Pharmparty Quiz

14 Questions

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Chemistry Quizzes & Trivia

Literally, a pharmparty is a situation in which we have random exchange in prescription drugs to be toxicated. This quiz however, dwells more on the different aspects of drugs and chemical components.


Questions and Answers
  • 1. 
    Ion-trapping in the kidney
    • A. 

      Weak acids are usually excreted slower in alkaline urine

    • B. 

      Weak bases are usually excreted faster in acidic urine

    • C. 

      Both

    • D. 

      Neither

  • 2. 
    • A. 

      More of the weak acid drug will be in the lipid-soluble form at alkaline pH.

    • B. 

      More of the weak acid drug will be in the lipid soluble form at acid pH.

    • C. 

      More of the weak base drug will be in the lipid soluble form at alkaline pH

    • D. 

      A & C

    • E. 

      B & C

  • 3. 
    Dramatic decrease in systemic availability of a drug following oral administration is most likely due to:
    • A. 

      Extreme drug instability at stomach pH

    • B. 

      Hepatic "first-pass" effect

    • C. 

      drug metabolized by gut flora

    • D. 

      tablet does not dissolve

    • E. 

      Patient non-complance

  • 4. 
    Increasing ionization at pH ABOVE pKa:
    • A. 

      Weak acid

    • B. 

      Weak base

  • 5. 
    Weak organic acid, pKa 6.5. Percent ionization at pH 7.5
    • A. 

      1%

    • B. 

      10%

    • C. 

      50%

    • D. 

      90%

    • E. 

      99%

  • 6. 
    Drug with this ionization property most likely to diffuse from intestine (pH 8.4) to blood (pH 7.4)
    • A. 

      Weak acid (pKa 7.4)

    • B. 

      weak base (pKa 8.4)

    • C. 

      Weak acid (pKa 8.4)

    • D. 

      Weak base (pKa 6.4)

    • E. 

      Weak acid (pKa 6.4)

  • 7. 
    Weak base at alkaline pH
    • A. 

      Relatively lipid-soluble

    • B. 

      Probably uncharged

    • C. 

      Both

    • D. 

      Neither

  • 8. 
    Factor(s) which may change intrinsic drug clearance:
    • A. 

      Smoking

    • B. 

      Dietary consideration

    • C. 

      Age

    • D. 

      Genetics

    • E. 

      All of the above

  • 9. 
    Factor(s) influencing the volume of distribution:
    • A. 

      Patient's gender

    • B. 

      Patient's age

    • C. 

      Patient's disease state

    • D. 

      Patient's body composition

    • E. 

      All of the above

  • 10. 
    Property/properties of phase II conjugates
    • A. 

      Don't pick me, I am wrong (FREEEBIE!!!)

    • B. 

      Relatively nonpolar

    • C. 

      Generally biologically active

    • D. 

      Rapidly excreted in the urine

    • E. 

      All of the above

  • 11. 
    Most important organ for unchanged drug/drug metabolite elimination
    • A. 

      Liver

    • B. 

      Lung

    • C. 

      Kidney

    • D. 

      None of the above

    • E. 

      All of the above

  • 12. 
    Absorption rate proportional to the drug concentration dissolved in the gastrointestinal tract
    • A. 

      Zero order

    • B. 

      First order

    • C. 

      Neither

    • D. 

      Both

    • E. 

      All of the above

  • 13. 
    Drug mechanism/mechanisms which may increase the amount of cytochrome P450 enzyme
    • A. 

      Increase enzyme degradation rate

    • B. 

      Increase enzyme synthesis rate

    • C. 

      Both

    • D. 

      Neither

    • E. 

      All of the above

  • 14. 
    Parent drug is altered by introducing or exposing a functional group such as -OH or NH2
    • A. 

      Phase 1

    • B. 

      Phase 2