A practice test on anaesthesia trivia quiz! There are different types of drugs given to a patient so that they can be unconscious or some parts of their body made numb of feeling. In some instances, not drugs but gasses are used. As an aspiring anaesthetic, how much do you know about different benzodiazepines, their effect as well as consumption in different types of patients? This quiz will help you find out!
Sedation
Anxiolysis
Retrograde Amnesia
Anticonvulsant
Spinal Cord mediated skeletal muscle relaxation
Lorazepam- due to lower lipid solubility
Midazolam- due to its water solubility
Diazepam- due to rapid redistribution
Lorazepam
Diazepam
Midazolam
Thiopental
Significant increase in initial dose and anticipate marked decrease in duration of action
Modest decrease in initial dose and anticipate marked increase in duration of action
No change in dose or frequency or duration from that of an healthy 25 year old patient.
None of above
True
False
Shortened
Prolonged
No significant change.
Inhibit or block responses caused by an agonist
Drugs which alter the physiology of a cell by binding to plasma membrane or intracellular receptors
The strength of binding between drug and receptor
Binds to a site other than the agonist-binding domain
Antagonist
Competitive Agonist
Competitive Antagonist
Agonist
Inhibit or block responses caused by an agonist
A drug which alters the physiology of a cell by binding to plasma membrane or intracellular receptors
Biochemical messengers, often called 2ndmessengers
The strength of binding between drug and receptor
Blockade of chloride channels leading to depolarization and inhibition of neurotransmitter
Inhibition of cyclooxygenase activity
Inhibition of GABA receptor binding which leads to degredation of GABA, preventing it from exerting it's effect.
Enhances the inhibitory effects of various neurotransmitter by facilitating GABA receptor binding. This opens chloride channels and causes hyperpolarization.
Midazolam has 2 times the affinity for benzo receptors
Diazepam has 3 times the affinity for benzo receptors
Diazepam is hydrophilic
Midazolam has a much londer elimination half time
All are highly alkaline solutions
Composed of a benzene ring fused to a seven-membered diazepine ring
They are safe to be given during pregnancy
Composed of malonic acid and urea
It is the only benzo safe to give to pregnant women.
Is known to cause pain upon injection, but has minimal respiratory depression
It is hydrophilic and becomes lipid soluble upon exposure to blood.
It is not highly protein bound like the other benzo's and thus more is available for use by the body.
Lorazepam
Flumazenil
Midazolam
Diazepam
0.5 mg/kg
1 mg/kg
2-3 mg
10 - 20 mcg/ kg
0.5 mg/kg
0.1 mg/kg
2-3 mg
4 mg/kg
3-5 minutes
20-25 minutes
30-60 seconds
2 minutes
You would need to increase the amount given in order to reach the desired effect
You would not change the dose at all.
You would decrease the amount of drug given since this pt may be at risk for overdose.
Midazolam < Diazepam < Lorazepam
Diazepam < Lorazepam < Midazolam
Lorazepam < Midazolam < Diazepam
Midazolam < Lorazepam < Diazepam
21-37 hours
1-4 hours
10-20 hours
5-10 hours
1-4 hours
21-37 hours
10-20 hours
5-10 hours
5-10 hours
1-4 hours
10-20 hours
21-37 hours
Metabolized by liver and excreted in the urine
Metabolized in kidneys and excreted in feces
Metabolized by liver and excreted in feces
Metabolized in kidneys and excreted by urine
No effect on cardiovascular system, even at high doses.
Decrease BP & PVR, especially in hypovolemic pt
Decrease ABP, CO & HR
Increase HR and decrease SV
True
False
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