Block 9 Pharm Pharmacodydamics W/Exp Part 1

15 Questions | Total Attempts: 445

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Block 9 Pharm Pharmacodydamics W/Exp Part 1 - Quiz

Drugs when introduced to the system have specific effects and at times what is expected is different from what is viewed. It is important therefore for a pharmacologist to understand the effects of drugs and the ways which they achieve that effect. The Block 9 Pharm Pharmacodynamics W/exp Part 1 quiz will test you on this and more. Try it out!


Questions and Answers
  • 1. 
    Which of the following cell constituents most likely function as drug receptors?
    • A. 

      G-proteins

    • B. 

      Ion channel proteins

    • C. 

      Cyclic AMP

    • D. 

      Membrane lipids

    • E. 

      Water molecules

  • 2. 
    Which of the following terms best describes a specific region of the receptor molecule where the drug binds?
    • A. 

      Activation region

    • B. 

      Recognition site

    • C. 

      Effector

    • D. 

      G-protein

    • E. 

      Spare receptor

  • 3. 
    A new drug was tested in an in vitro system. It was found that only one enantiomer of the racemic pair bound substantially to a specific receptor, whereas the other enantiomer showed a negligible binding. Which of the following terms best defines this property?
    • A. 

      Intrinsic activity

    • B. 

      Affinity

    • C. 

      Stereo-selectivity

    • D. 

      Potency

    • E. 

      Variability

    • F. 

      Maximal efficacy

  • 4. 
    A 16-year-old girl suffering from seasonal rhinitis started a therapy with loratadine, a drug that binds to H1 histamine receptors. Which of the following terms best defines the intrinsic ability of a drug to bind to a receptor?
    • A. 

      Intrinsic activity

    • B. 

      Potency

    • C. 

      Efficacy

    • D. 

      Affinity

    • E. 

      Receptor activation

  • 5. 
    Drugs can bind to receptors via different types of chemical bonds. Which of the following is the least common drug-receptor bond?
    • A. 

      Ionic

    • B. 

      Hydrophobic

    • C. 

      Hydrogen

    • D. 

      Van der Waals

    • E. 

      Covalent

  • 6. 
    Two new drugs, A and B, are tested in an in vitro system. The drugs turn out to have the same slope of the log dose-response curves and the same maximal efficacy. Which of the following pairs of statements best describes drugs A and B?
    • A. 

      A full agonist , B full agonist

    • B. 

      A full agonist , B partial agonist

    • C. 

      A full agonist , B competitive antagonist

    • D. 

      A partial agonist, B noncompetitive antagonist

    • E. 

      A partial agonist, B functional antagonist

  • 7. 
    Which of the following terms best defines a drug with intrinsic activity higher than 0% and lower than 100%?
    • A. 

      Full agonist

    • B. 

      Pharmacological antagonist

    • C. 

      Partial agonist

    • D. 

      Functional antagonist

    • E. 

      Chemical antagonist

  • 8. 
    Two drugs, tested in an in vitro system, turn out to have equal affinity for the same receptor and intrinsic activities of 1.0 and 0.25 respectively. Which of the following would be the correct percent of the maximal response, when both drugs are present at the same time in maximally effective concentrations?
    • A. 

      12.5%

    • B. 

      25%

    • C. 

      62.5%

    • D. 

      75%

    • E. 

      100%

  • 9. 
    Five new diuretic drugs were tested in healthy volunteers. The results are given below: Which of the following drugs was the most effective?
    • A. 

      Drug A

    • B. 

      Drug B

    • C. 

      Drug C

    • D. 

      Drug D

    • E. 

      Drug E

  • 10. 
    Drug A and Drug B, tested in an in vitro system, turn out to have equal affinity for the same receptor and intrinsic activities greater than zero. The maximal efficacy of drug B is 100%. When Drug B is co-administered with a fixed dose of Drug A, the log dose-effect curve of Drug B is shifted to the right. Which of the following terms best defines drug A?
    • A. 

      Full agonist

    • B. 

      Partial agonist

    • C. 

      Competitive antagonist

    • D. 

      Irreversible antagonist

    • E. 

      Functional antagonist

  • 11. 
    A 3-year-old boy was admitted to the emergency room after e generalized tonic colonic seizure. His mother reported that the boy apparently ingested several tablets of propranolol (a beta-blocking drug) found in his father drawer. The boy received an IM injection of glucagon, a hormone that can bind to glucagon receptors in the heart, so causing a significant increase in heart contractility. In this way It can counteract the decrease in heart contractility brought about by a toxic dose of a beta-blocker. Which of the following terms best defines the antagonism between glucagon and beta-blockers?
    • A. 

      Chemical

    • B. 

      Competitive

    • C. 

      Functional (or physiological)

    • D. 

      Pharmacokinetic

    • E. 

      Pharmacological

  • 12. 
    The figure below, depicts the log dose-response curves of different drugs tested in an in vitro system where no spare receptors are present . Which of the curves best depicts the log dose-response curve of drug C when a fixed dose of an irreversible antagonist is given concomitantly?
    • A. 

      Curve A

    • B. 

      Curve B

    • C. 

      Curve C

    • D. 

      Curve D

    • E. 

      Curve E

  • 13. 
    A 65-year-old woman, admitted to the hospital with a myocardial infarction, developed a ventricular tachicardia and received an IV injection of lidocaine. The cardiologist knew that the dose given must be within the range of doses that have a high probability of therapeutic success. Which of the following terms best defines this range?
    • A. 

      Intrinsic activity

    • B. 

      Efficacy

    • C. 

      Potency

    • D. 

      Therapeutic index

    • E. 

      Therapeutic window

  • 14. 
    A new beta-blocker was tested in voluntary subjects. The cumulative frequency distribution of subjects showing a decrease of 10 bpm in the heart rate, was plotted against the log dose. Which of the following drug parameters can be determined from this cumulative frequency distribution?
    • A. 

      Affinity

    • B. 

      Median effective dose

    • C. 

      Therapeutic index

    • D. 

      Therapeutic window

    • E. 

      Maximal efficacy

  • 15. 
    Which of the following terms best defines a drug that binds to alpha adrenergic receptors, has no intrinsic activity, and cannot be displaced by epinephrine?
    • A. 

      Competitive antagonist

    • B. 

      Partial agonist

    • C. 

      Chemical antagonist

    • D. 

      Irreversible antagonist

    • E. 

      Functional antagonist

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