Pg Blazer - Online Test Series 2 - Medicine | Attempts: 948

2.

Autoimmune hemolytic anemia is associated with malignancy of which lineage?

A. T cell
B. B cell
C. Pre B cell
D. Pre T cell

Correct Answer

A. B. B cell

Explanation

Autoimmune hemolytic anemia is associated with malignancy of B cell lineage. This means that the condition is often seen in individuals with B cell malignancies, such as B cell lymphomas or chronic lymphocytic leukemia. In autoimmune hemolytic anemia, the immune system mistakenly attacks and destroys red blood cells, leading to anemia. This can be a complication of certain cancers, particularly those arising from B cells.

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3.

Which of the following findings is diagnostic of iron deficiency anemia?

A. Increased TIBC, decreased serum ferritin
B. Decreased TIBC, decreased serum ferritin
C. Increased TIBC, increased serum ferritin
D. Decreased TIBC, increased serum ferritin

Correct Answer

A. A. Increased TIBC, decreased serum ferritin

Explanation

Iron deficiency anemia is characterized by low levels of iron in the body. TIBC (total iron-binding capacity) measures the amount of iron that can be bound to transferrin, a protein that transports iron in the blood. In iron deficiency anemia, TIBC is increased because there is less iron available to bind to transferrin. Serum ferritin is a protein that stores iron, and its levels decrease in iron deficiency anemia because there is less iron to store. Therefore, the correct answer is A. Increased TIBC, decreased serum ferritin.

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4.

A normotensive patient with normal hemoglobin suffered massive blood loss. The following findings would be present in him except:

A. Increased PCV
B. Increased MCV
C. Thrombocytosis
D. Reticulocytosis

Correct Answer

A. A. Increased PCV

Explanation

A normotensive patient with normal hemoglobin who suffers massive blood loss would not have an increased packed cell volume (PCV). PCV is a measure of the percentage of red blood cells in the total blood volume. In this case, the patient has suffered blood loss, which would lead to a decrease in the PCV as the overall blood volume decreases. Therefore, an increased PCV would not be present in this patient.

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5.

Pancytopenia with cellular marrow is seen in:

A. PNH
B. G6PD deficiency
C. Acquired aplastic anemia
D. Thalassemia

Correct Answer

A. A. PNH

Explanation

Pancytopenia refers to a decrease in all three blood cell types: red blood cells, white blood cells, and platelets. When pancytopenia is accompanied by a cellular marrow, it suggests that the bone marrow is still producing cells, but they are being destroyed or damaged before they can mature and enter the bloodstream. PNH (paroxysmal nocturnal hemoglobinuria) is a rare acquired disorder characterized by the destruction of red blood cells, white blood cells, and platelets due to the absence of certain proteins on the cell surface. This leads to pancytopenia with a cellular marrow, making it the correct answer.

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6.

Bone marrow biopsy is absolutely indicated in,

A. Acute leukemia
B. Megaloblastic anemia
C. Hairy cell leukemia
D. Thalassemia

Correct Answer

A. C. Hairy cell leukemia

Explanation

Bone marrow biopsy is absolutely indicated in Hairy cell leukemia. Hairy cell leukemia is a rare type of chronic leukemia that affects the bone marrow and causes abnormal white blood cells to accumulate. A bone marrow biopsy is necessary to confirm the diagnosis of Hairy cell leukemia and assess the extent of bone marrow involvement. It helps in determining the stage of the disease and guiding treatment decisions.

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7.

ln PML, all of the following are seen except :

A. Retinoic acid is used in treatment
B. 15/17 translocation may be seen
C. CD 15/34 both seen in same cell
D. Associated with Disseminated Intravascular Coagulation (DIC)

Correct Answer

A. C. CD 15/34 both seen in same cell

Explanation

In PML (Promyelocytic leukemia), the correct answer is C. CD 15/34 both seen in same cell. CD15 and CD34 are both cell surface markers that are used to identify different types of cells. In PML, CD15 is typically expressed on the surface of the promyelocytes, while CD34 is not usually seen in these cells. Therefore, the presence of both CD15 and CD34 on the same cell would be atypical and not commonly seen in PML.

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8.

80 year old, asymptomatic man present with a Total Leucocyte Count of 1 lakh, with 80% lymphocytes and 20% PMC’s, What is the most probable diagnosis?

A. HIV
B. CML
C. CLL
D. TB

Correct Answer

A. C. CLL

Explanation

The most probable diagnosis in this case is CLL (Chronic Lymphocytic Leukemia). CLL is a type of cancer that starts in the bone marrow and affects the lymphocytes, a type of white blood cell. In this case, the patient is asymptomatic and has a high total leukocyte count, with 80% lymphocytes. These findings are consistent with CLL, as it is characterized by an increased number of mature lymphocytes in the blood. The age of the patient (80 years old) is also typical for CLL, as it commonly affects older individuals.

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9.

Which of the following statements about Mycosis fungoides is not true:

A. lt is the most common form of cutaneous lymphoma
B. Pautriers microabscess
C. lndolent course and easily amenable to treatment
D. Erythroderma seen and spreads to peripheral circulation

Correct Answer

A. C. lndolent course and easily amenable to treatment

Explanation

Mycosis fungoides is a form of cutaneous lymphoma, making statement A true. Pautrier's microabscess is a characteristic histopathological finding in Mycosis fungoides, making statement B true. Erythroderma, which is a widespread redness of the skin, is commonly seen in Mycosis fungoides and the disease can spread to the peripheral circulation, making statement D true. However, Mycosis fungoides is not known for having an indolent course or being easily amenable to treatment, making statement C false.

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10.

Erythropoietin is increased in all of the following conditions except:

A. Hepatocellular carcinoma
B. Renal cell carcinoma
C. Cerebellar Hemangioblastoma
D. Pancreatic carcinoma

Correct Answer

A. D. Pancreatic carcinoma

Explanation

Erythropoietin is a hormone that stimulates the production of red blood cells in the bone marrow. It is primarily produced by the kidneys in response to low oxygen levels in the blood. Hepatocellular carcinoma, renal cell carcinoma, and cerebellar hemangioblastoma are all conditions that can cause low oxygen levels in the blood, leading to an increase in erythropoietin production. However, pancreatic carcinoma does not typically cause low oxygen levels in the blood, so erythropoietin levels would not be increased in this condition.

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Pg Blazer - Online Test Series 2 - Medicine

The most useful therapeutic agent in high altitude pulmonary oedema is:

Quiz Preview

Autoimmune hemolytic anemia is associated with malignancy of which lineage?

Which of the following findings is diagnostic of iron deficiency anemia?

A normotensive patient with normal hemoglobin suffered massive blood loss. The following findings would be present in him except:

Pancytopenia with cellular marrow is seen in:

Bone marrow biopsy is absolutely indicated in,

ln PML, all of the following are seen except :

80 year old, asymptomatic man present with a Total Leucocyte Count of 1 lakh, with 80% lymphocytes and 20% PMC’s, What is the most probable diagnosis?

Which of the following statements about Mycosis fungoides is not true:

Erythropoietin is increased in all of the following conditions except: