Quiz 2 Practical Kinetics II ( Lab 5 & 7)

A women 50 kg given IV two compartment 2 mg/kg and conc. of elemination is 5 mg/l the conc. of distribution when volume of central compartment equal 10 mg/l is

 By using Sigma Minus method,A Single IV dose of new Antibiotic was given to 50 kg women at dose level 10 mg/kg. Urine and Blood samples were removed periodically and examined for parent drug. the data is tabulated Excretion rate constant is: 

A  Single IV dose of new Antibiotic was given to 50 kg women at dose level 20 mg/kg. Urine and Blood samples were removed periodically and examined for parent drug found elemination rate constant equal 0.679 hr^-1 at 10 hours the rate of drug accumulation in the urine when total amount of drug excreted in urine is 0.9 g

A drug follows two compartment open model was given IV and the following data are obtained the dose was given 1 gm Calculate the rate of elemination constant(Kel) :

A drug follows two compartment open model was given IV at plasma drug  concentration 15 mg/l and after 3 hrs if found plasma concentration 10 mg/l when conc. of distribution equal 2.5 mg/l and β equal 0.109 hr^-1 ,so slope of distribution equal