Schizophrenia- Disorder And Treatment
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Pharmaco-Therapeutics Quiz for Schizophrenia
- 1.A patient MZ has recently been diagnosed with schizophrenia. His doctor wants to start him on a second generation antipsychotic that can be taken orally, but later switched over to an IV or IM formulation that is LONG ACTING, since MZ has had a history of non-compliance. The doc can't remember what options he has... you tell him:
- A.
Geodon
- B.
Zyprexa
- C.
Risperdal
- D.
Haldol
- E.
All of the above
- 2.The two SGA's listed with the HIGHEST tendency to cause QT prolongation as a side effect are:
- A.
Iloperidone and Ziprasidone
- B.
Aripiprazole and Ziprasidone
- C.
Aripiprazole and Thioridizine
- D.
Iloperidone and Thioridizine
- E.
Thioridizine and Ziprasidone
- 3.Which of the following are a BLACK BOX warning for clozapine
- A.
Agranulocytosis
- B.
Myocarditis
- C.
Respiratory Depression
- D.
A and C
- E.
All of the above
- 4.A patient is taking clozapine for over a month at a dose of 200mg per day. WBC is being monitored weekly and today the patients WBC count is at 2550/mm^3. You suggest:
- A.
Keep the patient going on the medication; the drop in WBC is expected
- B.
Perform twice weekly WBC counts now
- C.
Stop therapy until WBC counts go back above 3000 with no signs of infection
- D.
A and B
- E.
B and C
- 5.Which of the following are positive symptoms of schizophrenia?
- A.
Hallucinations
- B.
Anhedonia
- C.
Poor hygeine/grooming
- D.
Alogia
- E.
None of the above
- 6.Choose the INCORRECT pair of EPS and its treatment:
- A.
Acute dystonia- Benztropine IM
- B.
Akathisia- Diphenhydramine PO
- C.
Pseudoparkinsonism- Trihexyphenidyl PO
- D.
Neuroleptic Malignant Syndrome- Bromocriptine and Dantroline
- E.
All of the above are correct
- 7.Which is true of antipsychotics in the treatment of shizophrenia?
- A.
A perfect drug would INCREASE dopamine in the Mesocortical pathway but DECREASE dopamine in the Mesolimbic pathway.
- B.
FGA's tend to treat the positive symptoms of shizophrenia, while SGA's tend to treat both positive AND negative symptoms.
- C.
FGA's differ from SGA's in the fact that SGA's have less incidence of EPS and better mood stabilizing properties.
- D.
A common side effect of antipsychotics is that they decrease the seizure threshold.
- E.
All of the above.
- 8.Select the true statement regarding FGAs.
- A.
Haloperidol, a low potency agent, tends to have more EPS but less anticholinergic effects.
- B.
Haloperidol, a high potency agent, tends to have more EPS but less anticholinergic effects.
- C.
Chlorpromazine, a low potency agent, tends to have more EPS but less anticholinergic effects.
- D.
Chlorpromazine, a high potency agent, tends to have more EPS but less anticholinergic effects.
- 9.When switching from oral Haldol to Haldol Depot injection:
- A.
Oral medication should be tapered over 16 weeks.
- B.
It is okay to start the depot formulation if the patient was not on oral haloperidol first.
- C.
The depot injection dose given should be 10X the oral dose.
- D.
None of the above.
- E.
All of the above.
- 10.What is your favorite SGA and why?
- A.
Clozapine because it's got so many black box warnings
- B.
Ziprasidone because it has very few side effects besides its silly QT prolongation warnings
- C.
Paliperidone because its brand name is so awesome: Invega Sustena
- D.
Olanzapine because it makes people Fatties!
- E.
All of the above
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