Group of MUST Pharmacy
Pharmacokinetics
Practical Quiz 2
Questions and Answers
1.
A women 50 kg given IV two compartment 2 mg/kg and conc. of elemination is 5 mg/l the conc. of distribution when volume of central compartment equal 10 mg/l is
A. 
3 mg/l
B. 
5 mg/l
C. 
0 mg/l
D. 
20 mg/l
2.
By using Sigma Minus method,A Single IV dose of new Antibiotic was given to 50 kg women at dose level 10 mg/kg. Urine and Blood samples were removed periodically and examined for parent drug. the data is tabulated
Excretion rate constant is:
A. 
1.2/hr
B. 
0.9/hr
C. 
1.046/hr
D. 
0.9/min
3.
A Single IV dose of new Antibiotic was given to 50 kg women at dose level 20 mg/kg. Urine and Blood samples were removed periodically and examined for parent drug found elemination rate constant equal 0.679 hr-1 at 10 hours the rate of drug accumulation in the urine when total amount of drug excreted in urine is 0.9 g
A. 
0.687 mg/l
B. 
6.87 mg/l
C. 
0.687 mg/hr
D. 
6.87 X 10-4 mg/hr
4.
A drug follows two compartment open model was given IV and the following data are obtained the dose was given 1 gm
Calculate the rate of elemination constant(Kel) :
A. 
0,25 hr-1
B. 
0.24 hr-1
C. 
0.52 hr-1
D. 
0.14 hr-1
5.
A drug follows two compartment open model was given IV at plasma drug concentration 15 mg/l and after 3 hrs if found plasma concentration 10 mg/l when conc. of distribution equal 2.5 mg/l and β equal 0.109 hr-1 ,so slope of distribution equal