Nausea And Vomiting Quiz

52 Questions | Total Attempts: 672

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Nausea And Vomiting Quiz

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Questions and Answers
  • 1. 
    Which 5HT-3 receptor antagonist is used for acute AND delayed N/V?
    • A. 

      Ondansetron

    • B. 

      Palonsetron

    • C. 

      Granisetron

    • D. 

      Dolasetron

  • 2. 
    Which dose is correct when used in combination with aprepitant?
    • A. 

      Ondansetron 32mg IV

    • B. 

      Dexamethasone 12mg IV

    • C. 

      Dexamethasone 20mg IV

    • D. 

      Palonsetron 0.5mg IV

  • 3. 
    Which neurotransmitter does NK1RA (Neurokinin-1 Receptor Antagonist) affect?
    • A. 

      Substance P

    • B. 

      Dopamine

    • C. 

      GABA

    • D. 

      Serotonin

  • 4. 
    Acute N/V occurs within the first...
    • A. 

      24 hours

    • B. 

      6 hours

    • C. 

      48 hours

    • D. 

      12 hours

  • 5. 
    Which drugs cause significant delayed N/V? (select all that apply)
    • A. 

      Carboplatin

    • B. 

      Cyclophosphamide

    • C. 

      Cisplatin

    • D. 

      Doxorubicin

    • E. 

      Vincristine

    • F. 

      Etoposide

  • 6. 
    Which NK1RA does NOT inhibit CYP3A4?
    • A. 

      Rolapitant

    • B. 

      Netupitant

    • C. 

      Aprepitant

    • D. 

      All inhibit CYP3A4

  • 7. 
    Which drug causes severe extravasation reactions?
    • A. 

      Promethazine

    • B. 

      Metoclopramide

    • C. 

      Aprepitant

    • D. 

      Haloperidol

  • 8. 
    Which is correct dosing (Highly Emetogenic Cheotherapy) HEC?
    • A. 

      Zofran 16mg IV, Dexamethasone 20mg IV, Fosaprepitant 150mg IV

    • B. 

      Zofran 32mg IV, Dexamethasone 20mg IV, Olanzapine 10mg PO

    • C. 

      Aloxi 0.25mg IV, Dexamethasone 12mg IV, Olanzapine 10mg PO

    • D. 

      Zofran 16mg PO, Dexamethasone 12mg PO, Aprepitant 125mg PO

  • 9. 
    Neurotransmitters involved in N/V include: (select all that apply)
    • A. 

      Dopamine

    • B. 

      Histamine

    • C. 

      Endorphins

    • D. 

      Serotonin

    • E. 

      Acetylcholine

    • F. 

      Substance P

    • G. 

      GABA

    • H. 

      Norepinephrine

    • I. 

      Glutamate

  • 10. 
    Risk factors for Chemotherapy Induced Nausea and Vomiting (CINV) include:
    • A. 

      Age < 50

    • B. 

      Females

    • C. 

      Males

    • D. 

      Infrequent alcohol use

    • E. 

      Frequent alcohol use

    • F. 

      History of motion sickness

    • G. 

      Prior exposure to chemotherapy

    • H. 

      No previous exposure to chemotherapy

  • 11. 
    What is the correct dosing and route for Dolasetron for CINV?
    • A. 

      100mg PO

    • B. 

      100mg IV

    • C. 

      100mg topically

    • D. 

      50mg PO

  • 12. 
    What is the correct dosing and route for Granisetron for CINV? (select all that apply)
    • A. 

      2mg PO

    • B. 

      1mg IV

    • C. 

      3.1mg/hr topically (patch)

    • D. 

      1mg/hr topically (patch)

    • E. 

      2mg IV

    • F. 

      1mg PO

  • 13. 
    What is the correct dosing and route for Ondansetron for CINV? (select all that apply)
    • A. 

      16-24mg PO

    • B. 

      8-16mg IV

    • C. 

      4-8mg IV

    • D. 

      4-8mg PO

  • 14. 
    What is the correct dosing and route for Palonsetron for CINV?
    • A. 

      0.25mg IV

    • B. 

      0.25mg PO

    • C. 

      25mg IV

    • D. 

      25mg PO

  • 15. 
    5-HT3 antagonists are effective for delayed CINV (Chemotherapy Induced Nausea and Vomiting).
    • A. 

      True

    • B. 

      False

  • 16. 
    5-HT3 antagonist work by blocking enterochromaffin cells in the GI and blocking serotonin receptors in the medulla.
    • A. 

      True

    • B. 

      False

  • 17. 
    Increasing the dose of a 5-HT3 antagonist will always increase the antiemetic effect but will also increase the side effects.
    • A. 

      True

    • B. 

      False

  • 18. 
    IV 5HT-3 antagonists should be given ____ prior to chemo, while PO should be given ____ prior to chemo.
    • A. 

      30; 60

    • B. 

      60; 30

    • C. 

      10; 30

    • D. 

      15; 30

  • 19. 
    To avoid QT prolongation, the dose of ondansetron should not exceed ____mg/dose.
    • A. 

      32

    • B. 

      16

    • C. 

      12

    • D. 

      48

  • 20. 
    Dexamethasone is FDA approved for the prevention of CINV (Chemotherapy Induced Nausea and Vomiting).
    • A. 

      True

    • B. 

      False

  • 21. 
    Dexamethasone works synergistically with ___________ and __________ to increase effectiveness by 20-30%
    • A. 

      Metoclopramide

    • B. 

      5-HT3 antagonists

    • C. 

      Olanzapine

    • D. 

      Lorazepam

  • 22. 
    Dexamethasone is used in acute and delayed N/V.
    • A. 

      True

    • B. 

      False

  • 23. 
    Dexamethasone can cause transient perineal, vaginal, and renal burning so it should be at a slow rate for IV administration.
    • A. 

      True

    • B. 

      False

  • 24. 
    Dexamethasone does not have any major drug-drug interactions.
    • A. 

      True

    • B. 

      False

  • 25. 
    Which is the correct dosing and route for Fosaprepitant for CINV?
    • A. 

      150mg IV

    • B. 

      125mg PO

    • C. 

      150mg IV

    • D. 

      80mg PO

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