Pharmacology Second Messenger System/ Pharmacodynamics

20 Questions

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Pharmacology Quizzes & Trivia

Second messengers are molecules that relay the signals received at receptors on the cell surface to target molecules in the cytosol or nucleus. This Pharmacology second messenger system/ Pharmacodynamics quiz is perfect for helping you see just how much you know about second messengers and how they achieve their function. Give it a shot and see how high your score is.


Questions and Answers
  • 1. 
    What do lipid-soluble drugs, steroids and thyroid hormones bind to?
    • A. 

      Cytokine receptors

    • B. 

      Intracellular receptors

    • C. 

      Tyrosine kinase receptors

    • D. 

      G protein-coupled receptors

    • E. 

      Transmembrane ion channels

  • 2. 
    What inhibitory constraint is relieved by the binding on the transcription-activating domain of the intracellular receptor?
    • A. 

      Hsp-30

    • B. 

      Hsp-60

    • C. 

      Hsp-70

    • D. 

      Hsp-90

    • E. 

      None of the above

  • 3. 
    What inhibitors of TK receptors bind to the extracellular domain?
    • A. 

      Small permeant molecules

    • B. 

      Monoclonal antibodies

    • C. 

      Both

    • D. 

      Neither

  • 4. 
    What inhibits a receptor's TK activity in the cytoplasm?
    • A. 

      Small permeant molecules

    • B. 

      Monoclonal antibodies

    • C. 

      Both

    • D. 

      Neither

  • 5. 
    What receptors involve JAK and STAT molecules and are activated by growth hormone, erythropoietin and interferon?
    • A. 

      Cytokine receptors

    • B. 

      Intracellular receptors

    • C. 

      Tyrosine kinase receptors

    • D. 

      G protein-coupled receptors

    • E. 

      Transmembrane ion channels

  • 6. 
    What is not a function of transmembrane ion channels?
    • A. 

      Cardiac conduction

    • B. 

      Muscle contraction

    • C. 

      Neurotransmission

    • D. 

      Secretion

    • E. 

      None of the above

  • 7. 
    How much time elapses between the ligand binding and the cellular response?
    • A. 

      Milliseconds

    • B. 

      Several seconds to minutes

    • C. 

      Hours

    • D. 

      Days

    • E. 

      Weeks

  • 8. 
    Where are G protein-coupled receptors activated by G proteins?
    • A. 

      Extracellular domain

    • B. 

      Intracellular regions

    • C. 

      Seven membrane domains

    • D. 

      All of the above

    • E. 

      None of the above

  • 9. 
    Which of the following is an effector that generates intracellular second messengers?
    • A. 

      Enzymes

    • B. 

      Ion channels

    • C. 

      GTP-alpha

    • D. 

      A and B

    • E. 

      All of the above

  • 10. 
    Which of the following is not a second messenger?
    • A. 

      Beta-arrestin

    • B. 

      CAMP

    • C. 

      CGMP

    • D. 

      IP3

    • E. 

      DAG

  • 11. 
    Stimulation of G protein-coupled receptors results in responses that last how long?
    • A. 

      Milliseconds

    • B. 

      Several seconds to minutes

    • C. 

      Hours

    • D. 

      Days

    • E. 

      Weeks

  • 12. 
    What is the molecular weight of most drugs?
    • A. 

      1-10

    • B. 

      100-1000

    • C. 

      10000-100000

    • D. 

      Cannot determine

  • 13. 
    What is the binding of a drug to a nonregulatory molecule such as plasma albumin is called what?
    • A. 

      Partial agonist

    • B. 

      Inert binding site

    • C. 

      Antagonist

    • D. 

      Agonist

    • E. 

      None of the above

  • 14. 
    Drugs that bind and activate the receptor directly or indirectly are?
    • A. 

      Partial agonist

    • B. 

      Inert binding site

    • C. 

      Antagonist

    • D. 

      Agonist

    • E. 

      None of the above

  • 15. 
    Drugs that bind to a receptor and prevent the binding of other molecules are?
    • A. 

      Partial agonist

    • B. 

      Inert binding site

    • C. 

      Antagonist

    • D. 

      Agonist

    • E. 

      None of the above

  • 16. 
    What binds and activates the receptor but does not evoke a full response?
    • A. 

      Partial agonist

    • B. 

      Inert binding site

    • C. 

      Antagonist

    • D. 

      Agonist

    • E. 

      None of the above

  • 17. 
    If EC50 is small then? 
    • A. 

      Potency is high

    • B. 

      Potency is low

    • C. 

      Affinity is high

    • D. 

      Affinity is low

    • E. 

      None of the above

  • 18. 
    If Kd is small then? 
    • A. 

      Potency is high

    • B. 

      Potency is low

    • C. 

      Affinity is high

    • D. 

      Affinity is low

    • E. 

      None of the above

  • 19. 
    Which of the following displays a hyperbolic curve?
    • A. 

      Graded dose-binding relationship

    • B. 

      Graded dose-response relationship

    • C. 

      Quantal dose-response relationship

    • D. 

      A and B

    • E. 

      B and C

  • 20. 
    Efficacy can be determined by?
    • A. 

      Graded dose-response curve only

    • B. 

      Quantal dose-response curve only

    • C. 

      Both

    • D. 

      Neither