Pharmacology Exam 3 Hyperlipidemias
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What causes about half of all deaths in the US currently?(or the most appropriate listed here)
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Coronary artery disease
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Pharmacology PA School Exams
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Heart failure
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DVTs/PEs
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About This Quiz
Pharmacology Exam 3 Hyperlipidemias focuses on understanding and managing hyperlipidemia and its complications. It assesses knowledge on the effects of coronary artery disease, the mechanisms and efficacy of statins, and the role of niacin in increasing HDL and reducing clotting risk.
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- 2.
Which of these is one of the main ways statins work? (the MOST)
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Raising LDL levels and decreasing LDL receptor expression
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Lowering LDL levels and increased LDL receptor expression
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Raising LDL levels and raising triglycerides
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Nothing to do with LDL. raises HDL and lowers triglycerides
Correct Answer
A. Lowering LDL levels and increased LDL receptor expressionExplanation
Statins are a class of drugs commonly used to lower cholesterol levels. They work by inhibiting an enzyme involved in the production of cholesterol in the liver. By doing so, statins help to decrease the levels of LDL (low-density lipoprotein) cholesterol, which is often referred to as "bad" cholesterol. Additionally, statins have been found to increase the expression of LDL receptors on liver cells. These receptors help remove LDL cholesterol from the bloodstream, further contributing to the lowering of LDL levels. Therefore, the correct answer is "lowering LDL levels and increased LDL receptor expression."Rate this question:
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- 3.
Stains can be used for (homozygous) familial hyperlipidemias
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True
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False
Correct Answer
A. FalseExplanation
Stains are not used for (homozygous) familial hyperlipidemias. Familial hyperlipidemias are genetic disorders characterized by high levels of lipids in the blood. Statins, on the other hand, are medications used to lower cholesterol levels in individuals with high cholesterol. While statins may be effective in treating some forms of hyperlipidemia, they are not typically used for the homozygous form of the condition. Other treatment options, such as lipid-lowering drugs and lifestyle changes, are usually recommended for homozygous familial hyperlipidemias. Therefore, the statement is false.Rate this question:
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- 4.
What percentage of patients on statins still have coronary events?
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10%
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25%
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50%
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65%
Correct Answer
A. 25%Explanation
Statins are commonly prescribed to lower cholesterol levels and reduce the risk of coronary events. The given answer, 25%, suggests that even with statin treatment, a significant proportion of patients still experience coronary events. This highlights the fact that statins are not completely effective in preventing such events, and other factors like lifestyle, genetics, and individual response to the medication may also play a role. It emphasizes the need for additional interventions and lifestyle modifications to further reduce the risk of coronary events in these patients.Rate this question:
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- 5.
Which of these is the MOST effective agent in increasing HDL levels?
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Statins
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Bile Drugs
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Niacin
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Cholesterol inhibitor
Correct Answer
A. NiacinExplanation
Niacin is the most effective agent in increasing HDL levels. Niacin, also known as vitamin B3, has been shown to significantly raise HDL ("good") cholesterol levels while lowering LDL ("bad") cholesterol levels. It works by inhibiting the breakdown of HDL in the body, leading to increased levels of this beneficial cholesterol. Statins, bile drugs, and cholesterol inhibitors may also have some effect on HDL levels, but niacin is considered the most effective agent for this purpose.Rate this question:
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- 6.
You have a patient with a lot of risk factors for clotting on top of those associated with hypercholesteremia and atherosclerosis. Which of these drugs can you give them to hope lower that risk because they increase the secretion of tPA?
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Statins
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Bile drugs
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Niacin
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Cholesterol inhibitors
Correct Answer
A. NiacinExplanation
Niacin can be given to the patient to lower the risk of clotting because it increases the secretion of tissue plasminogen activator (tPA). Tissue plasminogen activator is responsible for breaking down blood clots, so by increasing its secretion, niacin can help prevent clot formation and reduce the risk of clotting.Rate this question:
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- 7.
Niacin is useful in the treatment of familial hyperlipidemia.
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True
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False
Correct Answer
A. TrueExplanation
Niacin is indeed useful in the treatment of familial hyperlipidemia. Familial hyperlipidemia is a genetic disorder characterized by high levels of cholesterol and triglycerides in the blood. Niacin, also known as vitamin B3, has been shown to effectively lower LDL cholesterol levels and increase HDL cholesterol levels, making it beneficial for managing this condition. Niacin works by inhibiting the production of certain enzymes involved in cholesterol synthesis, reducing the amount of cholesterol produced by the liver. Therefore, it is a valid statement to say that niacin is useful in the treatment of familial hyperlipidemia.Rate this question:
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- 8.
Some of the initial AEs of niacin include cutaneous flushing, pruritus and predisposition to hyperurecemia and gout. Which drug can you give them to decrease the risk of these AEs?
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Aspirin
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Immediate release niacin
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NSAID
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Coumadin
Correct Answer
A. AspirinExplanation
Aspirin can be given to decrease the risk of cutaneous flushing, pruritus, and predisposition to hyperurecemia and gout, which are some of the initial adverse effects (AEs) of niacin. Aspirin is known to reduce the flushing effect caused by niacin by inhibiting prostaglandin synthesis. This can help alleviate the discomfort and minimize the occurrence of these AEs when niacin is administered.Rate this question:
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- 9.
Which of these are the effects of the fibrates?
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Raise serum triglycerides and increase HDL
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Raise LDL and lower triglycerides
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Raise triglycerides and lower HDL
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Lower triglycerides and increase HDL
Correct Answer
A. Lower triglycerides and increase HDLExplanation
Fibrates are a class of medications commonly used to treat high cholesterol and triglyceride levels. One of the main effects of fibrates is to lower triglyceride levels in the blood. They achieve this by increasing the breakdown of triglycerides and decreasing their production in the liver. Additionally, fibrates have been shown to increase the levels of high-density lipoprotein (HDL) cholesterol, often referred to as the "good" cholesterol. This is beneficial as higher levels of HDL cholesterol are associated with a reduced risk of heart disease. Therefore, the correct answer is "lower triglycerides and increase HDL."Rate this question:
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- 10.
Which of the fibrates are MORE effective in lowering LDL and TG levels?
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Fenofibrate
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Gemfibrozil
Correct Answer
A. FenofibrateExplanation
Fenofibrate is more effective in lowering LDL and TG levels compared to Gemfibrozil. This is because Fenofibrate has been shown to have a stronger impact on reducing LDL cholesterol and triglyceride levels. It works by activating a specific receptor in the liver, which helps to break down and remove LDL cholesterol from the bloodstream. Additionally, Fenofibrate also reduces the production of triglycerides in the liver. Gemfibrozil, on the other hand, is also a fibrate medication but it is generally considered to be less effective in lowering LDL cholesterol levels.Rate this question:
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- 11.
Which of the following is the most common side effect of antihyperlipidemia drug therapy including the fibrates?
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Elevated blood pressure
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GI disturbance
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Neurologic problems
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Heart palpitations
Correct Answer
A. GI disturbanceExplanation
The most common side effect of antihyperlipidemia drug therapy, including the fibrates, is gastrointestinal (GI) disturbance. This can manifest as symptoms such as nausea, vomiting, diarrhea, and abdominal pain. These drugs work by reducing the levels of lipids in the blood, which can cause irritation and disruption in the GI tract. Therefore, GI disturbance is a common side effect that patients may experience when taking antihyperlipidemia medications.Rate this question:
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- 12.
Which of the following is associated with elevated plasma levels of chylomicrons and has NO drug therapy available to lower plasma lipoprotein levels?
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Type 1
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Type 2
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Type 3
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Type IV
Correct Answer
A. Type 1Explanation
Type 1 is associated with elevated plasma levels of chylomicrons and has no drug therapy available to lower plasma lipoprotein levels. This type of disorder is known as familial chylomicronemia syndrome (FCS) or type 1 hyperlipoproteinemia. It is a rare genetic disorder characterized by a deficiency or dysfunction of lipoprotein lipase (LPL), an enzyme responsible for breaking down chylomicrons. Without functional LPL, chylomicrons accumulate in the blood, leading to high levels of triglycerides. Management of type 1 hyperlipoproteinemia involves dietary modifications, such as a low-fat diet, and avoiding alcohol and certain medications.Rate this question:
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- 13.
Fibrates increase the risk of which of the following?
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Gallstones
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Kidney Stones
Correct Answer
A. GallstonesExplanation
Fibrates are a class of medications commonly used to lower cholesterol levels. One of the potential side effects of fibrates is an increased risk of developing gallstones. Gallstones are hardened deposits that form in the gallbladder, causing pain and discomfort. The mechanism by which fibrates increase the risk of gallstones is not fully understood, but it is believed to be related to changes in bile composition and flow. It is important for individuals taking fibrates to be aware of this potential side effect and to discuss any concerns with their healthcare provider.Rate this question:
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- 14.
Fibrates interact with coumadin for plasma protein binding sites. These patients would thus do what because of the new activity?
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Increased clotting
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Increased bleeding
Correct Answer
A. Increased bleedingExplanation
potentiates the anticoagulant effectRate this question:
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- 15.
Fibrates are known to be safe in pregnant women
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True
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False
Correct Answer
A. FalseExplanation
not testedRate this question:
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- 16.
Another name for bile acid sequestrants is
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Bile agonists
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Bile antagonists
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Bile resins
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Bile fibrates
Correct Answer
A. Bile resinsExplanation
Bile acid sequestrants are also known as bile resins. These medications work by binding to bile acids in the intestine, preventing their reabsorption and promoting their elimination from the body. This helps to lower cholesterol levels and is often used as a treatment for high cholesterol. The term "bile resins" accurately describes the mechanism of action of these drugs, as they act as resins to sequester or bind bile acids. Therefore, the correct answer is bile resins.Rate this question:
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- 17.
Which of these is NOT a bile acid drug?
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Cholestyramine
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Colestipol
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Colesvelam
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Ezetimide
Correct Answer
A. EzetimideExplanation
Ezetimide is not a bile acid drug. Bile acid drugs, such as cholestyramine, colestipol, and colesvelam, work by binding to bile acids in the intestines, preventing their reabsorption and promoting their excretion. This helps to lower cholesterol levels in the body. Ezetimide, on the other hand, is a cholesterol absorption inhibitor. It works by blocking the absorption of cholesterol from the diet in the intestines, reducing the amount of cholesterol that enters the bloodstream.Rate this question:
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- 18.
How do the bile hyperlipidemia drugs work?
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They increase reabsorption into the intestines of the bile acids and salts.
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They decrease reabsorption into the intestine of the bile acids and salts
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They decrease LDL receptor expression
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They decrease HDL receptor expression.
Correct Answer
A. They decrease reabsorption into the intestine of the bile acids and saltsExplanation
Bile hyperlipidemia drugs work by decreasing the reabsorption of bile acids and salts into the intestine. This helps to reduce the levels of these substances in the body, which can contribute to hyperlipidemia. By inhibiting reabsorption, these drugs promote the excretion of bile acids and salts, leading to a decrease in their concentration in the bloodstream. This can help to lower cholesterol levels and improve lipid metabolism.Rate this question:
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- 19.
What class of drugs decrease the absorption of fat-soluble vitamins?
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Statins
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Niacin
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Cholesterol inhibitors
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Bile resins
Correct Answer
A. Bile resinsExplanation
Bile resins are a class of drugs that decrease the absorption of fat-soluble vitamins. These drugs work by binding to bile acids in the intestine, preventing their reabsorption and promoting their excretion. Since fat-soluble vitamins require bile acids for absorption, the presence of bile resins reduces their absorption. This can lead to deficiencies in fat-soluble vitamins such as vitamins A, D, E, and K. Therefore, bile resins can interfere with the body's ability to absorb these essential vitamins.Rate this question:
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- 20.
ADEK are the fat-soluble vitamins
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True
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False
Correct Answer
A. TrueExplanation
ADEK are the fat-soluble vitamins. This statement is true. ADEK refers to four specific vitamins: vitamin A, vitamin D, vitamin E, and vitamin K. These vitamins are classified as fat-soluble because they are absorbed and stored in the body's fat tissues. Unlike water-soluble vitamins, which are not stored in the body and are excreted in urine, fat-soluble vitamins can be stored for longer periods of time. They play important roles in various bodily functions, such as vision (vitamin A), bone health (vitamin D), antioxidant protection (vitamin E), and blood clotting (vitamin K).Rate this question:
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- 21.
Cholesterol Inhibitors work by decreasing stores of cholesterol where?
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Liver
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Kidney
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Pancreas
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Bladder??
Correct Answer
A. LiverExplanation
Cholesterol Inhibitors work by decreasing stores of cholesterol in the liver. The liver is responsible for producing and regulating cholesterol levels in the body. Cholesterol Inhibitors, also known as statins, work by blocking an enzyme in the liver that is involved in cholesterol synthesis. This leads to a decrease in the amount of cholesterol produced by the liver, ultimately lowering overall cholesterol levels in the body.Rate this question:
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- 22.
Which patient should NOT get a cholesterol inhibitor? (or at least the contraindication listed in our slides)
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48 yo Female with hepatic insufficiency
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65 yo male with COPD
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30 yo female with overactive bladder syndrome
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62 yo male with history of kidney stones
Correct Answer
A. 48 yo Female with hepatic insufficiencyExplanation
A cholesterol inhibitor is a medication used to lower cholesterol levels in the body. However, hepatic insufficiency refers to a condition where the liver is not functioning properly. The liver plays a crucial role in metabolizing medications, including cholesterol inhibitors. In patients with hepatic insufficiency, the liver may not be able to effectively process and eliminate the medication, leading to potential toxicity or adverse effects. Therefore, a patient with hepatic insufficiency should not be given a cholesterol inhibitor.Rate this question:
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- 23.
Which of the following should always be measured prior to starting a statin?
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CBC w/ diff
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Clotting factors
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Liver enzymes
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Cardiac enzymes
Correct Answer
A. Liver enzymesExplanation
Liver enzymes should always be measured prior to starting a statin because statins can potentially cause liver damage. Measuring liver enzymes, such as alanine transaminase (ALT) and aspartate transaminase (AST), helps to assess the baseline liver function and identify any pre-existing liver conditions. By monitoring liver enzymes, healthcare providers can detect any abnormalities or elevations in liver function that may indicate liver toxicity caused by statin therapy. This precaution is important to ensure the safety and effectiveness of statin treatment and to prevent potential liver complications.Rate this question:
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- 24.
Which of these (classes of hyperlipidemia) is more common in obese and diabetics?
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Type 1
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Type 3
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Type IV
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Type 5
Correct Answer
A. Type 5Explanation
Type 5 hyperlipidemia is more common in obese and diabetics. This type of hyperlipidemia is characterized by high levels of chylomicrons and VLDL (very low-density lipoprotein) in the blood. Obesity and diabetes are both risk factors for developing type 5 hyperlipidemia, as they can lead to insulin resistance and impair the body's ability to properly metabolize and clear these lipoproteins from the bloodstream. This can result in elevated levels of triglycerides and cholesterol, increasing the risk of cardiovascular disease.Rate this question:
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- 25.
Which of the following decreases de novo cholesterol synthesis by inhibiting the enzyme 3-hydroxyl....A reductase?
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Fenofibrate
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Niacin
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Cholestyramine
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Lovastatin
Correct Answer
A. LovastatinExplanation
Book question.Rate this question:
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- 26.
Which one of the following drugs causes a decrease in liver triacylglycerol synthesis by limiting available free fatty acids needed as building blocks for this pathway?
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Niacin
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Fenofibrate
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Cholestyramine
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Gemfibrozil
Correct Answer
A. NiacinExplanation
at gram doses niacin strongly inhibits lipolysis in adipose tissueRate this question:
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- 27.
Which one of the following drugs binds bile acids in the intestine, thus preventing their return to the liver via the enterohepatic circulation?
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Niacin
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Fenofibrate
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Cholestyramine
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Fluvastatin
Correct Answer
A. CholestyramineExplanation
Cholestyramine is a drug that binds bile acids in the intestine, preventing their reabsorption and return to the liver through the enterohepatic circulation. This action reduces the amount of bile acids available for reabsorption, leading to increased excretion of cholesterol and a decrease in serum cholesterol levels. Niacin, fenofibrate, and fluvastatin are not known to have this specific mechanism of action.Rate this question:
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