Pharmacology Exam 3 Hyperlipidemias

27 Questions | Total Attempts: 44

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Pharmacology Exam 3 Hyperlipidemias

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Questions and Answers
  • 1. 
    What causes about half of all deaths in the US currently?(or the most appropriate listed here)
    • A. 

      Coronary artery disease

    • B. 

      Pharmacology PA School Exams

    • C. 

      Heart failure

    • D. 

      DVTs/PEs

  • 2. 
    Which of these is one of the main ways statins work?  (the MOST)
    • A. 

      Raising LDL levels and decreasing LDL receptor expression

    • B. 

      Lowering LDL levels and increased LDL receptor expression

    • C. 

      Raising LDL levels and raising triglycerides

    • D. 

      Nothing to do with LDL. raises HDL and lowers triglycerides

  • 3. 
    Stains can be used for (homozygous) familial hyperlipidemias
    • A. 

      True

    • B. 

      False

  • 4. 
    What percentage of patients on statins still have coronary events?
    • A. 

      10%

    • B. 

      25%

    • C. 

      50%

    • D. 

      65%

  • 5. 
    Which of these is the MOST effective agent in increasing HDL levels?
    • A. 

      Statins

    • B. 

      Bile Drugs

    • C. 

      Niacin

    • D. 

      Cholesterol inhibitor

  • 6. 
    You have a patient with a lot of risk factors for clotting on top of those associated with hypercholesteremia and atherosclerosis.  Which of these drugs can you give them to hope lower that risk because they increase the secretion of tPA?
    • A. 

      Statins

    • B. 

      Bile drugs

    • C. 

      Niacin

    • D. 

      Cholesterol inhibitors

  • 7. 
    Niacin is useful in the treatment of familial hyperlipidemia.
    • A. 

      True

    • B. 

      False

  • 8. 
    Some of the initial AEs of niacin include cutaneous flushing, pruritus and predisposition to hyperurecemia and gout.  Which drug can you give them to decrease the risk of these AEs?
    • A. 

      Aspirin

    • B. 

      Immediate release niacin

    • C. 

      NSAID

    • D. 

      Coumadin

  • 9. 
    Which of these are the effects of the fibrates?
    • A. 

      Raise serum triglycerides and increase HDL

    • B. 

      Raise LDL and lower triglycerides

    • C. 

      Raise triglycerides and lower HDL

    • D. 

      Lower triglycerides and increase HDL

  • 10. 
    Which of the fibrates are MORE effective in lowering LDL and TG levels?
    • A. 

      Fenofibrate

    • B. 

      Gemfibrozil

  • 11. 
    Which of the following is the most common side effect of antihyperlipidemia drug therapy including the fibrates?
    • A. 

      Elevated blood pressure

    • B. 

      GI disturbance

    • C. 

      Neurologic problems

    • D. 

      Heart palpitations

  • 12. 
    Which of the following is associated with elevated plasma levels of chylomicrons and has NO drug therapy available to lower plasma lipoprotein levels?
    • A. 

      Type 1

    • B. 

      Type 2

    • C. 

      Type 3

    • D. 

      Type IV

  • 13. 
    Fibrates increase the risk of which of the following?
    • A. 

      Gallstones

    • B. 

      Kidney Stones

  • 14. 
    Fibrates interact with coumadin for plasma protein binding sites.  These patients would thus do what because of the new activity?
    • A. 

      Increased clotting

    • B. 

      Increased bleeding

  • 15. 
    Fibrates are known to be safe in pregnant women
    • A. 

      True

    • B. 

      False

  • 16. 
    Another name for bile acid sequestrants is
    • A. 

      Bile agonists

    • B. 

      Bile antagonists

    • C. 

      Bile resins

    • D. 

      Bile fibrates

  • 17. 
    Which of these is NOT a bile acid drug?
    • A. 

      Cholestyramine

    • B. 

      Colestipol

    • C. 

      Colesvelam

    • D. 

      Ezetimide

  • 18. 
    How do the bile hyperlipidemia drugs work?
    • A. 

      They increase reabsorption into the intestines of the bile acids and salts.

    • B. 

      They decrease reabsorption into the intestine of the bile acids and salts

    • C. 

      They decrease LDL receptor expression

    • D. 

      They decrease HDL receptor expression.

  • 19. 
    What class of drugs decrease the absorption of fat-soluble vitamins?
    • A. 

      Statins

    • B. 

      Niacin

    • C. 

      Cholesterol inhibitors

    • D. 

      Bile resins

  • 20. 
    ADEK are the fat-soluble vitamins
    • A. 

      True

    • B. 

      False

  • 21. 
    Cholesterol Inhibitors work by decreasing stores of cholesterol where?
    • A. 

      Liver

    • B. 

      Kidney

    • C. 

      Pancreas

    • D. 

      Bladder??

  • 22. 
    Which patient should NOT get a cholesterol inhibitor? (or at least the contraindication listed in our slides)
    • A. 

      48 yo Female with hepatic insufficiency

    • B. 

      65 yo male with COPD

    • C. 

      30 yo female with overactive bladder syndrome

    • D. 

      62 yo male with history of kidney stones

  • 23. 
    Which of the following should always be measured prior to starting a statin?
    • A. 

      CBC w/ diff

    • B. 

      Clotting factors

    • C. 

      Liver enzymes

    • D. 

      Cardiac enzymes

  • 24. 
    Which of these (classes of hyperlipidemia) is more common in obese and diabetics?
    • A. 

      Type 1

    • B. 

      Type 3

    • C. 

      Type IV

    • D. 

      Type 5

  • 25. 
    Which of the following decreases de novo cholesterol synthesis by inhibiting the enzyme 3-hydroxyl....A reductase?
    • A. 

      Fenofibrate

    • B. 

      Niacin

    • C. 

      Cholestyramine

    • D. 

      Lovastatin

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