A condition in which a blood clot forms most often in the deep veins of the leg is known as Venous thromboembolism (VTE. This causes pain for the patient and can be corrected through different ways. Below is a pharmacotherapy test on Venous Thromboembolism. Give it a shot and get to refresh your memory on all that we have learnt do far.
Acute medical illness
Commonly used for DVT diagnosis
Not commonly used for DVT diagnosis
Cannot detect small blood clots in distal veins
Can detect small blood clots in distal veins
Check for Homan's sign.
Check lab tests.
Do an invasive test (such as angiography or venography).
Nothing, if the doppler is negative there is no need to go further.
SQ onset of action 1-2 hours.
IV if need rapid anticoagulation.
Intra- and interpatient variability to response.
T ½ is dose dependent.
Treatment dose related to patients weight.
Use actual body weight if not obese.
The therapeutic range is 1.5 to 2.5x the control aPTT value.
Check aPTT baseline, 4 hours after starting UFH infusion, and 4 hours after each dose change.
Pregnancy category X.
Pregnancy category B.
Monitor Hgb, Hct, and BP. Lower the dose of UFH. Administer IV protamine sulfate.
Monitor Hgb, Hct, and BP. Discontinue UFH. Administer IV protamine sulfate.
Monitor Hgb, Hct, and BP. Lower the dose of UFH. Administer IV Vitamin K and fresh frozen plasma.
Monitor Hgb, Hct, and BP. Discontinue UFH. Administer IV Vitamin K and fresh frozen plasma.
Not UFH, because it is not safe during breastfeeding.
Not UFH, because there is a risk of maternal hemorrhage.
LMWH is a better alternative because it does not cross the placenta.
These drugs cross the placenta.
In every patient
Weight < 50 kg
Morbid obesity (BMI > 50 or > 150kg)
CBC with platelet