Antiviral Agents Practice Quiz

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| By De_aqui
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De_aqui
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Quizzes Created: 1 | Total Attempts: 257
| Attempts: 257
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  • 1/12 Questions

    Amantadine is used for patients infected with Influenza A.

    • True
    • False
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About This Quiz

The 'Antiviral Agents Practice Quiz' assesses knowledge on antiviral treatments for viruses like HSV, VZV, Hepatitis B, and C. It focuses on understanding the correct usage of antiviral drugs such as Amantidine, Lamivudine, and Ribavirin, crucial for medical professionals.

Antiviral Agents Practice Quiz - Quiz

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  • 2. 

    Activation of Acyclovir does not require 3 rounds of phosphorylations.

    • True

    • False

    Correct Answer
    A. False
    Explanation
    Activation of Acyclovir in HSV-infected cells:
    ACV is converted to acylguanosine monophosphate (acylo-GMP) by herpes-specific viral Thymidine Kinase, then to acycloguanosine diphosphate (acylo-GDP) and to acycloguanosine triphosphate (acylo-GTP) by cellular kinases. The process requires 3 ATP molecules.

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  • 3. 

    What is the Tx. of choice for Hep. C virus?

    • Lamivudine

    • IFNa and Ribavirin

    • Adeno dipivoxil

    • IFNa

    Correct Answer
    A. IFNa and Ribavirin
    Explanation
    IFNa and Ribavirin are the treatment of choice for Hepatitis C virus. IFNa (Interferon-alpha) is a type of protein that helps boost the immune system's response to the virus, while Ribavirin is an antiviral medication that works by inhibiting the replication of the virus. The combination of these two drugs has been shown to be effective in suppressing the Hepatitis C virus and improving liver function in patients. Lamivudine and Adeno dipivoxil are not the recommended treatments for Hepatitis C.

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  • 4. 

    Which of the following is not an antiviral dx. for HSV and VZV?

    • Penciclovir

    • Acyclovir

    • Amantidine

    • Iododeoxyuridine

    • Valacyclovir

    • Famciclovir

    • Trifluridine

    Correct Answer
    A. Amantidine
    Explanation
    Amantidine is not an antiviral drug for HSV (Herpes Simplex Virus) and VZV (Varicella-Zoster Virus). Acyclovir, Valacyclovir, Penciclovir, Famciclovir, Iododeoxyuridine, and Trifluridine are all antiviral drugs used to treat HSV and VZV infections. However, Amantidine is primarily used as an antiviral medication for the treatment of influenza A virus.

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  • 5. 

    The chemical structure in the Gag-Pol polyprotein that serves as a natural substrate of HIV-I protease cleavage site is used to develop the peptidomimetic protease inhibitor Ro 31-8959. What sequence of amino acids is used for the peptidomimetic PI?

    • Asparagine-Tyrosine-Proline

    • Glucamine-Asparagine-Tyrosine

    • Serine-Glucamine-Asparagine

    • Proline-Isoleucine-Valine

    Correct Answer
    A. Glucamine-Asparagine-Tyrosine
    Explanation
    The peptidomimetic protease inhibitor Ro 31-8959 is developed based on the chemical structure in the Gag-Pol polyprotein that serves as a natural substrate of HIV-I protease cleavage site. The sequence of amino acids used for the peptidomimetic PI is Glucamine-Asparagine-Tyrosine.

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  • 6. 

    What is the Tx. of choice for Hep. B virus?

    • Lamivudine

    • Ribavirin

    • IFNa

    • Adefovir dipivoxil

    Correct Answer
    A. Lamivudine
    Explanation
    Lamivudine is the treatment of choice for Hepatitis B virus because it is a nucleoside analogue that inhibits the reverse transcriptase enzyme, which is essential for viral replication. It has been shown to effectively suppress viral replication, reduce liver inflammation, and improve liver function in patients with chronic Hepatitis B. Lamivudine is well-tolerated and has a low risk of side effects, making it a suitable option for long-term treatment.

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  • 7. 

    Formivirsen (Vitravene) is:

    • A potent and selective antiviral agent for CMV retinitis

    • An antisense phosphorothioate oligonucleotide that blocks transcription in CMV-infected cells

    • Will not cure CMV retinitis

    • Administered intravitreally (injected into the eye)

    • All of the above

    • None of the above

    Correct Answer
    A. All of the above
    Explanation
    Formivirsen (Vitravene) is a potent and selective antiviral agent for CMV retinitis. It is an antisense phosphorothioate oligonucleotide that blocks transcription in CMV-infected cells. While it is effective in treating CMV retinitis, it does not cure the condition. It is administered intravitreally, meaning it is injected into the eye. Therefore, all of the statements in the answer are correct.

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  • 8. 

    Select only NNRTI

    • Nevirapine

    • Zidovudine (ZDV)

    • Azidothymine (AZT)

    • Dideoxyinosine

    • Stavudine (d4T)

    • Delavirdine

    • Lamivudine (3TC)

    • Dideoxycytidine

    Correct Answer(s)
    A. Nevirapine
    A. Delavirdine
    Explanation
    Nevirapine and Delavirdine are both non-nucleoside reverse transcriptase inhibitors (NNRTIs). NNRTIs are a class of antiretroviral drugs used in the treatment of HIV/AIDS. They work by binding to and inhibiting the reverse transcriptase enzyme, which is necessary for the replication of the HIV virus. By inhibiting this enzyme, NNRTIs prevent the virus from multiplying and spreading throughout the body. Azidothymine (AZT), Zidovudine (ZDV), Dideoxycytidine, Dideoxyinosine, Stavudine (d4T), and Lamivudine (3TC) are nucleoside reverse transcriptase inhibitors (NRTIs), which work in a different way by blocking the reverse transcriptase enzyme at a different site. Therefore, the correct answer is Nevirapine and Delavirdine as they are the only NNRTIs listed.

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  • 9. 

    Select only NARTI

    • Azidothymidine (AZT)

    • Nevirapine

    • Dideoxycytidine

    • Delavirdine

    • Stavudine (d4T)

    • Lamivudine (3TC)

    • Dideoxyinosine

    • Zidovudine (ZDV)

    Correct Answer(s)
    A. Azidothymidine (AZT)
    A. Dideoxycytidine
    A. Stavudine (d4T)
    A. Lamivudine (3TC)
    A. Dideoxyinosine
    A. Zidovudine (ZDV)
    Explanation
    The correct answer includes the drugs Azidothymidine (AZT), Zidovudine (ZDV), Dideoxycytidine, Dideoxyinosine, Stavudine (d4T), and Lamivudine (3TC). These drugs are all nucleoside reverse transcriptase inhibitors (NRTIs) used in the treatment of HIV/AIDS. They work by inhibiting the reverse transcriptase enzyme, which is necessary for the replication of the HIV virus. By blocking this enzyme, these drugs can help slow down the progression of the disease and improve the immune system's ability to fight off infections.

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  • 10. 

    Select only the non-nucleoside antiviral Dx.

    • Amantadine

    • Acyclovir

    • Arildone

    • Phosphonoformate

    • Dideoxyinosine

    • Phosphonoacetic acid

    • Lamivudine

    • RIbavirin

    • Rimantidine

    • Stavudine

    Correct Answer(s)
    A. Amantadine
    A. Arildone
    A. Phosphonoformate
    A. Phosphonoacetic acid
    A. Rimantidine
    Explanation
    The correct answer includes Amantadine, Rimantidine, Phosphonoformate, Phosphonoacetic acid, and Arildone. These are all non-nucleoside antiviral drugs. Amantadine and Rimantidine are used to treat influenza A virus infections, while Phosphonoformate and Phosphonoacetic acid are experimental antiviral agents. Arildone is an antiviral drug used against herpes simplex virus. The other options, such as Acyclovir, RIbavirin, Lamivudine, and Stavudine, are nucleoside antiviral drugs.

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  • Current Version
  • Mar 20, 2023
    Quiz Edited by
    ProProfs Editorial Team
  • Sep 21, 2014
    Quiz Created by
    De_aqui
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