correct Answer
    A. Basal ganglia
    Explanation
    P124

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  • 11. 

    Inhibitory D2 type (D2, D3, and D4) receptors inhibit adenylyl cyclase, reducing cAMP. What are two other mechanism in which these D2 type receptor inhibit neuronal activity? Check TWO that apply.

    • Inhibition of potassium channels

    • Activation of potassium channels

    • Inhibition of voltage-sensitive calcium channels

    • Activation of voltage-sensitive calcium channels

    • Activation of sodium channels

    Correct Answer(s)
    A. Activation of potassium channels
    A. Inhibition of voltage-sensitive calcium channels
    Explanation
    P126

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  • 12. 

    Dopamine receptors are categorized into two types: D1 and D2. Which of the following are included in the D1 classification? Check ALL that apply.

    • D1

    • D2

    • D3

    • D4

    • D5

    Correct Answer(s)
    A. D1
    A. D5
  • 13. 

    True or False: Dopaminergic neuron degeneration causes a decrease in inhibitory [dopamine] as well as an increase in excitatory [acetylcholine], causing an imbalance of neurotransmission in the basal ganglia.

    • True

    • False

    Correct Answer
    A. False
    Explanation
    P128 -- the imbalance occurs, but ACh is relatively UNAFFECTED. It's just [DA] that decreases.

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Quiz Review Timeline (Updated): Jan 11, 2013 +

Our quizzes are rigorously reviewed, monitored and continuously updated by our expert board to maintain accuracy, relevance, and timeliness.

  • Current Version
  • Jan 11, 2013
    Quiz Edited by
    ProProfs Editorial Team
  • Mar 30, 2010
    Quiz Created by
    Teatimebarbie
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