A Quick Test On Pharmacotherapy Of HIT
(313).jpg "A Quick Test On Pharmacotherapy Of HIT - Quiz")
Pharmacotherapy is just like therapy, but one uses pharmaceutical drugs. Patients with HIT are at high risk for thrombotic events and are mostly prescribed to undergo pharmacotherapy. As a pharmacology student, what do you know about the process as a whole? Take up the quick quiz below on the pharmacotherapy of HIT topic and get to refresh your memory. All the best!
- 1.Which of the following is valid for HAT?
- A.
Onset is within 4 days
- B.
Onset is usually 5 to 10 days
- C.
Platelet count typically 100-150
- D.
Platelet count typically 20-150
- E.
Incidence is more common than HIT
- F.
Incidence is less common than HIT
- G.
Recovery is longer than with HIT
- H.
Recovery is shorter than with HIT
- I.
Caused by direct drug induced platelet aggregation
- J.
Cause is immune-mediated
- 2.IgG antibodies + thrombocytopenia without thromboembolic events are:
- A.
Seroconversion
- B.
Isolated HIT
- C.
Heparin-induced thrombocytopenia thrombosis syndrome (HITTS)
- 3.IgG antibodies to heparin-platelet factor 4 complexes but not thrombocytopenia is:
- A.
Seroconversion
- B.
Isolated HIT
- C.
HITTS
- 4.If we suspect HIT, check the patient's serum for HIT antibodies, assess for thrombosis, and diagnose a patient with HIT; Which of the following should we do next?
- A.
Give the patient FULL therapeutic doses of an alternative anticoagulant such as a LMWH.
- B.
Give the patient FULL therapeutic doses of an alternative anticoagulant, such as lepirudin, argatroban, or fondaparinux.
- C.
If a thrombus is found, begin warfarin only after platelet count has substantially recovered (>150k).
- D.
Consider platelet transfusion.
- 5.Which of the following is NOT a risk factor for developing HIT?
- A.
Recent heparin (past 100 days).
- B.
Heparin duration > 2 days
- C.
UFH > LMWH
- D.
Female > male
- E.
Post surgery
- 6.IgG antibodies + thrombocytopenia + thromboembolism is:
- A.
Seroconversion
- B.
Isolated HIT
- C.
HITTS
- 7.First, heparin binds to platelet factor 4 tetramers that are secreted by platelet, which form an antigenic complex. What happens immediately after this?
- A.
Heparin: PF4 complex binds to the anchored IgG Ab and crosslinks with other IgG Abs on the platelet, producing additional PF4 which perpetuates further platelet activation.
- B.
B lymphocytes generate IgG antibodies to the complex, which then bind to the Fc receptors on platelet cell surfaces.
- C.
The platelets release PF4 and microparticles, which are thrombogenic and promote thrombin production.
- 8.Which of the following would help us diagnose HIT?
- A.
Platelet counts fall below
- B.
Median platelet count is about 55x10^9/L
- C.
Most commonly thrombocytopenia occurs 5-10 days after heparin exposure.
- D.
IgG antibodies to heparin-PF4 complexes.
- 9.HIT can occur even if platelets do not fall below 100 x 10^9/L.
- A.
True
- B.
False
- 10.If a patient has kidney failure, which is the best agent to use?
- A.
Lepirudin
- B.
Fondaparinux
- C.
Argatroban
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