Pharmacology Second Messenger System/ Pharmacodynamics
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Second messengers are molecules that relay the signals received at receptors on the cell surface to target molecules in the cytosol or nucleus. This Pharmacology second messenger system/ Pharmacodynamics quiz is perfect for helping you see just how much you know about second messengers and how they achieve their function. Give it a shot and see how high your score is.
- 1.What do lipid-soluble drugs, steroids and thyroid hormones bind to?
- A.
Cytokine receptors
- B.
Intracellular receptors
- C.
Tyrosine kinase receptors
- D.
G protein-coupled receptors
- E.
Transmembrane ion channels
- 2.What inhibitory constraint is relieved by the binding on the transcription-activating domain of the intracellular receptor?
- A.
Hsp-30
- B.
Hsp-60
- C.
Hsp-70
- D.
Hsp-90
- E.
None of the above
- 3.What inhibitors of TK receptors bind to the extracellular domain?
- A.
Small permeant molecules
- B.
Monoclonal antibodies
- C.
Both
- D.
Neither
- 4.What inhibits a receptor's TK activity in the cytoplasm?
- A.
Small permeant molecules
- B.
Monoclonal antibodies
- C.
Both
- D.
Neither
- 5.What receptors involve JAK and STAT molecules and are activated by growth hormone, erythropoietin and interferon?
- A.
Cytokine receptors
- B.
Intracellular receptors
- C.
Tyrosine kinase receptors
- D.
G protein-coupled receptors
- E.
Transmembrane ion channels
- 6.What is not a function of transmembrane ion channels?
- A.
Cardiac conduction
- B.
Muscle contraction
- C.
Neurotransmission
- D.
Secretion
- E.
None of the above
- 7.How much time elapses between the ligand binding and the cellular response?
- A.
Milliseconds
- B.
Several seconds to minutes
- C.
Hours
- D.
Days
- E.
Weeks
- 8.Where are G protein-coupled receptors activated by G proteins?
- A.
Extracellular domain
- B.
Intracellular regions
- C.
Seven membrane domains
- D.
All of the above
- E.
None of the above
- 9.Which of the following is an effector that generates intracellular second messengers?
- A.
Enzymes
- B.
Ion channels
- C.
GTP-alpha
- D.
A and B
- E.
All of the above
- 10.Which of the following is not a second messenger?
- A.
Beta-arrestin
- B.
CAMP
- C.
CGMP
- D.
IP3
- E.
DAG
- 11.Stimulation of G protein-coupled receptors results in responses that last how long?
- A.
Milliseconds
- B.
Several seconds to minutes
- C.
Hours
- D.
Days
- E.
Weeks
- 12.What is the molecular weight of most drugs?
- A.
1-10
- B.
100-1000
- C.
10000-100000
- D.
Cannot determine
- 13.What is the binding of a drug to a nonregulatory molecule such as plasma albumin is called what?
- A.
Partial agonist
- B.
Inert binding site
- C.
Antagonist
- D.
Agonist
- E.
None of the above
- 14.Drugs that bind and activate the receptor directly or indirectly are?
- A.
Partial agonist
- B.
Inert binding site
- C.
Antagonist
- D.
Agonist
- E.
None of the above
- 15.Drugs that bind to a receptor and prevent the binding of other molecules are?
- A.
Partial agonist
- B.
Inert binding site
- C.
Antagonist
- D.
Agonist
- E.
None of the above
- 16.What binds and activates the receptor but does not evoke a full response?
- A.
Partial agonist
- B.
Inert binding site
- C.
Antagonist
- D.
Agonist
- E.
None of the above
- 17.If EC50 is small then?
- A.
Potency is high
- B.
Potency is low
- C.
Affinity is high
- D.
Affinity is low
- E.
None of the above
- 18.If Kd is small then?
- A.
Potency is high
- B.
Potency is low
- C.
Affinity is high
- D.
Affinity is low
- E.
None of the above
- 19.Which of the following displays a hyperbolic curve?
- A.
Graded dose-binding relationship
- B.
Graded dose-response relationship
- C.
Quantal dose-response relationship
- D.
A and B
- E.
B and C
- 20.Efficacy can be determined by?
- A.
Graded dose-response curve only
- B.
Quantal dose-response curve only
- C.
Both
- D.
Neither
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