Organ Pathology - Handout 4 - Red Blood Cell Disorders

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| Written by Eddy Sidra
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Eddy Sidra
Community Contributor
Quizzes Created: 13 | Total Attempts: 29,565
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Organ Pathology - Handout 4 - Red Blood Cell Disorders - Quiz

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Questions and Answers
  • 1. 

    A normal male hematocrit number would be

    • A. 

      0.36

    • B. 

      150 g/L

    • C. 

      0.45

    • D. 

      120 g/L

    Correct Answer
    C. 0.45
    Explanation
    A normal male hematocrit number refers to the proportion of red blood cells in the total volume of blood. A hematocrit of 0.45 means that 45% of the blood volume is made up of red blood cells. This value falls within the normal range for males, indicating a healthy level of red blood cells in the bloodstream.

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  • 2. 

    For an anemia of a chronic disease, what would be the most appropriate expected MCV finding?

    • A. 

      90 fl

    • B. 

    • C. 

      >100 fl

    • D. 

      Microcytic anemia MCF

    Correct Answer
    A. 90 fl
    Explanation
    Chronic disease is a normocytic anemia where MCV would be between 80-100 fl

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  • 3. 

    Iron deficiency anemia will show which? (Select 2)

    • A. 

      Low iron

    • B. 

      High transferrin

    • C. 

      High ferritin

    • D. 

      Low transferrin

    Correct Answer(s)
    A. Low iron
    B. High transferrin
    Explanation
    Low iron for obvious reasons. High transferrin to make as much iron available as possible.

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  • 4. 

    Your patient is diagnosed with megaloblastic anemia, they are most likely deficient in what? (Select 2)

    • A. 

      Vit. B6

    • B. 

      Vit. B12

    • C. 

      Folate

    • D. 

      Vit. C

    Correct Answer(s)
    B. Vit. B12
    C. Folate
    Explanation
    The patient's diagnosis of megaloblastic anemia suggests a deficiency in two nutrients: folate and vitamin B12. Megaloblastic anemia is characterized by the production of abnormally large red blood cells, which are unable to function properly. Both folate and vitamin B12 are essential for the production of healthy red blood cells. Folate is necessary for DNA synthesis and cell division, while vitamin B12 is required for the maturation of red blood cells. Deficiencies in either of these nutrients can lead to the development of megaloblastic anemia.

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  • 5. 

    Excessive cytokine release is characteristic of which type of anemia?

    • A. 

      Macrocytic

    • B. 

      Anemia of chronic disease

    • C. 

      Iron deficiency anemia

    • D. 

      Megaloblastic anemia

    Correct Answer
    B. Anemia of chronic disease
    Explanation
    Excessive cytokine release is characteristic of anemia of chronic disease. Anemia of chronic disease is a type of anemia that occurs as a result of chronic inflammation or underlying medical conditions such as autoimmune diseases, chronic infections, or malignancies. In these conditions, there is an overproduction of cytokines, which are signaling molecules that regulate the immune response. The excessive cytokine release leads to a disruption in the normal production of red blood cells, resulting in anemia.

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  • 6. 

    Which of the following is not true regarding aplastic anemia?

    • A. 

      There will often be increased levels of circulating blood EPO

    • B. 

      There will be decreased Iron

    • C. 

      The problem is primarily attributed to chronic renal failure

    • D. 

      It is treated with a bone marrow transplant

    • E. 

      It is a stem cell disorder

    Correct Answer
    C. The problem is primarily attributed to chronic renal failure
    Explanation
    Its pathogenesis is rooted in bone marrow failure

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  • 7. 

    Which one of these is the greatest contributor to End Stage Renal Disease?

    • A. 

      High Cholesterol

    • B. 

      Hypertension

    • C. 

      Diabetic Retinopathy

    • D. 

      Diabetic Nephropathy

    Correct Answer
    D. Diabetic Nephropathy
    Explanation
    Hypertension is second most.

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  • 8. 

    One lady has Rheumatoid Arthritis and another is encompassed by toxins and radiation everyday. They both developed the same type of anemia (with very bad prognosis) because of these things. Which type of anemia is it?

    • A. 

      Thalassemia

    • B. 

      Aplastic Anemia

    • C. 

      Polycythemia

    • D. 

      Microcytic anemia

    Correct Answer
    B. Aplastic Anemia
    Explanation
    Aplastic anemia can be caused by autoimmune diseases, toxins, cancer, chemotherapy, drugs and antibiotics.

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  • 9. 

    A Mediterranean girl has been advised to stay away from fava beans. Which sex-linked disorder must one of her parents have?

    • A. 

      G6PDH deficiency

    • B. 

      Incontinentia pigmenti

    • C. 

      Anemia of Endocrine Failure

    • D. 

      Hemophilia

    Correct Answer
    A. G6PDH deficiency
    Explanation
    G6PDH deficiency is a sex-linked disorder that primarily affects males. It is caused by a mutation in the gene responsible for producing the enzyme glucose-6-phosphate dehydrogenase (G6PDH). This enzyme plays a crucial role in protecting red blood cells from oxidative damage. Fava beans contain a substance called vicine, which can trigger a reaction in individuals with G6PDH deficiency, leading to the destruction of red blood cells and the development of anemia. Since the Mediterranean girl has been advised to stay away from fava beans, it suggests that one of her parents must have G6PDH deficiency.

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