Crack Mci Mock Test Pharmacology

Anti epileptics
1. Barbiturates -phenobarbitone
2. Deoxy barbiturate- primidine
3. Hydantion- phenytoin
4. Iminostilbene -carbamazepine
5. Succi nimide- ethosux imide
6. Aliphatic carboxylic acid
- Valporic acid
7. Benzodiazepines- clonazepam
-Diazepam
- Clobazepam
8. Pheny triazine- vigabatrin
9. Cyclic GABA analogue-gabapentin
10. Venus drugs-vigabatrin
Topiramate
Tiagabine
Levetiracetam

Propranolol worsens chronic obstructive lung disease can precipitate life threatening attack of bronchial asthma.
Propranolol is contraindicated in asthamatics.

- Higjly plasma protein bound
- Inhibits peripheral conversion of T4 to T3
- Less transferred across placenta and in milk.
- Plasma T1/2 1-2 hours.
- SIngle dose acts for 4-8 hours.
- No active metabolic.
- Multiple daily doses needed (2-3)

Classification of NSAID's
Non-selective cox inhibitors
1. Salicylates -Aspirin, Diflunisal
2. Pyrazolone-derivatives
- Phenylbutazone, oxyphenbutazone
3. Indole derivatives -
4. Propionoic acid derivatives-
- - Ibuprofen, Naproxen, kertoprofen, flurbiprofen
Antharanilic acid derivatives
- Mephenamic acid
6. Oxicam derivatives-piroxican, tenoxicam
Pyrrolo pyrrole derivatives-ketorolac
Preferrntial COX2-inhibitors.
-Nimesulide, meloxicam, nabumetone
Selective COX-2 inhibitors.
Celecxib, Antipyretic with poor and inflammatory action.
Analgesic, Antipyretic derivatives-paracetomaol.
1. Para aminophenol derovative -paracetamol.
2. Pyrazolone derivatives-metamizol, propihenazone
3. Benzoxaaocine derivatives-nefopam.

Long-term use of antipsychotic medication can lead to a condition called tardive dyskinesia. Tardive dyskinesia is characterized by involuntary movements of the face, tongue, and other parts of the body. It is believed to be caused by the prolonged use of antipsychotic drugs, particularly first-generation antipsychotics. This side effect can be irreversible and may persist even after discontinuing the medication. It is important for healthcare providers to monitor patients on long-term antipsychotic treatment for the development of tardive dyskinesia and consider alternative treatment options if necessary.

Hypoglycemia due to hyper insulinemia is the most important side effect of i.v quinine it can be prevented by 5% Dextrose infusion.

heparin- Adverse effects
1. Bleeding-hematuria first sign
2. Thrombocytopenia
3. Alopecia-transient and reversible
4. Osteoporosis-on long term use.
5. Hypersensitivity-urticaria, Rigor, fever, anaphylaxis, diathesis.

Cyclophosphamide is a chemotherapy drug that is known to cause hemorrhagic cystitis, which is inflammation and bleeding in the bladder. This side effect occurs due to the toxic effects of the drug on the bladder lining. It can lead to symptoms such as blood in the urine, pain during urination, and frequent urination. Monitoring and management of this side effect is important to prevent complications and ensure patient comfort during cancer treatment.

Acetazolamide Adverse effects
- Acidosis, hypokalemia, drowosiness
- Parasthesias, fatigue, abdominal discomfort.
- Hypersensitivity reactions- fever, rashes
- Bone marrow depression
- Contraindicated in liver disease acid may precipitate hepatic coma.

Cisplatin is a chemotherapy drug that is known to cause various side effects. However, it does not cause cardiomyopathy, which is a disease affecting the heart muscle. Cardiomyopathy can be caused by other factors such as genetics, infections, or certain medications, but not cisplatin.

GIT α Actions -contraction of sphincter
Relaxation of Intestines
Heart -Little action
Blood vessels-Constriction of arterioles and veins
Bladder-Trig one constriction
Uterus-Contraction
Liver-Glycogenolysis.
- Spleenic capsule contraction.
- Neuromuscular transmission fascillated Ach release.
- Insulin secretion inhibited.
- Male sex organs-ejaculation.
- Salivary gland-K+ and water secretion (α1)
- Radial muscles of iris-contraction mydriasis.

Reserpine
- Rauwoolfia sewrpentina-derived alkaloid.
- Higher doses deplete catacholamines and 5 ht in thebrain as well as peripheral nerve endings.
Causes- Sedation. mental depression
- Mild Antipsychotic effect and
- Extra pyramidal symptoms
- Bradycardia, diarrhoea, increased acid secretion in stomach and miosis postural hypotension, suicidal tendency, weight gain, nasal stuffness and impotence.

Bleomycin
It is the mixture of closely related glycopeptides antibiotics having potent and activity.
Use-Testicular and squamous cell carcinoma of skin, head and neck, genito urinary tract and esophagus. Hodgkin's lymphoma.
Side effects-Mucocutaneous toxicity
Pulmonary fibrosis
Myelosuppresion (mild)

Ciproflaxcin interactions
- Plasma concentration of theophylli9ne, caffeine and warfarin are increased by ciproflaxacine due to inhibition of metabolism, toxicity of these drugs can occur.
- NSAID's may enhance the CNS toxicity of FQ's seizures are reported.

Malignant neuron leptic syndrome
- This is a serious complications of narcoleptic medication.
- High mortality 20%
- Muscle rigidity with myonecrosis.
Altered mental status -resembling cataonia.
Autonomic dysfunction
- Hypothermia
- Tachy cardia
Treatment: Intermediate cessation ofthe offending anti payschotic drug as well as lithium of anti cholinergic agents.
- Dopamine agonist-Levodopa, Amantadine and Benzodiazepines, as well as Dantrolene.
- Antipyretics, cooling blankets, fluid and measures to maintain B.P.

Drugs causing vitamin B6 deficiency
- Isoniazide
- L dopa
- Pencillamine
- Cycloserine

Opium is a derivative of Papaver somniferum, which is commonly known as the opium poppy. Nicotiana tobacum is a species of tobacco plant and is not related to opium production. Solanum tuberosum is the scientific name for the potato, and Datura stromonium is a species of plant in the nightshade family. Therefore, the correct answer is Papaver somniferum.

1. Choreocarcinoma -methotrexate- (apparently curative)
2. Wilms tumor -vincristine.

Sucralfate
- Dietary proteins get deposited on sucralfate coat forming and another layer.
- Interactions of sucralfate poly anions with surface proteins of eroded mucros interface with binding of pepsin to digest them.

Weight gain is a common side effect of many medications, including Chlorpromazine, Sodium valproate, and Carbamazepine. However, Phentermine is an appetite suppressant that is commonly used for weight loss. It works by suppressing appetite and increasing metabolism, which can lead to weight loss rather than weight gain. Therefore, weight gain is not seen with Phentermine.