Crack Mci Mock Test Pharmacology

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Quizzes Created: 15 | Total Attempts: 27,906
Questions: 20 | Attempts: 737

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Pharmacology Quizzes & Trivia

Crack mci mock test pharmacology


Questions and Answers
  • 1. 

    I.v. Quinine patient presents with restlessness, the cause is

    • A.

      Hypoglycaemia

    • B.

      Cinchonism

    • C.

      Arrhythmias

    • D.

      Sweating

    Correct Answer
    A. Hypoglycaemia
    Explanation
    Hypoglycemia due to hyper insulinemia is the most important side effect of i.v quinine it can be prevented by 5% Dextrose infusion.

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  • 2. 

    All are seen with Heparin therapy except

    • A.

      Skin necrosis

    • B.

      Thrombosis & thrombocytopenia

    • C.

      Osteoporosis

    • D.

      Alopecia

    Correct Answer
    A. Skin necrosis
    Explanation
    heparin- Adverse effects
    1. Bleeding-hematuria first sign
    2. Thrombocytopenia
    3. Alopecia-transient and reversible
    4. Osteoporosis-on long term use.
    5. Hypersensitivity-urticaria, Rigor, fever, anaphylaxis, diathesis.

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  • 3. 

    The following drug contraindicated in Bronchial asthma

    • A.

      Propranolol

    • B.

      Ipratropium bromide

    • C.

      Theophyline

    • D.

      Ketotifen

    Correct Answer
    A. Propranolol
    Explanation
    Propranolol worsens chronic obstructive lung disease can precipitate life threatening attack of bronchial asthma.
    Propranolol is contraindicated in asthamatics.

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  • 4. 

    Acetazolamide side effects include all except

    • A.

      Indigestion

    • B.

      Drowsiness

    • C.

      Diarrhoea

    • D.

      Paraesthesia

    Correct Answer
    C. Diarrhoea
    Explanation
    Acetazolamide Adverse effects
    - Acidosis, hypokalemia, drowosiness
    - Parasthesias, fatigue, abdominal discomfort.
    - Hypersensitivity reactions- fever, rashes
    - Bone marrow depression
    - Contraindicated in liver disease acid may precipitate hepatic coma.

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  • 5. 

    Sodium valporate is a

    • A.

      Antiepileptic drug

    • B.

      Antihypertensive drug

    • C.

      Antituberculous drug

    • D.

      Antipsychotic drug

    Correct Answer
    A. Antiepileptic drug
    Explanation
    Anti epileptics
    1. Barbiturates -phenobarbitone
    2. Deoxy barbiturate- primidine
    3. Hydantion- phenytoin
    4. Iminostilbene -carbamazepine
    5. Succi nimide- ethosux imide
    6. Aliphatic carboxylic acid
    - Valporic acid
    7. Benzodiazepines- clonazepam
    -Diazepam
    - Clobazepam
    8. Pheny triazine- vigabatrin
    9. Cyclic GABA analogue-gabapentin
    10. Venus drugs-vigabatrin
    Topiramate
    Tiagabine
    Levetiracetam

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  • 6. 

    Vitamin-B6 deficiency is seen with the use of all of the following drugs except

    • A.

      Cycloserine

    • B.

      Cyclosporine

    • C.

      INH

    • D.

      D-Penicillamine

    Correct Answer
    B. Cyclosporine
    Explanation
    Drugs causing vitamin B6 deficiency
    - Isoniazide
    - L dopa
    - Pencillamine
    - Cycloserine

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  • 7. 

    Catecholamine action on α receptors causes

    • A.

      Increased atrial contraction

    • B.

      Increased heart rate

    • C.

      Detrusor relaxation

    • D.

      Gastrointestinal sphincter contraction

    Correct Answer
    D. Gastrointestinal sphincter contraction
    Explanation
    GIT α Actions -contraction of sphincter
    Relaxation of Intestines
    Heart -Little action
    Blood vessels-Constriction of arterioles and veins
    Bladder-Trig one constriction
    Uterus-Contraction
    Liver-Glycogenolysis.
    - Spleenic capsule contraction.
    - Neuromuscular transmission fascillated Ach release.
    - Insulin secretion inhibited.
    - Male sex organs-ejaculation.
    - Salivary gland-K+ and water secretion (α1)
    - Radial muscles of iris-contraction mydriasis.

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  • 8. 

    Treatment of malignant neuroleptic syndrome include all except

    • A.

      Chlorpromazine

    • B.

      Dantrolene

    • C.

      Peripheral cooling

    • D.

      Diazepam

    Correct Answer
    A. Chlorpromazine
    Explanation
    Malignant neuron leptic syndrome
    - This is a serious complications of narcoleptic medication.
    - High mortality 20%
    - Muscle rigidity with myonecrosis.
    Altered mental status -resembling cataonia.
    Autonomic dysfunction
    - Hypothermia
    - Tachy cardia
    Treatment: Intermediate cessation ofthe offending anti payschotic drug as well as lithium of anti cholinergic agents.
    - Dopamine agonist-Levodopa, Amantadine and Benzodiazepines, as well as Dantrolene.
    - Antipyretics, cooling blankets, fluid and measures to maintain B.P.

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  • 9. 

    Cyclophosphamide can cause

    • A.

      Hemorrphagic cystitis

    • B.

      Cardiomyopathy

    • C.

      Neuropathy

    • D.

      Convulsions

    Correct Answer
    A. Hemorrphagic cystitis
    Explanation
    Cyclophosphamide is a chemotherapy drug that is known to cause hemorrhagic cystitis, which is inflammation and bleeding in the bladder. This side effect occurs due to the toxic effects of the drug on the bladder lining. It can lead to symptoms such as blood in the urine, pain during urination, and frequent urination. Monitoring and management of this side effect is important to prevent complications and ensure patient comfort during cancer treatment.

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  • 10. 

    Long-term anti[sychotic use indefinitely causes

    • A.

      Depression

    • B.

      Mania

    • C.

      Schizophrenia

    • D.

      Tardive dyskinesia

    Correct Answer
    D. Tardive dyskinesia
    Explanation
    Long-term use of antipsychotic medication can lead to a condition called tardive dyskinesia. Tardive dyskinesia is characterized by involuntary movements of the face, tongue, and other parts of the body. It is believed to be caused by the prolonged use of antipsychotic drugs, particularly first-generation antipsychotics. This side effect can be irreversible and may persist even after discontinuing the medication. It is important for healthcare providers to monitor patients on long-term antipsychotic treatment for the development of tardive dyskinesia and consider alternative treatment options if necessary.

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  • 11. 

    Opium is a derivative of

    • A.

      Solanum tuberosum

    • B.

      Datura stromonium

    • C.

      Papaver somniferum

    • D.

      Nicotiana tobacum

    Correct Answer
    D. Nicotiana tobacum
    Explanation
    Opium is a derivative of Papaver somniferum, which is commonly known as the opium poppy. Nicotiana tobacum is a species of tobacco plant and is not related to opium production. Solanum tuberosum is the scientific name for the potato, and Datura stromonium is a species of plant in the nightshade family. Therefore, the correct answer is Papaver somniferum.

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  • 12. 

    Weight gain is not seen with

    • A.

      Chlorpromazine

    • B.

      Sodium valproate

    • C.

      Carbamazepine

    • D.

      Phentermine

    Correct Answer
    D. Phentermine
    Explanation
    Weight gain is a common side effect of many medications, including Chlorpromazine, Sodium valproate, and Carbamazepine. However, Phentermine is an appetite suppressant that is commonly used for weight loss. It works by suppressing appetite and increasing metabolism, which can lead to weight loss rather than weight gain. Therefore, weight gain is not seen with Phentermine.

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  • 13. 

    Cisplatin does not cause

    • A.

      Cardiomyopathy

    • B.

      Nephromyopathy

    • C.

      Neuropathy

    • D.

      Tinnitus

    Correct Answer
    A. Cardiomyopathy
    Explanation
    Cisplatin is a chemotherapy drug that is known to cause various side effects. However, it does not cause cardiomyopathy, which is a disease affecting the heart muscle. Cardiomyopathy can be caused by other factors such as genetics, infections, or certain medications, but not cisplatin.

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  • 14. 

    Not an NSAID

    • A.

      Ketoralac

    • B.

      Prednisolone

    • C.

      Acetylsalicylic acid

    • D.

      Ibuprofen

    Correct Answer
    B. Prednisolone
    Explanation
    Classification of NSAID's
    Non-selective cox inhibitors
    1. Salicylates -Aspirin, Diflunisal
    2. Pyrazolone-derivatives
    - Phenylbutazone, oxyphenbutazone
    3. Indole derivatives -
    4. Propionoic acid derivatives-
    - - Ibuprofen, Naproxen, kertoprofen, flurbiprofen
    Antharanilic acid derivatives
    - Mephenamic acid
    6. Oxicam derivatives-piroxican, tenoxicam
    Pyrrolo pyrrole derivatives-ketorolac
    Preferrntial COX2-inhibitors.
    -Nimesulide, meloxicam, nabumetone
    Selective COX-2 inhibitors.
    Celecxib, Antipyretic with poor and inflammatory action.
    Analgesic, Antipyretic derivatives-paracetomaol.
    1. Para aminophenol derovative -paracetamol.
    2. Pyrazolone derivatives-metamizol, propihenazone
    3. Benzoxaaocine derivatives-nefopam.

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  • 15. 

    Chemotherapy is not useful in

    • A.

      Chondrosarcoma

    • B.

      Wilm's tumor

    • C.

      Choriocarcinoma

    • D.

      All

    Correct Answer
    A. Chondrosarcoma
    Explanation
    1. Choreocarcinoma -methotrexate- (apparently curative)
    2. Wilms tumor -vincristine.

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  • 16. 

    Depression occurs as a side effect due to the use of

    • A.

      Reserpine

    • B.

      Propranolol

    • C.

      Morphine

    • D.

      Amphetamine

    Correct Answer
    A. Reserpine
    Explanation
    Reserpine
    - Rauwoolfia sewrpentina-derived alkaloid.
    - Higher doses deplete catacholamines and 5 ht in thebrain as well as peripheral nerve endings.
    Causes- Sedation. mental depression
    - Mild Antipsychotic effect and
    - Extra pyramidal symptoms
    - Bradycardia, diarrhoea, increased acid secretion in stomach and miosis postural hypotension, suicidal tendency, weight gain, nasal stuffness and impotence.

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  • 17. 

    Conversion of T4 to T3 inhibition is associated with

    • A.

      Prophythiouracil

    • B.

      Ampicillin

    • C.

      Amiodorone

    • D.

      Carbimazole

    Correct Answer
    A. Prophythiouracil
    Explanation
    - Higjly plasma protein bound
    - Inhibits peripheral conversion of T4 to T3
    - Less transferred across placenta and in milk.
    - Plasma T1/2 1-2 hours.
    - SIngle dose acts for 4-8 hours.
    - No active metabolic.
    - Multiple daily doses needed (2-3)

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  • 18. 

    Seizure threshold with ciprofloxacin is increased by

    • A.

      Ampicillin

    • B.

      Theophyline

    • C.

      Amiodorome

    • D.

      All of the above

    Correct Answer
    B. Theophyline
    Explanation
    Ciproflaxcin interactions
    - Plasma concentration of theophylli9ne, caffeine and warfarin are increased by ciproflaxacine due to inhibition of metabolism, toxicity of these drugs can occur.
    - NSAID's may enhance the CNS toxicity of FQ's seizures are reported.

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  • 19. 

    The following appears to effect the  integrity of the adherent gel of Sucralfate action

    • A.

      Antacids

    • B.

      Food

    • C.

      Proteins in foodstuffs

    • D.

      Mucin

    Correct Answer
    C. Proteins in foodstuffs
    Explanation
    Sucralfate
    - Dietary proteins get deposited on sucralfate coat forming and another layer.
    - Interactions of sucralfate poly anions with surface proteins of eroded mucros interface with binding of pepsin to digest them.

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  • 20. 

    Lung fibrosis is caused by

    • A.

      Streptomycin

    • B.

      Actinomycin

    • C.

      Bleomycin

    • D.

      All

    Correct Answer
    C. Bleomycin
    Explanation
    Bleomycin
    It is the mixture of closely related glycopeptides antibiotics having potent and activity.
    Use-Testicular and squamous cell carcinoma of skin, head and neck, genito urinary tract and esophagus. Hodgkin's lymphoma.
    Side effects-Mucocutaneous toxicity
    Pulmonary fibrosis
    Myelosuppresion (mild)

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